CN117959228B - Anti-dandruff and anti-hair-loss shampoo containing natural plant components and preparation method thereof - Google Patents

Abstract

The invention discloses an anti-dandruff and anti-hair-loss shampoo containing natural plant components and a preparation method thereof, and relates to the technical field of washing and caring products. The shampoo adopts natural plant extract components, such as cacumen biotae extract, polygonum multiflorum root extract, ginger root extract, swertia extract, pandanus extract, mugwort leaf extract, tea extract and European Isatis indigotica leaf extract, and caffeine and piroctone olamine salt are matched, so that the effects of improving qi and blood, promoting scalp blood circulation, promoting hair follicle body cell to actively grow, providing nutrition for scalp, fundamentally improving hair quality and preventing alopecia are achieved; the shampoo can also effectively inhibit malassezia on scalp, achieves the effects of relieving itching and effectively radically treating dandruff, and selects other cleaning, surface active and thickening components compatible with natural plant extracts, so that the shampoo is mild and non-irritating to scalp, rich in system foam, good in combing property and long-term stability.

Description

Anti-dandruff and anti-hair-loss shampoo containing natural plant components and preparation method thereof

Technical Field

The invention relates to the technical field of washing and caring products, in particular to anti-dandruff and anti-hair-loss shampoo containing natural plant components and a preparation method thereof.

Background

With the current development of society, the life rhythm of people is accelerated and various working pressures are increased, and the dandruff and itching problems are more and more common. Dandruff production is mainly related to three important factors of scalp microecological imbalance, excessive sebum secretion and scalp stratum corneum barrier damage. According to professional investigation, about 67% of people have the problem of dandruff, namely 2/3 of people have the problem of dandruff. Most of the anti-dandruff shampoos on the market at present temporarily eliminate dandruff from the appearance by degreasing, serious dandruff trouble occurs again once the shampoo is stopped, scalp sensitivity can be caused by removing the dandruff by degreasing for a long time, skin barrier is destroyed, unbalance of grease secretion occurs, and other scalp problems can be caused seriously. The shortcomings of the commercial anti-dandruff shampoo are that one of the following two points: the shampoo containing the chemical anti-dandruff agent is effective when the shampoo is used at the beginning, the effect is weakened for a long time, even no obvious effect is achieved, the chemical anti-dandruff agent only stays on the surface of the scalp to clean, the dandruff cannot be thoroughly eradicated, the chemical components remain on the scalp, further irritation and damage are caused to the scalp, and the three major balance problems of scalp with excessive dandruff including head oil, itching and dandruff are not fundamentally solved. And two,: although the shampoo containing the Chinese herbal medicines has small irritation, the shampoo has less ideal anti-dandruff and antipruritic effects because the shampoo has short contact time with scalp in the use process, so that the active ingredients in the Chinese herbal medicine components are difficult to fully exert the effects in a short time.

In addition, hair loss is a first major hair health problem which disturbs consumers, hair is sparse, even baldness is caused, the light person affects the beauty of the individual, and the heavy person causes trauma to the psychological of the individual. It was found that hair loss is mainly caused by the following causes: firstly, the ecological scalp of a human body is deteriorated, so that the scalp environment is disturbed, and hair follicles are loosened or blocked; secondly, the metabolism disorder in the body stimulates the sebaceous gland to secrete exuberance, so that a large amount of grease is pressed against the root of the hair, the blood and nutrition supply required by the hair is blocked, and seborrheic alopecia occurs; thirdly, the hair follicle is malnourished and difficult to grow due to the lack of trace elements. In addition to hair loss due to pathology and stress, improper use of shampoos can also lead to increased hair loss problems.

For example, literature: li Qiufang, dragon's disease, hu Yongzhi, etc., research on Chinese herbal hair loss preventing shampoo [ J ]. Chinese detergent industry, 2016, 000 (006): 75-80. The action mechanism of Chinese herbal medicine and research progress of Chinese herbal plant hair loss preventing shampoo are disclosed, the hair loss preventing effect of six plant components of mulberry leaf, cacumen Platycladi, fructus Viticis, ligusticum wallichii, cortex Mori and tea bran in shampoo is researched, and the result shows that the related Chinese herbal shampoo has good hair loss preventing effect, has small side effect, and is not easy to cause skin allergy problem, etc. Chinese patent application CN 116211765A discloses an anti-hair loss shampoo and a preparation method thereof, which can specifically kill scalp bacteria, microorganisms and the like, protect scalp health, have good anti-inflammation and antipruritic effects on the dermatitis, and further realize good effects of inhibiting hair loss and preventing hair loss. However, the concentrated anti-hair loss essence applied in the shampoo needs to be prepared into a solution for use, the operation is complex, and the bad effect can be brought to the conditioning property of the shampoo due to different batches. The Chinese patent CN115006336A discloses a plant shampoo capable of preventing hair loss, strengthening hair, removing dandruff and relieving itching and a preparation method thereof, and the plant shampoo prepared by introducing plant combination extract, cocamidopropyl PG-dimethyl ammonium chloride phosphate and piroctone olamine to act synergistically is safe and mild, has the effects of preventing hair loss, strengthening hair, removing dandruff and relieving itching, but only achieves short-term anti-dandruff effect and has limited antibacterial capability.

In addition, shampoo compositions as a mixture of various components are required to have long-term storage-stable properties such as viscosity, pH, and appearance stability; when a plurality of plant extracts are added into the shampoo, the phenomenon of unstable properties, layering, floccule precipitation and the like are often caused, and the effect of the product is affected due to the incompatibility of the plant extract components and other components in the shampoo, such as cleaning, surface activity, thickening and the like.

Therefore, the anti-dandruff and anti-hair loss shampoo which can improve qi and blood, promote scalp blood circulation, promote hair follicle somatic cell to actively grow, provide nutrition ingredients for the scalp, radically improve hair quality, prevent alopecia, effectively inhibit malassezia on the scalp, achieve the effects of relieving itching and effectively radically treating dandruff, and has mild and non-irritating scalp, rich system foam, good combing property and stability for long-term use is of great importance.

Disclosure of Invention

Aiming at the problems existing in the prior art, the invention provides the shampoo containing natural plant components and the preparation method thereof, and the prepared shampoo has excellent stability and anti-dandruff, anti-hair-loss and antibacterial effects through the compounding of the raw materials. In order to achieve the above purpose, the technical scheme adopted by the invention is as follows.

The invention provides anti-dandruff and anti-hair loss shampoo containing natural plant components, which consists of A phase, B phase, C phase and D phase.

The phase A raw materials comprise the following components in parts by weight: 20-60 parts of deionized water, 5-35 parts of sodium lauroyl sarcosinate, 5-30 parts of cocamidopropyl betaine and 2-8 parts of cocoyl glucoside; as a more preferred embodiment, phase A also includes 0.01 to 0.5 parts disodium EDTA. The cocoyl glucoside and sodium lauroyl sarcosinate and cocamidopropyl betaine are compounded to form a surfactant aqueous solution system, so that the basic stability of the shampoo is maintained.

The raw materials of the phase B comprise the following components in parts by weight: 1-6 parts of cocamidomethyl MEA, 0.5-3 parts of PPG-2 hydroxyethyl cocamide, 0.1-3 parts of PEG-150 pentaerythritol tetrastearate, 0.1-1.5 parts of stearic acid, and citric acid and sodium chloride for adjusting the pH value of shampoo to 5.0-6.5 and the viscosity to 1500-4000 mPa.s; preferably, the citric acid in the phase B is 0.01-1 part and the sodium chloride is 0.01-1 part. As a more preferred embodiment, phase B further comprises 0.1 to 0.5 parts salicylic acid, 0.1 to 0.3 parts butylated hydroxytoluene, and 0.1 to 0.8 parts sodium benzoate. Thickening the shampoo by cocoamidomethyl MEA, PPG-2 hydroxyethyl cocoamide, PEG-150 pentaerythritol tetrastearate and stearic acid, adjusting the pH and viscosity of the shampoo by citric acid and sodium chloride, and combining the aqueous solution system of the surfactant to form a compound system which can be stable for a long time and is compatible with functional components such as a hair conditioner, a plant extract and the like.

