CN113303469A - 一种助消化、缓解睡眠障碍及改善血脂的组合物及其应用 - Google Patents
一种助消化、缓解睡眠障碍及改善血脂的组合物及其应用 Download PDFInfo
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- CN113303469A CN113303469A CN202110419641.0A CN202110419641A CN113303469A CN 113303469 A CN113303469 A CN 113303469A CN 202110419641 A CN202110419641 A CN 202110419641A CN 113303469 A CN113303469 A CN 113303469A
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Abstract
本发明属于生物食品技术领域,具体涉及一种助消化、缓解睡眠障碍及改善血脂的组合物及其应用。本发明提供的组合物包括如下组分及其用量:综合果蔬发酵粉0.4‑8.7份,膳食纤维19.5‑260.9份,酸枣仁1.2‑26.1份,茶叶茶氨酸0.6‑13.9份,植物甾醇酯0.8‑135.7份。本发明制成的营养组合物可用于乳粉、一般普通食品及多种营养食品领域,不仅有助于缓解睡眠障碍,促进人体的消化吸收功能,还在一定程度上促进血脂的改善。
Description
技术领域
本发明属于生物食品技术领域,具体涉及一种助消化、缓解睡眠障碍及改善血脂的组合物及其应用。
背景技术
随着年龄的增加消化系统机能逐渐衰退,营养吸收效果显著下降,而现在人们生活水平的提高、饮食习惯的不合理,导致食用过多的难消化、难吸收的高脂肪食物。此外,生活节奏的加快、无规律的生活及用餐习惯,以及垃圾食品和快餐的大量摄入等种种原因,首当其冲使人体肠道受到最大的伤害,结果是造成了消化系统的未老先衰,进而对人体营养的摄入带来直接影响,严重影响人们的健康和生活。
消化酶的催化能力,可以使一些大分子化合物转化为人体可直接吸收利用的营养物质,并可以通过适当的运动将其作为能量进行代谢。消化酶具有专一性,根据分解对象的不同,主要有蛋白酶、脂肪酶、纤维素酶、淀粉酶、乳糖酶。膳食纤维在胃和小肠内不被消化吸收,稳定地通过上消化道直至大肠,被肠道微生物菌群代谢发酵,这种生理功能可以有效改善肠道功能,如促进排便、缓解便秘以及提高肠胃舒适度。膳食纤维尤其是可溶性膳食纤维因不被消化而进人大肠后,被肠道内的有益菌如双歧杆菌、乳酸杆菌等选择性吸收利用,促进了有益菌的增殖,调节肠道菌群平衡,还有使肠道内pH下调,利于矿物质的吸收等健康功效。
同时,一项涉及中国老年人的睡眠障碍横断面调查数据显示,睡眠障碍发生几率为35%。持续的睡眠障碍将引发人体慢性疲劳、记忆力减退、免疫力低下、心血管损害及代谢性紊乱等多种相关疾病,严重者甚至导致自杀。
我国有4000万以上的中老年心脑血管病、高血压、动脉硬化、糖尿病等患者,有效防治中老年心脑血管病是全社会关注的问题。
上述问题涉及到的消化系统衰退、睡眠障碍及心脑血管疾病等均为我国常见的危害人体健康的症状,然而,现有技术中已知的药物均是针对其中一种问题进行改善,尚未发现可以同时改善上述三种问题的产品。而随着诱发人类疾病的因素越来越多,人们对各种药物的敏感度逐渐升高,开发一种可以同时治疗多种疾病的产品也越来越重要。
发明内容
针对现有技术存在的缺陷,本发明提供了一种助消化、缓解睡眠障碍及改善血脂的组合物及其应用。本发明制成的营养组合物可用于乳粉、一般普通食品及多种营养食品领域,不仅有助于缓解睡眠障碍,促进人体的消化吸收功能,还在一定程度上促进血脂的改善。
为了达到上述目的,本发明采用的技术方案为:
