CN113546138A - Skin care ointment and preparation method thereof - Google Patents
Skin care ointment and preparation method thereof Download PDFInfo
- Publication number
- CN113546138A CN113546138A CN202110899747.5A CN202110899747A CN113546138A CN 113546138 A CN113546138 A CN 113546138A CN 202110899747 A CN202110899747 A CN 202110899747A CN 113546138 A CN113546138 A CN 113546138A
- Authority
- CN
- China
- Prior art keywords
- parts
- temperature
- stirring
- extract
- skin care
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Sustainable Development (AREA)
- Toxicology (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to the technical field of biology, and particularly relates to a skin care ointment and a preparation method thereof, wherein the skin care ointment comprises the following components in parts by mass: 40-60 parts of vaseline, 2-8 parts of microcrystalline wax, 3-4 parts of monoglyceride stearate, 1.5-2.5 parts of cetostearyl alcohol, 2-5 parts of triglyceryl stearate, 3-5 parts of caprylic/capric triglyceride, 4-6 parts of zinc oxide, 0.4-0.6 part of purslane extract, 0.4-0.6 part of white willow bark extract, 0.4-0.6 part of rice chaff extract, 0.4-0.5 part of ferulic acid, 4-6 parts of glycerol, 2-3 parts of panthenol, 0.4-0.5 part of allantoin, 60.5-0.6 part of vitamin B, 0.3-0.4 part of dipotassium glycyrrhizinate, 3-5 parts of pentanediol, 0.02-0.03 part of copper sulfate, 0.015-0.018 part of zinc sulfate, 0.3-1.3 part of yeast glucan and 26-40 parts of water. The invention solves the problem of the existing dermatitis plaster that antibiotics are abused, and the allantoin is matched with the white willow bark extract, the rice chaff extract and the yeast glucan to form a cell repair system, thereby effectively promoting the repair of the skin barrier function.
Description
Technical Field
The invention belongs to the technical field of biology, and particularly relates to a skin care ointment and a preparation method thereof.
Background
Dermatitis is a relatively common disease in clinic, and is classified into contact dermatitis, eczema, allergic dermatitis and other types of dermatitis according to the dermatitis classification recommended by the allergic organization in the world. Dermatitis represents an allergic reaction of the skin to various substances such as chemicals, proteins, bacteria, and fungi. At present, for dermatitis treatment medicines, the western medicine mainly adopts corticoids, and antihistamines and antibiotics medicines are taken orally, wherein the antihistamines mainly play a role in calming and relieving itching, the antibiotics are used for infected skin lesions, and the medicine containing the corticoids has a remarkable curative effect on mild dermatitis when being externally applied. However, in recent years, skin damage caused by external hormone preparations has increased sharply, and adverse reactions have become a social problem of high concern. If the drug containing the corticoids is frequently or massively used for a long time, sensitive skin is caused, and the whole body of the skin can be sensitive; a large amount of external hormone can be absorbed by skin to enter blood circulation for a long time, causing diabetes and the like; abuse of antibiotics may lead to increased bacterial resistance and reduced immune function of the body, which leads to repeated and difficult recovery.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a skin care ointment, which solves the problem of the existing dermatitis ointment that antibiotics are abused, and the allantoin is matched with white willow bark extract, rice chaff extract and yeast glucan to form a cell repair system, so that the repair of the skin barrier function is effectively promoted.
In order to achieve the technical purpose, the technical scheme of the invention is as follows:
a skin care ointment comprises the following components in parts by mass:
40-60 parts of vaseline, 2-8 parts of microcrystalline wax, 3-4 parts of monoglyceride stearate, 1.5-2.5 parts of cetostearyl alcohol, 2-5 parts of triglyceryl stearate, 3-5 parts of caprylic/capric triglyceride, 4-6 parts of zinc oxide, 0.4-0.6 part of purslane extract, 0.4-0.6 part of white willow bark extract, 0.4-0.6 part of rice chaff extract, 0.4-0.5 part of ferulic acid, 4-6 parts of glycerol, 2-3 parts of panthenol, 0.4-0.5 part of allantoin, 60.5-0.6 part of vitamin B, 0.3-0.4 part of dipotassium glycyrrhizinate, 3-5 parts of pentanediol, 0.02-0.03 part of copper sulfate, 0.015-0.018 part of zinc sulfate, 0.3-1.3 part of yeast glucan and 26-40 parts of water.
Further, the mass ratio of the ointment is as follows:
40-50 parts of vaseline, 2-4 parts of microcrystalline wax, 3.0-3.4 parts of monoglyceride stearate, 1.5-2.0 parts of cetostearyl alcohol, 2-3 parts of triglyceryl stearate, 3-4 parts of caprylic/capric triglyceride, 4-5 parts of zinc oxide, 0.4-0.6 part of purslane extract, 0.4-0.6 part of white willow bark extract, 0.4-0.6 part of rice chaff extract, 0.4-0.5 part of ferulic acid, 4-5 parts of glycerol, 2-3 parts of panthenol, 0.4-0.5 part of allantoin, 60.5-0.6 part of vitamin B, 0.3-0.4 part of dipotassium glycyrrhizinate, 3-4 parts of pentanediol, 0.02-0.03 part of copper sulfate, 0.015-0.018 part of zinc sulfate, 0.3-0.7 part of glucan and 26-40 parts of water.
Still further, the mass ratio of the ointment is as follows:
40 parts of vaseline, 2 parts of microcrystalline wax, 3.2 parts of monoglyceride stearate, 1.8 parts of cetostearyl alcohol, 3 parts of triglycerol stearate, 3 parts of caprylic/capric triglyceride, 5 parts of zinc oxide, 0.5 part of purslane extract, 0.5 part of white willow bark extract, 0.5 part of rice chaff extract, 0.5 part of ferulic acid, 4 parts of glycerol, 2 parts of panthenol, 0.4 part of allantoin, 60.5 parts of vitamin B, 0.3 part of dipotassium glycyrrhizinate, 3 parts of pentanediol, 0.02 part of copper sulfate, 0.015 part of zinc sulfate, 0.5 part of yeast glucan and 34 parts of water.
The vaseline is smeared on the skin to form a film on the surface, so that the water is not easy to evaporate and dissipate, the skin can be kept in a moist state, and bacteria in the air can be prevented from contacting with the skin, thereby reducing the possibility of infection.
