CN117084927A - Facial mask liquid composition, preparation method thereof and brightening facial mask - Google Patents

Facial mask liquid composition, preparation method thereof and brightening facial mask Download PDF

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Publication number
CN117084927A
CN117084927A CN202311262315.9A CN202311262315A CN117084927A CN 117084927 A CN117084927 A CN 117084927A CN 202311262315 A CN202311262315 A CN 202311262315A CN 117084927 A CN117084927 A CN 117084927A
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Prior art keywords
percent
phase
liquid composition
skin
mask liquid
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Inventor
杜万锋
黄振振
曹波
李金印
杨菊
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Guangdong Bailichen Biotechnology Co ltd
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Guangdong Bailichen Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212Face masks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/445Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof aromatic, i.e. the carboxylic acid directly linked to the aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/522Antioxidants; Radical scavengers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

Abstract

The invention discloses a mask liquid composition, a preparation method thereof and a brightening mask, wherein the mask liquid composition comprises a phase A and a phase B; based on the total weight of the mask liquid composition, the phase A comprises 0.2 to 0.4 percent of thickening agent, 7 to 16 percent of first humectant and the balance of solvent, and the phase B comprises 1.5 to 5 percent of first skin conditioning agent, 1 to 4 percent of second skin conditioning agent, 0.33 to 1.6 percent of third skin conditioning agent and 0.4 to 0.6 percent of second humectant; wherein the first skin conditioning agent comprises tranexamic acid and niacinamide, the second skin conditioning agent comprises hydroxyethylpiperazine ethane sulfonic acid and inositol, and the third skin conditioning agent comprises dihydrooat acyl anthranilic acid and dipotassium glycyrrhizinate. The mask liquid composition provided by the invention not only has the effect of quickly brightening, but also has the function of relieving, is mild and non-irritating, and is suitable for sensitive and fragile skin.

Description

Facial mask liquid composition, preparation method thereof and brightening facial mask
Technical Field
The invention relates to the technical field of cosmetics, in particular to a mask liquid composition, a preparation method thereof and a brightening mask.
Background
The facial mask is an important category in the cosmetic skin care products, and has a large market proportion in the field of skin care products. The facial mask is prepared by using natural cotton or silk cloth as a carrier, soaking the natural cotton or silk cloth in facial mask liquid, and filling each bag with one piece of facial mask cloth. The product is convenient to use and carry, and can enable consumers to have a rest slightly after 15-30 minutes of face coating, and the effects of quickly supplementing water, repairing and brightening skin color can be easily achieved, so that the product is deeply favored by consumers.
At present, the types of facial masks on the market are various, and the effects of the facial masks are different. Although many masks have the effects of whitening and brightening, the effects can be exerted only after long-time use. Meanwhile, with the abuse of skin care products, the skin of a user is more sensitive, and the problems of redness, swelling, acne and the like are easy to occur. Therefore, it is necessary to provide a mask liquid with a soothing and quick lightening function.
Disclosure of Invention
The mask liquid composition provided by the invention not only has the effect of quickly brightening, but also has the function of relieving, is mild and non-irritating, and is suitable for sensitive and fragile skin.
In a first aspect, the present invention provides a mask liquid composition comprising a phase a and a phase B; the phase A comprises 0.2 to 0.4 percent of thickening agent, 7 to 16 percent of first humectant and the balance of solvent, and the phase B comprises 1.5 to 5 percent of first skin conditioner, 1 to 4 percent of second skin conditioner, 0.33 to 1.6 percent of third skin conditioner and 0.4 to 0.6 percent of second humectant according to the total weight of the mask liquid composition; wherein the first skin conditioning agent comprises tranexamic acid and niacinamide, the second skin conditioning agent comprises hydroxyethylpiperazine ethane sulfonic acid and inositol, and the third skin conditioning agent comprises dihydrooat acyl anthranilic acid and dipotassium glycyrrhizinate.
Tranexamic acid, also known as tranexamic acid, is used clinically mainly as an antifibrinolytic agent. It has been found that tranexamic acid can prevent ultraviolet-induced pigmentation, and because it is a plasmin inhibitor, it can reduce the accumulation of plasmin in melanocytes and interfere with the plasmin/zymogen system, thereby achieving the objective of reducing melanin production and transfer. In addition, tranexamic acid has the effects of reducing DNA damage, resisting oxidation and inflammation, promoting repair of skin barrier, inhibiting skin inflammation, and reducing wrinkles.
