CN104147103B - A kind of Chinese medicine composition and preparation method thereof of anti-dandruff sterilizing and itch-relieving, piliation - Google Patents
A kind of Chinese medicine composition and preparation method thereof of anti-dandruff sterilizing and itch-relieving, piliation Download PDFInfo
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Abstract
The present invention provides a kind of anti-dandruff sterilizing and itch-relieving, the Chinese medicine composition of piliation, and Chinese medicine composition bulk drug by mass is：14 parts of Isatis tinctoria leaf, 27 parts of cnidium monnieri seed, 26 parts of emblic, 26 parts of kuh-seng, 14 parts of Ligusticum wallichii.The present invention also provides educates hair products, hair washing product and hair products containing the Chinese medicine composition.Because the present invention is rich in the plant essence that is extracted from Isatis tinctoria leaf, cnidium monnieri seed, emblic, kuh-seng, Ligusticum wallichii, can moisten hair follicle, improvement scalp situation, hairy root nourishing, can effectively anti-dandruff sterilizing and itch-relieving, and contribute to hair growth.
Description
Technical field
The invention belongs to medical cosmetic technical field, and in particular to a kind of anti-dandruff sterilizing and itch-relieving, the Chinese medicine group of piliation
Compound and preparation method thereof.
Background technology
The generation of dandruff is because scalp is ceaselessly carrying out metabolism, once metabolism is not normal, just has excess
Scalp cells peel off, become seedless, abiotic cuticula, so as to cause dandruff problem.Research finds, in China, 60%
Adult all perplexed to some extent by dandruff, this do not pay attention to mainly due to Chinese Consumer's skin of head health care, with
And uncomfortable wash, caused by hair products is selected.And anti-dandruff and itching-relieving used by the dandruff control shampoo containing on domestic market
Agent is essentially all chemical substance (such as ZPT and climbazole), but these materials have certain sensitization, excitant and not
Stability.
Scalp fat secretion amount keeps balance, and scurf will produce naturally, natural metabolism, would not have a large amount of scalps
The phenomenon of bits.
The content of the invention
The purpose of the present invention is to overcome deficiency of the prior art, there is provided it is a kind of using the entirety of the traditional Chinese medical science, balance theory as
Foundation, multicomponent combination, preparation technology simple a kind of anti-dandruff sterilizing and itch-relieving, the Chinese medicine composition of piliation and its preparation side
Method；The present invention also provides educates hair products, hair washing product and hair products containing the Chinese medicine composition.
To achieve these goals, technical scheme provided by the invention is：A kind of anti-dandruff sterilizing and itch-relieving, the Chinese medicine of piliation
Composition, Chinese medicine composition bulk drug by mass are：Isatis tinctoria leaf 1-4 parts, cnidium monnieri seed 2-7 parts, emblic 2-6
Part, kuh-seng 2-6 parts, Ligusticum wallichii 1-4 parts.
The present invention is using theory of traditional Chinese medical science marrow " balance " theory and " entirety " idea as theoretical foundation, from machine caused by dandruff
Reason is started with, and selection passes through entirety, balance theory with anti-dandruff sterilization, the strong plant for nourishing, recovering scalp hair follicles healthy functions
Prescription, thoroughly improve scalp function, anti-dandruff and itching-relieving sterilization, promote hair growth.
Isatis tinctoria, is referred to as that Wu Sima is careless, also known as raw eyebrow grass in Xinjiang.Theory of traditional Chinese medical science：With clearing heat and detoxicating, cool blood disappears
The effect of spot；Uygur medicine is theoretical：Raw dry heat, dispelling cold and eliminating dampness, black hair, strengthen the hair, hair tonic, is relieved pain, convergence, dissipating bind.Cure mainly wet
Cold or lymphatic temperament disease, as capillary root is weak, trichomadesis, prematured white hair etc..
Emblic：For the fruit of euphorbia plant emblic.Rich in tannin and phenolic acid compound (dry fruit is up to 14%),
Flavone compound, containing vitamin C, vitamin B1, vitamin B2, carrotene, vitamin A, pellagra preventive factor etc., be especially enriched in
Vitamin C, its content is up to 0.6%~0.92%, containing 17 kinds of amino acid, includes 8 kinds of amino acid of needed by human body, its amino
Sour total content reaches 185mg/100g, mainly there is glutamic acid, proline, aspartic acid, alanine and lysine.Containing more in fruit
Kind trace element, its content are enriched than apple, mainly there is selenium, zinc, calcium, phosphorus, iron, potassium etc..Emblic seed fatty acids 26%,
Mainly include：Leukotrienes, linoleic acid, oleic acid, stearic acid, palmitic acid, myristic acid etc..Alcohol extract can obtain good antibacterial and live
Property material, rich in vitamin C, nutritious effect.With cool blood, strengthen the hair, black hair, nourishing effects on neural system.《Bencao Shiyi》：Main benefit
Benefit, strong strength.Take sub- pressure to take juice and oily coating head hair tonic, go pruritus, rendering hair is de-, rear raw as painted.
Ligusticum wallichii：For the dry rhizome of samphire Ligusticum wallichii, there is wind-dispelling, promoting blood circulation, moisturizing, it is antipruritic the effect of, be advantageous to
Nutrition is transformed.Modern pharmacology proves, Ligusticum wallichii energy enlarged head capillary, stimulates circulation, and increases hair nutrition, and make head
Hair has good pliability and is not easy the function of becoming fragile, and white hair can be delayed to grow, and keeps hair lubrication gloss.