The flavone and saponin contained in herba Portulacae have effects of scavenging free radicals and resisting oxidation, and can be used for delaying skin aging and improving skin comfort. The vegetable polysaccharide and vitamins in herba Portulacae extract can nourish skin and promote endocrine system of squamous epithelial cell to be normal, and reduce callosity and stratum corneum transformation caused by dryness. The carbohydrates in the purslane extracting solution can gather vascular smooth muscles, have the nerve center and peripheral nerve functions of gathering effect, and can relieve skin and inhibit skin itching caused by dryness.
The main active ingredients in the white willow bark extract are salicin and glucan, the salicin is an inhibitor of oxidase (NADH oxidase), has the effects of resisting wrinkles and aging, and can increase the glossiness and elasticity of skin; has aspirin-like property and anti-inflammatory effect, and can be used for relieving facial acne, herpetic inflammation and sunburn. Salicin plays an important role in the production and maintenance of collagen, one of key proteins in the skin, so that the salicin can increase the elasticity of the skin and achieve the anti-wrinkle effect, has a certain anti-inflammatory effect due to the aspirin-like property, and can be used for relieving facial acne, herpetic inflammation and sunburn.
Ferulic acid mainly has whitening, anti-radiation and anti-oxidation effects, is rich in protein and fatty acid, and is an indispensable trace element for the duration of human vitality. The ferulic acid can fully absorb vitamins. Ferulic acid has strong antioxidant activity as a phenolic plant component, and has great promotion effect on human health. The ferulic acid can obviously increase the content of glutathione and nicotinamide adenine dinucleotide phosphate in irradiated cells and has protective effect on irradiated endothelial cells. Ferulic acid can inhibit free radical producing enzyme of living body, and increase free radical scavenging enzyme. Meanwhile, ferulic acid can greatly enhance the activities of the awake reductase and the glutaminyl transsulfurase and control the proportion of the active tyrosinase.
Panthenol, also known as panthenol, is mainly provitamin B5, and has effects of stimulating skin cell division and regeneration, moisturizing and whitening skin, promoting skin wound healing, and relieving inflammation and killing bacteria. Panthenol is a vitamin compound, and is applied to the skin to produce vitamin B25 after being absorbed by the skin, thus being beneficial to protecting the skin and relieving the skin from stains, wrinkles, melanin and the like.
Allantoin is a derivative of uric acid, which acts as an antioxidant and produces allantoin after the action of free radicals. Research shows that allantoin can directly act on keratin of skin, increase and promote hydration ability of stratum corneum, reduce water loss, moisten skin to make skin smooth, moist and pliable, and relieve and treat xerosis cutis. Meanwhile, allantoin also has the physiological functions of promoting cell growth, accelerating wound healing and softening keratin.
The pentanediol is used as an emollient and a humectant, has the effects of moisturizing the skin while preserving the skin, can improve the skin feeling of the product, and is mild and free of irritation and the like. The pentanediol has antibacterial activity, high formula flexibility, and is not affected by hydrolysis, temperature and pH value.
The rice chaff extract has antioxidant, anti-mutation and anticancer activities; promoting skin collagen regeneration, enhancing cell basal layer cell activity, and keeping skin elasticity and compactness; resisting oxidation, inhibiting free radical activity, and regulating skin immunity; lightening melanin deposition, and renewing skin cells; the moisture retention of the skin is increased, and skin cells are activated and renewed; anti-allergy and protective effect, and can protect skin from external injury.
The yeast glucan has strong biological activity of enhancing immunity, removing toxin, resisting radiation, repairing cells and reducing blood fat. The active structure of yeast glucans is a polysaccharide composed of glucose units, most of which are bound via β -1,3, which is the way glucose chains are attached. It has unique reverse triple helix structure, and can neutralize toxin in vivo, promote hemopoietic function, activate macrophage, neutrophil, etc., thus can increase the content of leucocyte element, cytokinin and special antibody, and has excellent repairing effect on damaged cell while stimulating the immune system of body comprehensively.
The preparation method of the skin care ointment comprises the following steps:
step 1, stirring cetostearyl alcohol, triglycerol stearate, caprylic/capric triglyceride, purslane extract, white willow bark extract, rice chaff extract, ferulic acid, panthenol, allantoin, vitamin B6, dipotassium glycyrrhizinate, pentanediol, copper sulfate, zinc sulfate and yeast glucan at constant temperature to form mixed powder, and then performing ball milling and crushing to form mixed fine powder, wherein the stirring temperature at constant temperature is 10-30 ℃, and the stirring speed is 500-800 r/min; the ball milling pressure of the ball milling and crushing is 0.5-0.9MPa, and the temperature is 20-30 ℃;
step 2, uniformly stirring glycerol and distilled water to form a mixed solution, adding mixed fine powder and performing ultrasonic dispersion to form a mixed dissolved solution, wherein the stirring speed is 1000-2000r/min, the adding speed of the mixed fine powder is 10-20g/min, the ultrasonic dispersion temperature is 20-50 ℃, and the ultrasonic frequency is 40-80 kHz;
step 3, adding microcrystalline wax and zinc oxide into the mixed solution, and rapidly stirring until the microcrystalline wax and the zinc oxide are completely dispersed to obtain microemulsion; the speed of the rapid stirring is 2000-2500r/min, and the temperature is 30-50 ℃;
and 4, adding vaseline into the microemulsion, and carrying out constant-temperature ultrasound for 40-80min to obtain the nursing ointment, wherein the constant-temperature ultrasound temperature is 30-40 ℃, and the ultrasound frequency is 60-90 kHz.