Nicotinamide is the amide form of niacin (vitamin B3). In cells, nicotinamide is used to synthesize Nicotinamide Adenine Dinucleotide (NAD) and Nicotinamide Adenine Dinucleotide Phosphate (NADP). Studies have shown that nicotinamide can down-regulate melanosome transport from melanocytes to keratinocytes without inhibiting tyrosinase activity or cell proliferation, thereby affecting skin pigmentation, and it can also interfere with cell signaling pathways between keratinocytes and melanocytes, reducing melanogenesis. On the other hand, nicotinamide acts on melanin already produced, reducing its transfer to superficial cells. When the nicotinamide is used as a whitening component, the concentration of the nicotinamide is 2% -5%, and the nicotinamide proves to have a certain effect on treating chloasma and hyperpigmentation caused by ultraviolet rays. Topical nicotinamide can increase the levels of free fatty acids and ceramides in the skin, stimulate microcirculation in the dermis and prevent loss of skin moisture. It also increases protein synthesis (e.g., keratin), increases intracellular NADPH levels, and accelerates differentiation of keratin cells. In addition, the irritation to the skin caused by the surfactant, the solvent and the like can be relieved. In addition, nicotinamide also has the effects of resisting aging, preserving moisture and the like. Hydroxyethyl piperazine ethane sulfonic acid is a very effective biological buffer, has strong water solubility, weak cell membrane permeability, strong acid-base continuity, almost no metal chelating property, strong chemical stability and no toxic effect on cells. The hydroxyethyl piperazine ethane sulfonic acid can reform the stratum corneum, promote metabolism of skin keratinocytes, and further promote metabolism of melanin; can soften cutin, promote the exfoliation of old cutin cells of skin epidermis, and reduce wrinkles.
Inositol, also known as inositol, is widely distributed in animals and plants, the most abundant stereoisomer of inositol among the celluloses and is the only biologically active considered as a growth factor for animals, microorganisms. Inositol can increase growth factors, keep the dermis layer stem cells prone to stability, and is beneficial to promoting the generation of fibroblast interstitial hyaluronic acid, collagen and elastin. Inositol can protect the keratinocytes from penetration and uv stress.
The dihydro oat acyl anthranilic acid can inhibit the activity of a receptor, reduce MC degranulation and inhibit keratinocytes and macrophages from releasing inflammatory factors such as IL-6 and the like; the anti-inflammatory, soothing and anaphylactic reaction relieving effects can be achieved by inhibiting the release of histamine by the mast cells and simultaneously preventing the P substance released by nerve endings from binding with NK-1 receptors of the mast cells.
Dipotassium glycyrrhizinate has various effects of inhibiting bacteria, diminishing inflammation, detoxifying, resisting allergy, deodorizing and the like, can prevent histamine from being released, effectively eliminates superoxide ions and hydroxyl radicals, remarkably inhibits the action of liposome peroxide, and is similar to the action of adrenocortical hormone; can neutralize or reduce toxic substances of cosmetics, and can also prevent allergic reaction of cosmetics.
In the invention, the inventor finds that the combined use of the skin conditioning agents of tranexamic acid, nicotinamide, hydroxyethyl piperazine ethane sulfonic acid, inositol, dihydro oat acyl anthranilic acid and dipotassium glycyrrhizinate produces a synergistic technical effect, so that the mask liquid composition has the effects of quickly brightening and relieving. Specifically, when tranexamic acid and nicotinamide are used in a matched mode, a cell passage can be opened, hydroxyethyl piperazine ethane sulfonic acid and inositol can quickly permeate into skin, and therefore an instant brightening effect is achieved.
In addition, when dipotassium glycyrrhizinate and dihydro oat acyl anthranilic acid are used together, fragile skin can be repaired, skin barrier is enhanced, mast cells are effectively protected, and release of inflammatory mediators is inhibited, so that the anti-inflammatory and soothing effects are good. Compared with the single use of dipotassium glycyrrhizinate, dihydro oat acyl anthranilic acid and other anti-inflammatory components, the dipotassium glycyrrhizinate and dihydro oat acyl anthranilic acid in the invention have the advantages that when combined use, the anti-inflammatory and soothing effects are obviously improved, and the use is safer, which indicates that the two anti-inflammatory components produce synergistic effect.