Kuh-seng：Damp-heat in lower-JIAO can be removed, and desinsection is antipruritic, there is good mitigation, Neng Gouping to pruitus
Weigh fat secretion, dredges and restrains pore, removes skin endotoxin contamination, abundant herbal nutrition, promotes damaged blood vessels nerve
The growth and reparation of cell, recover subcutaneous capillary cell viability, skin, which reappears, to compact fine and smooth, plays the work of beauty and skin care
With.Alcohol extract has stronger bacteriostasis to staphylococcus aureus.
Cnidium monnieri seed：Cnidium monnieri seed bitter, it is mild-natured, and partially wet, hardship can eliminating dampness, temperature can cold dispelling, so external application can eliminating dampness it is antipruritic, it is existing
During generation is clinical, cloudy itch, trichomonas vaginitis, allergy under cnidium monnieri seed treatment multiple dermatosis and pruritus, such as woman are commonly used
Property dermatitis, skin eczema, children's tinea, head sore, malignant sore etc..
Second object of the present invention there is provided the preparation method of above-mentioned Chinese medicine composition, be by each component of mass parts
Ethanol extracts what is obtained after being mixed according to proportioning.
Preferably, methods described is：
Isatis tinctoria leaf, cnidium monnieri seed, emblic seed, kuh-seng, Ligusticum wallichii are mixed according to proportioning, add the 8-15 of mixture quality
The alcohol reflux that concentration of volume percent again is 10-80% extracts 2-3 times, each 1.0-3.0 hours, filtering, merging filtrate,
Vacuum-concentrcted is to medicinal material：Ethanol extract mass ratio is 1:2-15, centrifugation or refrigeration are stood, and are discarded precipitation, are taken supernatant,
Obtain the Chinese medicine composition of the present invention.
Third object of the present invention is to provide a kind of educates hair products containing above-mentioned Chinese medicine composition.
Preferably, it is described to educate in hair products containing described in the claims in the present invention 1 that mass percent is 5-60%
Chinese medicine composition, remaining is assistant agent.
Fourth object of the present invention is to provide the above-mentioned preparation method for educating hair products, and step is as follows：
(1) Chinese medicine composition of the thickener of formula ratio, water and the present invention are added into cold and hot agitated kettle, while stirring progressively
75-80 DEG C is heated to, is stirred, keeps 20-40min, mixing speed is 40-70r/min；
(2) cool, when cold and hot agitated kettle is cooled to 40-45 DEG C, sequentially add the NMF of formula ratio, pH adjusting agent,
Aromatic, preservative, stir；
(3) discharged when cold and hot stirring pot temperature is down to 30-35 DEG C, it is filling；Obtain the present invention educates hair products.
The 5th purpose of the present invention is to provide a kind of hair washing product containing above-mentioned Chinese medicine composition.
Preferably, containing described in the claims in the present invention 1 that mass percent is 0.5-20% in the hair washing product
Chinese medicine composition, remaining is assistant agent.
The 6th purpose of the present invention is to provide the preparation method of above-mentioned hair washing product, and step is as follows：
(1) deionized water of formula ratio is added in cold and hot agitated kettle, the surfactant of formula ratio is added, is heated to
75-80 DEG C of stirring and dissolving is uniform, keeps 20-40min, adds pearling agent, stirring is to being completely dissolved；
(2) when cold and hot agitated kettle is cooled to 40-45 DEG C, the Chinese medicine composition, antistatic additive, soft of the present invention is sequentially added
Along agent, NMF, anti-dandruff agent, thickener, pH adjusting agent, preservative, aromatic, stir；
(3) discharged when cold and hot stirring pot temperature is down to 30-35 DEG C, obtain hair washing product.
The 7th purpose of the present invention is to provide a kind of hair products containing above-mentioned Chinese medicine composition.
Preferably, containing described in the claims in the present invention 1 that mass percent is 0.5-20% in the hair products
Chinese medicine composition, remaining is assistant agent.
The 8th purpose of the present invention is to provide the preparation method of above-mentioned hair products, and step is as follows：
(1) water of formula ratio and thickener are added in aqueous phase pot, stirring, are heated to 75-80 DEG C, keep 20-40min,
Mixing speed is 25-45r/min；The pH adjusting agent and cationic surfactant of formula ratio are added, is sufficiently stirred mixing；
(2) softener of formula ratio and NMF are added into oil phase pot, is heated with stirring to 80 DEG C；
(3) homogeneous pot is warming up to 80 DEG C, is pumped into compound in step 1 aqueous phase pot, open stirring, add step 2 oil
The compound of phase pot, homogeneous 3-5 minutes, 45 DEG C are cooled to, sequentially add the remaining material of formula ratio, stir；
(4) discharged when homogeneous pot temperature is down to 30-35 DEG C, it is filling, obtain the hair products of the present invention.
The 9th purpose of the present invention is to provide above-mentioned Chinese medicine composition, educates hair products, hair washing product, hair products
Application in anti-dandruff sterilizing and itch-relieving, piliation.