The zinc oxide adopts micro-nano zinc oxide fine powder, and the preparation method of the zinc oxide comprises the following steps: a1, adding zinc chloride into ether, and stirring to form a stable dissolved solution, wherein the concentration of the zinc chloride in the ether is 30-70g/L, the stirring temperature is 10-20 ℃, and the stirring speed is 500-900 r/min; a2, adding oxalic acid into ether, and stirring uniformly to form an oxalic acid solution, wherein the concentration of the oxalic acid in the ether is 5-10g/L, and the stirring speed is 1000-2000 r/min; a3, uniformly spraying the oxalic acid solution into the solutionPerforming constant temperature ultrasonic treatment for 10-20min to obtain suspension; the molar weight of oxalic acid in the oxalic acid dissolving solution is 130% of that of zinc chloride in the dissolving solution, the spraying speed is 2-4mL/min, and the area is 10-200cm2The temperature of constant temperature ultrasonic is 5-10 ℃, and the ultrasonic frequency is 40-80 kHz; a4, spraying the suspension at constant temperature, keeping the temperature, standing for 2-4h, and blowing dry nitrogen to obtain micro-nano particles; the spraying amount of the constant-temperature spraying is 2-10mL/min, and the spraying area is 10-100cm2The temperature is 100-130 ℃, and the temperature for heat preservation and standing is 100-120 ℃; the standing pressure is 0.2-0.3 MPa. Zinc oxide is an important and widely used sunscreen agent and belongs to a physical sunscreen agent, and the principle of shielding ultraviolet rays is absorption and scattering. Zinc oxide belongs to an N-type semiconductor, and electrons in the valence band can undergo energy transition in ultraviolet rays, which is the principle of absorption of ultraviolet rays. The function of scattering ultraviolet rays is related to the particle size of the material, and when the size is much smaller than the wavelength of ultraviolet rays, the particles can scatter the ultraviolet rays acting thereon in all directions, thereby reducing the intensity of the ultraviolet rays in the irradiation direction. In the preparation process of the micro-nano zinc oxide particles, a stable dissolving system is formed by utilizing the co-solubility of zinc chloride and oxalic acid in diethyl ether, zinc oxalate and hydrogen chloride are formed in the reaction process, meanwhile, the oxalic acid diethyl ether liquid is sprayed into the dissolving liquid, the forming speed of zinc oxalate particles is effectively controlled, meanwhile, based on the addition dispersibility of oxalic acid, the zinc oxalate forms dispersive deposition and forms a crystal structure, and in the subsequent spraying process, the zinc oxalate is heated and decomposed to form zinc oxide and gas, so that gas-solid separation is achieved, and the micro-nano zinc oxide is obtained.
The preparation method of the yeast glucan comprises the following steps:
step 1, adding common yeast cell walls into distilled water, stirring uniformly to form a suspension, then slowly adding calcium oxide, sealing and stirring for 2-4h, preserving heat for 2-4h, and centrifuging to obtain a precipitate; the concentration of the yeast cell wall in the distilled water is 30-50g/L, and the stirring speed for uniformly stirring is 500-800 r/min; the adding amount of the calcium oxide is 20-40% of the cell wall mass of the common yeast, the slow adding speed is 1-2g/L, and the stirring speed of sealing stirring is 1000-2000 g/L; the temperature of heat preservation is 80-90 ℃;
step 2, adding the precipitate into distilled water, stirring, adding protease for enzymolysis for 4-6h at constant temperature, then dropwise adding dilute hydrochloric acid until the solution is acidic, stirring at constant temperature for reaction for 1-3h, centrifuging, and washing with water to obtain insoluble substances; the concentration of the precipitate in distilled water is 100-300g/L, the stirring speed is 500-1000r/min, the adding amount of the protease is 0.05-0.15% of the mass of the precipitate, the protease is alkaline protease, and the temperature of constant-temperature enzymolysis is 30-40 ℃; the pH value of the dilute hydrochloric acid is 3-5, the dropping speed is 2-5mL/min, the acidity after dropping is 4-5, the temperature of the constant-temperature stirring reaction is 10-30 ℃, and the stirring speed is 1000 r/min;
step 3, adding insoluble substances into acetone for microwave reaction for 2-5h, filtering, and freeze-drying to obtain yeast glucan powder; the concentration of the insoluble substances in the acetone in the step 3 is 30-50g/L, the temperature of the microwave reaction is 20-30 ℃, and the power is 500-700W; the freeze drying comprises pre-freezing at-70 deg.C for 22h, and freeze drying at-60 deg.C for 6-10 h.
In the process of the yeast glucan, calcium oxide is used as a heating agent, and is converted into calcium hydroxide in the process of reaction with distilled water, a large amount of heat is released, yeast cell walls are cooked to cause cell wall curing, and meanwhile, excessive calcium oxide can generate enough heat to form deep curing, so that the stability of a curing frame in the yeast cell walls is ensured, and the yeast glucan is completely released; calcium hydroxide belongs to a slightly soluble structure, and with the addition of calcium oxide and the conversion of calcium hydroxide after the addition, excessive calcium hydroxide can form crystals to form precipitates; when the precipitate is taken as a solute, calcium hydroxide is also converted into a precipitate dissolving solution, and a good constant-temperature enzymolysis effect is achieved by matching with the synergistic effect of alkaline protease, and further, the protease is stimulated by calcium ions to achieve the effect of improving the enzymolysis effect and form an alkali extraction effect; when the pH value of the dilute hydrochloric acid is adjusted to reach an acidic system, the calcium hydroxide is converted into calcium chloride to form good dissolution, and the calcium hydroxide in the precipitate is converted into calcium chloride, so that calcium hydroxide impurities in the precipitate are reduced, and meanwhile, the constant-temperature stirring under the acidic condition can generate an acid extraction effect; thereby improving the extraction amount of the yeast glucan. In the process, the microwave reaction is adopted to promote the precipitate to form vibration dispersion, and simultaneously promote the impurities in the precipitate to be quickly dissolved, so that the residue of the impurities is reduced. The glucan prepared by the method has a good activity effect, and is beneficial to improving the performance of the glucan and being used together with other materials.
From the above description, it can be seen that the present invention has the following advantages:
1. the invention solves the problem of the existing dermatitis plaster that antibiotics are abused, and the allantoin is matched with the white willow bark extract, the rice chaff extract and the yeast glucan to form a cell repair system, thereby effectively promoting the repair of the skin barrier function.
2. The invention utilizes zinc oxide to form a radiation protection system by matching yeast glucan, the zinc oxide has good physical sun-screening effect, the ultraviolet intensity of unit area is effectively reduced, the ultraviolet radiation is effectively reduced, and meanwhile, the radiation-resistant effect of glucan is the result of promoting the hematopoietic function. The yeast glucan can enhance the generating activity of blood cells, including the generation of granulocytes, the generation of mononuclear leukocytes and organ tissue cells, so that body cells damaged by lethal dose of radiation are recovered; therefore, the combination of the two greatly improves the formation of a protective layer on the skin under the irradiation of ultraviolet light. Furthermore, zinc oxide can form free radicals while forming a sun-screening system, so that adverse effects are caused on healing of dermatitis wounds, and in order to solve the problem, the rice chaff extract and the ferulic acid form a good free radical inhibition effect, so that the generation of free radicals on the surface of the skin is prevented, the transfer of free radicals in the ointment can be effectively prevented, and meanwhile, the purslane extract, the yeast glucan and the white willow bark extract can play a role in eliminating the free radicals; based on the inhibition and elimination of free radicals, the influence of the free radicals caused by zinc oxide can be effectively avoided.