Further, the thickener comprises at least one of carbomer and hydroxyethyl cellulose; and/or the number of the groups of groups,
the first humectant comprises at least one of glycerin and butanediol; and/or, the second humectant comprises 1, 2-hexanediol; and/or the number of the groups of groups,
the solvent comprises water.
Further, the first skin conditioning agent comprises: 0.5 to 2 percent of tranexamic acid and 1 to 3 percent of nicotinamide; and/or, the second skin conditioning agent comprises: 0.5 to 2 percent of hydroxyethyl piperazine ethane sulfonic acid and 0.5 to 2 percent of inositol; and/or, the third skin conditioning agent comprises: 0.3 to 1.5 percent of dihydro oat acyl anthranilic acid and 0.03 to 0.1 percent of dipotassium glycyrrhizinate.
Further, the a phase further includes: 0.4 to 0.6 percent of antioxidant and 0.4 to 1 percent of fourth skin conditioner; the antioxidant comprises p-hydroxyacetophenone, and the fourth skin conditioner comprises at least one of panthenol and allantoin.
Panthenol, also known as vitamin B5, can be converted to pantothenic acid after long-term use and is synthesized into coa by tissues, which can be present in tissues and is essential for cellular material metabolism. The panthenol can improve cell activity, repair damaged skin and strengthen skin barrier function after long-term use. Allantoin has effects of promoting water absorption of skin and hair outermost layer tissue, reducing water loss, softening skin, improving elasticity, luster, preventing skin chapping, etc., and has unique property of keratolytic protein, and can promote cell metabolism, soften keratolytic protein, and reduce wrinkle. In addition, when allantoin is used in combination with dipotassium glycyrrhizinate and dihydro oat acyl anthranilic acid, the anti-inflammatory and soothing effects can be further improved.
Further, the B phase further includes: 0.05 to 0.1 percent of pH regulator and 1 to 3 percent of fifth skin conditioner; the pH adjuster comprises aminomethylpropanol and the fifth skin conditioner comprises a yeast extract.
In the invention, the yeast extract is rich in natural active ingredients such as small molecular amino acids, peptides, nucleotides, vitamins, mineral elements and the like, is easy to be absorbed and utilized by skin, can increase the immune function of the skin, and has the effects of moisturizing, repairing, supplementing nutrition for the skin and the like.
Further, based on the total weight of the mask liquid composition, the phase A consists of the following raw materials:
and (3) a thickening agent: 0.1 to 0.2 percent of carbomer and 0.1 to 0.2 percent of hydroxyethyl cellulose;
first humectant: 2-6% of glycerol and 5-10% of butanediol;
antioxidant: 0.4 to 0.6 percent of p-hydroxyacetophenone;
fourth skin conditioner: 0.3 to 0.8 percent of panthenol and 0.1 to 0.2 percent of allantoin;
solvent: the balance of water;
the phase B consists of the following raw materials in terms of the total weight of the mask liquid composition:
first skin conditioning agent: 0.5 to 2 percent of tranexamic acid and 1 to 3 percent of nicotinamide;
second skin conditioning agent: 0.5 to 2 percent of hydroxyethyl piperazine ethane sulfonic acid and 0.5 to 2 percent of inositol;
third skin conditioner: 0.3 to 1.5 percent of dihydro oat acyl anthranilic acid and 0.03 to 0.1 percent of dipotassium glycyrrhizinate;
fifth skin conditioner: 1-3% of yeast extract;
and a second humectant: 0.4 to 0.6 percent of 1, 2-hexanediol;
pH regulator: 0.05 to 0.1 percent of aminomethylpropanol.
