CN1131556A - 一种胃康胶丸及其制备方法 - Google Patents
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Abstract
本发明涉及一种治疗胃脘痛的胃康胶丸及其制备方法，胃康胶丸系藜科植物土荆芥与茜科植物水团花，经蒸馏收集的挥发油，加精炼植物油溶解稀释；另取明胶和甘油，在蒸馏水中溶解、过滤，制成明胶溶液，经滴丸机滴成胶丸。
Description
本发明涉及一种治疗胃脘痛的胃康胶丸及其制备方法，属于中草药制剂。
胃脘痛是临床常见病、多发病、发病率高，胃脘痛的治疗目的是消除症状、促进愈合和防止复发与并发症。现治疗胃脘痛主要采用甲氰咪胍、雷尼替丁、胃仙优、丽珠得乐、胃得安片等。土荆芥为藜科植物土荆芥(Chenopodiumambrosiodes L)的有果穗的全草。全草含挥发油(土荆芥油)0.4—1％，油中主要成分为驱蛔素、对聚伞花素及其他萜类物质如土荆价酮、柠檬浠等；具有祛风、杀虫、通经，止痛的功能。水团花学名为茜草科植物水团花(Adinapilnlifeya(lam)Fr)，叶含混合酸性皂甙，水解后产生奎诺酸及其醋酸盐，另含B一谷甾醇，茎含奎诺酸，B一谷甾醇以及混合皂甙，混合皂水解得奎诺酸；桦皮酸及辛可利酸，糖的部分主为葡萄糖醛酸；具有清热利湿，消瘀止痛，止血生肌等功能。
本发明的目的就是要提供一种由中草药研制而成，能治疗胃脘痛且服用方便、价格低廉的胶丸。
本发明提出的胃康胶丸是一种内含油状液体的胶丸，其油状液体含有土荆芥油、水团花油和植物油，其土荆芥油和水团花油含量分别为18--70MG和0.5--5MG。
本发明提出的胃康胶丸是这样实现的：从50％--70％(重量)的土荆芥和30％--50％(重量)水团花中蒸馏提取混合油，加植物油溶解稀释；另取明胶和甘油，在蒸馏水中溶解、过滤，制成明胶溶液；经滴丸机滴成内含油状液体的胶丸。
由于胃康胶丸含有土荆芥和水团花；土荆芥理气止痛，水团花散瘀止痛，气血双调，既能绶解气滞的胃脘痛，又能绶解血瘀的胃脘痛；同时土荆芥健胃消食，水团花清热解毒，既适用于虚寒的胃脘痛，又适用于郁热的胃脘痛；因此，对各种证型的胃脘痛有良好的疗效。
下面结合典型病例介绍：
例一：陈珍艺，男32岁，已婚，厦门市马巷镇友民街人，个人史无特殊，心窝部反复疼痛近8年，经厦门多所医院诊断为十二脂肠球部溃疡，自述曾服胃仙优一瓶，胃必治六瓶，雷尼替丁四瓶等无效，苦楚难言，于1990年4月29日经朋友介绍来院治疗，中医疹断：症状：胃痛甚，额冒汗、手足冷、暧气呕恶、不思食、喜暧畏寒、冶簿白、脉弦细、证属脾胃虚寒、健运失司、治宜健脾和胃、理气定痛。服该胃康胶丸数天则疼痛消失，服用一疗程后，至今饮食如常。无何不适，最近胃肠钡透提示：溃疡面已愈合，胃粘膜正常。
例二：陈珍狮：男，36岁，已婚。厦门市马巷镇五星村人，自诉上腹部反复疼痛5--8年，胃部隐痛，喜暧喜按，劳累后症状加重。反复发作。89年2月23日于厦门医院胃肠钡透提示：十二指肠球部溃疡、胃窦炎。同时服胃酶素，雷尼替丁等数瓶无效。中药诊断：症状：脘腹剧痛数月、空腹尤甚、常便秘、暧气、嘈杂，舌薄黄、脉细弦。证属寒邪客胃、脾胃素弱、脾失健运、肝木乘侮。治以：理气止痛兼散寒，健胃利湿。于90年1月2日用该胃康胶丸治疗二个疗程，疼痛消失，眠食均佳。91年5月11日胃肠钡透复查，无异常发现，患部粘膜光滑。93年11月7日厦门医院胃镜复查提示：溃疡面已愈合。
例三：朱艺玲，男，26岁，已婚，马巷烟草公司负责人，心窝部疼痛5--7年，89年11月11日同民医院胃肠钡透示：1、胃窦炎；2、十二指肠溃疡(球部)经多种胃药治疗无效，住院治疗后又带回三瓶雷尼替丁连续服完，停药后即又疼痛。中医诊断：症见痛作绵绵、喜按喜暧、食减腹胀、苔薄白、脉沉细、证属脾胃虚寒、运化失职、治宜健胃消食、理气止痛。后经该胃康胶丸治疗一疗程，其患若失，后又索药治疗一疗程，至今未见疼痛，随访时其言经常喝洒，未见不适。91年4月7日胃肠钡透复查：溃疡面已愈合。93年7月份胃镜复查溃疡面已愈合。
下面结合本发明的实施例，对本发明的胃康胶丸作进一步的说明。
实施例1：取土荆芥茎叶600g，水团花茎叶400g装在蒸馏锅内用水蒸气蒸馏，提取挥发油(土荆芥油和水团花油的混合油)；取上述挥发油加精炼食用植物油(在0℃左右脱去固体脂肪酸的花生油、菜仔油等植物油)，溶解稀释制成胃康原料油；取药用明胶和适量药用甘油在70℃左右的蒸馏水中溶解，过滤，制成适当浓度的明胶溶液；将上述胃康原料油与明胶溶液置于滴丸机中，滴制成内含18--70MG土荆芥油和0.5--5MG水团花油重30mg--120mg的胶丸。制成的胶丸经定型、干燥、洗涤、消毒、整理后包装即可。
实施例2：取土荆芥茎叶500g，水团花茎叶500g装在蒸馏锅内用水蒸气蒸馏，提取挥发油(土荆油和水团花油的混合油)取上述挥发油加等量精炼食用植物油(在0℃左右脱去固体脂肪酸)，溶解稀释制成胃康原料油；取药用明胶和适量药用甘油在60℃左右的蒸馏水中溶解，过滤，制成适当浓度的明胶溶液；将上述胃康原料油与明胶溶液置于滴丸机中，滴制成重40mg--100mg的胶丸。