3. According to the invention, a composite structure is formed by the self hydroxyl structure of materials such as glycerol and the like and the active hydroxyl formed by the micro-nano zinc oxide in water, so that uniform dispersion is ensured, and the agglomeration problem is reduced.
4. The invention utilizes the water retention and barrier effect of vaseline, combines the hydration ability of the allantoin to stimulate the cuticle and the moisturizing effect of pentanediol to form the moisturizing and nourishing effect, and forms the multi-effect water retention effect by the water retention performance of glycerol.
5. The invention can be applied to the moisture retention and the nourishment of daily skin, the auxiliary treatment of common skin diseases and the maintenance of problem skin.
6. The ointment prepared by the invention does not contain hormone, antibiotics and alcohol, basically has no allergy phenomenon, and has fine paste body, good ductility and no pollution.
Detailed Description
A specific embodiment of the present invention will be described in detail with reference to examples, but the present invention is not limited to the claims.
Example 1
A skin care ointment comprises the following components in parts by mass:
40g of vaseline, 2g of microcrystalline wax, 3g of monoglyceride stearate, 1.5g of hexadecanol, 2g of triglycerol stearate, 3g of caprylic/capric triglyceride, 4g of zinc oxide, 0.4g of purslane extract, 0.4g of white willow bark extract, 0.4g of rice chaff extract, 0.4g of ferulic acid, 4g of glycerol, 2g of panthenol, 0.4g of allantoin, 60.5 g of vitamin B, 0.3g of dipotassium glycyrrhizinate, 3g of pentanediol, 0.02g of copper sulfate, 0.015g of zinc sulfate, 0.3g of yeast glucan and 26g of water.
The preparation method of the skin care ointment comprises the following steps:
step 1, stirring cetostearyl alcohol, triglycerol stearate, caprylic/capric triglyceride, purslane extract, white willow bark extract, rice chaff extract, ferulic acid, panthenol, allantoin, vitamin B6, dipotassium glycyrrhizinate, pentanediol, copper sulfate, zinc sulfate and yeast glucan at constant temperature to form mixed powder, and then performing ball milling to obtain mixed fine powder, wherein the stirring temperature at constant temperature is 10 ℃ and the stirring speed is 500 r/min; the ball milling pressure of the ball milling and crushing is 0.5MPa, and the temperature is 20 ℃;
step 2, uniformly stirring glycerol and distilled water to form a mixed solution, adding the mixed fine powder, and performing ultrasonic dispersion to form a mixed dissolved solution, wherein the stirring speed is 1000r/min, the adding speed of the mixed fine powder is 10g/min, the ultrasonic dispersion temperature is 20 ℃, and the ultrasonic frequency is 40 kHz;
step 3, adding microcrystalline wax and zinc oxide into the mixed solution, and rapidly stirring until the microcrystalline wax and the zinc oxide are completely dispersed to obtain microemulsion; the speed of the rapid stirring is 2000r/min, and the temperature is 30 ℃;
and 4, adding vaseline into the microemulsion, and carrying out constant-temperature ultrasound for 40min to obtain the nursing ointment, wherein the constant-temperature ultrasound temperature is 30 ℃, and the ultrasound frequency is 60 kHz.
The zinc oxide adopts micro-nano zinc oxide fine powder, and the preparation method of the zinc oxide comprises the following steps: a1, adding zinc chloride into ether, and stirring to form a stable dissolved solution, wherein the concentration of the zinc chloride in the ether is 30g/L, the stirring temperature is 10 ℃, and the stirring speed is 500 r/min; a2, adding oxalic acid into ether, and stirring uniformly to form an oxalic acid solution, wherein the concentration of the oxalic acid in the ether is 5g/L, and the stirring speed is 1000 r/min; a3, uniformly spraying an oxalic acid solution into the solution, and carrying out constant-temperature ultrasonic treatment for 10min to obtain a suspension; the molar weight of oxalic acid in the oxalic acid solution is 100 percent of the molar weight of zinc chloride in the solution, the spraying speed is 2mL/min, and the area is 10cm2The temperature of constant temperature ultrasonic is 5 ℃, and the ultrasonic frequency is 40 kHz; a4, spraying the suspension at constant temperature, keeping the temperature and standing for 2 hours, and blowing dry nitrogen to obtain micro-nano particles; the spraying amount of the constant-temperature spraying is 2mL/min, and the spraying area is 10cm2The temperature is 100 ℃, and the temperature for heat preservation and standing is 100 ℃; the standing pressure is 0.2 MPa.
The preparation method of the yeast glucan comprises the following steps: b1, adding common yeast cell walls into distilled water, uniformly stirring to form a suspension, slowly adding calcium oxide, sealing and stirring for 2 hours, preserving heat for 2 hours, and centrifuging to obtain a precipitate; the concentration of the yeast cell walls in distilled water is 30g/L, and the stirring speed for uniformly stirring is 500 r/min; the adding amount of the calcium oxide is 20 percent of the mass of the cell wall of the common yeast, the slow adding speed is 1g/L, and the stirring speed of sealing and stirring is 1000 g/L; the temperature of heat preservation is 80 ℃; b2, adding the precipitate into distilled water, stirring, adding protease for enzymolysis at constant temperature for 4h, then dropwise adding dilute hydrochloric acid until the solution is acidic, stirring at constant temperature for reaction for 1h, centrifuging, and washing with water to obtain insoluble substances; the concentration of the precipitate in distilled water is 100g/L, the stirring speed is 500r/min, the adding amount of the protease is 0.05 percent of the mass of the precipitate, the protease is alkaline protease, and the temperature of constant-temperature enzymolysis is 30 ℃; the pH value of the dilute hydrochloric acid is 3, the dropping speed is 2mL/min, the acidity after dropping is 4, the temperature of constant-temperature stirring reaction is 10 ℃, and the stirring speed is 500 r/min; b3, adding insoluble substances into acetone, performing microwave reaction for 2 hours, filtering, and freeze-drying to obtain yeast glucan powder; the concentration of the insoluble substances in the acetone in the step 3 is 30g/L, the temperature of the microwave reaction is 20 ℃, and the power is 500W; the freeze drying comprises pre-freezing at-70 deg.C for 22h, and freeze drying at-60 deg.C for 6 h.