Because the present invention is rich in the plant essence extracted from Isatis tinctoria leaf, cnidium monnieri seed, emblic, kuh-seng, Ligusticum wallichii, energy
Moisten hair follicle, improve scalp situation, hairy root nourishing, can effectively anti-dandruff sterilizing and itch-relieving, and contribute to hair growth.Educated in the present invention
The occupation mode of hair products can be that the liquid preparation being prepared through different formulations is applied directly at alopecia, and use finger
Gently massage, and retain 5-10 minutes, once a day, reusable if necessary, such a usage is to compare to piliation effect
Significantly.
It is of the invention to educate hair products and be used in mixed way completely with shampoo of course for simplifying step, in hair washing
During directly carry out anti-dandruff sterilizing and itch-relieving, oil-control, anticreep hair care, its effect is also pretty good.
Hair care product made of the auxiliary material that the Chinese medicine composition of the present invention is received plus hair-washing hair-care field has
Suppress the abnormal procreation generation of bacterium or fungi, accelerate blood circulation, allow scalp to obtain the absorption of height, play nourishing, oil-control,
The effect of anti-dandruff and itching-relieving, hair submissive such as silk, fluffy non-greasy are made after, reaches and treats both principal and secondary aspect of disease.The Chinese medicine composition of the present invention
Prepare simply, steady quality is safe, can be widely used for preparing hair-washing hair-care articles for use.
The present invention product have the function that quickly anti-dandruff sterilizing and itch-relieving, adhere to use can promote hair growth, hair care,
Hair care, and play anticreep effect.
Embodiment
Following embodiment facilitates a better understanding of the present invention, but does not limit the present invention.Experiment in following embodiments
Method, it is conventional method unless otherwise specified.
Embodiment 1
Anti-dandruff sterilizing and itch-relieving provided by the present invention, the Chinese medicine composition of piliation are prepared by the component of following mass fraction
Form：Isatis tinctoria leaf 1-4 parts, cnidium monnieri seed 2-7 parts, emblic 2-6 parts, kuh-seng 2-6 parts, Ligusticum wallichii 1-4 parts.
The anti-dandruff sterilizing and itch-relieving of the present invention, the preparation method of the Chinese medicine composition of piliation are as follows：
Each raw material is weighed by quality proportioning；Isatis tinctoria leaf, cnidium monnieri seed, emblic, kuh-seng, Ligusticum wallichii is mixed according to proportioning
Close, the alcohol reflux extraction that 8-15 times of concentration of volume percent for adding mixture quality is 10-80% 2-3 times, every time
1.0-3.0 hours, filtering, merging filtrate, vacuum-concentrcted to medicinal material：Ethanol extract mass ratio is 1:2-15, centrifugation or
Refrigeration is stood, and is discarded precipitation, is taken supernatant, obtains the ethanol extraction of Isatis tinctoria leaf, cnidium monnieri seed, emblic, kuh-seng, Ligusticum wallichii
Liquid, it is the Chinese medicine composition of the present invention.
The applicant by long-term a large number of experiments show that, use in above range any proportioning with above-mentioned preparation method
Prepare, obtained Chinese medicine composition can reach extraordinary anti-dandruff sterilizing and itch-relieving, piliation effect, and table 1 specifically lists
Several proportioning modes therein, in table 1, the mass parts can be gram, kilogram or other unit of weights, and whether which kind of is measured
Unit can form the formula with anti-dandruff sterilizing and itch-relieving, piliation effect.
1 anti-dandruff sterilizing and itch-relieving of table, piliation Chinese medicine composition formula
| Medicinal material | ① | ② | ③ | ④ | ⑤ |
| Isatis tinctoria leaf | 2 parts | 1 part | 4 parts | 3 parts | 2.5 part |
| Cnidium monnieri seed | 7 parts | 3 parts | 2 parts | 4 parts | 5 parts |
| Emblic | 2 parts | 2.5 part | 3 parts | 4 parts | 6 parts |
| Kuh-seng | 2 parts | 2.5 part | 6 parts | 5 parts | 4 parts |
| Ligusticum wallichii | 3 parts | 1 part | 2 parts | 4 parts | 2.5 part |
By sequence number 2. in formula exemplified by, a kind of anti-dandruff sterilizing and itch-relieving of the invention, piliation Chinese medicine composition system
Preparation Method is：
Isatis tinctoria leaf 10g, cnidium monnieri seed 30g, emblic 25g, kuh-seng 25g, Ligusticum wallichii 10g are weighed, is well mixed, with mixing
The alcohol reflux that the percent by volume that 10 times of thing gross mass is 60% extracts 2 times, 2 hours every time, filters, merging filtrate, vacuum
It is 1 to be concentrated under reduced pressure into medicinal material and extract solution mass ratio:5,6000r/min, 8min is centrifuged, precipitation is abandoned, takes supernatant, obtain European ancient name for Chinese cabbage
Lan Ye, cnidium monnieri seed, emblic, kuh-seng, Ligusticum wallichii ethanol extract, that is, obtain the present invention a kind of plant sterilization is antipruritic, piliation
Chinese medicine composition.
By sequence number 3. in formula exemplified by, a kind of anti-dandruff sterilizing and itch-relieving of the invention, piliation Chinese medicine composition system
Preparation Method is：
Isatis tinctoria leaf 40g, cnidium monnieri seed 20g, emblic 30g, kuh-seng 60g, Ligusticum wallichii 20g are weighed, is well mixed, with mixing
The alcohol reflux that the percent by volume that 15 times of thing gross mass is 80% extracts 2 times, 3 hours every time, filters, merging filtrate, vacuum
It is 1 to be concentrated under reduced pressure into medicinal material and extract solution mass ratio:15, refrigeration is stood overnight, and is abandoned precipitation, is taken supernatant, obtain Isatis tinctoria leaf,
Cnidium monnieri seed, emblic, kuh-seng, Ligusticum wallichii ethanol extract, that is, a kind of plant sterilization for obtaining the present invention is antipruritic, Chinese medicine of piliation
Composition.