Further, based on the total weight of the mask liquid composition, the phase A consists of the following raw materials:
and (3) a thickening agent: carbomer 0.15%, hydroxyethyl cellulose 0.12%;
first humectant: glycerol 4% and butanediol 6%;
antioxidant: 0.4% of p-hydroxyacetophenone;
fourth skin conditioner: 0.6% of panthenol and 0.2% of allantoin;
solvent: the balance of water;
the phase B consists of the following raw materials in terms of the total weight of the mask liquid composition:
first skin conditioning agent: 0.5% of tranexamic acid and 2% of nicotinamide;
second skin conditioning agent: 1% of hydroxyethyl piperazine ethane sulfonic acid and 1% of inositol;
third skin conditioner: 0.5% of dihydro oat acyl anthranilic acid and 0.05% of dipotassium glycyrrhizinate;
fifth skin conditioner: 2% of yeast extract;
and a second humectant: 0.4% of 1, 2-hexanediol;
pH regulator: aminomethylpropanol 0.09%.
In a second aspect, the present invention provides a method for preparing the foregoing mask liquid composition, including the following steps:
adding the phase A raw material into an emulsifying pot, heating to 80-85 ℃, and stirring at 600-800 rpm until the phase A raw material is completely dissolved; then continuing to homogenize for 3-5 min at the rotating speed of 1500-2000 rpm; after stopping homogenizing, preserving heat for 10-15 min and then cooling;
cooling the materials in the emulsifying pot to below 45 ℃, adding the B-phase raw material into the emulsifying pot, and stirring at 600-800 rpm until the B-phase raw material is completely dissolved; and then filtering and discharging to obtain the mask liquid composition.
Further, the preparation method of the mask liquid composition comprises the following steps:
adding the phase A raw material into an emulsifying pot, heating to 85 ℃, and stirring at 800rpm until the phase A raw material is completely dissolved; then, homogenizing for 5min at 1500 rpm; after stopping homogenizing, preserving heat for 15min, and cooling;
cooling the materials in the emulsifying pot to below 45 ℃, adding the B-phase raw material into the emulsifying pot, and stirring at 800rpm until the B-phase raw material is completely dissolved; and then filtering and discharging to obtain the mask liquid composition.
In a third aspect, the invention provides a lightening mask, comprising a mask substrate, wherein the mask substrate contains the mask liquid composition.
Through one or more of the above embodiments of the present invention, at least the following technical effects can be achieved:
1. in the mask liquid composition provided by the invention, when tranexamic acid and nicotinamide are matched for use, a cell passage can be opened, so that hydroxyethyl piperazine ethane sulfonic acid and inositol quickly permeate into skin, and an instant lightening effect can be achieved.
2. Compared with the single use of dipotassium glycyrrhizinate, dihydro oat acyl anthranilic acid and other anti-inflammatory components, the mask liquid composition provided by the invention has the advantages that when dipotassium glycyrrhizinate and dihydro oat acyl anthranilic acid are combined for use, a synergistic effect is generated, and the anti-inflammatory and soothing effects are obviously improved.
3. In the mask liquid composition provided by the invention, allantoin not only can promote metabolism of cells, soften keratin and reduce wrinkles, but also can play roles in moisturizing and repairing skin; in addition, when allantoin is used in combination with dipotassium glycyrrhizinate and dihydro oat acyl anthranilic acid, the anti-inflammatory and soothing effects can be further improved.
Drawings
FIG. 1 is a photograph of a mask fluid sample of example 1 and comparative example 1, respectively, applied to the arms of volunteers;
FIG. 2 is a diagram of the skin condition after 15 minutes of use;
where a is the sample using comparative example 1 and b is the sample using example 1.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings and the embodiments of the present invention. It will be apparent that the described embodiments are only some, but not all, embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to fall within the scope of the invention.
In the following examples and comparative examples, the raw materials used were all commercially available unless otherwise specified.
Examples 1 to 3
Examples 1-3 provide a mask liquid composition prepared from phase A and phase B raw materials, and the specific formula is shown in Table 1.
TABLE 1
The mask liquid composition can be prepared by the following steps:
s1, putting the raw materials 1-8 in the phase A into an emulsifying pot, heating to 85 ℃, stirring at a rotating speed of 800 until the raw materials in the phase A are completely dissolved and have no particles, and homogenizing at a rotating speed of 1500rpm for 5min; then keeping the temperature at 85 ℃ for 15min, and cooling for standby;
s2, cooling the materials in the emulsifying pot to below 45 ℃, adding 9-17 of B-phase raw materials, stirring at 800rpm for 10min to completely dissolve the B-phase raw materials without particles, filtering and discharging to obtain the mask liquid composition.