The raw materials of the phase C comprise the following components in parts by weight: 0.05 to 0.5 part of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.05 to 0.5 part of polyquaternium-10, 0.05 to 1.5 part of stearamidopropyl dimethylamine and 0.35 to 4.5 parts of hair conditioner; preferably, the hair conditioner 0.35-4.5 parts consists of 0.1-1 parts of PPG-3 octyl ether, 0.05-0.4 parts of hydrolyzed keratin, 0.05-0.5 parts of vitamin E, 0.1-1 parts of nicotinamide, 0.01-0.5 parts of sodium hyaluronate, 0.01-0.5 parts of dipotassium glycyrrhizinate, 0.02-0.15 parts of panthenol, 0.02-0.15 parts of fermentation product filtrate of the saccharomyces cerevisiae and 0.01-0.3 parts of ceramide. The hydroxypropyl guar gum hydroxypropyl trimethyl ammonium chloride, the polyquaternium-10 and the stearamidopropyl dimethylamine not only can cooperatively improve the conditioning effect of the shampoo, but also can keep compatibility with the hair conditioner and prevent precipitation of hair conditioner components or system delamination.

The raw materials of the phase D comprise the following components in parts by weight: 3.1-31 parts of plant extract, 0.1-0.4 part of caffeine and 0.1-1 part of piroctone olamine salt; preferably, 3.1-31 parts of the plant extract consists of 1-12 parts of biota orientalis leaf extract, 0.5-5 parts of polygonum multiflorum root extract, 0.5-3 parts of ginger root extract, 0.5-3 parts of swertia extract, 0.1-3 parts of Isatis indigotica leaf extract, 0.1-1 part of moldavica leaf extract, 0.2-2 parts of mugwort leaf extract and 0.2-2 parts of tea leaf extract. As a more preferred embodiment, the D phase further comprises 0.01-4 parts of essence, 0.1-4 parts of PEG-40 hydrogenated castor oil, 0.1-5 parts of 1, 3-propanediol, 0.1-5 parts of glycerin, 0.1-5 parts of 1, 2-hexanediol, 0.1-0.8 part of benzyl alcohol, 0.1-1 part of phenoxyethanol and 0.1-0.8 part of p-hydroxyphenylethanol.

Preferably, the raw materials of the phase A comprise the following components in parts by weight: 30-50 parts of deionized water, 10-28 parts of sodium lauroyl sarcosinate, 10-25 parts of cocamidopropyl betaine, 2-5 parts of cocoyl glucoside and 0.01-0.35 part of EDTA disodium;

the raw materials of the phase B comprise the following components in parts by weight: 1 to 4 parts of cocamidomethyl MEA, 0.5 to 2.5 parts of PPG-2 hydroxyethyl cocoamide, 0.1 to 2.8 parts of PEG-150 pentaerythritol tetrastearate, 0.1 to 1.2 parts of stearic acid, 0.01 to 0.85 part of citric acid, 0.01 to 0.8 part of sodium chloride, 0.1 to 0.35 part of salicylic acid, 0.1 to 0.2 part of butylhydroxytoluene and 0.1 to 0.5 part of sodium benzoate; the citric acid and the sodium chloride are used for adjusting the pH value of the shampoo to be 5.0-6.5 and the viscosity to be 1500-4000 mPa.s;

The raw materials of the phase C comprise the following components in parts by weight: 0.05 to 0.4 part of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.05 to 0.4 part of polyquaternium-10, 0.05 to 1 part of stearamidopropyl dimethylamine, 0.1 to 0.8 part of PPG-3 octyl ether, 0.05 to 0.25 part of hydrolyzed keratin, 0.05 to 0.3 part of vitamin E, 0.1 to 0.5 part of nicotinamide, 0.01 to 0.35 part of sodium hyaluronate, 0.01 to 0.4 part of dipotassium glycyrrhizinate, 0.02 to 0.12 part of panthenol, 0.02 to 0.12 part of filtrate of fermentation product of two split yeasts and 0.01 to 0.25 part of ceramide;

The raw materials of the phase D comprise the following components in parts by weight: 1-10 parts of cacumen biotae extract, 0.5-3 parts of polygonum multiflorum root extract, 0.5-2 parts of ginger root extract, 0.5-2 parts of swertia extract, 0.1-2 parts of Isatis tinctoria leaf extract, 0.1-0.28 part of caffeine, 0.1-0.6 part of chikungunya leaf extract, 0.2-1 part of mugwort leaf extract, 0.2-1 part of tea leaf extract, 0.1-0.8 part of piroctone olamine salt, 0.01-3.5 parts of essence, 0.1-2.5 parts of PEG-40 hydrogenated castor oil, 0.1-3 parts of 1, 3-propanediol, 0.1-3 parts of glycerin, 0.1-3.5 parts of 1, 2-hexanediol, 0.1-0.6 part of benzyl alcohol, 0.1-0.75 part of phenoxyethanol and 0.1-0.7 part of p-hydroxyphenylethanol.

More preferably, the raw materials of the phase A comprise the following components in parts by weight: 30-45 parts of deionized water, 10-22 parts of sodium lauroyl sarcosinate, 10-20 parts of cocamidopropyl betaine, 2-3 parts of cocoyl glucoside and 0.01-0.25 part of EDTA disodium;

The raw materials of the phase B comprise the following components in parts by weight: 1-3 parts of cocoamidomethyl MEA, 0.5-1 part of PPG-2 hydroxyethyl cocoamide, 0.25-2 parts of PEG-150 pentaerythritol tetrastearate, 0.25-0.8 part of stearic acid, 0.01-0.75 part of citric acid, 0.01-0.65 part of sodium chloride, 0.1-0.2 part of salicylic acid, 0.1-0.15 part of butylhydroxytoluene and 0.1-0.4 part of sodium benzoate; the citric acid and the sodium chloride are used for adjusting the pH value of the shampoo to be 5.0-6.5 and the viscosity to be 1500-4000 mPa.s;

The raw materials of the phase C comprise the following components in parts by weight: 0.1 to 0.3 part of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1 to 0.3 part of polyquaternium-10, 0.1 to 0.6 part of stearamidopropyl dimethylamine, 0.1 to 0.5 part of PPG-3 octyl ether, 0.05 to 0.15 part of hydrolyzed keratin, 0.05 to 0.2 part of vitamin E, 0.1 to 0.45 part of nicotinamide, 0.01 to 0.2 part of sodium hyaluronate, 0.01 to 0.2 part of dipotassium glycyrrhizinate, 0.02 to 0.1 part of panthenol, 0.02 to 0.1 part of fermentation product filtrate of the saccharomyces cerevisiae and 0.01 to 0.15 part of ceramide;

The raw materials of the phase D comprise the following components in parts by weight: 1-10 parts of cacumen biotae extract, 0.5-3 parts of polygonum multiflorum root extract, 0.5-2 parts of ginger root extract, 0.5-2 parts of swertia extract, 0.1-2 parts of Isatis tinctoria leaf extract, 0.1-0.28 part of caffeine, 0.1-0.6 part of chikungunya leaf extract, 0.2-1 part of mugwort leaf extract, 0.2-1 part of tea leaf extract, 0.1-0.8 part of piroctone olamine salt, 0.01-3.5 parts of essence, 0.1-2.5 parts of PEG-40 hydrogenated castor oil, 0.1-3 parts of 1, 3-propanediol, 0.1-3 parts of glycerin, 0.1-3.5 parts of 1, 2-hexanediol, 0.1-0.6 part of benzyl alcohol, 0.1-0.75 part of phenoxyethanol and 0.1-0.7 part of p-hydroxyphenylethanol.

