CN113831345A - 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途 - Google Patents

二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途 Download PDF

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Publication number
CN113831345A
CN113831345A CN202111157002.8A CN202111157002A CN113831345A CN 113831345 A CN113831345 A CN 113831345A CN 202111157002 A CN202111157002 A CN 202111157002A CN 113831345 A CN113831345 A CN 113831345A
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compound
weight
pyrazin
methoxycyclohexyl
trans
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CN202111157002.8A
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Chinese (zh)
Inventor
玛丽·乔治·彼彻姆斯
安东尼奥·克里斯蒂安·费雷蒂
胡安·安东尼奥·甘博亚
凯文·克洛普弗
威廉·爱德华·柯内可
马修·迈克尔·克雷莱茵
阿尼尔·门诺
阿曼达·尼科尔·米克洛斯
约翰·菲茨杰拉德·特拉弗斯
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Signal Pharmaceuticals LLC
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Signal Pharmaceuticals LLC
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Publication of CN113831345A publication Critical patent/CN113831345A/zh
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
CN202111157002.8A 2013-05-29 2014-05-28 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途 Pending CN113831345A (zh)

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CN201811517073.2A Active CN109503591B (zh) 2013-05-29 2014-05-28 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途
CN201710769972.0A Active CN107474051B (zh) 2013-05-29 2014-05-28 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途

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CN201710769972.0A Active CN107474051B (zh) 2013-05-29 2014-05-28 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途

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CA (2) CA2912627C (enExample)
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CN110062624B (zh) * 2016-10-14 2023-07-28 中国医学科学院药物研究所 二氢小檗碱型化合物在制备治疗stat3信号通路相关肿瘤疾病药品中的用途
IL271491B2 (en) 2017-06-22 2023-09-01 Celgene Corp Treatment of carcinoma of the liver characterized by hepatitis b virus infection
BR112021021405A2 (pt) 2019-04-26 2022-02-15 Bobby Gallagher Capacidade de manutenção de estação e desconexão de emergência melhoradas para uma embarcação conectada a um poço submarino em águas rasas

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