实施例3：取土荆芥茎叶700g，水团花茎叶300g装在蒸馏锅内用水蒸气蒸馏，提取挥发油(土荆油和水团花油的混合油)取上述挥发油加等量精炼食用植物油(在0℃左右脱去固体脂肪酸)，溶解稀释制成胃康原料油；取药用明胶和适量药用甘油在100℃左右的蒸馏水中溶解，过滤，制成适当浓度的明胶溶液；将上述胃康原料油与明胶溶液置于滴丸机中，滴制成重40mg--120mg的胶丸。
实施例4：取土荆芥茎叶600g，水团花茎叶400g装在蒸馏锅内用水蒸气蒸馏，提取挥发油(土荆芥油和水团花油的混合油)；取上述挥发油加精炼食用植物油(在0℃左右脱去固体脂肪酸的花生油、菜仔油等植物油)，溶解稀释制成胃康原料油；取药用明胶和适量药用甘油在70℃左右的蒸馏水中溶解，过滤，制成适当浓度的明胶溶液；将上述胃康原料油与明胶溶液置于滴丸机中，滴制成内含45MG土荆芥油和水团花油及35MG植物油的胶丸。
Claims (5)
1、一种胃康胶丸，其特征是：上述胃康胶丸内含有土荆芥油、水团花油和植物油。
2、根据权利要求1所述的胃康胶丸，其土荆芥油和水团花油含量分别为18--70MG、0.5--5MG。
3、根据权利要求1所述的胃康胶丸制备方法：从土荆芥和水团花中蒸馏提取混合油，加植物油溶解稀释；另取明胶和甘油，在蒸馏水中溶解、过滤，制成明胶溶液；经滴丸机滴成内含油状液体的胶丸。
4、根据权利要求3所述的胃康胶丸制备方法：从50％--70％(重量)的土荆芥和30％--50％(重量)水团花中蒸馏提取混合油，加植物油溶解稀释；另取明胶和甘油，在蒸馏水中溶解、过滤，制成明胶溶液；经滴丸机滴成内含油状液体的胶丸。
5、根据权利要求4所述的胃康胶丸制备方法：取50％--70％(重量)的土荆芥茎叶和30％--50％(重量)水团花茎叶装在蒸馏锅内用水蒸气蒸馏，提取挥发油取上述挥发油加精炼食用植物油，溶解稀释制成胃康原料油；取药用明胶和适量药用甘油在60℃—100℃的蒸馏水中溶解，过滤，制成明胶溶液；将上述胃康原料油与明胶溶液置于滴丸机中，滴制成重30mg--120mg的胶丸。
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95114819A CN1052646C (zh) | 1995-03-23 | 1995-03-23 | 一种治疗胃脘痛的胶丸及其制备方法 |
| US08/913,946 US6344219B1 (en) | 1995-03-23 | 1996-03-25 | Chinese drug composition for treatment of peptic ulcer and preparation thereof |
| AU51410/96A AU5141096A (en) | 1995-03-23 | 1996-03-25 | A chinese drug composition for treatment of peptic ulcer and preparation thereof |
| EP96907988A EP0815868B1 (en) | 1995-03-23 | 1996-03-25 | A chinese drug composition for treatment of peptic ulcer |
| KR1019970706649A KR100427623B1 (ko) | 1995-03-23 | 1996-03-25 | 소화성궤양치료용한약조성물및그제조방법 |
| PCT/CN1996/000020 WO1996029084A1 (fr) | 1995-03-23 | 1996-03-25 | Composition medicamenteuse chinoise servant au traitement des ulceres gastro-duodenaux, et sa preparation |
| JP52795496A JP4002296B2 (ja) | 1995-03-23 | 1996-03-25 | 消化性潰瘍を処置するための漢方薬組成物およびその調製 |
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| CN95114819A CN1052646C (zh) | 1995-03-23 | 1995-03-23 | 一种治疗胃脘痛的胶丸及其制备方法 |
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| Publication Number | Publication Date |
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| CN1131556A true CN1131556A (zh) | 1996-09-25 |
| CN1052646C CN1052646C (zh) | 2000-05-24 |
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| CN95114819A Expired - Lifetime CN1052646C (zh) | 1995-03-23 | 1995-03-23 | 一种治疗胃脘痛的胶丸及其制备方法 |
