CN113304065A - Scalp care composition and application thereof - Google Patents
Scalp care composition and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention relates to the technical field of skin care, and discloses a scalp care composition and application thereof, wherein the scalp care composition comprises the following components in parts by weight: ceramide, carnosine and a yeast fermentation product; can be applied to scalp care essence, scalp care shampoo and scalp care hair conditioner; the preparation method of the scalp care essence comprises the following steps: mixing and dissolving the freshener and the solubilizer, and uniformly mixing the freshener, the preservative and the humectant to be clear and transparent to prepare a solution A; adding ethanol, nicotinamide, skin conditioner and chelating agent into the scalp care composition, and uniformly mixing to obtain solution B; and (3) uniformly mixing the solution A and the solution B, and adding an acid-base regulator to regulate the pH value to 4.5-6.0 to prepare the scalp care essence. The ceramide, the carnosine and the yeast for bifidus fermentation product help the scalp to resist glycosylation and oxidation from multiple dimensions through different action mechanisms, and the three synergistically act to jointly realize the anti-aging effect of the scalp.
Description
Technical Field
The invention relates to the technical field of skin care, in particular to the technical field of head skin care, and specifically relates to a scalp care composition and application thereof.
Background
The scalp is the soft tissue covering the outside of the skull, and is the continuation of the skin of the face and neck, and the scalp is the second thin skin next to the canthus throughout the body. The scalp has rich sebaceous gland density, vigorous sebum secretion, high hair follicle density and high free radical content, so that the scalp has higher aging speed than the skin of the face and other parts of the body, and for people without alopecia, the scalp is covered by more hairs, the aging characteristic of the scalp is usually not easy to notice, so the aging problem of the scalp is easy to ignore.
Aging of the scalp is mainly manifested by: the scalp is pale and dry, has reduced elasticity, increased brittleness, thinned and relaxed, and the like, and the scalp is used as soil of hair, and the aging of the scalp inevitably causes changes of the hair, such as thinning, deterioration of the hair quality, graying and the like. In addition, scalp aging causes various cells in hair follicles to be weakened and insufficient in nutrition supply, and the hair follicles gradually enter a catagen phase, thereby causing alopecia and baldness.
At present, the concept of scalp care is relatively thin, scalp care is mainly performed by cleaning, active substances with the effects of removing dandruff and sterilizing are introduced while the scalp is cleaned, and the effects of sterilizing, removing dandruff, relieving itching, controlling oil and the like are achieved.
Meanwhile, although the structure of the scalp is the same as that of the facial skin and comprises pores, hair follicles and sebaceous glands, compared with the facial skin, the scalp has larger pores, higher density of the hair follicles, richer density of the sebaceous glands and stronger sebum secretion, and is also the topmost skin of a human body and the most critical natural barrier for resisting ultraviolet light damage, so that the scalp is the part which is most prone to oil production, has the highest free radical content and is most prone to aging, the aging speed of the scalp is 12 times that of the facial skin, and compared with the facial skin, the scalp care is more important, and the scalp barrier function is particularly important in maintaining. In addition, due to the high density of hair follicles in the scalp, hair coverage causes the scalp to be more difficult to clean than the skin of the face; the scalp has large pores and is easy to store dirt and block, so that the scalp is not suitable for nursing the face skin by selecting the cream with high grease content. The cream for caring the face skin is used for caring the scalp, easily causes hair follicle blockage, is easily infected by microorganisms such as bacteria and fungi, causes inflammatory reaction such as folliculitis and is not beneficial to scalp health.
Disclosure of Invention
The present invention is directed to a scalp care composition and uses thereof that address one or more of the problems of the prior art, and that provides at least one useful alternative or creation.
In order to overcome the technical problems, the technical scheme adopted by the invention is as follows:
a scalp care composition comprising: ceramide, carnosine and a yeast fermentation product.
According to the theory of free radical aging, when the oxygen free Radical (ROS) in human body is excessive, the ROS can activate the mitogen activated protein kinase pathway in the human body, and finally the skin structure is damaged; further stimulates the production of matrix metalloproteinases, which can degrade intact collagen and elastin in the dermal tissue while inhibiting the production of procollagen DNA, ultimately leading to the destruction of the dermal structure, leading to skin aging. The reductive saccharide reacts with amino acids, polypeptides and amino groups in proteins to generate Schiff base, unsaturated aldehyde ketone intermediate products such as deoxyo-ketoaldehyde and the like are further formed, the intermediate products can be conjugated and crosslinked with amino groups in proteins and nucleic acids to generate advanced glycosylation end products (AGEs), and the process can cause aging processes such as structural protein hardening, functional enzyme damage, antioxidase passivation, activity reduction of repairman, imbalance of balance function and the like.
Wherein: glycosylation refers to the reaction of saccharides with amino acids, polypeptides and amino groups in proteins, and ultimately produces glycosylation end products (AGEs), a process known as glycosylation, and damage to proteins caused by glycosylation is considered to be one of the major causes of protein aging.
