CN1052646C - 一种治疗胃脘痛的胶丸及其制备方法 - Google Patents
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Abstract
本发明涉及一种治疗胃脘痛的胶丸及其制备方法，其系藜科植物土荆芥与茜科植物水团花，经蒸馏收集的挥发油，加精炼植物油溶解稀释；另取明胶和甘油，在蒸馏水中溶解、过滤，制成明胶溶液；经滴丸机滴成胶丸。
Description
本发明涉及一种治疗胃脘痛的胶丸，特别是涉及一种以植物中草药为原料制成的治疗胃脘痛的胶丸，本发明还涉及该胶丸的制备方法。
胃脘痛是临床常见病、多发病、发病率高。胃脘痛的治疗目的是消除症状、促进愈合和防止复发与并发症。现治疗胃脘痛主要采用甲氰咪胍、雷尼替丁、胃仙优、丽珠得乐、胃得安片等。土荆芥为藜科植物土荆芥(Chenopodiumambrosiodes L)的有果穗的全草。全草含挥发油(土荆芥油)0.4％-1％，油中主要成分为驱蛔素、对聚伞花素及其他萜类物质如土荆芥酮、柠檬烯等；具有祛风、杀虫、通经，止痛的功能。水团花学名为茜草科植物水团花(AdinaPilnlifera(lan)Fr)，叶含混合酸性皂甙，水解后产生奎诺酸及其醋酸盐，另含β-谷甾醇，茎含奎诺酸，β-谷甾醇以及混合皂甙，混合皂甙水解得奎诺酸；桦皮酸及辛可利酸，糖的部分主为葡萄糖醛酸，具有清热利湿，消瘀止痛，止血生肌等功能。
本发明的目的就是要提供一种主要由土荆芥和水团花有效成分组成的具有治疗胃脘痛且服用方便、价格低廉的胶丸及其制备方法。
本发明提出的治疗胃脘痛的胶丸是一种内含油状液体的胶丸，其油状液体含有土荆芥油、水团花油和植物油，其土荆芥油、水团花油含量分别为18-70mg和0.5-50mg，且所述的土荆芥油和水团花油是由占重量配比50％-70％的土荆芥和30％-50％的水团花用水蒸馏方法提取的混合挥发油。
上述治疗胃脘痛的胶丸是由占重量配比50％-70％的土荆芥和30％-50％的水团花按下述方法制成的：取土荆芥和水团花，用水蒸馏法提取其混合挥发油，加植物油溶解稀释；另取明胶和甘油，在蒸馏水中溶解过滤，制成明胶溶液；将混合挥发油与明胶溶液经滴丸机滴制成内含油状液体的胶丸。
本发明治疗胃脘痛的胶丸制备方法：取占重量配比50％-70％的土荆芥和30％-50％的水团花用水蒸馏提取其混合挥发油，加植物油溶解稀释制成原料油；另取明胶和甘油，在蒸馏水中溶解过滤，制成明胶溶液；将原料油与明胶溶液经滴丸机滴制成内含油状液体的胶丸。
由于治疗胃脘痛的胶丸含有土荆芥和水团花，土荆芥理气止痛，水团花散瘀止痛，气血双调，既能缓解气滞的胃脘痛，又能绶解血瘀的胃脘痛；同时土荆芥健胃消食，水团花清热解毒，既适用于虚寒的胃脘痛，又适用于郁热的胃脘痛，因此，对各种证型的胃脘痛有良好的疗效。
下面结合典型病例介绍：
例一：陈珍艺，男32岁，已婚，厦门市马巷镇友民街人，个人史无特殊，心窝部反复疼痛近8年，经厦门多医院诊断为十二脂肠球部溃疡，自述曾服胃仙优一瓶，胃必治六瓶，雷尼替丁四瓶等无效，苦楚难言，于1990年4月29日经朋友介绍来院治疗，中医疹断：症状：胃痛甚，额冒汗、手足冷、暖气呕恶、不思食、喜暖畏寒、冶薄白、脉弦细、证属脾胃虚寒、健运失司、治宜健脾和胃、理气定痛。服该治疗胃脘痛的胶丸数天则疼痛消失，服用一个疗程后，至今饮食如常。无何不适，最近胃肠钡透提示：溃疡面已愈合，胃粘膜正常。
例二：陈珍狮，男36岁，已婚，厦门市马巷镇五星村人，自述上腹部反复疼痛5-8年，胃部隐痛，喜暖喜按，劳累后症状加重。反复发作。89年2月23日于厦门医院胃肠钡透提示：十二指肠球部溃疡、胃窦炎。同时服胃酶素，雷尼替丁等数瓶无效。中药诊断：症状：脘腹剧痛数月、空腹尤甚、常便秘、暖气、嘈杂，舌薄黄、脉细弦。证属寒邪客胃、脾胃素弱、脾失健运、肝木乘侮。治以：理气止痛兼散寒，健胃利湿。于90年1月2日用该治疗胃脘痛的胶丸治疗二个疗程，疼痛消失，眠食均佳。91年5月11日胃肠钡透复查，无异常发现，患部粘膜光滑。93年11月7日厦门医院胃镜复查提示：溃疡面已愈合。
例三：朱艺玲，男，26岁，已婚，马巷烟草公司负责人，心窝部疼痛5-7年，89年11月11日同民医院胃肠钡透示：1、胃窦炎；2、十二指肠溃疡(球部)经多种胃药治疗无效，住院治疗后又带回三瓶雷尼替丁连续服完，停药后即又疼痛。中医诊断：症见痛作绵绵、喜按喜暧、食减腹胀、苔薄白、脉沉细、证属脾胃虚寒、运化失职、治宜健胃消食、理气止痛。后经该治疗胃脘痛的胶丸治疗一个疗程，其患若失，后又索药治疗一个疗程，至今未见疼痛，随访时其言经常喝酒，未见不适。91年4月7日胃肠钡透复查：溃疡面已愈合。93年7月份胃镜复查溃疡面已愈合。