By sequence number 5. in formula exemplified by, a kind of anti-dandruff sterilizing and itch-relieving of the invention, piliation Chinese medicine composition system
Preparation Method is：
Isatis tinctoria leaf 2.5kg, cnidium monnieri seed 5kg, emblic 6kg, kuh-seng 4kg, Ligusticum wallichii 2.5kg are weighed, is well mixed, with
The alcohol reflux that the percent by volume that 8 times of mixture gross mass is 10% extracts 3 times, 1 hour every time, filters, merging filtrate, very
It is 1 that sky, which is concentrated under reduced pressure into medicinal material and extract solution mass ratio,:2,5000r/min, 10min is centrifuged, precipitation is abandoned, takes supernatant, obtain Europe
Continent woaded blue leaf, cnidium monnieri seed, emblic, kuh-seng, Ligusticum wallichii ethanol extract, that is, a kind of plant sterilization for obtaining the present invention are antipruritic, raw
The Chinese medicine composition of hair.
Fungistatic effect of the above-mentioned concentrated extracting solution to chlosma is determined, is as a result shown, by the mass fraction of above range
The Chinese medicine composition concentrated extracting solution of preparation has the function that substantially to suppress chlosma；It is from inbred strais C57BL/6 mouse
Animal model, lost hair or feathers with 8% vulcanized sodium, using distilled water as control, carry out educating hair experiment.Compared with distilled water control group, this
The Chinese medicine composition of invention can substantially shorten the time (P ＜ 0.05) of skin color blackening after the depilation of C57BL/6 mouse, may be used also
The obvious time (P ＜ 0.01) for shortening skin darkening and epidermis being grown to hair, prompt that there is obvious trichogenous work
With.
A kind of formula and preparation method for educating hair products of embodiment 2
A kind of hair products of educating provided by the present invention are prepared by the component of following mass percent：
The thickening of Chinese medicine composition, 1-5% NMF, 0.1-0.5% prepared by the 5-60% embodiment of the present invention 1
Agent, appropriate pH adjusting agent, appropriate aromatic, 0.3-0.6% preservative, remaining is deionized water.
Above-mentioned NMF is one kind or several in tocopherol (vitamin E), propane diols, glycerine, D-pantothenyl aleohol, hyaluronic acid etc.
Kind combination.
Thickener is the one or more combination in guar gum, hydroxyethyl cellulose, xanthans etc..
PH adjusting agent is the one or more combination in citric acid, triethanolamine, NaOH solution etc..
Aromatic is the aromatic raw materials such as daily essence or essential oil.
Preservative is methylchloroisothiazandnone, methylisothiazolinone, methyl hydroxybenzoate, propylben, nipalgin
One or more combination in butyl ester, Phenoxyethanol, DMDMH etc..
It should be noted that NMF described above, thickener, pH adjusting agent, preservative etc. are not limited to institute of the present invention
This enumerated is several, as long as the substitute products that can play identical function are all feasible.
The preparation method for educating hair products of the present invention is as follows：
1. the Chinese medicine composition of the thickener of formula ratio, water and the present invention are added into cold and hot agitated kettle, while stirring progressively
75-80 DEG C is heated to, is stirred, keeps 20-40min, mixing speed is 40-70r/min；
2. cooling, when cold and hot agitated kettle is cooled to 40-45 DEG C, sequentially adds NMF, pH adjusting agent, the virtue of formula ratio
Pastil, preservative, stir；
3. discharged when cold and hot stirring pot temperature is down to 30-35 DEG C, it is filling；Obtain the present invention educates hair products.
Table 2 specifically lists several proportioning modes therein.
Table 2 educates hair products formula
By sequence number 3. in formula exemplified by, the preparation method for educating hair products of the invention is：
1st, by the sequence number of embodiment 1 2. in formula prepare Chinese medicine composition：Weigh Isatis tinctoria leaf 10g, cnidium monnieri seed 30g,
Emblic 25g, kuh-seng 25g, Ligusticum wallichii 10g, it is well mixed, using the concentration of volume percent of 10 times of mixture gross mass as 60%
Alcohol reflux extracts 2 times, and 2 hours every time, filtering, merging filtrate, vacuum-concentrcted to medicinal material and extract solution mass ratio were 1:
5,6000r/min, 8min is centrifuged, precipitation is abandoned, takes supernatant, obtain Isatis tinctoria leaf, cnidium monnieri seed, emblic, kuh-seng, Ligusticum wallichii ethanol
Extract solution, i.e. Chinese medicine composition of the invention；
2nd, the Chinese medicine composition prepared the thickener, water and step 1 of formula ratio adds cold and hot agitated kettle, while stirring by
Step is heated to 78 DEG C, stirs, and keeps 30min, mixing speed is 60r/min；
3rd, cool, when cold and hot agitated kettle is cooled to 42 DEG C, sequentially add NMF, pH adjusting agent, the fragrance of formula ratio
Agent, preservative, stir；
4th, discharged when cold and hot stirring pot temperature is down to 32 DEG C, it is filling；Obtain the present invention educates hair products.