Oxidation refers to free radical oxidation. According to the theory of free radicals, the aging is considered as the accumulation result of the free radicals continuously generated by the tissue cells of the organism, so that the aging can be delayed by timely eliminating the excessive free radicals.
Specifically, ceramide is a major constituent of lipid bodies among stratum corneum cells present in the outermost layer of human skin, and 40% to 50% of sebum in the stratum corneum is composed of ceramide, and plays an important role in maintaining the moisture balance of the stratum corneum and maintaining the skin barrier function. When ceramide is reduced in the stratum corneum, the skin becomes dry and glossy, the stratum corneum becomes thinner, and the elasticity is reduced. The ceramide supplement increases the ceramide content in the horny layer of the epidermis, can increase the thickness of the horny layer, recover the barrier capability of the skin and enhance the elasticity of the skin, and meanwhile, the ceramide has strong capability of associating water molecules, maintains the moisture of the skin by forming a network structure in the horny layer, and improves the symptoms of dry skin and the like.
Carnosine is a natural, highly active biological dipeptide, an effective radical scavenger, which scavenges superoxide anions, hydroxyl radicals and other reactive oxygen species, and superoxide Radicals (ROO), thereby inhibiting lipid oxidation; carnosine has an activity similar to that of superoxide dismutase (SOD), and can inhibit oxidation reactions promoted by a large number of different lipid strong oxidants such as hydroperoxide activated hemoglobin, lipoxygenase, photosensitized riboflavin (producing singlet oxygen), and the like. In addition, carnosine can react with sugar instead of protein in vivo to react with sugar before the sugar erodes the skin, thereby helping to protect the protein from glycosylation and achieving the effect of resisting glycation.
Meanwhile, the carnosine has an imidazole ring in the structure, so that copper ions and iron ions can be chelated to form a complex, and the capability of catalyzing lipid oxidation by the copper ions is reduced; also inhibit phospholipid oxidation catalyzed by iron ions. In addition, the hydrogen atoms on the two nitrogen atoms on the imidazolyl group can combine with free radicals and lipid peroxides to form a temporary complex, thereby reducing the ROS content. In addition, carnosine inhibits the formation of further oxidation products by reducing the production of key intermediates, reactive carbonyl species or preventing their binding to proteins, etc. The free amino acid group derived from beta-alanine in carnosine can preferentially react with reactive dicarbonyl compounds, thereby reducing AGEs production and protecting proteins from glycosylation.
The yeast bifidus fermentation product is a metabolite, a cytoplasm fragment, a cell wall component and a polysaccharide complex obtained by culturing and inactivating and decomposing bifidobacterium, contains natural active ingredients such as micromolecular amino acid, peptide, nucleotide, vitamin and the like, is a high-quality yeast essence, has the function of slightly peeling off cutin, can capture free radicals, inhibit lipid peroxidation, and has the functions of whitening and resisting aging. The yeast fermentation product can permeate into skin through small molecular amino acids and polypeptides, provide nutrition for synthesizing collagen and elastin for scalp, recover elasticity of aged epidermis, and simultaneously, nucleotide can improve protein synthesis rate, promote metabolism, and improve scalp resistance.
The ceramide, the carnosine and the yeast for bifidus fermentation product help the scalp to resist glycosylation and oxidation from multiple dimensions through different action mechanisms, and simultaneously, the three raw materials have synergistic action to jointly realize the anti-aging effect of the scalp.
In some embodiments of the present application, the scalp care composition further comprises a dispersing aid.
Preferably, the dispersing aid is selected from at least one of sterols, polyglycerol esters, fatty acid esters, and polyols, and has a primary function of helping to disperse the ceramide, so as to obtain more uniform and stable ceramide.
In some embodiments of the present application, the composition of the scalp care composition comprises, in parts by weight: 0.01-0.5 part of ceramide, 0.01-10 parts of carnosine, 78-99.73 parts of yeast bifidus fermentation product and 0.25-12.5 parts of dispersing auxiliary agent. Further, according to the research, the comprehensive performance of the scalp care composition is better when the composition of the scalp care composition comprises 0.5 part of ceramide, 1 part of carnosine, 86 parts of yeast dehiscence product and 12.5 parts of dispersing auxiliary agent according to the parts by weight.
Specifically, by selecting specific components of the scalp care composition, each component exerts the function thereof and is synergistic with other components, so as to remove scalp free radicals, help the scalp to resist glycosylation and oxidation, and achieve the effect of delaying scalp aging.
In some embodiments of the present application, the ceramide is selected from any one of ceramide 1, ceramide 2, ceramide 3, ceramide 6. Preferably ceramide 2, more preferably ceramide 2 having optical activity of 90% or more, ceramide 2 being the most important constituent of ceramide in human hair and skin, and ceramide 2 having optical activity is more effective in skin barrier repair and moisturizing than general ceramide 2.
In some embodiments of the present application, the split yeast fermentation product is selected from a split yeast fermentation product lysate and/or a split yeast fermentation product filtrate.
The invention also provides an application of the scalp care composition, namely a scalp care essence which comprises the scalp care composition.