Example 2
A skin care ointment comprises the following components in parts by mass:
60g of vaseline, 8g of microcrystalline wax, 4g of monoglyceride stearate, 2.5g of hexadecanol, 5g of triglycerol stearate, 5g of caprylic/capric triglyceride, 6g of zinc oxide, 0.6g of purslane extract, 0.6g of white willow bark extract, 0.6g of rice chaff extract, 0.5g of ferulic acid, 6g of glycerol, 3g of panthenol, 0.5g of allantoin, 60.6 g of vitamin B, 0.4g of dipotassium glycyrrhizinate, 5g of pentanediol, 0.03g of copper sulfate, 0.018g of zinc sulfate, 1.3g of yeast glucan and 40g of water.
The preparation method of the skin care ointment comprises the following steps:
step 1, stirring cetostearyl alcohol, triglycerol stearate, caprylic/capric triglyceride, purslane extract, white willow bark extract, rice chaff extract, ferulic acid, panthenol, allantoin, vitamin B6, dipotassium glycyrrhizinate, pentanediol, copper sulfate, zinc sulfate and yeast glucan at constant temperature to form mixed powder, and then performing ball milling to obtain mixed fine powder, wherein the stirring temperature at constant temperature is 30 ℃ and the stirring speed is 800 r/min; the ball milling pressure of the ball milling and crushing is 0.9MPa, and the temperature is 30 ℃;
step 2, uniformly stirring glycerol and distilled water to form a mixed solution, adding the mixed fine powder, and performing ultrasonic dispersion to form a mixed dissolved solution, wherein the stirring speed is 2000r/min, the adding speed of the mixed fine powder is 20g/min, the ultrasonic dispersion temperature is 50 ℃, and the ultrasonic frequency is 80 kHz;
step 3, adding microcrystalline wax and zinc oxide into the mixed solution, and rapidly stirring until the microcrystalline wax and the zinc oxide are completely dispersed to obtain microemulsion; the speed of the rapid stirring is 2500r/min, and the temperature is 50 ℃;
and 4, adding vaseline into the microemulsion, and carrying out constant-temperature ultrasound for 80min to obtain the nursing ointment, wherein the constant-temperature ultrasound temperature is 40 ℃, and the ultrasound frequency is 90 kHz.
The zinc oxide adopts micro-nano zinc oxide fine powder, and the preparation method of the zinc oxide comprises the following steps: a1, adding zinc chloride into ether, and stirring to form a stable dissolved solution, wherein the concentration of the zinc chloride in the ether is 70g/L, the stirring temperature is 20 ℃, and the speed is 900 r/min; a2, adding oxalic acid into ether, and stirring uniformly to form an oxalic acid solution, wherein the concentration of the oxalic acid in the ether is 10g/L, and the stirring speed is 2000 r/min; a3, uniformly spraying an oxalic acid solution into the solution, and carrying out constant-temperature ultrasonic treatment for 20min to obtain a suspension; the molar weight of oxalic acid in the oxalic acid solution is 130% of the molar weight of zinc chloride in the solution, the spraying speed is 4mL/min, and the area is 200cm2The temperature of constant temperature ultrasonic is 10 ℃, and the ultrasonic frequency is 80 kHz; a4, spraying the suspension at constant temperature, keeping the temperature, standing for 4 hours, and blowing dry nitrogen to obtain micro-nano particles; the spraying amount of the constant-temperature spraying is 10mL/min, and the spraying area is 100cm2The temperature is 130 ℃, and the temperature for heat preservation and standing is 120 ℃; the standing pressure was 0.3 MPa.
The preparation method of the yeast glucan comprises the following steps: b1, adding common yeast cell walls into distilled water, uniformly stirring to form a suspension, slowly adding calcium oxide, sealing and stirring for 4 hours, preserving heat for 4 hours, and centrifuging to obtain a precipitate; the concentration of the yeast cell walls in distilled water is 50g/L, and the stirring speed for uniformly stirring is 800 r/min; the adding amount of the calcium oxide is 40 percent of the mass of the cell wall of the common yeast, the slow adding speed is 2g/L, and the stirring speed of the sealed stirring is 2000 g/L; the temperature of heat preservation is 90 ℃; b2, adding the precipitate into distilled water, stirring, adding protease for enzymolysis at constant temperature for 6h, then dropwise adding dilute hydrochloric acid until the solution is acidic, stirring at constant temperature for reaction for 3h, centrifuging, and washing with water to obtain insoluble substances; the concentration of the precipitate in distilled water is 300g/L, the stirring speed is 1000r/min, the adding amount of the protease is 0.15 percent of the mass of the precipitate, the protease is alkaline protease, and the temperature of constant-temperature enzymolysis is 40 ℃; the pH value of the dilute hydrochloric acid is 4, the dropping speed is 5mL/min, the acidity after dropping is 5, the temperature of constant-temperature stirring reaction is 30 ℃, and the stirring speed is 1000 r/min; b3, adding insoluble substances into acetone, performing microwave reaction for 5 hours, filtering, and freeze-drying to obtain yeast glucan powder; the concentration of the insoluble substances in the b3 in acetone is 50g/L, the temperature of the microwave reaction is 30 ℃, and the power is 700W; the freeze drying comprises pre-freezing at-70 deg.C for 22h, and freeze drying at-60 deg.C for 10 h.
Example 3
A skin care ointment comprises the following components in parts by mass:
50g of vaseline, 4g of microcrystalline wax, 3.4g of monoglyceride stearate, 2g of hexadecanol octadecanol, 3g of triglycerol stearate, 4g of caprylic/capric triglyceride, 5g of zinc oxide, 0.6g of purslane extract, 0.6g of white willow bark extract, 0.6g of rice chaff extract, 0.5g of ferulic acid, 5g of glycerol, 3g of panthenol, 0.5g of allantoin, 60.6 g of vitamin B, 0.4g of dipotassium glycyrrhizinate, 4g of pentanediol, 0.03g of copper sulfate, 0.018g of zinc sulfate, 0.7g of yeast glucan and 40g of water.