The applicant by long-term a large number of experiments show that, use in above range any proportioning with above-mentioned preparation method
Prepare, obtained product, which has, extraordinary educates hair effect.
A kind of 3 sterilizing and itch-relieving of embodiment, piliation hair washing product formula and preparation method
A kind of sterilizing and itch-relieving, the hair washing product of piliation of the present invention is prepared by the component of following mass percent：
10-25% surfactant, 1.2-1.6% pearling agents, 0.5-20% Chinese medicine composition of the invention, 1-
The thickening of 5% softener, 0-0.5% anti-dandruff agent, 0.5-3% antistatic additive, 0.5-5% NMF, 0.2-0.5%
Agent, appropriate pH adjusting agent, appropriate aromatic, 0.05-0.57% preservative, remaining is deionized water.
Above-mentioned surfactant is laureth sulfuric ester ammonium, bay alcohol sulfuric ester ammonium, cocamidopropyl propyl amide hydroxyl sulphur
One or more combination in base glycine betaine, coconut oleoyl amine MEA etc..
Pearling agent is glycol distearate.
Softener is dimethyl silicone polymer, ammonia end dimethyl silicone polymer, dimethiconol, dimethyl silica
One or more combination in the silicone oil such as alkane.
Antistatic additive be one kind in Polyquaternium-10, polyquaternium -6, polyquaternium -7, lactic acid fat quaternary ammonium salt etc. or
Several combinations.
Anti-dandruff agent is the one or more combination in ZPT, piroctone olamine salt etc..
NMF is one or more of groups in D-pantothenyl aleohol, tocopherol (vitamin E), glycerine, propane diols, hyaluronic acid etc.
Close.
Thickener is the one or more combination in guar gum, xanthans, hydroxyethyl cellulose, sodium chloride etc..
PH adjusting agent is the one or more combination in triethanolamine, citric acid, NaOH solution etc..
Aromatic is the aromatic raw materials such as daily essence or essential oil.
Preservative is methylchloroisothiazandnone, methylisothiazolinone, methyl hydroxybenzoate, propylben, nipalgin
One or more combination in butyl ester, Phenoxyethanol, DMDMH, Climbazole etc..
Surfactant described above, softener, antistatic additive, anti-dandruff agent, NMF, thickener, pH adjusting agent, anti-corrosion
Agent etc. be not limited to that the present invention enumerated this is several, as long as the substitute products that can play identical function are all feasible.
A kind of sterilizing and itch-relieving of the present invention, the preparation method of piliation Chinese medicine hair washing product are as follows：
1. adding the deionized water of formula ratio in cold and hot agitated kettle, the surfactant of formula ratio is added, is heated to
75-80 DEG C of stirring and dissolving is uniform, keeps 20-40min, adds pearling agent, stirring is to being completely dissolved；
2. when cold and hot agitated kettle is cooled to 40-45 DEG C, the Chinese medicine composition of the invention, anti-quiet of formula ratio is sequentially added
Electric agent, softener, NMF, anti-dandruff agent, thickener, pH adjusting agent, preservative, aromatic, stir；
3. discharged when cold and hot stirring pot temperature is down to 30-35 DEG C, it is filling, you can to obtain a kind of anti-dandruff sterilizing and itch-relieving, life
The hair washing product of hair.
The applicant by long-term a large number of experiments show that, use in scope of the present invention any proportioning with the present invention
Prepared by described preparation method, obtained hair washing product plays the role of extraordinary sterilizing and itch-relieving, piliation.Table 3 specifically arranges
Several proportioning modes therein are lifted.
A kind of formula of the hair washing product of sterilizing and itch-relieving piliation of table 3
By sequence number 6. in formula exemplified by, the preparation method of hair washing product of the invention is：
1st, by Isatis tinctoria leaf 100g, cnidium monnieri seed 300g, emblic 250g, kuh-seng 250g, Ligusticum wallichii 100g, it is well mixed,
Extracted 2 times, 2 hours every time, filtered, merging filtrate, vacuum-concentrcted with 10 times of 60% alcohol reflux of mixture gross mass
It is 1 to medicinal material and extract solution mass ratio:5,6000r/min, 8min is centrifuged, precipitation is abandoned, takes supernatant, obtain Isatis tinctoria leaf, snake
Bed seed, emblic, kuh-seng, Ligusticum wallichii ethanol extract, i.e. Chinese medicine composition of the invention；
2nd, the deionized water of formula ratio is added in cold and hot agitated kettle, the surfactant of formula ratio is added, is heated to
75-80 DEG C of stirring and dissolving is uniform, keeps 20-40min, adds pearling agent, stirring is to being completely dissolved；
3rd, when cold and hot agitated kettle is cooled to 40-45 DEG C, sequentially add formula ratio step 1 prepare Chinese medicine composition,
Antistatic additive, softener, NMF, anti-dandruff agent, thickener, pH adjusting agent, preservative, aromatic, stir；
4th, discharged when cold and hot stirring pot temperature is down to 30-35 DEG C, it is filling, you can to obtain a kind of anti-dandruff sterilizing and itch-relieving, life
The hair washing product of hair.