In some embodiments of the present application, the scalp care essence further comprises at least one of ethanol, niacinamide, a humectant, a cooling agent, a solubilizer, a skin conditioner, a chelating agent, a preservative, an acid-base modifier, and a fragrance.
In some embodiments of the present application, the composition of the scalp care serum comprises, in parts by weight: 75-85 parts of scalp care composition, 10-15 parts of ethanol, 0.5-2 parts of nicotinamide, 2-4 parts of humectant, 0.05-0.3 part of freshener, 0.5-2 parts of solubilizer, 0.5-2 parts of sebum inhibitor, 0.1-0.5 part of skin conditioner, 0.01-0.1 part of chelating agent, 0.5-2.5 parts of preservative, 0.1-1 part of acid-base regulator and 0-0.2 part of essence. Further, according to research, the comprehensive performance of the scalp care essence is better when the scalp care essence comprises 82.25 parts of scalp care composition, 10 parts of ethanol, 2 parts of humectant, 1 part of nicotinamide, 1 part of 10-hydroxydecanoic acid, 0.1 part of freshener, 0.8 part of solubilizer, 0.4 part of skin conditioner, 2 parts of 1, 2-hexanediol, 0.3 part of 1, 2-pentanediol, 0.05 part of chelating agent, 0.8 part of lactic acid and 0.02 part of sodium lactate.
Preferably, the humectant is at least one selected from glycerin, propylene glycol, butylene glycol, sodium pyrrolidone carboxylate (sodium PCA).
Preferably, the cooling agent is at least one selected from menthol, borneol and cooling agents.
Preferably, the solubilizer is selected from PEG-40 hydrogenated castor oil or PEG-60 hydrogenated castor oil.
Preferably, the sebum inhibitor is 10-hydroxydecanoic acid.
Preferably, the skin conditioning agent is selected from dipotassium glycyrrhizinate or allantoin and/or bisabolol.
Preferably, the chelating agent is at least one selected from sodium glucoheptonate, disodium ethylenediaminetetraacetate (disodium EDTA) and tetrasodium ethylenediaminetetraacetate (tetrasodium EDTA).
Preferably, the preservative is at least one selected from phenoxyethanol, sodium benzoate, 1, 2-hexanediol and 1, 2-pentanediol.
Preferably, the pH regulator is at least one selected from lactic acid, sodium lactate, citric acid and sodium citrate.
The invention also provides a technical scheme that the preparation method of the scalp care essence comprises the following steps:
mixing and dissolving the freshener and the solubilizer, and uniformly mixing the freshener, the preservative and the humectant to be clear and transparent to prepare a solution A;
adding ethanol, nicotinamide, skin conditioner and chelating agent into the scalp care composition, and uniformly mixing to obtain solution B;
and (3) uniformly mixing the solution A and the solution B, and adding an acid-base regulator to regulate the pH value to 4.5-6.0 to prepare the scalp care essence.
Specifically, the acid-base regulator is used for regulating the pH value of the scalp care essence and controlling the pH value to be 4.5-6.0, if the pH value is too high or too low, scalp irritation is easily caused, and the acid-base balance of the scalp can be damaged after long-term use, so that respective scalp problems are caused.
In some embodiments of the present application, a method of preparing a scalp care serum comprises the steps of:
mixing the freshener with the solubilizer, heating to dissolve completely, cooling to room temperature, mixing with the antiseptic and the humectant, stirring, and making into solution A.
Adding ethanol, nicotinamide, skin conditioner and chelating agent into the scalp care composition, and stirring at the speed of 400-600rpm/min for 20 minutes at room temperature to prepare a solution B.
And (3) uniformly mixing the solution A and the solution B, adding lactic acid and sodium lactate to adjust the pH value to 4.5-6.0, and preparing the scalp care essence.
Specifically, the buffer solution is formed by compounding lactic acid and sodium lactate, is weakly acidic, is close to the pH value of the scalp, is mild and non-irritant, and can be used for a long time.
The invention also provides a technical scheme that the scalp care composition used as the second application is scalp care shampoo, the raw material composition of the scalp care shampoo comprises the scalp care composition, and the content of the scalp care composition in the scalp care shampoo is 1-2 wt%.
The invention also provides a technical scheme that the scalp care composition for the third application is a scalp care hair conditioner, the raw material composition of the scalp care hair conditioner comprises the scalp care composition, and the scalp care composition is contained in the scalp care hair conditioner in an amount of 1-2 wt%.
The technical scheme provided by the embodiment of the application at least has the following technical effects or advantages:
the scalp care composition of the present invention takes full advantage of the efficacy of ceramides, carnosine and yeast bifidus fermentation products from multiple dimensions, wherein: ceramides play an important role in maintaining the water balance of the stratum corneum and in maintaining the skin barrier function; carnosine can inhibit lipid oxidation, help protect protein from being saccharified, and has anti-saccharide effect; the yeast fermentation product has the functions of whitening, resisting aging and nourishing skin, and can prevent photoaging of dermis. Meanwhile, three components of ceramide, carnosine and a yeast fermentation product are synergistic, so that the effect of resisting aging of the scalp is jointly realized.