以下结合本发明的实施例，对本发明的治疗胃脘痛的胶丸及其制备方法作进一步的说明。
实施例1：取土荆芥茎叶600g，水团花茎叶400g装在蒸馏锅内用水蒸气蒸馏，提取挥发油(土荆芥油和水团花油的混合油)；取上述挥发油加精炼食用植物油(在0℃左右脱去固体脂肪酸的花生油、菜仔油等植物油)，溶解稀释制成原料油；取药用明胶和适量药用甘油在70℃左右的蒸馏水中溶解，过滤，制成适当浓度的明胶溶液；将上述原料油与明胶溶液置于滴丸机中，滴制成内含18-70mg土荆芥油和0.5-5mg水团花油重30mg-120mg的胶丸。制成的胶丸经定型、干噪、洗涤、消毒、整理后包装即可。
实施例2：取土荆芥茎叶500g，水团花茎叶500g装在蒸馏锅内用水蒸气蒸馏，提取挥发油(土荆芥油和水团花油的混合油)；取上述挥发油加精炼食用植物油(在0℃左右脱去固体脂肪酸)，溶解稀释制成原料油；取药用明胶和适量药用甘油在60℃左右的蒸馏水中溶解，过滤，制成适当浓度的明胶溶液；将上述原料油与明胶溶液置于滴丸机中，滴制成重40mg-100mg的胶丸。
实施例3：取土荆芥茎叶700g，水团花茎叶300g装在蒸馏锅内用水蒸气蒸馏，提取挥发油(土荆芥油和水团花油的混合油)；取上述挥发油加精炼食用植物油(在0℃左右脱去固体脂肪酸)，溶解稀释制成原料油；取药用明胶和适量药用甘油在100℃左右的蒸馏水中溶解，过滤，制成适当浓度的明胶溶液；将上述原料油与明胶溶液置于滴丸机中，滴制成重40mg-120mg的胶丸。
实施例4：取土荆芥茎叶600g，水团花茎叶400g装在蒸馏锅内用水蒸气蒸馏，提取挥发油(土荆芥油和水团花油的混合油)；取上述挥发油加精炼食用植物油(在0℃左右脱去固体脂肪酸)，溶解稀释制成原料油；取药用明胶和适量药用甘油在70℃左右的蒸馏水中溶解，过滤，制成适当浓度的明胶溶液；将上述原料油与明胶溶液置于滴丸机中，滴制成内含45mg土荆芥油和水团花油及35mg植物油的胶丸。
Claims (4)
1、一种治疗胃脘痛的胶丸，其特征在于：它含有土荆芥油和水团花油，且所述的土荆芥油和水团花油是由占重量配比50％-70％的土荆芥和30％-50％的水团花用水蒸馏方法提取的混合挥发油。
2、根据权利要求1所述的治疗胃脘痛的胶丸，其特征在于：由占重量配比50％-70％的土荆芥和30％-50％的水团花按下述方法制成的：取土荆芥和水团花，用水蒸馏法提取其混合挥发油，加植物油溶解稀释；另取明胶和甘油，在蒸馏水中溶解过滤，制成明胶溶液；将混合挥发油与明胶溶液经滴丸机滴制成内含油状液体的胶丸。
3、根据权利要求1所述的治疗胃脘痛的胶丸的制备方法，其特征在于：取占重量配比50％-70％的土荆芥和30％-50％的水团花用水蒸馏提取其混合挥发油，加植物油溶解稀释制成原料油；取明胶和甘油，在蒸馏水中溶解过滤，制成明胶溶液；将原料油与明胶溶液经滴丸机滴制成内含油状液体的胶丸。
4、根据权利要求3所述的治疗胃脘痛的胶丸的制备方法，其特征在于：取占重量配比50％-70％的土荆芥茎叶和30％-50％的水团花茎叶装在蒸馏锅内用水蒸气蒸馏，提取其混合挥发油，加植物油溶解稀释制成原料油；取药用明胶和适量甘油在60℃-100℃的蒸馏水中溶解，过滤，制成明胶溶液；将原料油与明胶溶液置于滴丸机中，滴制成重30mg-120mg胶丸。
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95114819A CN1052646C (zh) | 1995-03-23 | 1995-03-23 | 一种治疗胃脘痛的胶丸及其制备方法 |
| US08/913,946 US6344219B1 (en) | 1995-03-23 | 1996-03-25 | Chinese drug composition for treatment of peptic ulcer and preparation thereof |
| JP52795496A JP4002296B2 (ja) | 1995-03-23 | 1996-03-25 | 消化性潰瘍を処置するための漢方薬組成物およびその調製 |
| EP96907988A EP0815868B1 (en) | 1995-03-23 | 1996-03-25 | A chinese drug composition for treatment of peptic ulcer |