The preparation method of the anti-dandruff and anti-hair loss shampoo comprises the following steps:

Step S1: heating the phase A component to 80-85 ℃ and mixing and dissolving to form transparent solution;

step S2: adding other components except citric acid and sodium chloride in phase B and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, polyquaternium-10 and stearamidopropyl dimethylamine in phase C, mixing at 80-85deg.C until dissolved, and cooling;

Step S3: cooling to 42-45deg.C, adding the rest C phase component and D phase component, stirring, homogenizing, adding sodium chloride and citric acid to adjust pH to 5.0-6.5 and viscosity to 1500-4000 mPa.s, and stirring under heat preservation; preferably, the stirring and homogenizing time is 5-10min, and the heat preservation and stirring time is 10-30min;

step S4: cooling to room temperature, and standing for 6-8h to obtain the anti-dandruff and anti-hair loss shampoo.

The biota orientalis leaf extract is from biota orientalis leaves, has the effects of diminishing inflammation, sterilizing, nourishing blood and promoting blood circulation, can promote proliferation of human dermal papilla cells, prolongs the growing period of hair follicles, and has good alopecia preventing effect. The mechanism is mainly that the total flavone component contained in the biota orientalis leaves can divide, proliferate and differentiate by activating stem cell characteristics of hair mother cells, and the hair growth speed is improved, the hair fibers become relatively thick and the hair follicle can be restored to vitality because the division and proliferation of the hair mother cells are active. Along with the activation of hair mother cells, the requirement of hair follicles with reduced hair growth capacity for nutrients is increased, and the blood circulation is further promoted, so that the nutrition is supplemented. The folium Platycladi extract can be selected from folium Platycladi extract C-II of Guangzhou Mailuojie biotechnology limited company.

The extract of radix Polygoni Multiflori contains chrysophanol, emodin, rhein, physcion, huang Fen ketone, lecithin, crude fat and starch, and the extract of radix Polygoni Multiflori contains nutritional components such as phospholipid, which can nourish hair root, make hair melanin, make hair blacker, and can be used as hair nutritional conditioner for hair care, hair nourishing or hair growth cosmetic. The Polygoni Multiflori radix extract C-II of Guangzhou Mailuojie biotechnology Co., ltd.

Gingerol in the ginger root extract is a compound with stimulation effect, can promote scalp blood circulation, promote hair follicle somatic cell to actively grow, and has the effect of assisting hair growth. Ginger root extract C of Guangzhou Mailuojie biotechnology limited company can be selected.

The swertia extract is a natural herbal extract with hair-growing effect, is safer than minoxidil, has no alopecia adaptation period, and is widely used in alopecia and alopecia-preventing products. The main components of the composition comprise oleanolic acid and swertiamarin. Oleanolic acid can inhibit apoptosis in hair follicle to a certain extent, and promote hair growth by prolonging hair follicle growth period and delaying entry into catagen. It can promote hair follicle cell synthesis and secretion of vascular endothelial growth factor, further enhance scalp blood supply, and provide sufficient nutrition for hair follicle, thereby achieving hair growth promoting effect. Swertiamarin has various biological activities including antioxidation, antibiosis and antiphlogosis, and regulating immune system, and can relieve scalp inflammatory reaction, dilate capillary vessel, and increase scalp blood supply. The swertia extract is derived from natural plants, has no irritation or side effects, and contains other active ingredients such as flavonoids, which also have a certain effect on hair growth. The SWERTIA JAPONICA (SWERTIA JAPONICA) extract is selected from the company limited of Hui biotechnology, guangzhou.

The extract of Isatis tinctoria leaf is a variety of Isatis tinctoria, is a two-year-old cruciferous herb, has dark green leaf, is similar to a salix leaf, contains rich effective components for promoting activation of hair follicle, contains wogonin, sinigrin, etc., and can promote eyebrow and hair growth. The extract of Isatis tinctoria L of Guangzhou medical plant biotechnology Co., ltd can be selected.

Caffeine is a Phosphodiesterase (PDE) inhibitor, increases the levels of cyclic adenosine monophosphate (cAMP, also known as "second messenger") in cells, and promotes cell proliferation by stimulating cellular metabolism-a mechanism that counteracts (counteract) testosterone/DHT-induced hair follicle miniaturization. The in vitro study results show that DHT-induced inhibition of hair follicle growth is completely reversed when caffeine is added at a concentration of 0.001% -0.005%. In addition, caffeine can significantly stimulate hair follicle growth. In another in vitro study of hair follicles in men and women, caffeine was found to enhance hair shaft elongation, prolong growth phase, and stimulate proliferation of hair matrix keratinocytes. Caffeine counteracts testosterone-induced transforming growth factor- β2 expression in male hair follicles, a major antagonistic hair growth regulator. Caffeine is also a natural purinyl alkaloid and has good permeability.

The extract of the leaves of the paphiopedilum, namely the leaves of the paphiopedilum and the leaves of the paphiopedilum, which are fresh leaves of the paphiopedilum family, are widely distributed in the regions of the Styrain, the peninsula malaise and the Philippines, are the only plants with aromatic flavor in the seeds of the paphiopedilum, and the leaves of the paphiopedilum contain special aroma, namely the rice dumpling aroma, and are introduced and cultivated in the regions of the Hainan, the Yunnan and the like in China at present. The leaf of the Vaccinium myrtillus contains rich linoleic acid, squalene, vitamin K3, phytol, estriol, etc. The skin moisturizing agent has good skin moisturizing, hyaluronidase activity inhibiting, inflammatory factor releasing inhibiting and excellent antioxidant capacity, can effectively relieve skin dryness, sensitivity, itching and other symptoms, and has good moisturizing and relieving effects. The extract of folium Foeniculi of Guangdong Latifolia Biotechnology Co., ltd.

The folium Artemisiae Argyi extract is dried leaf of Artemisia princeps Pampanini belonging to Compositae, picking when summer flower is not opened, removing impurities, and sun drying. The mugwort leaves are shrunken and crushed, have short handles, are soft in quality, fragrant in smell and bitter in taste, and have good antibacterial activity and antioxidant activity. Folium Artemisiae Argyi extract of Biochemical limited company of Jiamei of Huzhou can be selected.

The tea extract contains flavonoids, alkaloids (caffeine, theophylline, etc.), amino acids (theanine), vitamin C, etc., and its main effective components are tea polyphenols, also called tea tannin, which is a type of hydroxyphenol compound existing in tea, and can be used as antioxidant, antiinflammatory antibacterial agent, and odor inhibitor (deodorizing) in cosmetics. Tea extract of Huzhou Jiamei biochemical Co., ltd.

The mechanism of the piroctone olamine for removing dandruff and relieving itching is that the piroctone olamine can decompose peroxide, reduce the stimulation to scalp caused by peroxidation products, has good oxidation resistance, can radically block the external channel generated by dandruff, thereby effectively and radically treating the dandruff and itching, but not temporarily eliminating the dandruff from the surface in a degreasing mode, and is one of the reasons that the anti-dandruff and itching-relieving properties of the piroctone olamine are superior to those of similar products, and in addition, the piroctone olamine has a certain antibacterial effect.

Compared with the prior art, the invention has the following beneficial effects:

(1) In the shampoo, natural plant extract components such as cacumen biotae extract, polygonum multiflorum root extract, ginger root extract, swertia extract, pandanus mongolicus leaf extract, mugwort leaf extract, tea leaf extract and European Isatis indigotica leaf extract are adopted to match with caffeine and piroctone olamine salt, so that the effects of improving qi and blood, promoting scalp blood circulation and promoting hair follicle body cell to actively grow are achieved, nutrition ingredients are provided for the scalp, the hair quality is fundamentally improved, and alopecia is prevented; the malassezia on the scalp can be effectively inhibited, and the effects of relieving itching and effectively radically treating dandruff are achieved;

(2) Other cleaning, surface active and thickening components compatible with the natural plant extract are selected, so that the shampoo is mild and non-irritating to scalp, rich in system foam, good in combing property and long-term in stability.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

Figure 1 is a photograph of a sample shampoo of example 1 of the present invention after 3 months of placement in an environment at 40 c.