Detailed Description
The present invention is described in detail below by way of examples to facilitate understanding of the present invention by those skilled in the art, and it is to be specifically noted that the examples are provided only for the purpose of further illustrating the present invention and are not to be construed as limiting the scope of the present invention.
Example 1
A scalp care composition comprises the following components in parts by weight: 10.5 parts of ceramide, 10 parts of carnosine, 78 parts of schizosaccharomyces cerevisiae fermentation product lysate, and 12.5 parts of dispersing auxiliary polyol and sterol.
Example 2
A scalp care composition comprises the following components in parts by weight: 30.5 parts of ceramide, 0.5 part of carnosine, 87.5 parts of secondary fission yeast fermentation product filtrate and 12.5 parts of polyglycerol ester serving as a dispersion auxiliary agent.
Example 3
A scalp care composition comprises the following components in parts by weight: 60.01 parts of ceramide, 0.01 part of carnosine, 99.73 parts of schizosaccharomyces cerevisiae fermentation product lysate and 0.25 part of dispersing auxiliary agent fatty acid ester.
Example 4
A scalp care composition comprises the following components in parts by weight: 20.5 parts of ceramide with optical activity of more than 90 percent, 0.5 part of carnosine, 87.5 parts of schizosaccharomyces cerevisiae fermentation product lysate and 12.5 parts of dispersing auxiliary polyol.
Example 5
A scalp care essence comprises the following components in parts by weight: 82.25 parts of scalp care composition, wherein the composition of the scalp care composition is the same as that in example 2, 10 parts of ethanol, 1 part of nicotinamide, 2 parts of humectant glycerin, 0.1 part of menthol as a cooling agent, 0.8 part of PEG-40 hydrogenated castor oil as a solubilizer, 1 part of 10-hydroxydecanoic acid, 1 part of 2% 1, 2-hexanediol and 0.3% 1, 2-pentanediol as preservatives, 0.4 part of dipotassium glycyrrhizinate as a skin conditioner, 0.05 part of sodium glucoheptonate as a chelating agent, and 0.1 part of lactic acid as an acid-base regulator.
A preparation method of scalp care essence comprises the following steps:
mixing menthol as a freshener and PEG-40 hydrogenated castor oil as a solubilizer, heating to completely dissolve, then cooling to room temperature, and uniformly stirring and mixing the menthol and the hydrogenated castor oil with a preservative of 2 percent of 1, 2-hexanediol and 0.3 percent of 1, 2-pentanediol and humectant glycerin until the mixture is clear and transparent to prepare a solution A;
adding ethanol, nicotinamide, skin conditioner dipotassium glycyrrhizinate and chelating agent sodium glucoheptonate into the scalp care composition, stirring at the speed of 400rpm/min for 20 minutes at room temperature, and mixing uniformly to obtain solution B;
and (3) uniformly mixing the solution A and the solution B, adding an acid-base regulator lactic acid to regulate the pH value to 5.39, and preparing the scalp care essence.
Example 6
A scalp care essence comprises the following components in parts by weight: 75 parts of scalp care composition, wherein the composition of the scalp care composition is the same as that in example 2, 15 parts of ethanol, 0.5 part of nicotinamide, 4 parts of humectant propylene glycol, 0.3 part of borneol serving as a cooling agent, 2 parts of solubilizer PEG-60 hydrogenated castor oil, 2 parts of sebum inhibitor 10-hydroxydecanoic acid, 0.5 part of skin conditioner allantoin, 0.1 part of chelating agent EDTA disodium, 0.3 part of preservative 0.3% phenoxyethanol, 0.1 part of sodium lactate serving as an acid-base regulator and 0.2 part of essence.
A preparation method of scalp care essence comprises the following steps:
mixing Borneolum Syntheticum as freshener with PEG-60 hydrogenated castor oil as solubilizer, heating to dissolve completely, cooling to room temperature, mixing with 0.3% phenoxyethanol as antiseptic and propylene glycol as humectant, stirring, and making into solution A;
adding ethanol, nicotinamide, allantoin as a skin conditioner and disodium EDTA as a chelating agent into the scalp care composition, stirring at the speed of 500rpm/min for 20 minutes at room temperature, and uniformly mixing to obtain a solution B;
and (3) uniformly mixing the solution A and the solution B, adding sodium lactate as an acid-base regulator to regulate the pH value to 5.15, and preparing the scalp care essence.
Example 7
A scalp care essence comprises the following components in parts by weight: 85 parts of scalp care composition, wherein the composition of the scalp care composition is the same as that in example 2, 10 parts of ethanol, 0.5 part of nicotinamide, 2 parts of humectant butanediol, 0.5 part of cooling agent WS-230.05 parts of cooling agent, 0.5 part of solubilizer PEG-60 hydrogenated castor oil, 0.5 part of sebum inhibitor 10-hydroxydecanoic acid, 0.6 part of skin conditioner bisabolol, 0.1 part of chelating agent EDTA tetrasodium, 0.3% phenoxyethanol as preservative, 0.03 part of 0.3% sodium benzoate as preservative, 0.1 part of acid-base regulator citric acid and 0.1 part of essence.