| KR1019970706649A KR100427623B1 (ko) | 1995-03-23 | 1996-03-25 | 소화성궤양치료용한약조성물및그제조방법 |
| PCT/CN1996/000020 WO1996029084A1 (fr) | 1995-03-23 | 1996-03-25 | Composition medicamenteuse chinoise servant au traitement des ulceres gastro-duodenaux, et sa preparation |
| AU51410/96A AU5141096A (en) | 1995-03-23 | 1996-03-25 | A chinese drug composition for treatment of peptic ulcer and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95114819A CN1052646C (zh) | 1995-03-23 | 1995-03-23 | 一种治疗胃脘痛的胶丸及其制备方法 |
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| Publication Number | Publication Date |
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| CN1131556A CN1131556A (zh) | 1996-09-25 |
| CN1052646C true CN1052646C (zh) | 2000-05-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN95114819A Expired - Lifetime CN1052646C (zh) | 1995-03-23 | 1995-03-23 | 一种治疗胃脘痛的胶丸及其制备方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6344219B1 (zh) |
| EP (1) | EP0815868B1 (zh) |
| JP (1) | JP4002296B2 (zh) |
| KR (1) | KR100427623B1 (zh) |
| CN (1) | CN1052646C (zh) |
| AU (1) | AU5141096A (zh) |
| WO (1) | WO1996029084A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1990007B (zh) * | 2005-12-31 | 2011-08-10 | 天津天士力制药股份有限公司 | 一种治疗胃病的组合物、制备方法及其用途 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0914816A4 (en) * | 1997-05-19 | 2000-08-23 | Shiseido Co Ltd | SCALP CARE COMPOSITIONS |
| CN100350897C (zh) * | 2003-01-08 | 2007-11-28 | 江西本草天工科技有限责任公司 | 中药双相硬胶囊 |
| US20070059358A1 (en) * | 2003-07-02 | 2007-03-15 | Tianjin Tasly Pharmaceutical Co., Ltd., China | Matrix adjuvants and the drop pills prepared with them |
| CN101362591B (zh) | 2003-08-20 | 2011-06-15 | 昭和电工株式会社 | 立方氮化硼、制造立方氮化硼的方法、含有立方氮化硼的砂轮、和烧结立方氮化硼压制体 |
| US8361515B2 (en) | 2005-12-31 | 2013-01-29 | Tasly Pharmaceutical Group Co., Ltd. | Extracts of Chenopodium ambrosioides L., the compositions comprising said extracts, the preparing process and application thereof |
