CN113272275A - 一种左乙拉西坦中间体的制备方法 - Google Patents

一种左乙拉西坦中间体的制备方法 Download PDF

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Publication number
CN113272275A
CN113272275A CN202080008317.3A CN202080008317A CN113272275A CN 113272275 A CN113272275 A CN 113272275A CN 202080008317 A CN202080008317 A CN 202080008317A CN 113272275 A CN113272275 A CN 113272275A
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China
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oxo
ethyl
alpha
acid
acetic acid
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CN202080008317.3A
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CN113272275B (zh
Inventor
刘冰欣
龚玉龙
朱元勋
颜峰峰
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Zhejiang Huahai Pharmaceutical Co Ltd
Zhejiang Huahai Tiancheng Pharmaceutical Co Ltd
Zhejiang Huahai Zhicheng Pharmaceutical Co Ltd
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Zhejiang Huahai Pharmaceutical Co Ltd
Zhejiang Huahai Tiancheng Pharmaceutical Co Ltd
Zhejiang Huahai Zhicheng Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)

Abstract

本申请提供了一种通过消旋回收获得高质量的(RS)‑α‑乙基‑2‑氧代‑1‑吡咯烷乙酸，本申请提供的方法可以显著提高消旋回收产品(RS)‑α‑乙基‑2‑氧代‑1‑吡咯烷乙酸的质量和外观，且对产品收率无影响。

Description

PCT国内申请，说明书已公开。

Claims (6)

  1. PCT国内申请，权利要求书已公开。
CN202080008317.3A 2019-04-23 2020-04-17 一种左乙拉西坦中间体的制备方法 Active CN113272275B (zh)

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CN2019103284629 2019-04-23
CN201910328462.9A CN110003074A (zh) 2019-04-23 2019-04-23 一种左乙拉西坦中间体的制备方法
PCT/CN2020/085370 WO2020216146A1 (zh) 2019-04-23 2020-04-17 一种左乙拉西坦中间体的制备方法

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EP (1) EP3960732A4 (zh)
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Publication number Priority date Publication date Assignee Title
CN110003074A (zh) * 2019-04-23 2019-07-12 浙江华海药业股份有限公司 一种左乙拉西坦中间体的制备方法
US11384050B1 (en) 2021-02-03 2022-07-12 Vitaworks Ip, Llc Method for preparing levetiracetam and intermediates thereof
CN114702426A (zh) * 2022-05-24 2022-07-05 雅本化学股份有限公司 一种左乙拉西坦中间体的合成方法

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2006053441A1 (en) * 2004-11-22 2006-05-26 Apotex Pharmachem Inc. Improved process for the preparation of (s)-alpha-etyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
CN101333180A (zh) * 2007-06-29 2008-12-31 浙江华海药业股份有限公司 一种制备左乙拉西坦中间体的方法
CN108707099A (zh) * 2018-06-19 2018-10-26 浙江华海药业股份有限公司 一种左乙拉西坦中间体的制备方法

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GB8412357D0 (en) 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
IN2005MU01546A (zh) * 2005-12-13 2007-08-24 M.M.V. Ramana
CN101838211B (zh) * 2009-03-16 2014-07-02 黄冈华阳药业有限公司 生产左乙拉西坦的中间体2-氨基丁酸的工艺方法
CN104370791B (zh) * 2014-11-28 2018-09-21 上虞京新药业有限公司 一种左乙拉西坦的纯化方法
CN110003074A (zh) * 2019-04-23 2019-07-12 浙江华海药业股份有限公司 一种左乙拉西坦中间体的制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006053441A1 (en) * 2004-11-22 2006-05-26 Apotex Pharmachem Inc. Improved process for the preparation of (s)-alpha-etyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
CN101333180A (zh) * 2007-06-29 2008-12-31 浙江华海药业股份有限公司 一种制备左乙拉西坦中间体的方法
CN108707099A (zh) * 2018-06-19 2018-10-26 浙江华海药业股份有限公司 一种左乙拉西坦中间体的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘晓光;张存莉;王九;吴阳;杨秋燕;王俊臣;: "左乙拉西坦中间体LV30结晶母液回收的研究", 山东化工, no. 16, pages 29 *

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CN113272275B (zh) 2024-01-12
WO2020216146A1 (zh) 2020-10-29
EP3960732A1 (en) 2022-03-02
US20220162165A1 (en) 2022-05-26
CN110003074A (zh) 2019-07-12
EP3960732A4 (en) 2022-07-13

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