Figure 2 is a photograph of a sample shampoo of comparative example 2 of the present invention after 3 months of placement in an environment of 40 c.

Figure 3 is a photograph of a sample shampoo of comparative example 6 of the present invention after 3 months of placement in an environment at 40 c.

Fig. 4 is a photograph of a sample shampoo of comparative example 9 of the present invention after being left for 3 months at 40 c.

Fig. 5 is a photograph of a bacteriostasis ring for a shampoo according to the embodiment 1 of the present invention.

Fig. 6 is a photograph of a bacteriostasis ring of a shampoo of comparative example 19 according to the present invention.

Fig. 7 is a photograph of a bacteriostasis ring of a comparison example 20 shampoo of the present invention for bacteriostasis test.

Fig. 8 is a photograph of a bacteriostasis ring of shampoo of example 1, comparative example 20 and comparative example 21 according to the present invention (example 1, comparative example 20 and comparative example 21 from top to bottom).

Detailed Description

The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are some, but not all embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

Example 1

An anti-dandruff and anti-hair loss shampoo containing natural plant components comprises phase A, phase B, phase C and phase D;

the phase A raw material comprises the following components in parts by weight: 32 parts of deionized water, 21 parts of sodium lauroyl sarcosinate, 18 parts of cocamidopropyl betaine, 2.5 parts of cocoyl glucoside and 0.12 part of disodium EDTA;

The raw materials of the phase B comprise the following components in parts by weight: 2 parts of cocamidomethyl MEA, 0.8 part of PPG-2 hydroxyethyl cocamide, 1.8 parts of PEG-150 pentaerythritol tetrastearate, 0.6 part of stearic acid, 0.6 part of citric acid, 0.12 part of salicylic acid, 0.3 part of sodium chloride, 0.1 part of butylhydroxytoluene and 0.3 part of sodium benzoate;

The raw materials of the phase C comprise the following components in parts by weight: 0.15 part of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.25 part of polyquaternium-10, 0.3 part of stearamidopropyl dimethylamine, 0.4 part of PPG-3 octyl ether, 0.1 part of hydrolyzed keratin, 0.11 part of vitamin E, 0.3 part of nicotinamide, 0.08 part of sodium hyaluronate, 0.1 part of dipotassium glycyrrhizinate, 0.05 part of panthenol, 0.05 part of a fermentation product filtrate of a bifidus yeast and 0.11 part of ceramide;

The phase D comprises the following raw materials in parts by weight: 8 parts of cacumen biotae extract, 1.2 parts of polygonum multiflorum root extract, 1 part of ginger root extract, 1 part of swertia extract, 1 part of Isatis indigotica fort leaf extract, 0.12 part of caffeine, 0.2 part of chikungunya leaf extract, 0.25 part of folium artemisiae argyi extract, 0.2 part of tea leaf extract, 0.35 part of piroctone olamine salt, 1.5 parts of essence, 1.5 parts of PEG-40 hydrogenated castor oil, 2 parts of 1, 3-propanediol, 1.8 parts of glycerol, 2 parts of 1, 2-hexanediol, 0.4 part of benzyl alcohol, 0.5 part of phenoxyethanol and 0.35 part of p-hydroxyphenylethanol.

The preparation method of the anti-dandruff and anti-hair loss shampoo comprises the following steps:

step S1: adding the phase A component into a stirring pot, heating to 82 ℃, stirring, mixing and dissolving to obtain a transparent solution;

Step S2: sequentially adding other components except citric acid and sodium chloride in phase B and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, polyquaternium-10 and stearamidopropyl dimethylamine in phase C, stirring at 82 ℃ for 1.5h, mixing until the components are uniformly dissolved, and then cooling;

step S3: adding the rest C phase component and D phase component, stirring and homogenizing for 8min, adding sodium chloride and citric acid to adjust pH to 5.0-6.5 and viscosity to 1500-4000 mPa.s, and stirring for 20min under heat preservation;

Step S4: cooling to room temperature, filtering, discharging, and standing for 7 hours to obtain the anti-dandruff and anti-hair loss shampoo.

Example 2

An anti-dandruff and anti-hair loss shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as in example 1, except that 25 parts of sodium lauroyl sarcosine in phase A, 14 parts of cocamidopropyl betaine and 2.5 parts of cocoyl glucoside are adopted.

Example 3

A dandruff-removing and hair-loss-preventing shampoo containing natural plant components and a preparation method thereof are provided, wherein the specific steps are the same as in example 1, except that 2.5 parts of cocamidomethyl MEA in phase B and 0.5 part of PPG-2 hydroxyethyl cocamide in phase B are adopted.

Example 4

A natural plant component-containing anti-dandruff and anti-hair loss shampoo and a preparation method thereof are provided, and the specific steps are the same as in example 1, except that 0.2 part of PPG-3 octyl ether, 0.15 part of hydrolyzed keratin, 0.15 part of vitamin E, 0.4 part of nicotinamide, 0.05 part of sodium hyaluronate, 0.05 part of dipotassium glycyrrhizinate, 0.08 part of panthenol, 0.08 part of a fermentation product filtrate of the bifidus yeast and 0.15 part of ceramide in a C phase.

Example 5

An antidandruff and antidandruff shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as in example 1, except that 5 parts of cacumen biotae extract, 2 parts of polygonum multiflorum root extract, 1.5 parts of ginger root extract, 1.5 parts of swertia extract, 2 parts of Isatis tinctoria leaf extract and 0.2 part of caffeine in phase D.

Example 6

An anti-dandruff and anti-hair loss shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as in example 1, except that 0.3 part of extract of the Coelopsis grossedentata in phase D, 0.3 part of extract of folium artemisiae argyi, 0.25 part of extract of folium Camelliae sinensis and 0.25 part of piroctone olamine salt are adopted.

Example 7

An antidandruff and antidandruff shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as in example 1, except that disodium EDTA is not included in phase A.

Example 8

An antidandruff and antidandruff shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as in example 1, except that salicylic acid, butylated hydroxytoluene and sodium benzoate are not included in phase B.

Example 9

A shampoo containing natural plant components for removing dandruff and preventing hair loss is prepared from example 1, wherein the phase D does not contain essence, PEG-40 hydrogenated castor oil, 1, 3-propylene glycol, glycerol, 1, 2-hexanediol, benzyl alcohol, phenoxyethanol and p-hydroxyphenylethanol.

Comparative example 1

A dandruff-removing and hair-loss-preventing shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as in example 1, except that sodium lauroyl sarcosine in phase A is 40 parts, cocamidopropyl betaine is-35 parts, and cocoyl glucoside is 10 parts.

Comparative example 2

An anti-dandruff and anti-hair loss shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as in example 1, except that 3 parts of sodium lauroyl sarcosine in phase A, 7.5 parts of cocamidopropyl betaine and 1 part of cocoyl glucoside are adopted.

Comparative example 3

An antidandruff and antidandruff shampoo containing natural plant components and a preparation method thereof are the same as in example 1, except that the phase A is not included.

Comparative example 4

A natural plant component-containing anti-dandruff and anti-hair-loss shampoo and a preparation method thereof are provided, and the specific steps are the same as in example 1, except that the phase A is replaced by 32 parts of deionized water, 21 parts of sodium laureth sulfate, 18 parts of sodium C14-16 olefin sulfonate, 2.5 parts of sodium cocoyl amphoacetate and 0.12 part of disodium EDTA.