一种助消化、缓解睡眠障碍及改善血脂的组合物,包含如下组分及其重量份数:综合果蔬发酵粉0.4-8.7份,膳食纤维19.5-260.9份,酸枣仁1.2-26.1份,茶叶茶氨酸0.6-13.9份,植物甾醇酯0.8-135.7份。
优选地,每200mg综合果蔬发酵粉中包含淀粉酶3500DU、脂肪酶200FIP、蛋白酶5SAPU、纤维素酶50CU、乳糖酶100ALU。
优选地,所述酸枣仁与茶叶茶氨酸的添加比例为2:1。
优选地,所述膳食纤维选自低聚半乳糖、低聚果糖、低聚异麦芽糖、聚葡萄糖、抗性糊精中的2种或以上。
优选地,所述膳食纤维由低聚半乳糖、低聚果糖、低聚异麦芽糖按重量比1~5:1~4:2~8组成。
本发明还提供了一种所述组合物在制备营养食品中的应用。
优选地,所述组合物在营养食品中的添加量为0.5~8%。
酸枣仁、茶氨酸均有改善睡眠的作用。酸枣仁是临床常用于治疗失眠的一味中药,最早用于汉代名医张仲景所写的《金匮要略·血脾虚劳病脉证》,具有清热养血、安神除烦的功效,于2002年被我国录入药食同源名单。L-茶氨酸是一种在二十世纪九十年代由日本科学家发现于茶叶中的非蛋白质游离氨基酸,被证实具有改善睡眠的功效,于2014年被批准为新资源食品。
植物甾醇酯是植物甾醇与脂肪酸通过酯化反应制得,具有比游离植物甾醇更好的脂溶性,是一种新型的功能性食品基料,美国食品及药物管理局赋予植物固醇以“一般安全(GRAS)”的认可。植物甾醇和植物甾醇酯也于2010年被批准为新资源食品。研究显示,每天摄入1.2g植物甾醇酯可以起到很好的改善血脂的作用。
本发明提供的综合果蔬发酵粉是由多种天然鲜果、蔬菜等磨成粉混合而成,包括甘蓝、葡萄、木瓜、苹果、菜花、玉米等,这些果蔬任意混合搭配,以达到200g综合果蔬发酵粉中含有淀粉酶3500DU、脂肪酶200FIP、蛋白酶5SAPU、纤维素酶50CU、乳糖酶100ALU的标准。
本发明提供的组合物,可添加于多种营养食品中,以达到同时改善睡眠质量、改善血脂及促进消化吸收等作用,常见的营养食品包括奶粉、脱脂乳粉、牛初乳粉等各种乳品,还包括蜂胶、核桃粉、葡萄籽等多种保健营养食品。
与现有技术相比,本发明提供的营养组合物具有如下优点:
(1)目前的组合物多为集中针对1项问题,而本组合物同时以3个关注方向为靶点,筛选合适原料进行搭配,同时有助于缓解3个健康问题;
(2)目前针对消化吸收的,多以益生菌、益生元或营养成分作为主要功效原料,即使有添加酶,也是单一的酶,且以酶制剂添加,本组合物选用综合果蔬发酵粉,同时含有5种酶,针对需消化的不同食物成分,作用更加全面,而且来源天然,可以作用普通食品使用,应用更加广泛,与膳食纤维搭配,助消化的能力更加提高;
(3)酸枣仁是传统的药食同源原料,目前有见单用酸枣仁或以酸枣仁与其他药食同源原料搭配共用的产品,依据多为中药处方,用量未见明确。本组合物首次以酸枣仁与茶叶茶氨酸搭配,参照已有科学文献,搭配比例、用量较明确,且两个原料同属食品级别,使组合物的使用范围更加宽广。
具体实施方式
下面结合具体实施例对本发明作进一步解释,但是应当注意的是,以下实施例仅用以解释本发明,而不能用来限制本发明,所有与本发明相同或相近的技术方案均在本发明的保护范围之内。本实施例中未注明具体技术或条件者,按照本领域常规技术方法和仪器说明书内容进行操作;所用试剂或仪器未注明生产厂商者,均为可以通过市购获得的常规产品。
所述酸枣仁可购自河北乐尚食品有限公司;所述茶叶茶氨酸为L-茶氨酸,可购自西安沐森生物工程有限公司;所述植物甾醇酯为大豆植物甾醇酯,可购自武汉熠嘉生物科技有限公司。
实施例1一种助消化、缓解睡眠障碍及改善血脂的组合物
所述营养组合物包含如下组分及其重量份数:综合果蔬发酵粉0.4份,膳食纤维19.5份,酸枣仁1.2份,茶叶茶氨酸0.6份,植物甾醇酯0.8份;每200mg综合果蔬发酵粉中包含淀粉酶3500DU、脂肪酶200FIP、蛋白酶5SAPU、纤维素酶50CU、乳糖酶100ALU;所述膳食纤维由低聚半乳糖、低聚果糖、低聚异麦芽糖按重量比5:1:3组成。