A preparation method of scalp care essence comprises the following steps:
mixing coolant WS-23 and solubilizer PEG-60 hydrogenated castor oil, heating to dissolve completely, cooling to room temperature, mixing with antiseptic 0.3% phenoxyethanol and 0.3% sodium benzoate and humectant butanediol, stirring, and making into solution A;
adding ethanol, nicotinamide, skin conditioner bisabolol and chelating agent EDTA tetrasodium into the scalp care composition, stirring at 600rpm/min for 20 minutes at room temperature, and mixing uniformly to obtain solution B;
and (3) uniformly mixing the solution A and the solution B, and adding an acid-base regulator citric acid to regulate the pH value to 5.16 to prepare the scalp care essence.
Comparative example 1
A scalp care composition comprises the following components in parts by weight: a split yeast fermentation product lysate.
This comparative example compares to example 1 in that no carnosine, ceramide and adjuvant were added, only the split yeast fermentation product.
Comparative example 2
A scalp care composition comprises the following components in parts by weight: carnosine 10 parts, split yeast fermentation lysate 90 parts.
This comparative example compares to example 1 in that ceramide and adjuvant are not added and the amounts of ceramide and adjuvant are added to the split yeast product.
Comparative example 3
A scalp care composition comprises the following components in parts by weight: 10.5 parts of ceramide, 89.5 parts of schizosaccharomyces cerevisiae fermentation product lysate, and 12.5 parts of dispersing auxiliary polyol and sterol.
This comparative example compares to example 1 in that no carnosine is added and the amount of carnosine added to the split yeast product.
Comparative example 4
A scalp care essence comprises the following components in parts by weight: 10 parts of ethanol, 1 part of nicotinamide, 2 parts of humectant glycerol, 0.1 part of cooling agent menthol, 0.8 part of solubilizer PEG-40 hydrogenated castor oil, 1 part of 10-hydroxydecanoic acid, 1 part of preservative 2% 1, 2-hexanediol and 1.3 parts of 0.3% 1, 2-pentanediol, 0.4 part of skin conditioner dipotassium glycyrrhizinate, 0.05 part of chelating agent sodium glucoheptonate, 0.1 part of acid-base regulator lactic acid and 82.25 parts of water.
The scalp care essence of the present comparative example is different from the scalp care essence of example 5 in that: the scalp care composition of example 5 was replaced with water.
A preparation method of scalp care essence comprises the following steps:
mixing menthol as a freshener and PEG-40 hydrogenated castor oil as a solubilizer, heating to completely dissolve, then cooling to room temperature, and uniformly stirring and mixing the menthol and the hydrogenated castor oil with a preservative of 2 percent of 1, 2-hexanediol and 0.3 percent of 1, 2-pentanediol and humectant glycerin until the mixture is clear and transparent to prepare a solution A;
adding ethanol, nicotinamide, skin conditioner dipotassium glycyrrhizinate and chelating agent sodium glucoheptonate into water, stirring at the speed of 400rpm/min for 20 minutes at room temperature, and mixing uniformly to obtain solution B;
and (3) uniformly mixing the solution A and the solution B, adding an acid-base regulator lactic acid to regulate the pH value to 5.28, and preparing the scalp care essence.
Comparative example 5
A scalp care essence comprises the following components in parts by weight: 50 parts of scalp care composition, wherein the composition of the scalp care composition is the same as that in example 1, 10 parts of ethanol, 1 part of nicotinamide, 2 parts of humectant glycerin, 0.1 part of cooling agent menthol, 0.8 part of solubilizer PEG-40 hydrogenated castor oil, 1 part of 10-hydroxydecanoate, 1 part of preservative 2% 1, 2-hexanediol and 1.3 parts of 0.3% 1, 2-pentanediol, 0.4 part of skin conditioner dipotassium glycyrrhizinate, 0.05 part of chelating agent sodium glucoheptonate, 0.1 part of acid-base regulator lactic acid and 32.25 parts of water.
The scalp care essence of the present comparative example is different from the scalp care essence of example 5 in that: a portion of the scalp care composition of example 5 was replaced with water.
A preparation method of scalp care essence comprises the following steps:
mixing menthol as a freshener and PEG-40 hydrogenated castor oil as a solubilizer, heating to completely dissolve, then cooling to room temperature, and uniformly stirring and mixing the menthol and the hydrogenated castor oil with a preservative of 2 percent of 1, 2-hexanediol and 0.3 percent of 1, 2-pentanediol and humectant glycerin until the mixture is clear and transparent to prepare a solution A;
adding ethanol, nicotinamide, skin conditioner dipotassium glycyrrhizinate, chelating agent sodium glucoheptonate and water into the scalp care composition, stirring at the speed of 400rpm/min for 20 minutes at room temperature, and mixing uniformly to obtain solution B;
and (3) uniformly mixing the solution A and the solution B, adding an acid-base regulator lactic acid to regulate the pH value to 5.25, and preparing the scalp care essence.