The formula and preparation method thereof of a kind of 4 sterilizing and itch-relieving of embodiment, trichogenous hair products
A kind of sterilizing and itch-relieving of the present invention, trichogenous hair products are prepared by the component of following mass percent
Form：
0.5-20% Chinese medicine composition of the invention, 1-3% cationic surfactant, 5-15% softener,
2-5% hair antistatic additive, 1-5% NMFs, 0.3-0.7% thickener, appropriate pH adjusting agent, appropriate fragrance
Agent, 0.01-0.1% preservative, remaining is deionized water.
Cationic surfactant is the quaternary ammonium salt cationic surfactants such as stearyl trimethyl ammonium chloride.
Softener is in the silicone oil such as dimethyl silicone polymer, 16/18 alcohol, dimethiconol, dimethyl siloxane
One or more combination.
Hair antistatic additive is one in Polyquaternium-10, polyquaternium -6, polyquaternium -7, lactic acid fat quaternary ammonium salt etc.
Kind or several combinations.
NMF is one or more of groups in D-pantothenyl aleohol, tocopherol (vitamin E), glycerine, propane diols, hyaluronic acid etc.
Close.
Thickener is the one or more combination in guar gum, xanthans, hydroxyethyl cellulose, sodium chloride etc..
PH adjusting agent is the one or more combination in triethanolamine, citric acid, NaOH solution etc..
Aromatic is the aromatic raw materials such as essence or essential oil.
Preservative is methylchloroisothiazandnone, methylisothiazolinone, methyl hydroxybenzoate, propylben, nipalgin
One or more combination in butyl ester, Phenoxyethanol, DMDMH etc..
Cationic surfactant described above, softener, antistatic additive, NMF, thickener, pH adjusting agent, anti-corrosion
Agent etc. be not limited to that the present invention enumerated this is several, as long as the substitute products that can play identical function are all feasible.
A kind of sterilizing and itch-relieving of the present invention, the preparation method of trichogenous hair products are as follows：
1. the water of formula ratio and thickener are added in aqueous phase pot, stirring, 75-80 DEG C is heated to, keeps 20-40min, stir
It is 25-45r/min to mix speed；The pH adjusting agent and cationic surfactant of formula ratio are added, is sufficiently stirred mixing；
2. the softener of formula ratio and NMF are added into oil phase pot, 80 DEG C are heated with stirring to；
3. homogeneous pot is warming up into 80 DEG C, compound in step 1 aqueous phase pot is pumped into, opens stirring, adds step 2 oil phase
The compound of pot, homogeneous 3-5 minutes, is cooled to 45 DEG C, sequentially adds the remaining material of formula ratio, stir；
4. discharged when homogeneous pot temperature is down to 30-35 DEG C, it is filling, obtain the sterilizing and itch-relieving of the present invention, promote hair life
Long hair products.
The applicant by long-term a large number of experiments show that, use in scope of the present invention any proportioning with the present invention
Prepared by described preparation method, obtained hair products play the role of extraordinary sterilizing and itch-relieving, piliation.Table 4 specifically arranges
Several proportioning modes therein are lifted.
A kind of 4 sterilizing and itch-relieving of table, the formula of trichogenous hair products
By sequence number 5. in formula exemplified by, the preparation method of hair washing product of the invention is：
1st, by Isatis tinctoria leaf 100g, cnidium monnieri seed 300g, emblic 250g, kuh-seng 250g, Ligusticum wallichii 100g, it is well mixed,
Extracted 2 times with 8 times of 80% alcohol reflux of mixture gross mass, 2 hours every time, filtering, merging filtrate, vacuum-concentrcted was extremely
Medicinal material and extract solution mass ratio are 1:5,6000r/min, centrifuge 8min, abandon precipitation, take supernatant, obtain Isatis tinctoria, cnidium monnieri seed,
Emblic, kuh-seng, Ligusticum wallichii ethanol extract, i.e. Chinese medicine composition of the invention；
2nd, the water of formula ratio and thickener are added in aqueous phase pot, stirring, is heated to 75-80 DEG C, kept 20-40min, stir
It is 25-45r/min to mix speed；The pH adjusting agent and cationic surfactant of formula ratio are added, is sufficiently stirred mixing；
3rd, the softener of formula ratio and NMF are added into oil phase pot, is heated with stirring to 80 DEG C；
4th, homogeneous pot is warming up to 80 DEG C, is pumped into compound in step 1 aqueous phase pot, open stirring, add step 2 oil phase
The compound of pot, homogeneous 3-5 minutes, is cooled to 45 DEG C, sequentially adds the remaining material of formula ratio, stir；
5th, discharged when homogeneous pot temperature is down to 30-35 DEG C, it is filling.
Embodiment 5
A kind of Chinese medicine composition is prepared by the formula in the sequence number 5 of embodiment 1, then according to the formula in the sequence number 6 of embodiment 2
It is made and educates hair products, carries out the experiment that Whole Body educates hair.It is specific as follows：
Age 25-45 year, totally 30 people, wherein male 15 people, the people of female 15, whole body oligotrichosis or hairless symptom, divide three at random
Group.First group of 10 people, second group of 10 people, the 3rd group of 10 people.
Usage amount and method：Appropriate product is taken, smearing uses position, absorption is gently massaged into, afterwards with hot towel hot compress
5-10 minutes.Once in the morning and once at night.Some months is used continuously, checks for whole body and local adverse reaction daily.Use effect
Fruit：User has new hair or fine hair on birds or animals hair to bear.As a result referring to table 5.