实施例2一种助消化、缓解睡眠障碍及改善血脂的组合物
所述营养组合物包含如下组分及其重量份数:综合果蔬发酵粉8.7份,膳食纤维260.9份,酸枣仁26.1份,茶叶茶氨酸13.05份,植物甾醇酯135.7份;所述综合果蔬发酵粉与实施例1相同;所述膳食纤维由低聚半乳糖、低聚果糖、低聚异麦芽糖按重量比1:3:2组成。
实施例3一种助消化、缓解睡眠障碍及改善血脂的组合物
所述营养组合物包含如下组分及其重量份数:综合果蔬发酵粉4.3份,膳食纤维120份,酸枣仁13.4份,茶叶茶氨酸6.7份,植物甾醇酯62.3份;所述综合果蔬发酵粉与实施例1相同;所述膳食纤维由低聚半乳糖、低聚果糖、低聚异麦芽糖按重量比3:2:4组成。
实施例4一种助消化、缓解睡眠障碍及改善血脂的组合物
所述营养组合物包含如下组分及其重量份数:综合果蔬发酵粉1.5份,膳食纤维52.5份,酸枣仁5.6份,茶叶茶氨酸2.8份,植物甾醇酯15.6份;所述综合果蔬发酵粉与实施例1相同;所述膳食纤维由低聚半乳糖、低聚果糖、低聚异麦芽糖按重量比4:1:3组成。
实施例5一种助消化、缓解睡眠障碍及改善血脂的组合物
所述营养组合物包含如下组分及其重量份数:综合果蔬发酵粉6.3份,膳食纤维150.8份,酸枣仁21.2份,茶叶茶氨酸10.6份,植物甾醇酯102.5份;所述综合果蔬发酵粉与实施例1相同;所述膳食纤维由低聚半乳糖、低聚果糖、低聚异麦芽糖按重量比4:3:7组成。
实施例6一种助消化、缓解睡眠障碍及改善血脂的组合物
所述营养组合物包含如下组分及其重量份数:综合果蔬发酵粉1.8份,膳食纤维26.5份,酸枣仁4.2份,茶叶茶氨酸2.1份,植物甾醇酯3.5份;所述综合果蔬发酵粉与实施例1相同;所述膳食纤维由低聚半乳糖、聚葡萄糖、抗性糊精按重量比1:1:1组成。
实施例7一种助消化、缓解睡眠障碍及改善血脂的组合物
所述营养组合物包含如下组分及其重量份数:综合果蔬发酵粉7.1份,膳食纤维240.7份,酸枣仁23.2份,茶叶茶氨酸11.6份,植物甾醇酯102.5份;所述综合果蔬发酵粉与实施例1相同;所述膳食纤维由低聚半乳糖及低聚果糖按重量比1:1组成。
实施例8一种助消化、缓解睡眠障碍及改善血脂的组合物
所述营养组合物包含如下组分及其重量份数:综合果蔬发酵粉5.2份,膳食纤维140.5份,酸枣仁18.6份,茶叶茶氨酸9.3份,植物甾醇酯92.5份;所述综合果蔬发酵粉与实施例1相同;所述膳食纤维由低聚异麦芽糖、低聚果糖、聚葡萄糖及抗性糊精按重量比1:1:1:1组成。
对比例1一种助消化、缓解睡眠障碍及改善血脂的组合物
所述营养组合物包含如下组分及其重量份数:综合果蔬发酵粉4.3份,膳食纤维120份,酸枣仁13.4份,茶叶茶氨酸6.7份,植物甾醇酯62.3份;所述综合果蔬发酵粉与实施例1相同;所述膳食纤维由低聚半乳糖、低聚果糖、低聚异麦芽糖按重量比1:1:1组成。
所述营养组合物与实施例3类似;
与实施例3的区别在于,对比例1中的膳食纤维由低聚半乳糖、低聚果糖、低聚异麦芽糖按重量比1:1:1组成。
对比例2一种助消化、缓解睡眠障碍及改善血脂的组合物
所述营养组合物包含如下组分及其重量份数:综合果蔬发酵粉4.3份,膳食纤维120份,酸枣仁13.4份,茶叶茶氨酸13.4份,植物甾醇酯62.3份;所述综合果蔬发酵粉与实施例1相同;所述膳食纤维由低聚半乳糖、低聚果糖、低聚异麦芽糖按重量比7:3:5组成。
所述营养组合物与实施例3类似;
与实施例3的区别在于,对比例2中的茶叶茶氨酸的添加量为13.4份,与酸枣仁的添加量相同。
对比例3一种助消化、缓解睡眠障碍及改善血脂的组合物
所述营养组合物包含如下组分及其重量份数:综合果蔬发酵粉4.3份,膳食纤维120份,酸枣仁13.4份,茶叶茶氨酸6.7份,植物甾醇酯62.3份;所述膳食纤维由低聚半乳糖、低聚果糖、低聚异麦芽糖按重量比7:3:5组成。