Comparative example 6
A scalp care essence comprises the following components in parts by weight: 15 parts of ethanol, 2 parts of nicotinamide, 4 parts of humectant glycerol, 0.3 part of cooling agent menthol, 2 parts of solubilizer PEG-40 hydrogenated castor oil, 2 parts of 10-hydroxydecanoic acid, 1 part of preservative 2% 1, 2-hexanediol and 1.5 parts of 0.5% 1, 2-pentanediol, 0.5 part of skin conditioner dipotassium glycyrrhizinate, 0.1 part of chelating agent sodium glucoheptonate, 1 part of acid-base regulator lactic acid, 70.4 parts of water and 0.2 part of essence.
The scalp care essence of the present comparative example is different from the scalp care essence of example 5 in that: the comparative example did not add scalp care composition and adjusted the composition of the other raw materials.
A preparation method of scalp care essence comprises the following steps:
mixing menthol as a freshener and PEG-40 hydrogenated castor oil as a solubilizer, heating to completely dissolve, then cooling to room temperature, and uniformly stirring and mixing the menthol and the hydrogenated castor oil with a preservative of 2 percent of 1, 2-hexanediol and 0.5 percent of 1, 2-pentanediol and humectant glycerin until the mixture is clear and transparent to prepare a solution A;
adding ethanol, nicotinamide, skin conditioner dipotassium glycyrrhizinate and chelating agent sodium glucoheptonate into water, stirring at the speed of 400rpm/min for 20 minutes at room temperature, and mixing uniformly to obtain solution B;
and (3) uniformly mixing the solution A and the solution B, adding an acid-base regulator lactic acid to regulate the pH value to 4.99, and preparing the scalp care essence.
Comparative example 7
A skin care essence comprises the following components in parts by weight: 10 parts of skin composition (the components are 0.1 part of carnosine, 0.1 part of ceramide, 0.1 part of schizosaccharomyces fermentation product lysate, 9.7 parts of schizosaccharomyces fermentation product filtrate), 0.1 part of PPG-5-cetyl polyether-202 part, 0.1 part of phenoxyethanol, 0.1 part of methylparaben, 0.5 part of synthetic squalane, 0.05 part of macromolecular sodium hyaluronate, 0.05 part of low molecular sodium hyaluronate, 0.05 part of hydrolyzed sodium hyaluronate, 0.1 part of betaine, 0.1 part of hydroxyethyl urea and 86.95 parts of water.
The skin care essence of the comparative example was mainly used for facial skin care.
A preparation method of skin care essence comprises the following steps:
adding macromolecular sodium hyaluronate, low-molecular sodium hyaluronate, hydrolyzed sodium hyaluronate, betaine, hydroxyethyl urea and water into a water phase pot, uniformly mixing, heating to 75 ℃, and keeping the temperature for 20min until the materials are completely dissolved to obtain a mixture A.
Adding PPG-5-cetyl polyether-20 and synthetic squalane into an oil phase pot, mixing, heating to melt completely to 75 deg.C, and keeping the temperature for 20min to obtain oil phase B;
uniformly mixing the oil phase B and the mixture A in an emulsifying pot, homogenizing and emulsifying at 70 ℃ for 10min, and simultaneously performing vacuum defoaming to obtain a mixture C;
cooling the mixture C to 35 deg.C in cold water bath, adding skin composition, phenoxyethanol and methyl hydroxybenzoate, stirring at 50rpm/min, discharging at 33 deg.C, and making into scalp care essence with pH of 5.81.
Example 8: performance testing
The scalp care compositions or scalp care essences provided in examples 1 to 7 and comparative examples 1 to 7 were subjected to performance tests including:
(1) stability test
The scalp care essences prepared in examples 5 to 7 and comparative examples 4 to 7 were subjected to stability tests, and the results thereof are shown in table 1 below.
Table 1 table for stability test of each example and comparative example
As can be seen from the stability test results in table 1, the scalp care essence or skin care essence prepared in examples 5 to 7 and comparative examples 4 to 7 are qualified in the cold, heat and light resistant conditions, i.e., can satisfy the normal use under extreme temperature changes. Examples 2 and 3 and comparative example 3 were slightly yellow after 30 days of light exposure due to the addition of the perfume.
(2) Microbiological test
The scalp care essences prepared in examples 5 to 7 and comparative examples 4 to 7 were subjected to a microbiological test, and the results thereof are shown in table 2 below.
TABLE 2 comparison table of microbiological tests of each example and comparative example
As is clear from the results of the microbiological tests in Table 2, the microbiological tests of examples 5-7 and comparative examples 4-7 all satisfied the preservation requirements.
(3) Determination of antioxidant efficacy
And (2) adopting a chemical method, namely a DPPH removal method to carry out antioxidant efficacy determination, adding 2ml of 0.2mmol/L ethanol solution into a reaction tube during determination, adding 2ml of a sample to be determined, uniformly mixing, carrying out a dark reaction at room temperature for 30min, reading absorbance at 517nm as an experimental group, simultaneously taking the absorbance obtained after mixing 2ml of DPPH +2ml of buffer solution as a control group, and taking the absorbance obtained after mixing 2ml of double distilled water +2ml of ethanol as a normal group, and calculating the DPPH removal rate.