Comparative example 5

A dandruff-removing and hair-loss-preventing shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as in example 1, except that PEG-150 pentaerythritol tetrastearate in phase B is 4 parts and stearic acid is 2 parts.

Comparative example 6

A dandruff-removing and hair-loss-preventing shampoo containing natural plant components and a preparation method thereof are provided, wherein the specific steps are the same as in example 1, and the difference is that PEG-150 pentaerythritol tetrastearate in phase B is 0.05 part and stearic acid is 0.05 part.

Comparative example 7

A B-phase anti-dandruff and anti-hair loss shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as in example 1, except that the B-phase does not comprise cocamidomethyl MEA, PPG-2 hydroxyethyl cocamide, PEG-150 pentaerythritol tetrastearate and stearic acid.

Comparative example 8

A dandruff-removing and hair-loss-preventing shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as in example 1, except that cocoamidomethyl MEA, PPG-2 hydroxyethyl cocoamide, PEG-150 pentaerythritol tetrastearate and stearic acid are not included in the B phase, and 0.5 part of hydroxyethyl cellulose is added.

Comparative example 9

A natural plant component-containing anti-dandruff and anti-hair loss shampoo and a preparation method thereof are provided, and the specific steps are the same as in example 1, wherein PPG-3 octyl ether in C phase is 1.5 parts, hydrolyzed keratin is 0.5 part, vitamin E is 0.8 part, nicotinamide is 1.2 parts, sodium hyaluronate is 0.8 part, dipotassium glycyrrhizate is 0.5 part, panthenol is 0.35 part, fermentation product filtrate of two yeasts is 0.35 part, and ceramide is 0.3 part.

Comparative example 10

A natural plant component-containing anti-dandruff and anti-hair loss shampoo and a preparation method thereof are provided, and the specific steps are the same as in example 1, wherein PPG-3 octyl ether in C phase is 0.05 part, hydrolyzed keratin is 0.005 part, vitamin E is 0.01 part, nicotinamide is 0.01 part, sodium hyaluronate is 0.01 part, dipotassium glycyrrhizate is 0.01 part, panthenol is 0.01 part, and a fermentation product filtrate of Saccharomyces cerevisiae and ceramide are 0.005 part.

Comparative example 11

A shampoo containing natural plant components for removing dandruff and preventing hair loss is prepared by the same method as in example 1, except that PPG-3 octyl ether, hydrolyzed keratin, vitamin E, nicotinamide, sodium hyaluronate, dipotassium glycyrrhizinate and ceramide are not included in phase C.

Comparative example 12

A shampoo containing natural plant components for removing dandruff and preventing hair loss comprises the following steps of 0.6 part of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.6 part of polyquaternium-10 and 2 parts of stearamidopropyl dimethylamine in the phase C of the example 1.

Comparative example 13

A shampoo containing natural plant components for removing dandruff and preventing hair loss comprises the following steps of 0.01 part of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.01 part of polyquaternium-10 and 0.01 part of stearamidopropyl dimethylamine in the phase C of the example 1.

Comparative example 14

A shampoo containing natural plant components for removing dandruff and preventing hair loss is prepared by the same steps as in example 1, except that hydroxypropyl guar hydroxypropyl trimethylammonium chloride, polyquaternium-10 and stearamidopropyl dimethylamine are not included in phase C.

Comparative example 15

A shampoo containing natural plant components for removing dandruff and preventing hair loss comprises the following steps of 15 parts of cacumen Platycladi extract, 6 parts of radix Polygoni Multiflori extract, 4 parts of rhizoma Zingiberis recens extract, 4 parts of herba Swertiae Mileensis extract, 4 parts of Isatis tinctoria leaf extract and 0.5 part of caffeine in the phase D in example 1.

Comparative example 16

An antidandruff and antidandruff shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as in example 1, wherein the difference is that the extract of cacumen biotae in the D phase is 0.75 part, the extract of radix polygoni multiflori is 0.3 part, the extract of rhizoma zingiberis recens is 0.3 part, the extract of swertia is 0.1 part, the extract of Isatis indigotica fort is 0.1 part and caffeine is 0.075 part.

Comparative example 17

A shampoo containing natural plant components for removing dandruff and preventing alopecia and its preparation method are described in example 1, wherein the phase D does not include folium Platycladi extract, polygoni Multiflori radix root extract, rhizoma Zingiberis recens root extract, herba Swertiae Mileensis extract and Isatis tinctoria leaf extract.

Comparative example 18

An anti-dandruff and anti-hair loss shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as those of comparative example 1, except that caffeine is not included in phase D.

Comparative example 19

An anti-dandruff and anti-hair loss shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as in the example 1, except that the phase D does not comprise extract of Coelopsis grossedentata, extract of folium Artemisiae Argyi, extract of folium Camelliae sinensis and piroctone olamine.

Comparative example 20

An anti-dandruff and anti-hair loss shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as those of comparative example 1, except that the extract of the paphiopedilum leaves, the extract of the mugwort leaves and the extract of the tea leaves are not included.

Comparative example 21

An anti-dandruff and anti-hair loss shampoo containing natural plant components and a preparation method thereof are provided, and the specific steps are the same as those of comparative example 1, except that piroctone olamine salt is not included.

Comparative example 22

A shampoo containing natural plant components for removing dandruff and preventing hair loss and its preparation method are provided, which has the same specific steps as in example 1, except that phase B does not include citric acid and sodium chloride, i.e. pH and viscosity of the system are not adjusted in the preparation method.

Physical and chemical index

1. Viscosity and 10% aqueous pH testing

The shampoos of examples 1-9, comparative examples 1-22 were tested for viscosity and pH of 10% aqueous solutions.

Viscosity testing instrument:

The shampoo sample in the proper amount of the proposal is taken and placed in a beaker, and after eliminating bubbles, the sample is kept at the constant temperature: and (3) selecting the rotating speed of the rotor at 25+/-1 ℃, screwing the connecting screw rod into the rotor in a left-hand way, rotating the lifting button to enable the instrument to slowly descend, immersing the rotor in the center of the sample, marking the liquid level of the sample on the liquid level of the rotor, and preventing the rotor from generating bubbles. Adjusting the instrument level, starting a power switch, rotating a speed change knob to enable a rotor to rotate in liquid, directly reading data after the number to be read tends to be stable, wherein the data is the viscosity of a sample, and the test result is shown in table 1.

PH test instrument:

Weighing a certain amount of sample, diluting with water to obtain 10% aqueous solution, stirring to dissolve the sample sufficiently, immersing the electrode in the solution to be tested, and reading data to obtain pH value of the sample after the reading number is stable, wherein the test result is shown in Table 1.

TABLE 1 shampoo viscosities of examples 1-9, comparative examples 1-22 and pH of 10% aqueous solutions

Examples/comparative examples	Viscosity (mPa. S)	PH value of
			Example 1	3540	5.72
Example 2	3260	5.75
			Example 3	3920	5.86
Example 4	3860	5.63
			Example 5	3420	5.80
Example 6	3480	5.85
			Example 7	3180	5.71
Example 8	2660	6.37
			Example 9	1980	5.68
Comparative example 1	6280	5.82
			Comparative example 2	440	5.52
Comparative example 3	280	5.12
			Comparative example 4	8620	6.25
Comparative example 5	4320	5.35
			Comparative example 6	1480	5.92
Comparative example 7	900	6.18
			Comparative example 8	1140	6.24
Comparative example 9	2120	5.56
			Comparative example 10	3080	5.78
Comparative example 11	2340	5.89
			Comparative example 12	3960	5.52
Comparative example 13	2440	5.88
			Comparative example 14	2020	6.12
Comparative example 15	1160	5.41
			Comparative example 16	3640	5.81
Comparative example 17	3840	5.95
			Comparative example 18	3520	5.88
Comparative example 19	3620	5.94
			Comparative example 20	3540	5.94
Comparative example 21	3580	5.78
			Comparative example 22	520	6.68

As can be seen from the test results of examples 1-9 and comparative examples 1-22 in Table 1, after reasonable compounding of sodium lauroyl sarcosinate, cocamidopropyl betaine and coco glucoside, a shampoo with a suitable initial viscosity was obtained. And the addition of PEG-150 pentaerythritol tetrastearate and stearic acid further stabilizes the viscosity of the shampoo system in a proper range, thereby facilitating the use of the pump. The addition of the C phase and the D phase as effective components can reduce the pH value and the viscosity of the shampoo system; however, proper addition has little effect on the pH and viscosity of the system.