The preparation method of the skin care ointment comprises the following steps:
step 1, stirring cetostearyl alcohol, triglycerol stearate, caprylic/capric triglyceride, purslane extract, white willow bark extract, rice chaff extract, ferulic acid, panthenol, allantoin, vitamin B6, dipotassium glycyrrhizinate, pentanediol, copper sulfate, zinc sulfate and yeast glucan at constant temperature to form mixed powder, and then performing ball milling to obtain mixed fine powder, wherein the stirring temperature at constant temperature is 20 ℃, and the stirring speed is 600 r/min; the ball milling pressure of the ball milling and crushing is 0.7MPa, and the temperature is 25 ℃;
step 2, uniformly stirring glycerol and distilled water to form a mixed solution, adding the mixed fine powder, and performing ultrasonic dispersion to form a mixed dissolved solution, wherein the stirring speed is 1500r/min, the adding speed of the mixed fine powder is 15g/min, the ultrasonic dispersion temperature is 40 ℃, and the ultrasonic frequency is 60 kHz;
step 3, adding microcrystalline wax and zinc oxide into the mixed solution, and rapidly stirring until the microcrystalline wax and the zinc oxide are completely dispersed to obtain microemulsion; the speed of rapid stirring is 2300r/min, and the temperature is 40 ℃;
and 4, adding vaseline into the microemulsion, and carrying out constant-temperature ultrasound for 60min to obtain the nursing ointment, wherein the constant-temperature ultrasound temperature is 35 ℃, and the ultrasound frequency is 70 kHz.
The zinc oxide adopts micro-nano zinc oxide fine powder, and the preparation method of the zinc oxide comprises the following steps: a1, adding zinc chloride into ether, and stirring to form a stable dissolved solution, wherein the concentration of the zinc chloride in the ether is 50g/L, the stirring temperature is 15 ℃, and the stirring speed is 700 r/min; a2, adding oxalic acid into ether, and stirring uniformly to form an oxalic acid solution, wherein the concentration of the oxalic acid in the ether is 8g/L, and the stirring speed is 1500 r/min; a3, uniformly spraying an oxalic acid solution into the solution, and carrying out constant-temperature ultrasonic treatment for 15min to obtain a suspension; the molar weight of oxalic acid in the oxalic acid solution is 120 percent of the molar weight of zinc chloride in the solution, the spraying speed is 3mL/min, and the area is 100cm2The temperature of constant temperature ultrasonic is 7 ℃, and the ultrasonic frequency is 60 kHz; a4, spraying the suspension at constant temperature, keeping the temperature and standing for 3 hours, and blowing dry nitrogen to obtain micro-nano particles; the spraying amount of the constant-temperature spraying is 4mL/min, and the spraying area is 80cm2The temperature is 110 ℃, and the temperature for heat preservation and standing is 110 ℃; the standing pressure was 0.3 MPa.
The preparation method of the yeast glucan comprises the following steps: b1, adding common yeast cell walls into distilled water, uniformly stirring to form a suspension, slowly adding calcium oxide, sealing and stirring for 3 hours, preserving heat for 3 hours, and centrifuging to obtain a precipitate; the concentration of the yeast cell walls in the distilled water is 40g/L, and the stirring speed for uniformly stirring is 700 r/min; the adding amount of the calcium oxide is 30 percent of the mass of the cell wall of the common yeast, the slow adding speed is 2g/L, and the stirring speed of the sealed stirring is 1500 g/L; the temperature of heat preservation is 85 ℃; b2, adding the precipitate into distilled water, stirring, adding protease for enzymolysis for 5h at constant temperature, then dropwise adding dilute hydrochloric acid until the solution is acidic, stirring at constant temperature for reaction for 2h, centrifuging, and washing with water to obtain insoluble substances; the concentration of the precipitate in distilled water is 200g/L, the stirring speed is 700r/min, the adding amount of the protease is 0.10 percent of the mass of the precipitate, the protease is alkaline protease, and the temperature of constant-temperature enzymolysis is 35 ℃; the pH value of the dilute hydrochloric acid is 4, the dropping speed is 4mL/min, the acidity after dropping is pH 5, the temperature of constant-temperature stirring reaction is 20 ℃, and the stirring speed is 800 r/min; b3, adding insoluble substances into acetone, performing microwave reaction for 4 hours, filtering, and freeze-drying to obtain yeast glucan powder; the concentration of the insoluble substances in the b3 in acetone is 40g/L, the temperature of the microwave reaction is 25 ℃, and the power is 600W; the freeze drying comprises pre-freezing at-70 deg.C for 22h, and freeze drying at-60 deg.C for 8 h.
Example 4
A skin care ointment comprises the following components in parts by mass:
40g of vaseline, 2g of microcrystalline wax, 3.2g of monoglyceride stearate, 1.8g of cetostearyl alcohol, 3g of triglycerol stearate, 3g of caprylic/capric triglyceride, 5g of zinc oxide, 0.5g of purslane extract, 0.5g of white willow bark extract, 0.5g of rice chaff extract, 0.5g of ferulic acid, 4g of glycerol, 2g of panthenol, 0.4g of allantoin, 60.5 g of vitamin B, 0.3g of dipotassium glycyrrhizinate, 3g of pentanediol, 0.02g of copper sulfate, 0.015g of zinc sulfate, 0.5g of yeast glucan and 34g of water.
The preparation method of the skin care ointment comprises the following steps:
step 1, stirring cetostearyl alcohol, triglycerol stearate, caprylic/capric triglyceride, purslane extract, white willow bark extract, rice chaff extract, ferulic acid, panthenol, allantoin, vitamin B6, dipotassium glycyrrhizinate, pentanediol, copper sulfate, zinc sulfate and yeast glucan at constant temperature to form mixed powder, and then performing ball milling to obtain mixed fine powder, wherein the stirring temperature at constant temperature is 20 ℃, and the stirring speed is 600 r/min; the ball milling pressure of the ball milling and crushing is 0.7MPa, and the temperature is 25 ℃;
step 2, uniformly stirring glycerol and distilled water to form a mixed solution, adding the mixed fine powder, and performing ultrasonic dispersion to form a mixed dissolved solution, wherein the stirring speed is 1500r/min, the adding speed of the mixed fine powder is 15g/min, the ultrasonic dispersion temperature is 40 ℃, and the ultrasonic frequency is 60 kHz;
step 3, adding microcrystalline wax and zinc oxide into the mixed solution, and rapidly stirring until the microcrystalline wax and the zinc oxide are completely dispersed to obtain microemulsion; the speed of rapid stirring is 2300r/min, and the temperature is 40 ℃;
and 4, adding vaseline into the microemulsion, and carrying out constant-temperature ultrasound for 60min to obtain the nursing ointment, wherein the constant-temperature ultrasound temperature is 35 ℃, and the ultrasound frequency is 70 kHz.