DPPH clearance (%) [1- (experimental group a 517-normal group a 517)/control group a517] × 100%, the clearance of the samples to DPPH stable free radicals was tested.
The scalp care compositions or scalp care essences prepared in examples 1 to 7 and comparative examples 1 to 7 were subjected to the measurement of antioxidant effect, and the results thereof are shown in table 3 below.
TABLE 3 antioxidant efficacy measurement and comparison table for each example and comparative example
| Sample (I) | DPPH clearance (%) |
| Example 1 | 95.6 |
| Example 2 | 93.2 |
| Example 3 | 90.3 |
| Example 4 | 93.8 |
| Example 5 | 91.3 |
| Example 6 | 88.7 |
| Example 7 | 91.8 |
| Comparative example 1 | 85.5 |
| Comparative example 2 | 90.2 |
| Comparative example 3 | 68.7 |
| Comparative example 4 | 28.3 |
| Comparative example 5 | 48.5 |
| Comparative example 6 | 35.5 |
| Comparative example 7 | 41.4 |
(4) Anti-sugar efficacy assay
The method adopts a chemical method, namely an AGEs removing method to carry out anti-sugar efficacy determination, AGEs are products generated in the reaction processes of Maillard reaction, fat oxidation and the like, fluorescence intensity is determined under specific wavelength by establishing a Maillard simulation reaction system of bovine serum albumin and glucose, AGEs content is expressed by the fluorescence intensity, and the removing effect of a sample on glycosylated protein generation can be calculated.
Adding glucose and Bovine Serum Albumin (BSA) into a PB buffer solution (pH 7.0) to obtain saccharification systems with final concentrations of 400mmol/L and 40g/L respectively, uniformly mixing, incubating at 37 ℃ for 7 days to obtain AGEs solutions, adding different solutions to be tested into the AGEs solutions, setting a yin-yang control group, incubating at 37 ℃ for 1 day, measuring a fluorescence intensity value at 360nm by using a fluorescence photometer, and calculating the AGEs clearance rate.
AGEs clearance (%) [1- (A-B)/(C-D) ]
In the formula: a-fluorescence intensity of AGEs solution with sample added;
b-fluorescence intensity of PB solution with sample added;
c-fluorescence intensity of AGEs solution without sample;
d-fluorescence intensity of PB solution without sample.
The scalp care compositions or scalp care essences prepared in examples 1 to 7 and comparative examples 1 to 7 were subjected to the anti-sugar efficacy measurement, and the results thereof are shown in table 4 below.
TABLE 4 comparative table for anti-sugar efficacy measurement of each example and comparative example
| Sample (I) | AGEs clearance (%) |
| Example 1 | 85.5 |
| Example 2 | 78.6 |
| Example 3 | 56.5 |
| Example 4 | 81.5 |
| Example 5 | 72.8 |
| Example 6 | 68.9 |
| Example 7 | 75.5 |
| Comparative example 1 | 35.1 |
| Comparative example 2 | 82.2 |
| Comparative example 3 | 38.7 |
| Comparative example 4 | 0 |
| Comparative example 5 | 28.2 |
| Comparative example 6 | 0 |
| Comparative example 7 | 25.1 |
As can be seen from the antioxidant efficacy measurement results of table 3 and the anti-sugar efficacy measurement results of table 4: for the scalp care compositions, examples 1 to 4 and comparative example 2, which contain a certain amount of carnosine, both showed better DPPH clearance and AGEs clearance, i.e., carnosine had better anti-sugar anti-oxidant effect. Comparing example 1 with comparative examples 2 and 3, it can be seen that the schizosaccharomyces cerevisiae and ceramide also have a good synergistic effect on removing DPPH and AGEs.
For the scalp care essence, examples 5 to 7, which have much higher DPPH clearance and AGEs clearance than comparative examples 4 to 7, showed significant anti-sugar and anti-oxidation effects, and thus it can be seen that: the scalp composition has a good effect of removing DPPH and AGEs, and simultaneously, other components are supplemented, and the components act synergistically, so that excellent DPPH removal rate and AGEs removal rate are obtained.
(5) Test for Water loss through The Epidermis (TEWL)
The trans-epidermal water loss (TEWL) and skin moisture content data were measured by a skin moisture loss tester Tewameter TM300 of CK corporation, Germany, in combination with a scalp moisture loss test probe Tewameter TM Nano.
Selecting 48 volunteers aged 18-45 years, randomly dividing into 8 groups, selecting 1 test point on scalp at the top of head of a subject for 6 persons in each group, recording the position of the test point by using a positioning film, and measuring a TEWL value measured before use by a Tewameter (TM) Nano and marking as D0; TEWL values determined at day 14 and day 28 after use, as D14 and D28, for each test point (g/h/m)2) On average, the more the TEWL value decreases, indicating better skin barrier performance.