Comparative examples 1 to 5
Samples of the mask liquid compositions of comparative examples 1 to 5 were continuously prepared in the same manner as described above, wherein the formulations of comparative examples 1 to 5 are shown in Table 2:
TABLE 2
Efficacy testing
1. Whitening performance test
80 female volunteers aged 25-35 years were selected and divided into 8 groups of 10 persons each, and samples of examples 1-3 and comparative examples 1-5 of the present invention were applied, respectively. The using method comprises the following steps: the facial mask liquid composition sample is soaked by facial mask cloth and applied on an arm, and skin changes are observed after 15 minutes. Photographing before and after use. Scoring between 0 and 10 points according to the use effect: a score of 9-10 was good, 7-8 was good, 5-6 was general, 3-4 was poor, 1-2 was poor, and the average was taken and the results are shown in Table 3.
TABLE 3 Table 3
Sample of Scoring of
Example 1 9
Example 2 9
Example 3 8
Comparative example 1 4
Comparative example 2 4
Comparative example 3 6
Comparative example 4 6
Comparative example 5 5
The results in table 1 show that the mask liquid compositions of examples 1-3 all have good whitening efficacy, with the whitening effect of examples 1 and 2 being optimal.
The mask liquid composition of comparative example 1 was added with hydroxyethylpiperazine ethanesulfonic acid and inositol, but not with tranexamic acid and nicotinamide, and the mask liquid composition of comparative example 2 was added with tranexamic acid and nicotinamide, but not with hydroxyethylpiperazine ethanesulfonic acid and inositol, and as a result, the whitening effect was significantly lower than that of the examples, and the whitening score was only 4. The reason for this is: although the hydroxyethyl piperazine ethane sulfonic acid, inositol, tranexamic acid and nicotinamide are all whitening components, the whitening effect is not obvious when the hydroxyethyl piperazine ethane sulfonic acid, inositol, tranexamic acid and nicotinamide are used alone, the whitening effect can be achieved only after long-term use, and the effect of rapid brightening is not achieved. When the components of the hydroxyethyl piperazine ethane sulfonic acid, the inositol, the tranexamic acid and the nicotinamide are used in a combined mode, the tranexamic acid and the nicotinamide can open a cell passage, and promote absorption of the hydroxyethyl piperazine ethane sulfonic acid and the inositol by cells, so that the hydroxyethyl piperazine ethane sulfonic acid and the inositol can quickly permeate into the skin, and an instant brightening effect can be achieved. Therefore, the mask liquid compositions of examples 1 to 3 are indispensable for hydroxyethyl piperazine ethane sulfonic acid, inositol, tranexamic acid and nicotinamide, and they are used in combination with each other to perform a synergistic effect. Fig. 1 and 2 are skin state diagrams before and after using the samples of example 1 and comparative example 1. As can be seen from fig. 2, the whiteness of the skin is obviously improved after the mask liquid composition of example 1 is applied for 15min, and the effect of instant lightening is achieved. Whereas the skin was substantially unchanged after 15 minutes of application using the mask liquid composition of comparative example 1.
2. Test of soothing efficacy
The mask liquid compositions of examples 1-3 and comparative examples 1-5 were diluted to 10mg/mL with 20mmol/L PBS solution and used as a sample solution to be measured. 90 female volunteers between 25 and 35 years of age were selected as subjects and randomized into 9 groups of 10 persons each. The sample solution of 0.1mL was sucked into the drug chamber of the plaque test tape (PBS solution was used as a blank control), and the plaque test tape with the sample solution was immediately attached to the arm of the volunteer while gently pressing the drug chamber one by one to expel air and uniformly distribute the sample. The test sites were marked for observation. The skin is applied once a day for 7 days. The product irritation is evaluated by adopting a scoring system, whether various irritation symptoms (including red swelling, erythema, tingling, itching, pimple and the like) appear or not is taken as an evaluation index, the score is 5 minutes full, the higher the score is, the smaller the skin irritation response is, and the average score is calculated after each group removes the highest score and the lowest score. The results are shown in Table 4.