The zinc oxide adopts micro-nano zinc oxide fine powder, and the preparation method of the zinc oxide comprises the following steps: a1, adding zinc chloride into ether, and stirring to form a stable dissolved solution, wherein the concentration of the zinc chloride in the ether is 50g/L, the stirring temperature is 15 ℃, and the stirring speed is 700 r/min; a2, adding oxalic acid into ether, and stirring uniformly to form an oxalic acid solution, wherein the concentration of the oxalic acid in the ether is 8g/L, and the stirring speed is 1500 r/min; a3, uniformly spraying an oxalic acid solution into the solution, and carrying out constant-temperature ultrasonic treatment for 15min to obtain a suspension; the molar weight of oxalic acid in the oxalic acid solution is 120 percent of the molar weight of zinc chloride in the solution, the spraying speed is 3mL/min, and the area is 100cm2The temperature of constant temperature ultrasonic is 7 ℃, and the ultrasonic frequency is 60 kHz; a4, spraying the suspension at constant temperature, keeping the temperature and standing for 3 hours, and blowing dry nitrogen to obtain micro-nano particles; the spraying amount of the constant-temperature spraying is 4mL/min, and the spraying area is 80cm2The temperature is 110 ℃, and the temperature for heat preservation and standing is 110 ℃; the standing pressure was 0.3 MPa.
The preparation method of the yeast glucan comprises the following steps: b1, adding common yeast cell walls into distilled water, uniformly stirring to form a suspension, slowly adding calcium oxide, sealing and stirring for 3 hours, preserving heat for 3 hours, and centrifuging to obtain a precipitate; the concentration of the yeast cell walls in the distilled water is 40g/L, and the stirring speed for uniformly stirring is 700 r/min; the adding amount of the calcium oxide is 30 percent of the mass of the cell wall of the common yeast, the slow adding speed is 2g/L, and the stirring speed of the sealed stirring is 1500 g/L; the temperature of heat preservation is 85 ℃; b2, adding the precipitate into distilled water, stirring, adding protease for enzymolysis for 5h at constant temperature, then dropwise adding dilute hydrochloric acid until the solution is acidic, stirring at constant temperature for reaction for 2h, centrifuging, and washing with water to obtain insoluble substances; the concentration of the precipitate in distilled water is 200g/L, the stirring speed is 700r/min, the adding amount of the protease is 0.10 percent of the mass of the precipitate, the protease is alkaline protease, and the temperature of constant-temperature enzymolysis is 35 ℃; the pH value of the dilute hydrochloric acid is 4, the dropping speed is 4mL/min, the acidity after dropping is pH 5, the temperature of constant-temperature stirring reaction is 20 ℃, and the stirring speed is 800 r/min; b3, adding insoluble substances into acetone, performing microwave reaction for 4 hours, filtering, and freeze-drying to obtain yeast glucan powder; the concentration of the insoluble substances in the b3 in acetone is 40g/L, the temperature of the microwave reaction is 25 ℃, and the power is 600W; the freeze drying comprises pre-freezing at-70 deg.C for 22h, and freeze drying at-60 deg.C for 8 h.
Detecting data
Clinical experiments were conducted using the products of examples 1-4 as examples, and a commercially available conventional ointment was used as comparative example 1.
The product is used for treating 500 cases of patients with dermatitis and eczema, and the cure rate (%), the cure period (days) in the cured patients and the relapse rate (%) after one year of cure are counted.
| The cure rate is% | Period of healing (Tian) | The recurrence rate% | |
| Example 1 | 99.4 | 14 | 0.3 |
| Example 2 | 99.6 | 11 | 0.2 |
| Example 3 | 99.5 | 12 | 0.2 |
| Example 4 | 99.6 | 12 | 0.2 |
| Comparative example | 78.6 | 25 | 10.2 |
Hormone testing
The hormone test was carried out using the product of example 1 as a test sample.
The test method comprises the following steps: GB/T24800.2-2009, analyzed by LC-MS-MS. No glucocorticoid was detected in this sample.
It should be understood that the detailed description of the invention is merely illustrative of the invention and is not intended to limit the invention to the specific embodiments described. It will be appreciated by those skilled in the art that the present invention may be modified or substituted equally as well to achieve the same technical result; as long as the use requirements are met, the method is within the protection scope of the invention.
Claims (9)
1. A skin care ointment characterized by: the mass ratio is as follows:
40-60 parts of vaseline, 2-8 parts of microcrystalline wax, 3-4 parts of monoglyceride stearate, 1.5-2.5 parts of cetostearyl alcohol, 2-5 parts of triglyceryl stearate, 3-5 parts of caprylic/capric triglyceride, 4-6 parts of zinc oxide, 0.4-0.6 part of purslane extract, 0.4-0.6 part of white willow bark extract, 0.4-0.6 part of rice chaff extract, 0.4-0.5 part of ferulic acid, 4-6 parts of glycerol, 2-3 parts of panthenol, 0.4-0.5 part of allantoin, 60.5-0.6 part of vitamin B, 0.3-0.4 part of dipotassium glycyrrhizinate, 3-5 parts of pentanediol, 0.02-0.03 part of copper sulfate, 0.015-0.018 part of zinc sulfate, 0.3-1.3 part of yeast glucan and 26-40 parts of water.
2. The skin care ointment of claim 1, characterized in that: the ointment comprises the following components in parts by mass:
40-50 parts of vaseline, 2-4 parts of microcrystalline wax, 3.0-3.4 parts of monoglyceride stearate, 1.5-2.0 parts of cetostearyl alcohol, 2-3 parts of triglyceryl stearate, 3-4 parts of caprylic/capric triglyceride, 4-5 parts of zinc oxide, 0.4-0.6 part of purslane extract, 0.4-0.6 part of white willow bark extract, 0.4-0.6 part of rice chaff extract, 0.4-0.5 part of ferulic acid, 4-5 parts of glycerol, 2-3 parts of panthenol, 0.4-0.5 part of allantoin, 60.5-0.6 part of vitamin B, 0.3-0.4 part of dipotassium glycyrrhizinate, 3-4 parts of pentanediol, 0.02-0.03 part of copper sulfate, 0.015-0.018 part of zinc sulfate, 0.3-0.7 part of glucan and 26-40 parts of water.