2. Stability test

The shampoo of examples 1-9 and comparative examples 1-22 was placed in the environment of-8deg.C, 4deg.C, normal temperature and 40deg.C for 3 months, the stability of the samples was observed, and whether delamination, floccules, gels (hereinafter referred to as jelly) and off-flavors were observed, and the test results are shown in Table 2.

TABLE 2 shampoo stability test results for examples 1-9, comparative examples 1-22

As can be seen from the test results of examples 1-9 and comparative examples 1-22 in Table 2, the shampoos of examples 1-7 were stable in performance, and the shampoo sample of example 1 was shown in FIG. 1 after being left for 3 months at 40 ℃. Examples 8 to 9 were free of salicylic acid, essence, preservative stabilizer, etc., and the material was stored at normal or high temperature for a long period of time with acceptable odor change, but no delamination or flocculent precipitation was observed in appearance. In comparative example 2 with too low a surface active amount or comparative example 3 without adding a surface active, the material was opaque and white, the smell was changed, and the shampoo sample of comparative example 2 was left for 3 months at 40 ℃ as shown in fig. 2. Comparative example 6 in which the amount of PEG-150 pentaerythritol tetrastearate and stearic acid was too low, comparative example 7 in which PEG-150 pentaerythritol tetrastearate and stearic acid were not added, comparative example 8 in which the amount of the alternative thickener type was too high, or comparative example 22 in which the pH and viscosity of the system were not adjusted, and the like, the materials were layered or changed in smell, and the like, and a sample of the shampoo of comparative example 6 was left for 3 months at 40℃as shown in FIG. 3. The material of comparative example 1 having too high a surface active amount or comparative example 4 substituting for the surface active species or comparative example 5 having too high an amount of PEG-150 pentaerythritol tetrastearate and stearic acid may exhibit jelly or the like. In comparative example 9 and comparative example 12 in which the amount of the C-phase component was too high, flocculent precipitation of the material occurred, and the shampoo sample of comparative example 9 was left for 3 months at 40℃as shown in FIG. 4.

Therefore, the reasonable addition of the components of the invention does not affect the stability of the system.

Further, the shampoo with qualified physicochemical indexes of examples 1 to 7, comparative examples 10 to 11, comparative examples 13 to 14 and comparative examples 16 to 21 was subjected to the development performance test.

Performance test:

1. Laboratory internal evaluation data

The foam amount, wet hair slip, water-flushing property, softness after drying and fluffiness of the hair tresses were evaluated by 1 person of the laboratory professional by washing 11 hair tresses separately, and the scoring criteria were 6 minutes (1 minute means that the effect on the use feeling or on the test product was very unsatisfactory, and 6 minutes means that the effect on the use feeling or on the test product was very satisfactory).

TABLE 3 results of ex vivo tress test evaluation

Table 3 the results show that examples 1-7, comparative examples 10-11, comparative examples 13-14 and comparative examples 16-21 show that the overall experience of the shampoos after use is significantly deteriorated, particularly the wet and slippery feel and dry hair effect, with or without the addition of comparative examples 10-11 and comparative examples 13-14 having too low a C-phase content. And the comparative examples 16 to 21, in which the D-phase component was used in an excessively low amount or not, also had different effects on the hair drying effect after use of the shampoo, etc.

2. Laboratory comb test

The analysis was performed in conjunction with a carding machine test apparatus. The difference in combing resistance before and after the shampoo samples provided in example 1, and comparative examples 10 to 11, comparative examples 13 to 14, and comparative examples 16 to 21, respectively, was studied for the hair tresses ex vivo, and the combing effect of the products was evaluated and verified.

The method for testing the dry hair state comprises the following steps: step one, preprocessing an in-vitro hair bundle; step two, testing carding resistance of the isolated hair bundle in a dry state; and thirdly, washing the hair tresses in a dry state by pure water after using a shampoo product, and testing combing resistance after drying the hair tresses in a dry state.

The wet hair state testing method comprises the following steps: step one, preprocessing an in-vitro hair bundle; and step two, carrying out combing resistance test on the isolated hair bundle in a dry state. Step three, testing carding resistance after the isolated hair bundles are washed by pure water; and step four, after the shampoo product is used for the treated in-vitro hair tresses, the combing resistance of wet hair and dry hair after the pure water is washed clean is tested.

The test results are specifically recorded in table 4.

TABLE 4 carding resistance test results

As can be seen from the test results of Table 4, comparative examples 10 to 11, comparative examples 13 to 14 and comparative examples 16 to 21, in which the C-phase component and D-phase component were excessively low or absent, were poor in dry and wet hair combability of shampoos.

As can be seen from laboratory internal evaluation and carding instrument tests, the addition of the C-phase component and the D-phase component as the functional components can not only not influence the foam quantity, dry and wet hair combability, flushing property and the like of the shampoo, but also improve the fluffy effect and the soft effect of the shampoo.

3. Testing the bacteriostasis of malassezia bacteriostasis ring:

The malassezia inhibition zone test is theoretically to evaluate the anti-dandruff effect of the shampoo, and the shampoo of examples 1-6, comparative example 10, comparative example 13, comparative example 16 and comparative example 18-21 is respectively subjected to 3 parallel antibacterial performance tests according to malassezia inhibition zone test instruction, wherein the larger the antibacterial diameter D (mm) is, the better the antibacterial effect is, and the better the anti-dandruff effect is predicted.

The diameter test results of the inhibition zone are shown in the table.

Table 5 results of bacteriostasis test of inhibition zone

As can be seen from the test results of examples 1-6 and comparative examples 10, 13, 16, 18, 20, 21 in Table 5, each of the antibacterial holes had a diameter of more than 7 mm as measured, i.e., had an effect of inhibiting Malachi, color bacteria. The bacteriostasis ring of the shampoo of example 1 is shown in figure 5; the inhibition zone of the shampoo of comparative example 19 is shown in figure 6; the inhibition zone of the shampoo of comparative example 20 is shown in figure 7.

Specifically, comparative example 19 was free of added extracts of the leaves of the pandana, the extracts of the mugwort leaves, the extracts of the tea leaves and the piroctone olamine salt components, and the diameters of the measured antibacterial holes were all smaller than 7 mm, i.e. the antibacterial effect was not achieved. As can be seen from the test results of comparative examples 20 to 21, the diameters of the respective antibacterial holes were also larger than 7 mm, and although the antibacterial effect Kong Shaowei was smaller than that of examples 1 to 6 and comparative examples 10, 13, 16 and 18, the effect of malassezia was also effectively inhibited.

The comparison of the inhibition zones of the shampoos of example 1, comparative example 20 and comparative example 21 is shown in fig. 8, and the comparison shows that the extracts of the pandanus japonicus leaf, the mugwort leaf and the tea leaf cooperate to synergize the inhibition performance of the piroctone olamine. The addition of the extract of the bellyband, the extract of the mugwort leaf and the extract of the tea leaf in the phase D can effectively inhibit malassezia on scalp by the shampoo, and achieve the effects of relieving itching and effectively radically treating dandruff.