Table 5 uses the effect for educating hair products of the invention
30 people account for 73.3% without locally or systemically adverse reaction, its total effective rate.
Embodiment 6
By the sequence number of embodiment 1 2. in formula prepare a kind of Chinese medicine composition, then according to the sequence number of embodiment 3 3. in match somebody with somebody
Hair washing product is made in side, carries out human trial.It is specific as follows：
Using effect：Anti-dandruff and itching-relieving oil-control is sterilized.
Age 15-65 year, totally 50 people, wherein male 25 people, the people of female 25, scalp have different degrees of dandruff, scalp hair
Itch situation, random point three groups.First group of 17 people, second group of 17 people, the 3rd group of 16 people.
Usage amount and method：Use 2-3 times within one week, each 5-10 grams of shampoo of dosage, daily detailed inspection whether there is whole body
And local adverse reaction, effectively it is：User's dandruff significantly reduces or no longer produced dandruff, and gargalesthesia disappears, hair oil-free
Soapy feeling is kept for more than 1 day.As a result referring to table 6.
Table 6 uses the effect of the hair washing product of the present invention
| Group | Once come into force number | Come into force number twice | Come into force number three times | Total effective rate (%) |
| First group | 9 | 3 | 2 | 82.4 |
| Second group | 8 | 3 | 4 | 88.2 |
| 3rd group | 9 | 3 | 2 | 87.5 |
50 people account for 86.0% without locally or systemically adverse reaction, total effective rate.
Embodiment 7
By the sequence number of embodiment 1 2. in formula prepare a kind of Chinese medicine composition, then according to the sequence number of embodiment 3 6. in match somebody with somebody
Hair washing product is made in side, carries out human trial.It is specific as follows：
Age：15-65 year, totally 50 people, wherein male 25 people, the people of female 25.Scalp has different degrees of dandruff, scalp itch
Situation, random point three groups.First group of 17 people, second group of 17 people, the 3rd group of 16 people, daily detailed inspection whether there is whole body and part not
Good reaction.Effectively it is：User no longer produces scurf, and gargalesthesia disappears.
Usage amount and method：Use 2 times within one week, each 3-5 grams of hair washing product of dosage.As a result referring to table 7.
Table 7 uses the effect of the hair washing product of the present invention
50 people account for 62.0% without locally or systemically adverse reaction, its total effective rate.It can be seen that in the case that dosage is reduced,
Still there is good anti-dandruff effect.
Embodiment 8
As the technique described in embodiment 1, prepare a kind of containing plant sterilization is antipruritic, the production of the hair care of piliation Chinese medicine composition
Product, the mass ratio of main component are：Isatis tinctoria leaf：Cnidium monnieri seed：Emblic：Kuh-seng：Ligusticum wallichii is 3:6:6:4:1.Then according to
Hair products are made in formula in the sequence number 1 of embodiment 4 and the method provided, carry out human trial.It is specific as follows：
Using effect：Hair care, hair care
Age：25-65 year, totally 30 people, wherein male 15 people, the people of female 15, hair damage the wounded through scalding dye, influenceed attractive in appearance.At random
Divide three groups.First group of 10 people, second group of 10 people, the 3rd group of 10 people, daily detailed inspection whether there is whole body and local adverse reaction, had
Imitate and be：User's hair is smooth have it is glossy.
Usage amount and method：Use 1-2 times within one week, each 5-10 grams of hair products of dosage.It is applied to the hair tip to knead open, gently rubs
1-2 minutes, wash away afterwards, as a result referring to table 8.
Table 8 uses the effect of the hair products of the present invention
| Group | Use one month | Use 2 months | It is on probation 3 months | Use 4 months | Total effective rate % |
| First group | 2 | 3 | 1 | 1 | 70 |
| Second group | 3 | 1 | 1 | 2 | 70 |
| 3rd group | 1 | 3 | 2 | 2 | 80 |
30 people account for 73.3% without locally or systemically adverse reaction, its total effective rate.
Embodiment 9：
The hair washing product of human trial will be carried out in embodiment 6 and embodiment 8 and hair products are used cooperatively, carry out human body
Experiment, its method and result are as follows：
Age 15-65 year, totally 30 people, wherein male 15 people, the people of female 15.Scalp has a different degrees of dandruff, scalp itch,
Random point three groups.First group of 10 people, second group of 10 people, the 3rd group of 10 people, daily detailed inspection whether there is whole body and part is bad anti-
Should, effectively it is：User no longer produces scurf, and gargalesthesia disappears and generating and nourishing hair strengthen the hair.
Usage amount and method：Use 2 times within one week, each 3-5 grams of shampoo of dosage, 3-5 grams of hair products.
Table 9 is simultaneously using the hair washing product of the present invention and the effect of hair products
30 people account for 93.3% without locally or systemically adverse reaction, its total effective rate.
Finally it should be noted that：The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention,
Although the present invention is described in detail with reference to the foregoing embodiments, for those skilled in the art, it still may be used
To be modified to the technical scheme described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic.
Within the spirit and principles of the invention, any modification, equivalent substitution and improvements made etc., it should be included in the present invention's
Within protection domain.