3. The skin care ointment of claim 2, characterized in that: the ointment comprises the following components in parts by mass:
40 parts of vaseline, 2 parts of microcrystalline wax, 3.2 parts of monoglyceride stearate, 1.8 parts of cetostearyl alcohol, 3 parts of triglycerol stearate, 3 parts of caprylic/capric triglyceride, 5 parts of zinc oxide, 0.5 part of purslane extract, 0.5 part of white willow bark extract, 0.5 part of rice chaff extract, 0.5 part of ferulic acid, 4 parts of glycerol, 2 parts of panthenol, 0.4 part of allantoin, 60.5 parts of vitamin B, 0.3 part of dipotassium glycyrrhizinate, 3 parts of pentanediol, 0.02 part of copper sulfate, 0.015 part of zinc sulfate, 0.5 part of yeast glucan and 34 parts of water.
4. The skin care ointment of claim 1, characterized in that: the preparation method of the skin care ointment comprises the following steps:
step 1, stirring cetostearyl alcohol, triglycerol stearate, caprylic/capric triglyceride, purslane extract, white willow bark extract, rice chaff extract, ferulic acid, panthenol, allantoin, vitamin B6, dipotassium glycyrrhizinate, pentanediol, copper sulfate, zinc sulfate and yeast glucan at constant temperature to form mixed powder, and then performing ball milling to obtain mixed fine powder;
step 2, uniformly stirring glycerol and distilled water to form a mixed solution, and then adding the mixed fine powder and performing ultrasonic dispersion to form a mixed dissolved solution;
step 3, adding microcrystalline wax and zinc oxide into the mixed solution, and rapidly stirring until the microcrystalline wax and the zinc oxide are completely dispersed to obtain microemulsion;
and 4, adding vaseline into the microemulsion, and carrying out constant-temperature ultrasound for 40-80min to obtain the nursing ointment.
5. The skin care ointment of claim 4, characterized in that: the temperature of constant-temperature stirring in the step 1 is 10-30 ℃, and the stirring speed is 500-800 r/min; the ball milling pressure of the ball milling and crushing is 0.5-0.9MPa, and the temperature is 20-30 ℃.
6. The skin care ointment of claim 4, characterized in that: the stirring speed in the step 2 is 1000-2000r/min, the adding speed of the mixed fine powder is 10-20g/min, the temperature of ultrasonic dispersion is 20-50 ℃, and the ultrasonic frequency is 40-80 kHz.
7. The skin care ointment of claim 4, characterized in that: the speed of the rapid stirring in the step 3 is 2000-2500r/min, and the temperature is 30-50 ℃.
8. The skin care ointment of claim 4, characterized in that: the temperature of the constant temperature ultrasound in the step 4 is 30-40 ℃, and the ultrasound frequency is 60-90 kHz.
9. The skin care ointment of claim 1, characterized in that: the zinc oxide adopts micro-nano zinc oxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110899747.5A CN113546138A (en) | 2021-08-06 | 2021-08-06 | Skin care ointment and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110899747.5A CN113546138A (en) | 2021-08-06 | 2021-08-06 | Skin care ointment and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113546138A true CN113546138A (en) | 2021-10-26 |
Family
ID=78105437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110899747.5A Pending CN113546138A (en) | 2021-08-06 | 2021-08-06 | Skin care ointment and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113546138A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658470A (en) * | 2009-09-18 | 2010-03-03 | 北京欧凯纳斯科技有限公司 | Moisturizer and preparation method thereof |
| CN102764217A (en) * | 2012-07-29 | 2012-11-07 | 何黎 | Functional skin care product containing purslane extractive and preparation method thereof |
| CN112168760A (en) * | 2020-11-06 | 2021-01-05 | 河南汉方药业有限责任公司 | Acne-removing composition and preparation method thereof |
-
2021
- 2021-08-06 CN CN202110899747.5A patent/CN113546138A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658470A (en) * | 2009-09-18 | 2010-03-03 | 北京欧凯纳斯科技有限公司 | Moisturizer and preparation method thereof |
| CN102764217A (en) * | 2012-07-29 | 2012-11-07 | 何黎 | Functional skin care product containing purslane extractive and preparation method thereof |
| CN112168760A (en) * | 2020-11-06 | 2021-01-05 | 河南汉方药业有限责任公司 | Acne-removing composition and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110664635B (en) | Moisturizing and hydrating mask composition, mask and preparation method of mask | |
| CN113134087B (en) | Composition containing biological polysaccharide and application thereof | |
| CN104958242A (en) | Anti-ultraviolet mask liquid and preparation method thereof | |
| US20060013899A1 (en) | Topical compositions for treatment of skin disorders and methods of use thereof | |
| CN113397999A (en) | Polysaccharide composition with skin barrier repairing function and application thereof | |
| CN113368018A (en) | Anti-inflammatory acne-removing composition and preparation method thereof | |
| US6426081B1 (en) | Cosmetic firming formulation | |
| CN114848565A (en) | Acne removing composition, acne removing gel and preparation method of acne removing gel | |
| CN111514161B (en) | Anti-oral ulcer preparation and application thereof | |
| CN113546138A (en) | Skin care ointment and preparation method thereof | |
| CN108078868B (en) | Antiallergic composition for skin care products | |
| CN113855608A (en) | Skin care composition for resisting light pollution and light injury and preparation method and application thereof | |
| CN115177975A (en) | A method for extracting polysaccharides, polyphenols and triterpenes from medicinal fomes fomentarius by supramolecular process | |
| CN110652581A (en) | Medical ray protection solution with moisturizing and itching relieving effects and preparation method thereof | |
| KR20110120755A (en) | Manufacturing method for cosmetic cream | |
| KR20110139016A (en) | Process of manufacturing method of high-content ginsenoside rg3 using by acid treatment and far-infrared radiation dry | |
| CN114432195A (en) | Skin repairing and antibacterial composition, gel, application and preparation method | |
| CN104825379A (en) | Whitening peeling night cream capable of reducing melanin deposition and preparation method thereof | |
| KR102488255B1 (en) | Enzyme composition for fry poultice | |
| CN108703924A (en) | A kind of plant Shu Min Essences and preparation method thereof | |
| CN117414312B (en) | Preparation method and application of hydrolyzed sclerotium rolfsii with repairing and relieving effects | |
| EP2628487B1 (en) | Adjuvant composition for topical use | |
| CN114053329B (en) | Application of broussonetia papyrifera polysaccharide in preparation of medicines or sunscreen cosmetics for preventing and treating ultraviolet injury | |
| CN107970155B (en) | Composition with whitening effect and cosmetic | |
| CN111514076A (en) | Night mask made of noni plants |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211026 |
|
| RJ01 | Rejection of invention patent application after publication |