Questionnaire survey test

A questionnaire was developed on the use feeling and effect of the shampoo products of example 1, comparative example 10, comparative example 13, comparative example 16, and comparative examples 18 to 21. The questionnaire in terms of the use feeling and effect of the test product was given by the volunteer on the basis of self-feeling and referring to the scoring criteria using 6 points (1 point means that the effect on the use feeling or on the test product is very unsatisfactory, 6 points means that the effect on the use feeling or on the test product is very satisfactory). After shampoo application, volunteer questionnaire statistical analysis is shown in table 6:

table 6 results of investigation of use feeling and effect

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The results of the questionnaire tests conducted on shampoos of example 1, comparative example 10, comparative example 13, comparative example 16, and comparative examples 18-21 can be seen: the shampoo of the embodiment 1 has excellent use experience, and has 100% of identity in the aspects of alopecia prevention effect, dandruff removal and itching relieving effect, mildness and no stimulation. In contrast, when example 1 was compared with comparative examples 10 and 13, it was found that the use amount of the C-phase component was reduced, and the overall use experience and the anti-hair loss effect, the anti-dandruff and antipruritic effect, the product mildness and no irritation were significantly deteriorated. In contrast, example 1 was compared with comparative example 16, and found that the flavor and anti-hair loss effect of the product were significantly deteriorated by decreasing the contents of D-phase components (cacumen Platycladi extract, radix Polygoni Multiflori extract, rhizoma Zingiberis recens extract, swertia extract, isatis tinctoria extract and caffeine). In contrast, when example 1 was compared with comparative example 18, it was found that the anti-hair loss effect of the product was significantly deteriorated without caffeine. In contrast, example 1 was compared with comparative example 19, and found that the anti-dandruff and antipruritic effects of the product were significantly deteriorated without adding extract of the leaves of the pandanus, extract of mugwort leaf, extract of tea leaf and piroctone olamine in phase D. In contrast, example 1 was compared with comparative examples 20 to 21, and found that the anti-dandruff and antipruritic effects of the products were weaker without adding extract of the leaves of the Coccoli, extract of mugwort leaf and extract of tea leaf or piroctone olamine in phase D.

The reasonable addition of the C phase component can improve the overall experience of the product, the alopecia preventing effect and the dandruff removing and itching relieving effects. While the natural plant components in phase D, such as cacumen Platycladi extract, polygoni Multiflori radix root extract, rhizoma Zingiberis recens extract, swertia extract, and Isatis tinctoria leaf extract can be used in combination with caffeine to improve qi and blood and prevent alopecia; the extract of the pandana leaves, the extract of the mugwort leaves and the extract of the tea leaves can synergistically improve the antibacterial performance of the piroctone olamine.

5. Mild test

The test utilizes the characteristics of complete, clear and transparent chorioallantoic membrane vascular system in the middle period of the hatched chick embryo, a certain amount of the test object is directly contacted with the chick embryo allantoic membrane, and changes of chorioallantoic membrane toxicity effect indexes (such as bleeding, coagulation and vascular thawing) are observed after a period of action, the indexes reflect changes of morphological structures, colors and permeability of blood vessels and vascular networks, and reflect phenomena such as chorioallantoic membrane protein denaturation and the like and damage degree thereof, and finally a score is obtained by combination, so that the eye irritation of the test object is evaluated. Endpoint scoring stimulus classification: a) ES is less than or equal to 12, no/light irritation; b) Moderate irritation with ES less than 12 and ES less than 16; c) ES is more than or equal to 16 and has strong irritation/corrosiveness.

The mildness of the shampoos of examples 1-6 was tested and the results are shown in Table 7.

TABLE 7 results of mildness test of shampoos of examples 1-6

Examples 1-6 show that the reasonable addition of the functional components of the invention does not affect the mildness of the system.

6. Test of anti-alopecia Effect

10 Healthy adults aged 18-60 years are selected, and the hair length is between 5cm and 40 cm: there are excessive hair loss and mild sparseness of hair. And the hair loss count is more than 10 according to the 60 times of hair combing method, the hair loss count is still more than 10 after the 2 weeks of washing-out period, and no special hair-dressing treatment is performed during nearly 1 month. Local hair density: fixing a hair-cutting area of 1.5cm by 1.5cm on the head of the subject, positioning, and ensuring that the hair-cutting area is consistent when each visit is performed, wherein the residual length of hair is not more than 1mm: in the image acquisition process, an operator enables a subject to be in a comfortable position, the dermatoscope is placed at the center of a hair cutting area to carry out local hair image shooting, the dermatoscope lens is completely attached to the scalp and kept vertical during shooting, and the definition of a shot image is checked. The number (roots) and density (roots/cm 2) of local hair were counted and recorded using a manual counting method. Before use, the subjects were allowed to sit still in a laboratory at a temperature of 21 ℃ and a humidity of 50% for 30min, and after 4 weeks and 8 weeks of use of the shampoo of example 1, the subjects were allowed to sit still for 30min in a laboratory at a temperature of 21 ℃ and a humidity of 50% for 60 times, and the number of hair loss was recorded.

The comb method is carried out for 60 times: the subjects were unable to shampoo within 48#4 hours prior to each visit. The visiting day can not comb in the morning: each time after reaching the test facility to adapt to the environment. The same trained technician uses combs of the same specification, combs the hair 60 times (30 times each) at a constant speed in the order from left front to left back, right front to right back, collects the hair to be shed, and counts the hair.

The test results are shown in Table 8.

Table 8 example 1 shampoo anti-hair loss effect test

From the test results of fig. 8, it was revealed that after 4 weeks and 8 weeks of use, the number of hair loss was reduced or changed little, and the hair density was increased or changed little. The shampoo disclosed by the invention can improve qi and blood, promote scalp blood circulation, promote hair follicle somatic cell to actively grow, provide nutrition ingredients for scalp, radically improve hair quality and prevent alopecia.

In conclusion, the natural plant components such as the biota orientalis leaf extract, the polygonum multiflorum root extract, the ginger root extract, the swertia extract and the Isatis tinctoria leaf extract are adopted to match with caffeine, so that qi and blood can be improved, scalp blood circulation can be promoted, hair follicle cells can be promoted to actively grow, nutrition components can be provided for the scalp, hair quality can be fundamentally improved, and alopecia can be prevented. The extract of the pandana leaves, the extract of the mugwort leaves and the extract of the tea leaves are adopted to synergistically increase the piroctone olamine salt, so that malassezia on scalp can be effectively inhibited, and the effects of relieving itching and effectively radically treating dandruff can be achieved. The system is the anti-dandruff and anti-hair-loss shampoo which is mild and non-irritating to scalp, rich in foam, good in carding property and stable in natural plant components and can be used for a long time.

While the invention has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the invention. Therefore, the protection scope of the invention is subject to the protection scope of the claims.