TABLE 5 comparison table of scalp Water loss test for each example and comparative example
Under normal conditions, the scalp loses water to enable the TEWL value to be in an increasing trend, the scalp barrier function is reflected by the reduction of the TEWL value, the more the TEWL value is reduced, the better the scalp water retention capacity is, and the better the scalp barrier function is. For scalp care compositions, as can be seen from the results of the scalp water loss test of table 5: examples 1 to 4 all had a good repairing effect on the scalp barrier. Comparative examples 1 and 2 because the yeast schizosaccharomyces has a certain moisturizing effect and can provide a certain barrier effect, the TEWL values of comparative examples 1 and 2 are slightly increased and tend to be stable, but comparative example 2 has no repair function for the scalp barrier,
for the scalp care essence, examples 5 to 7 all had better scalp barrier efficacy; the TEWL values of comparative examples 4 and 6 increased significantly, indicating that there was no scalp barrier repair capability; comparative example 5 contains an amount of scalp composition and thus has partial barrier repair capability; comparative example 7 contains a certain amount of the scalp composition, but the water-holding capacity of the scalp was decreased and the barrier function was slightly decreased due to the excessive amount of the oil.
As can be seen from the test results of examples 5 to 7, when the scalp composition is contained in an amount of 75% to 85%, the scalp care essence has superior anti-sugar oxidation and scalp barrier repair effects, while the scalp care essence has poor or no efficacy when it contains no or only a part of the scalp care composition.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are intended to be within the scope of the invention.
Claims (10)
1. A scalp care composition characterized in that it comprises: ceramide, carnosine and a yeast fermentation product.
2. A scalp care composition according to claim 1 characterized in that: the scalp care composition further comprises a dispersing aid;
preferably, the composition of the scalp care composition comprises, in parts by weight: 0.01-0.5 part of ceramide, 0.01-10 parts of carnosine, 78-99.73 parts of yeast bifidus fermentation product and 0.25-12.5 parts of dispersing auxiliary agent.
3. A scalp care composition according to claim 1 or 2 characterized in that: the ceramide is selected from at least one of ceramide 1, ceramide 2, ceramide 3 and ceramide 6.
4. A scalp care composition according to claim 1 or 2 characterized in that: the split yeast fermentation product is selected from a split yeast fermentation product lysate and/or a split yeast fermentation product filtrate.
5. A scalp care essence is characterized in that: the scalp care essence comprising the scalp care composition according to any one of claims 1 to 4.
6. The scalp care essence according to claim 5, characterized in that: the scalp care essence also comprises at least one of ethanol, nicotinamide, a humectant, a freshener, a solubilizer, a skin conditioner, a chelating agent, a preservative, an acid-base regulator and essence;
preferably, the scalp care essence comprises the following components in parts by weight: 75-85 parts of scalp care composition, 10-15 parts of ethanol, 0.5-2 parts of nicotinamide, 2-4 parts of humectant, 0.05-0.3 part of freshener, 0.5-2 parts of solubilizer, 0.5-2 parts of sebum inhibitor, 0.1-0.5 part of skin conditioner, 0.01-0.1 part of chelating agent, 0.5-2.5 parts of preservative, 0.1-1 part of acid-base regulator and 0-0.2 part of essence.
7. The scalp care essence according to claim 6, characterized in that: the humectant is at least one selected from glycerin, propylene glycol, butanediol and sodium pyrrolidone carboxylate;
the cooling agent is at least one of menthol, borneol and cooling agent;
the solubilizer is selected from PEG-40 hydrogenated castor oil or PEG-60 hydrogenated castor oil;
the sebum inhibitor is preferably 10-hydroxydecanoic acid;
the skin conditioning agent is selected from dipotassium glycyrrhizinate or allantoin and/or bisabolol;
the chelating agent is at least one selected from sodium glucoheptonate, disodium ethylene diamine tetraacetate and tetrasodium ethylene diamine tetraacetate;
the preservative is at least one selected from phenoxyethanol or sodium benzoate, 1, 2-hexanediol and 1, 2-pentanediol;
the pH regulator is at least one selected from lactic acid, sodium lactate, citric acid and sodium citrate.
8. A method of preparing a scalp care essence according to any one of claims 5 to 7, characterized in that: the method comprises the following steps:
mixing and dissolving the freshener and the solubilizer, and uniformly mixing the freshener, the preservative and the humectant to be clear and transparent to prepare a solution A;
adding ethanol, nicotinamide, skin conditioner and chelating agent into the scalp care composition, and uniformly mixing to obtain solution B;
and (3) uniformly mixing the solution A and the solution B, and adding an acid-base regulator to regulate the pH value to 4.5-6.0 to prepare the scalp care essence.
9. A scalp care shampoo is characterized in that: the scalp care shampoo comprising the scalp care composition according to any one of claims 1 to 4.
10. A scalp care conditioner characterized by: the scalp care conditioner comprising the scalp care composition according to any one of claims 1 to 4.
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