CN113453702A - 细胞重编程以逆转衰老并促进组织和组织再生 - Google Patents

细胞重编程以逆转衰老并促进组织和组织再生 Download PDF

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CN113453702A
CN113453702A CN201980078793.XA CN201980078793A CN113453702A CN 113453702 A CN113453702 A CN 113453702A CN 201980078793 A CN201980078793 A CN 201980078793A CN 113453702 A CN113453702 A CN 113453702A
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nucleic acid
expression
composition
cell
oct4
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D.A.辛克莱尔
Y.卢
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Harvard University
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CN201980078793.XA 2018-09-28 2019-09-27 细胞重编程以逆转衰老并促进组织和组织再生 Pending CN113453702A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862738922P 2018-09-28 2018-09-28
US62/738,922 2018-09-28
US201962792283P 2019-01-14 2019-01-14
US62/792,283 2019-01-14
US201962865877P 2019-06-24 2019-06-24
US62/865,877 2019-06-24
US201962880488P 2019-07-30 2019-07-30
US62/880,488 2019-07-30
PCT/US2019/053545 WO2020069373A1 (en) 2018-09-28 2019-09-27 Cellular reprogramming to reverse aging and promote organ and tissue regeneration

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CN113453702A true CN113453702A (zh) 2021-09-28

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US (5) US12409207B2 (https=)
EP (1) EP3856226B1 (https=)
JP (2) JP7593639B2 (https=)
KR (1) KR20210068485A (https=)
CN (1) CN113453702A (https=)
AU (2) AU2019347666B2 (https=)
BR (1) BR112021004670A2 (https=)
CA (1) CA3113472A1 (https=)
IL (1) IL281470B2 (https=)
MX (1) MX2021003663A (https=)
WO (1) WO2020069373A1 (https=)

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CN110628821A (zh) * 2018-06-25 2019-12-31 首都医科大学宣武医院 一种细胞模型及其制备方法、应用
CN114240934A (zh) * 2022-02-21 2022-03-25 深圳大学 一种基于肢端肥大症的图像数据分析方法及系统
CN114622020A (zh) * 2022-03-30 2022-06-14 华南农业大学 一种与鸡生长性状相关的klhl31基因分子标记及应用
CN115607689A (zh) * 2022-10-13 2023-01-17 呈诺再生医学科技(北京)有限公司 Klf7基因在制备逆转细胞衰老的药物中的应用
CN116555432A (zh) * 2023-07-05 2023-08-08 广州凯普医药科技有限公司 一种膀胱癌快速检测试剂盒
CN116898988A (zh) * 2023-08-15 2023-10-20 臻赫医药(杭州)有限公司 皮肤重编程因子制剂、生物材料及用途
WO2024012502A1 (zh) * 2022-07-12 2024-01-18 南京瑞初医药有限公司 组合物及其使用方法
WO2024012504A1 (zh) * 2022-07-12 2024-01-18 南京瑞初医药有限公司 组合物及其使用方法
WO2024012503A1 (zh) * 2022-07-12 2024-01-18 南京瑞初医药有限公司 组合物及其使用方法
CN118831181A (zh) * 2024-09-20 2024-10-25 江苏集萃药康生物科技股份有限公司 一种三突变阿尔兹海默症小鼠模型的构建方法及其应用
WO2025011625A1 (zh) * 2023-07-11 2025-01-16 南京瑞初医药有限公司 组合物及其使用方法
WO2025035506A1 (zh) * 2023-08-15 2025-02-20 臻赫医药(杭州)有限公司 皮肤重编程因子制剂在制备促皮肤伤口愈合药物中的用途
CN119792490A (zh) * 2023-10-10 2025-04-11 中国科学院动物研究所 增加oskm含量或活性的物质在预防关节软骨衰老及治疗骨关节炎疾病中的应用

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MX2021003663A (es) 2018-09-28 2021-05-28 Harvard College Reprogramacion celular para revertir el envejecimiento y promover la regeneracion de organos y tejidos.
US12274733B2 (en) 2018-09-28 2025-04-15 President And Fellows Of Harvard College Cellular reprogramming to reverse aging and promote organ and tissue regeneration
US20240207449A1 (en) * 2021-04-09 2024-06-27 Washington University Compositions and methods for treatment of crx-mediated retinopathies
US20230302044A1 (en) * 2022-03-28 2023-09-28 Steve Reilly Composition to increase cellularlongevity
JP2025511883A (ja) 2022-04-06 2025-04-16 プレジデント アンド フェローズ オブ ハーバード カレッジ 中枢神経系の加齢を逆行させること
JP2025513861A (ja) * 2022-04-15 2025-04-30 ロノ ジェヤク インコーポレイテッド 老化細胞の若返りまたは細胞老化の遅延または防止用組成物
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EP4593855A1 (en) * 2022-09-28 2025-08-06 Altos Labs, Inc. Expression of regeneration factors in aged/senescent cells
CN116041477B (zh) * 2022-10-13 2023-08-08 呈诺再生医学科技(北京)有限公司 Tdgf1基因在制备治疗衰老相关疾病或逆转细胞衰老的药物中的应用
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JP2026504911A (ja) * 2023-01-19 2026-02-10 アルトス ラブス，インコーポレーテッド 臓器移植における再生因子の使用
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CN119265241A (zh) * 2023-06-30 2025-01-07 深圳菁童生命科学有限公司 一种无相分离转录因子介导启始阶段重编程使细胞年轻化的方法
WO2025213038A1 (en) * 2024-04-05 2025-10-09 Erik Berglund Systems and methods for kidney perfusion
WO2026024954A2 (en) * 2024-07-24 2026-01-29 Altos Labs, Inc. Use of regeneration factors in organ transplantation
CN119280375A (zh) * 2024-09-24 2025-01-10 深圳市第二人民医院(深圳市转化医学研究院) Oct4、sox2、klf4和tert基因在制备抗衰老的药物中的应用

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CN118831181A (zh) * 2024-09-20 2024-10-25 江苏集萃药康生物科技股份有限公司 一种三突变阿尔兹海默症小鼠模型的构建方法及其应用

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