所述营养组合物与实施例3类似;
与实施例3的区别在于,对比例3中每200mg综合果蔬发酵粉中包含淀粉酶3000DU、脂肪酶300FIP、蛋白酶10SAPU、纤维素酶70CU、乳糖酶200ALU。
试验例1缓解睡眠试验
1.试验样品:将本发明实施例1-8及对比例1-3的组合物加入奶粉中,每100g奶粉中加入的营养组合物的量分别为:实施例1组3%,实施例2组8%,实施例3组4%,实施例4组2%,实施例5组7%,实施例6组1%,实施例7组0.5%,实施例8组5%,对比例1-3组4%。
2.试验对象:选择雄性BALB/c小鼠240只,体重在20±2g,平均分成12组,每组20只,试验要求:各小鼠体型相似,身体健康,无明显不良反应。
3.试验过程:将上述各试验样品配好的奶粉按照每4.3g奶粉加30mL、45℃的水冲泡比例喂给小鼠,同时设置阴性对照组仅灌胃普通奶粉,不添加本发明组合物,按照10mL/kg灌胃给小鼠,每天灌胃3次,联系饲喂20天后,第21天开始,于小鼠的睡眠期间进行灯光惊醒实验,每隔1h突然开灯一次,共3次,记录小鼠有无惊醒。
判断小鼠进入睡眠状态方法:观察小鼠的翻正反射,用手轻轻地将小鼠侧卧或仰卧,小鼠能立即翻正体位、恢复正常姿势,说明翻正反射存在;将小鼠置于背卧位时,如超过30-60秒不能翻正者,即认为翻正反射消失,进入睡眠。
4.试验结果:具体试验结果见表1。
表1饲喂不同样品小鼠惊醒情况
由表1可知,与阴性对照组相比,添加本发明实施例1-8组营养组合物的奶粉饲喂小鼠后,小鼠睡眠状态时,被惊醒的明显减少,尤其是实施例3组,仅有1只或0只被惊醒,故实施例3组为本发明的最佳实施例,而对比例组被惊醒的小鼠数量均有不同程度的增加,这也从侧面反应了本申请各组分之间具有一定的相互协同促进作用,达到改善睡眠的效果。
试验例2促进消化试验
1.试验样品:实施例3及对比例1-3制得的组合物;
2.试验动物:SD雄性小鼠共50只,体重在120~150g,平均分成5组,每组10只,要求,各小鼠身体健康,无明显不良症状;
3.试验方法:试验分成试验组和对照组,试验组分别将奶粉与本发明实施例3及对比例1-3的组合物混合,混合比例为4%,对照组仅饲喂普通奶粉,不添加任何组合物。
将各组奶粉按4.3g用45℃、30mL的水混合,按照20mL/kg给予大鼠灌胃,每天处理3次,试验期间自由进食、进水,连续处理20天,记录大鼠体重增长、摄食量及食物利用率;以各组小鼠的平均值作为最终结果。
4.试验结果:具体试验结果参见表2。
表2不同试验样品的消化情况
试验样品 | 小鼠初重 | 小鼠终重 | 平均日增重 | 日摄食量 | 食物利用率 |
实施例3 | 125.88g | 266.90g | 7.05g | 20.74g | 0.34 |
对比例1 | 136.72g | 260.14g | 6.17g | 23.73g | 0.26 |
对比例2 | 132.15g | 263.20g | 6.55g | 22.59g | 0.29 |
对比例3 | 128.92g | 255.33g | 6.32g | 23.41g | 0.27 |
阴性对照组 | 141.55g | 263.15g | 6.08g | 25.33g | 0.24 |
由上述表2可知,与阴性对照组相比,添加本发明实施例3组组合物的奶粉被大鼠服用后,食物利用率明显增高,而相应的对比例1-3组,食物利用率均有不同程度的降低。
试验例3改善血脂试验
1.试验样品:实施例3及对比例1-3组制得的组合物;
2.试验动物:雄性Wistar大鼠50只,体重为100±10g,随机分成5组,每组10只,要求,每只大鼠在试验前身体健康,无明显不良症状。