TABLE 4 Table 4
Sample of Scoring of
Example 1 5.0
Example 2 5.0
Example 3 4.9
Comparative example 1 4.7
Comparative example 2 4.8
Comparative example 3 3.9
Comparative example 4 4.0
Comparative example 5 3.7
Blank control group 5.0
As can be seen from table 4, the blank group used PBS solution, without any irritation to the skin. The mask liquid compositions of examples 1 to 3 also had very low irritation to the skin, and the irritation score reached 4.9 or more, wherein examples 1 to 2 were optimal, and the score reached 5.0, and were not irritating to the skin at all. Therefore, the mask liquid composition of the embodiment has excellent soothing performance and is mild and not irritating.
In the mask liquid composition of example 3, allantoin is not added in the formula, and the irritation score is 4.9, which indicates that the allantoin has a certain effect on the improvement of irritation, and when the allantoin is used together with the dihydro oat acyl anthranilic acid and the dipotassium glycyrrhizinate, the anti-inflammatory and soothing effects of the composition can be further improved.
In contrast, the mask liquid compositions of comparative examples 1 to 5 all had a certain irritation to the skin. Wherein, in comparative examples 3 to 4, when only one of the dihydrooat acyl anthranilic acid and dipotassium glycyrrhizinate was used, the skin still had relatively high irritation, and the irritation scores were only 3.9 and 4.0; however, the combination of dihydrooat acyl anthranilic acid and dipotassium glycyrrhizinate significantly improves irritation. This shows that the combination of the dihydro oat acyl anthranilic acid and the dipotassium glycyrrhizinate can produce a synergistic effect, thereby greatly enhancing the anti-inflammatory and soothing effects of the composition.
In conclusion, the mask liquid composition provided by the invention has the effects of quickly brightening and relieving, is mild and does not stimulate, and is suitable for sensitive and fragile skin through the use of the active ingredients of tranexamic acid, nicotinamide, hydroxyethyl piperazine ethane sulfonic acid, inositol, dihydro oat acyl anthranilic acid and dipotassium glycyrrhizinate.
In summary, although the present invention has been described in terms of the preferred embodiments, the preferred embodiments are not limited to the above embodiments, and various modifications and changes can be made by one skilled in the art without departing from the spirit and scope of the invention, and the scope of the invention is defined by the appended claims.

Claims (10)

1. A facial mask liquid composition is characterized by comprising a phase A and a phase B; the phase A comprises 0.2 to 0.4 percent of thickening agent, 7 to 16 percent of first humectant and the balance of solvent, and the phase B comprises 1.5 to 5 percent of first skin conditioner, 1 to 4 percent of second skin conditioner, 0.33 to 1.6 percent of third skin conditioner and 0.4 to 0.6 percent of second humectant according to the total weight of the mask liquid composition; wherein the first skin conditioning agent comprises tranexamic acid and niacinamide, the second skin conditioning agent comprises hydroxyethylpiperazine ethane sulfonic acid and inositol, and the third skin conditioning agent comprises dihydrooat acyl anthranilic acid and dipotassium glycyrrhizinate.
2. The mask liquid composition of claim 1, wherein the thickener comprises at least one of carbomer, hydroxyethyl cellulose; and/or the number of the groups of groups,
the first humectant comprises at least one of glycerin and butanediol; and/or, the second humectant comprises 1, 2-hexanediol; and/or the number of the groups of groups,
the solvent comprises water.
3. The mask liquid composition of claim 1 wherein the first skin conditioning agent comprises: 0.5 to 2 percent of tranexamic acid and 1 to 3 percent of nicotinamide; and/or, the second skin conditioning agent comprises: 0.5 to 2 percent of hydroxyethyl piperazine ethane sulfonic acid and 0.5 to 2 percent of inositol; and/or the number of the groups of groups,
the third skin conditioning agent comprises: 0.3 to 1.5 percent of dihydro oat acyl anthranilic acid and 0.03 to 0.1 percent of dipotassium glycyrrhizinate.
4. The mask liquid composition of claim 1, wherein the a phase further comprises: 0.4 to 0.6 percent of antioxidant and 0.4 to 1 percent of fourth skin conditioner; the antioxidant comprises p-hydroxyacetophenone, and the fourth skin conditioner comprises at least one of panthenol and allantoin.