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| Country | Link |
|---|---|
| US (1) | US6344219B1 (zh) |
| EP (1) | EP0815868B1 (zh) |
| JP (1) | JP4002296B2 (zh) |
| KR (1) | KR100427623B1 (zh) |
| CN (1) | CN1052646C (zh) |
| AU (1) | AU5141096A (zh) |
| WO (1) | WO1996029084A1 (zh) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007076699A1 (fr) * | 2005-12-31 | 2007-07-12 | Tianjin Tasly Pharmaceutical Co. Ltd., China | Composition pharmaceutique contenant un extrait de chenopodium ambrosioides et son procédé de préparation et son application |
| CN100350897C (zh) * | 2003-01-08 | 2007-11-28 | 江西本草天工科技有限责任公司 | 中药双相硬胶囊 |
| CN1990006B (zh) * | 2005-12-31 | 2011-10-05 | 天津天士力制药股份有限公司 | 一种土荆芥提取物、其制剂、制备方法与用途 |
| CN101172132B (zh) * | 2006-10-30 | 2011-10-05 | 天津天士力制药股份有限公司 | 一种治疗胃病的自乳化制剂及其制备方法 |
| CN101194946B (zh) * | 2006-12-08 | 2013-06-05 | 天士力制药集团股份有限公司 | 一种治疗胃脘痛的药物及其制备方法 |
| CN106729719A (zh) * | 2016-12-20 | 2017-05-31 | 北京中医药大学东直门医院 | 治疗幽门螺杆菌感染的药物组合物及其用途 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0914816A4 (en) * | 1997-05-19 | 2000-08-23 | Shiseido Co Ltd | SCALP CARE COMPOSITIONS |
| US20070059358A1 (en) * | 2003-07-02 | 2007-03-15 | Tianjin Tasly Pharmaceutical Co., Ltd., China | Matrix adjuvants and the drop pills prepared with them |
| CN1836022A (zh) | 2003-08-20 | 2006-09-20 | 昭和电工株式会社 | 立方氮化硼、制造立方氮化硼的方法、含有立方氮化硼的砂轮、和烧结立方氮化硼压制体 |
| CN1990007B (zh) * | 2005-12-31 | 2011-08-10 | 天津天士力制药股份有限公司 | 一种治疗胃病的组合物、制备方法及其用途 |
| CN103940916B (zh) * | 2013-01-17 | 2017-11-21 | 天士力制药集团股份有限公司 | 一种荆花胃康胶丸指纹图谱分析方法 |
| CN109512995B (zh) * | 2019-01-17 | 2021-11-12 | 上海中华药业有限公司 | 一种抗肿瘤中药组合物及其挥发油提取物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB414353A (en) * | 1931-11-25 | 1934-07-25 | Wilhelm Hinz | Anthelmintic preparations and method of making same |
| US5290557A (en) * | 1992-07-16 | 1994-03-01 | W. Neudorff Gmbh Kg | Saponin containing anti-feedant and molluscicide for terrestrial mollusc control |
| CN1104098A (zh) * | 1993-12-26 | 1995-06-28 | 黎海华 | 湿热清中药液 |
| US5888984A (en) * | 1994-05-12 | 1999-03-30 | Dermal Research Laboratories, Inc. | Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same |
-
1995
- 1995-03-23 CN CN95114819A patent/CN1052646C/zh not_active Expired - Lifetime