Claims (12)
1. a kind of anti-dandruff sterilizing and itch-relieving, the Chinese medicine composition of piliation, it is characterised in that：The Chinese medicine composition is former by mass
Expect that medicine is：Isatis tinctoria leaf 1-4 parts, cnidium monnieri seed 2-7 parts, emblic 2-6 parts, kuh-seng 2-6 parts, Ligusticum wallichii 1-4 parts.
2. the preparation method of the Chinese medicine composition described in claim 1, it is characterised in that：Be by each component of mass parts according to
Extract what is obtained than ethanol after mixing.
3. preparation method according to claim 2, it is characterised in that：Methods described is：By Isatis tinctoria leaf, cnidium monnieri seed,
Emblic, kuh-seng, Ligusticum wallichii mix according to proportioning, and 8-15 times of concentration of volume percent for adding mixture quality is 10-80%'s
Alcohol reflux extracts 2-3 times, each 1.0-3.0 hours, filtering, merging filtrate, vacuum-concentrcted to medicinal material：Ethanol extract
Mass ratio is 1:2-15, centrifugation or refrigeration are stood, and are discarded precipitation, are taken supernatant, obtain Chinese medicine composition.
4. a kind of Chinese medicine composition containing described in claim 1 educates hair products.
5. according to claim 4 educate hair products, it is characterised in that：Described educate contains mass percent in hair products
For the Chinese medicine composition described in 5-60% claim 1, remaining is assistant agent.
6. the preparation method for educating hair products described in claim 4 or 5, it is characterised in that：Step is as follows：
（1）The thickener, water and Chinese medicine composition of prescription amount are added into cold and hot agitated kettle, are progressively heated to 75-80 while stirring
DEG C, stir, keep 20-40min, mixing speed is 40-70r/min；
（2）Cooling, when cold and hot agitated kettle is cooled to 40-45 DEG C, sequentially adds NMF, pH adjusting agent, the fragrance of prescription amount
Agent, preservative, stir；
（3）Discharged when cold and hot stirring pot temperature is down to 30-35 DEG C, it is filling；Obtain educating hair products.
A kind of 7. hair washing product of the Chinese medicine composition containing described in claim 1.
8. hair washing product according to claim 7, it is characterised in that：It is containing mass percent in the hair washing product
Chinese medicine composition described in 0.5-20% claim 1, remaining is assistant agent.
9. the preparation method of the hair washing product described in claim 7 or 8, it is characterised in that：Step is as follows：
（1）The deionized water of prescription amount is added in cold and hot agitated kettle, the surfactant of prescription amount is added, is heated to 75-
80 DEG C of stirring and dissolvings are uniform, keep 20-40min, add pearling agent, stirring is to being completely dissolved；
（2）When cold and hot agitated kettle is cooled to 40-45 DEG C, sequentially add Chinese medicine composition, antistatic additive, softener, NMF,
Anti-dandruff agent, thickener, pH adjusting agent, preservative, aromatic, stir；
（3）Discharged when cold and hot stirring pot temperature is down to 30-35 DEG C, obtain hair washing product.
A kind of 10. hair products of the Chinese medicine composition containing described in claim 1.
11. hair washing product according to claim 10, it is characterised in that：It is containing mass percent in the hair products
Chinese medicine composition described in 0.5-20% claim 1, remaining is assistant agent.
12. the preparation method of the hair products described in claim 10 or 11, it is characterised in that：Step is as follows：
（1）The water of prescription amount and thickener are added in aqueous phase pot, stirring, are heated to 75-80 DEG C, keeps 20-40min, stirring
Speed is 25-45r/min；The pH adjusting agent and cationic surfactant of prescription amount are added, is sufficiently stirred mixing；
（2）The softener of prescription amount and NMF are added into oil phase pot, are heated with stirring to 80 DEG C；
（3）Homogeneous pot is warming up to 80 DEG C, is pumped into step（1）Compound in aqueous phase pot, stirring is opened, add step（2）Oil phase
The compound of pot, homogeneous 3-5 minutes, is cooled to 45 DEG C, sequentially adds the remaining material of prescription amount, stir；
（4）Discharged when homogeneous pot temperature is down to 30-35 DEG C, it is filling, obtain hair products.
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| CN109846773A (en) * | 2018-11-26 | 2019-06-07 | 广州瑞誉化工科技有限公司 | A kind of scalp composition and its preparation method and application can inhibit alopecia seborrheica |
| CN112315858A (en) * | 2020-10-16 | 2021-02-05 | 清远市华宝生物科技有限公司 | Anti-hair loss, hair nourishing and anti-dandruff shampoo and preparation method thereof |
| CN115531243B (en) * | 2022-09-19 | 2023-12-29 | 北京尚捷优蓝科技有限公司 | Hair-fixing and hair-loss-preventing shampoo and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1134273A (en) * | 1996-01-31 | 1996-10-30 | 新疆伊藤俊化妆品有限公司 | Plant hair tonic cream and its preparation |
| CN103315932A (en) * | 2013-06-05 | 2013-09-25 | 片仔癀（上海）生物科技研发有限公司 | Itching-relieving body wash and preparation method thereof |
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2014
- 2014-08-13 CN CN201410400206.3A patent/CN104147103B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1134273A (en) * | 1996-01-31 | 1996-10-30 | 新疆伊藤俊化妆品有限公司 | Plant hair tonic cream and its preparation |
| CN103315932A (en) * | 2013-06-05 | 2013-09-25 | 片仔癀（上海）生物科技研发有限公司 | Itching-relieving body wash and preparation method thereof |
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