Claims (4)

1. An anti-dandruff and anti-hair-loss shampoo containing natural plant components is characterized by comprising an A phase, a B phase, a C phase and a D phase;

the phase A raw materials comprise the following components in parts by weight: 20-60 parts of deionized water, 5-35 parts of sodium lauroyl sarcosinate, 5-30 parts of cocamidopropyl betaine, 2-8 parts of cocoyl glucoside and 0.01-0.5 part of EDTA disodium;

the raw materials of the phase B comprise the following components in parts by weight: 1-6 parts of cocoamidomethyl MEA, 0.5-3 parts of PPG-2 hydroxyethyl cocoamide, 0.1-3 parts of PEG-150 pentaerythritol tetrastearate, 0.1-1.5 parts of stearic acid, 0.1-0.5 part of salicylic acid, 0.1-0.3 part of butylhydroxytoluene and 0.1-0.8 part of sodium benzoate, 0.01-1 part of citric acid and 0.01-1 part of sodium chloride;

The raw materials of the phase C comprise the following components in parts by weight: 0.05 to 0.5 part of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.05 to 0.5 part of polyquaternium-10, 0.05 to 1.5 part of stearamidopropyl dimethylamine and 0.35 to 4.5 parts of hair conditioner; the hair conditioner consists of 0.1-1 part of PPG-3 octyl ether, 0.05-0.4 part of hydrolyzed keratin, 0.05-0.5 part of vitamin E, 0.1-1 part of nicotinamide, 0.01-0.5 part of sodium hyaluronate, 0.01-0.5 part of dipotassium glycyrrhizinate, 0.02-0.15 part of panthenol, 0.02-0.15 part of fermentation product filtrate of the saccharomyces cerevisiae and 0.01-0.3 part of ceramide;

The raw materials of the phase D comprise the following components in parts by weight: 3.1 to 31 parts of plant extract, 0.1 to 0.4 part of caffeine, 0.1 to 1 part of piroctone olamine salt, 0.01 to 4 parts of essence, 0.1 to 4 parts of PEG-40 hydrogenated castor oil, 0.1 to 5 parts of 1, 3-propanediol, 0.1 to 5 parts of glycerol, 0.1 to 5 parts of 1, 2-hexanediol, 0.1 to 0.8 part of benzyl alcohol, 0.1 to 1 part of phenoxyethanol and 0.1 to 0.8 part of p-hydroxyphenylethanol; the plant extract consists of 1-12 parts of biota orientalis leaf extract, 0.5-5 parts of polygonum multiflorum root extract, 0.5-3 parts of ginger root extract, 0.5-3 parts of swertia japonica extract, 0.1-3 parts of Isatis indigotica leaf extract, 0.1-1 parts of pandan leaf extract, 0.2-2 parts of mugwort leaf extract and 0.2-2 parts of tea leaf extract.

2. The anti-dandruff and anti-hair loss shampoo containing natural plant components of claim 1, wherein the raw materials of phase a consist of the following components in parts by weight: 30-50 parts of deionized water, 10-28 parts of sodium lauroyl sarcosinate, 10-25 parts of cocamidopropyl betaine, 2-5 parts of cocoyl glucoside and 0.01-0.35 part of EDTA disodium;

The raw materials of the phase B comprise the following components in parts by weight: 1 to 4 parts of cocamidomethyl MEA, 0.5 to 2.5 parts of PPG-2 hydroxyethyl cocoamide, 0.1 to 2.8 parts of PEG-150 pentaerythritol tetrastearate, 0.1 to 1.2 parts of stearic acid, 0.01 to 0.85 part of citric acid, 0.01 to 0.8 part of sodium chloride, 0.1 to 0.35 part of salicylic acid, 0.1 to 0.2 part of butylhydroxytoluene and 0.1 to 0.5 part of sodium benzoate;

The raw materials of the phase C comprise the following components in parts by weight: 0.05 to 0.4 part of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.05 to 0.4 part of polyquaternium-10, 0.05 to 1 part of stearamidopropyl dimethylamine, 0.1 to 0.8 part of PPG-3 octyl ether, 0.05 to 0.25 part of hydrolyzed keratin, 0.05 to 0.3 part of vitamin E, 0.1 to 0.5 part of nicotinamide, 0.01 to 0.35 part of sodium hyaluronate, 0.01 to 0.4 part of dipotassium glycyrrhizinate, 0.02 to 0.12 part of panthenol, 0.02 to 0.12 part of filtrate of fermentation product of two split yeasts and 0.01 to 0.25 part of ceramide;

The raw materials of the phase D comprise the following components in parts by weight: 1-10 parts of cacumen biotae extract, 0.5-3 parts of polygonum multiflorum root extract, 0.5-2 parts of ginger root extract, 0.5-2 parts of swertia extract, 0.1-2 parts of Isatis tinctoria leaf extract, 0.1-0.28 part of caffeine, 0.1-0.6 part of chikungunya leaf extract, 0.2-1 part of mugwort leaf extract, 0.2-1 part of tea leaf extract, 0.1-0.8 part of piroctone olamine salt, 0.01-3.5 parts of essence, 0.1-2.5 parts of PEG-40 hydrogenated castor oil, 0.1-3 parts of 1, 3-propanediol, 0.1-3 parts of glycerin, 0.1-3.5 parts of 1, 2-hexanediol, 0.1-0.6 part of benzyl alcohol, 0.1-0.75 part of phenoxyethanol and 0.1-0.7 part of p-hydroxyphenylethanol.

3. The anti-dandruff and anti-hair loss shampoo containing natural plant components of claim 1, wherein the raw materials of phase a consist of the following components in parts by weight: 30-45 parts of deionized water, 10-22 parts of sodium lauroyl sarcosinate, 10-20 parts of cocamidopropyl betaine, 2-3 parts of cocoyl glucoside and 0.01-0.25 part of EDTA disodium;

The raw materials of the phase B comprise the following components in parts by weight: 1-3 parts of cocoamidomethyl MEA, 0.5-1 part of PPG-2 hydroxyethyl cocoamide, 0.25-2 parts of PEG-150 pentaerythritol tetrastearate, 0.25-0.8 part of stearic acid, 0.01-0.75 part of citric acid, 0.01-0.65 part of sodium chloride, 0.1-0.2 part of salicylic acid, 0.1-0.15 part of butylhydroxytoluene and 0.1-0.4 part of sodium benzoate;

The raw materials of the phase C comprise the following components in parts by weight: 0.1 to 0.3 part of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1 to 0.3 part of polyquaternium-10, 0.1 to 0.6 part of stearamidopropyl dimethylamine, 0.1 to 0.5 part of PPG-3 octyl ether, 0.05 to 0.15 part of hydrolyzed keratin, 0.05 to 0.2 part of vitamin E, 0.1 to 0.45 part of nicotinamide, 0.01 to 0.2 part of sodium hyaluronate, 0.01 to 0.2 part of dipotassium glycyrrhizinate, 0.02 to 0.1 part of panthenol, 0.02 to 0.1 part of fermentation product filtrate of the saccharomyces cerevisiae and 0.01 to 0.15 part of ceramide;

The raw materials of the phase D comprise the following components in parts by weight: 1-10 parts of cacumen biotae extract, 0.5-3 parts of polygonum multiflorum root extract, 0.5-2 parts of ginger root extract, 0.5-2 parts of swertia extract, 0.1-2 parts of Isatis tinctoria leaf extract, 0.1-0.28 part of caffeine, 0.1-0.6 part of chikungunya leaf extract, 0.2-1 part of mugwort leaf extract, 0.2-1 part of tea leaf extract, 0.1-0.8 part of piroctone olamine salt, 0.01-3.5 parts of essence, 0.1-2.5 parts of PEG-40 hydrogenated castor oil, 0.1-3 parts of 1, 3-propanediol, 0.1-3 parts of glycerin, 0.1-3.5 parts of 1, 2-hexanediol, 0.1-0.6 part of benzyl alcohol, 0.1-0.75 part of phenoxyethanol and 0.1-0.7 part of p-hydroxyphenylethanol.

4. A method for preparing the anti-dandruff and anti-hair loss shampoo according to any one of claims 1 to 3, comprising the steps of:

Step S1: heating the phase A component to 80-85 ℃ and mixing and dissolving to form transparent solution;

step S2: adding other components except citric acid and sodium chloride in phase B and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, polyquaternium-10 and stearamidopropyl dimethylamine in phase C, mixing at 80-85deg.C until dissolved, and cooling;

Step S3: cooling to 42-45deg.C, adding the rest C phase component and D phase component, stirring, homogenizing, adding sodium chloride and citric acid to adjust pH to 5.0-6.5 and viscosity to 1500-4000 mPa.s, and stirring under heat preservation;

step S4: cooling to room temperature, and standing for 6-8h to obtain the anti-dandruff and anti-hair loss shampoo.