-
1996
- 1996-03-25 WO PCT/CN1996/000020 patent/WO1996029084A1/zh active IP Right Grant
- 1996-03-25 KR KR1019970706649A patent/KR100427623B1/ko not_active IP Right Cessation
- 1996-03-25 EP EP96907988A patent/EP0815868B1/en not_active Expired - Lifetime
- 1996-03-25 JP JP52795496A patent/JP4002296B2/ja not_active Expired - Fee Related
- 1996-03-25 US US08/913,946 patent/US6344219B1/en not_active Expired - Fee Related
- 1996-03-25 AU AU51410/96A patent/AU5141096A/en not_active Abandoned
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100350897C (zh) * | 2003-01-08 | 2007-11-28 | 江西本草天工科技有限责任公司 | 中药双相硬胶囊 |
| WO2007076699A1 (fr) * | 2005-12-31 | 2007-07-12 | Tianjin Tasly Pharmaceutical Co. Ltd., China | Composition pharmaceutique contenant un extrait de chenopodium ambrosioides et son procédé de préparation et son application |
| CN1990006B (zh) * | 2005-12-31 | 2011-10-05 | 天津天士力制药股份有限公司 | 一种土荆芥提取物、其制剂、制备方法与用途 |
| US8361515B2 (en) | 2005-12-31 | 2013-01-29 | Tasly Pharmaceutical Group Co., Ltd. | Extracts of Chenopodium ambrosioides L., the compositions comprising said extracts, the preparing process and application thereof |
| US8586108B2 (en) | 2005-12-31 | 2013-11-19 | Tasly Pharmaceutical Group Co., Ltd | Extracts of Chenopodium ambrosioides L., the compositions comprising said extracts, the preparing process and application thereof |
| CN101172132B (zh) * | 2006-10-30 | 2011-10-05 | 天津天士力制药股份有限公司 | 一种治疗胃病的自乳化制剂及其制备方法 |
| CN101194946B (zh) * | 2006-12-08 | 2013-06-05 | 天士力制药集团股份有限公司 | 一种治疗胃脘痛的药物及其制备方法 |
| CN106729719A (zh) * | 2016-12-20 | 2017-05-31 | 北京中医药大学东直门医院 | 治疗幽门螺杆菌感染的药物组合物及其用途 |
| CN106729719B (zh) * | 2016-12-20 | 2019-03-15 | 北京中医药大学东直门医院 | 治疗幽门螺杆菌感染的药物组合物及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU5141096A (en) | 1996-10-08 |
| KR100427623B1 (ko) | 2004-07-12 |
| EP0815868A4 (en) | 1998-12-02 |
| EP0815868A1 (en) | 1998-01-07 |
| EP0815868B1 (en) | 2002-02-06 |
| US6344219B1 (en) | 2002-02-05 |
| JP4002296B2 (ja) | 2007-10-31 |
| WO1996029084A1 (fr) | 1996-09-26 |
| CN1052646C (zh) | 2000-05-24 |
| KR19980703245A (ko) | 1998-10-15 |
| JP2000514033A (ja) | 2000-10-24 |
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