3.试验过程:建立高脂模型:给予上述试验大鼠饲喂高脂饲料,高脂饲料由100g基础饲料中加入全脂奶粉20g,猪油8g,黄豆20g,对照组仅饲喂基础饲料,饲养环境清洁,饲养过程中自由饮水,喂养8周后,实验组Lee指数较对照组显著升高,即认定肥胖高脂大鼠造模成功。Lee指数=√w(g)/L(cm)×1000
将本发明实施例3及对比例1-3组的营养组合物添加至奶粉中,添加量均为4%,作为实验组,同样按照4.3g每30mL、25℃水混合,分别作为试验1组、试验2组、试验3组及试验4组,对照组饲喂普通奶粉(不添加营养组合物),添加量按照15mL/kg的剂量饲喂,每天饲喂3次,同时给上述各小鼠饲喂普通饲料,饮用自来水,连续处理12周,每两周一次监测体重。
12周后,给予各小鼠禁食不禁水12h,称重(W),然后处死所有大鼠,于下腔静脉取血后分离血清、血浆待测。利用酶法测定总胆固醇(TC)、甘油三酯(TG),用免疫比浊法测定高密度脂蛋白(HDL)、低密度脂蛋白(LDL),并计算动脉粥硬化指数(AI),AI=(TC-HDL)/HDL。
4.试验结果:具体试验结果参见表3。
表3不同试验样品的改善血脂情况对比
组别 | TC/mmol/L | TG/mmol/L | HDL/mmol/L | LDL/mmol/L | AI |
试验1组 | 1.64±0.42 | 0.58±0.15 | 0.52±0.12 | 0.48±0.21 | 2.15±0.38 |
试验2组 | 1.71±0.32 | 0.65±0.08 | 0.57±0.13 | 0.52±0.34 | 2.00±0.34 |
试验3组 | 1.68±0.45 | 0.67±0.27 | 0.59±0.21 | 0.57±0.18 | 1.85±0.47 |
试验4组 | 1.73±0.22 | 0.63±0.18 | 0.61±0.33 | 0.55±0.28 | 1.84±0.54 |
对照组 | 1.48±0.25 | 0.41±0.22 | 0.43±0.12 | 0.25±0.08 | 2.44±0.32 |
由表3可知,与对照组相比,食用本发明实施例3组(试验1组)的组合物差异最显著,改善血脂效果最好,而对比例1-3组均有不同程度的降低,进一步证明了本发明各组合物相互作用,可以改善血脂。
最后应当说明的是,上述的对实施例的描述是为便于该技术领域的普通技术人员能理解和使用发明。熟悉本领域技术的人员显然可以容易地对这些实施例做出各种修改,并把在此说明的一般原理应用到其他实施例中而不必经过创造性的劳动。因此,本发明不限于上述实施例,本领域技术人员根据本发明的揭示,不脱离本发明范畴所做出的改进和修改都应该在本发明的保护范围之内。
Claims (7)
1.一种助消化、缓解睡眠障碍及改善血脂的组合物及其应用,其特征在于,包含如下组分及其重量份数:综合果蔬发酵粉0.4-8.7份,膳食纤维19.5-260.9份,酸枣仁1.2-26.1份,茶叶茶氨酸0.6-13.9份,植物甾醇酯0.8-135.7份。
2.如权利要求1所述的组合物,其特征在于,每200mg综合果蔬发酵粉中包含淀粉酶3500DU、脂肪酶200FIP、蛋白酶5SAPU、纤维素酶50CU、乳糖酶100ALU。
3.如权利要求1所述的组合物,其特征在于,所述酸枣仁与茶叶茶氨酸的添加比例为2:1。
4.如权利要求1所述的组合物,其特征在于,所述膳食纤维选自低聚半乳糖、低聚果糖、低聚异麦芽糖、聚葡萄糖、抗性糊精中的2种或以上。
5.如权利要求4所述的组合物,其特征在于,所述膳食纤维由低聚半乳糖、低聚果糖、低聚异麦芽糖按重量比1~5:1~4:2~8组成。
6.一种如权利要求1-5任一项所述的组合物在制备营养食品中的应用。
7.如权利要求6所述的应用,其特征在于,所述组合物在营养食品中的添加量为0.5~8%。
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