5. The mask liquid composition of claim 1, wherein the B phase further comprises: 0.05 to 0.1 percent of pH regulator and 1 to 3 percent of fifth skin conditioner; the pH adjuster comprises aminomethylpropanol and the fifth skin conditioner comprises a yeast extract.
6. The mask liquid composition according to claim 4 or 5, wherein the a phase is composed of the following raw materials, based on the total weight of the mask liquid composition:
and (3) a thickening agent: 0.1 to 0.2 percent of carbomer and 0.1 to 0.2 percent of hydroxyethyl cellulose;
first humectant: 2-6% of glycerol and 5-10% of butanediol;
antioxidant: 0.4 to 0.6 percent of p-hydroxyacetophenone;
fourth skin conditioner: 0.3 to 0.8 percent of panthenol and 0.1 to 0.2 percent of allantoin;
solvent: the balance of water;
the phase B consists of the following raw materials in terms of the total weight of the mask liquid composition:
first skin conditioning agent: 0.5 to 2 percent of tranexamic acid and 1 to 3 percent of nicotinamide;
second skin conditioning agent: 0.5 to 2 percent of hydroxyethyl piperazine ethane sulfonic acid and 0.5 to 2 percent of inositol;
third skin conditioner: 0.3 to 1.5 percent of dihydro oat acyl anthranilic acid and 0.03 to 0.1 percent of dipotassium glycyrrhizinate;
fifth skin conditioner: 1-3% of yeast extract;
and a second humectant: 0.4 to 0.6 percent of 1, 2-hexanediol;
pH regulator: 0.05 to 0.1 percent of aminomethylpropanol.
7. The mask fluid composition of claim 6, wherein the phase a consists of the following materials, based on the total weight of the mask fluid composition:
and (3) a thickening agent: carbomer 0.15%, hydroxyethyl cellulose 0.12%;
first humectant: glycerol 4% and butanediol 6%;
antioxidant: 0.4% of p-hydroxyacetophenone;
fourth skin conditioner: 0.6% of panthenol and 0.2% of allantoin;
solvent: the balance of water;
the phase B consists of the following raw materials in terms of the total weight of the mask liquid composition:
first skin conditioning agent: 0.5% of tranexamic acid and 2% of nicotinamide;
second skin conditioning agent: 1% of hydroxyethyl piperazine ethane sulfonic acid and 1% of inositol;
third skin conditioner: 0.5% of dihydro oat acyl anthranilic acid and 0.05% of dipotassium glycyrrhizinate;
fifth skin conditioner: 2% of yeast extract;
and a second humectant: 0.4% of 1, 2-hexanediol;
pH regulator: aminomethylpropanol 0.09%.
8. A method of preparing the mask liquid composition according to any one of claims 1 to 7, comprising the steps of:
adding the phase A raw material into an emulsifying pot, heating to 80-85 ℃, and stirring at 600-800 rpm until the phase A raw material is completely dissolved; then continuing to homogenize for 3-5 min at the rotating speed of 1500-2000 rpm; after stopping homogenizing, preserving heat for 10-15 min and then cooling;
cooling the materials in the emulsifying pot to below 45 ℃, adding the B-phase raw material into the emulsifying pot, and stirring at 600-800 rpm until the B-phase raw material is completely dissolved; and then filtering and discharging to obtain the mask liquid composition.
9. The method of preparing a mask liquid composition according to claim 8, comprising the steps of:
adding the phase A raw material into an emulsifying pot, heating to 85 ℃, and stirring at 800rpm until the phase A raw material is completely dissolved; then, homogenizing for 5min at 1500 rpm; after stopping homogenizing, preserving heat for 15min, and cooling;
cooling the materials in the emulsifying pot to below 45 ℃, adding the B-phase raw material into the emulsifying pot, and stirring at 800rpm until the B-phase raw material is completely dissolved; and then filtering and discharging to obtain the mask liquid composition.
10. A lightening mask comprising a mask substrate, wherein the mask substrate comprises the mask liquid composition of any one of claims 1 to 7.
CN202311262315.9A 2023-09-27 2023-09-27 Facial mask liquid composition, preparation method thereof and brightening facial mask Pending CN117084927A (en)

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