| CN101172132B (zh) * | 2006-10-30 | 2011-10-05 | 天津天士力制药股份有限公司 | 一种治疗胃病的自乳化制剂及其制备方法 |
| CN1990006B (zh) * | 2005-12-31 | 2011-10-05 | 天津天士力制药股份有限公司 | 一种土荆芥提取物、其制剂、制备方法与用途 |
| CN101194946B (zh) * | 2006-12-08 | 2013-06-05 | 天士力制药集团股份有限公司 | 一种治疗胃脘痛的药物及其制备方法 |
| CN103940916B (zh) * | 2013-01-17 | 2017-11-21 | 天士力制药集团股份有限公司 | 一种荆花胃康胶丸指纹图谱分析方法 |
| CN106729719B (zh) * | 2016-12-20 | 2019-03-15 | 北京中医药大学东直门医院 | 治疗幽门螺杆菌感染的药物组合物及其用途 |
| CN109512995B (zh) * | 2019-01-17 | 2021-11-12 | 上海中华药业有限公司 | 一种抗肿瘤中药组合物及其挥发油提取物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB414353A (en) * | 1931-11-25 | 1934-07-25 | Wilhelm Hinz | Anthelmintic preparations and method of making same |
| US5290557A (en) * | 1992-07-16 | 1994-03-01 | W. Neudorff Gmbh Kg | Saponin containing anti-feedant and molluscicide for terrestrial mollusc control |
| CN1104098A (zh) * | 1993-12-26 | 1995-06-28 | 黎海华 | 湿热清中药液 |
| US5888984A (en) * | 1994-05-12 | 1999-03-30 | Dermal Research Laboratories, Inc. | Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same |
-
1995
- 1995-03-23 CN CN95114819A patent/CN1052646C/zh not_active Expired - Lifetime
-
1996
- 1996-03-25 EP EP96907988A patent/EP0815868B1/en not_active Expired - Lifetime
- 1996-03-25 AU AU51410/96A patent/AU5141096A/en not_active Abandoned
- 1996-03-25 US US08/913,946 patent/US6344219B1/en not_active Expired - Fee Related
- 1996-03-25 JP JP52795496A patent/JP4002296B2/ja not_active Expired - Fee Related
- 1996-03-25 WO PCT/CN1996/000020 patent/WO1996029084A1/zh active IP Right Grant
- 1996-03-25 KR KR1019970706649A patent/KR100427623B1/ko not_active IP Right Cessation
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| 中草药1987,18(11) 1987.1. 1 张庆生等，水团花抗心胶痛的研究 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1990007B (zh) * | 2005-12-31 | 2011-08-10 | 天津天士力制药股份有限公司 | 一种治疗胃病的组合物、制备方法及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0815868A1 (en) | 1998-01-07 |
| US6344219B1 (en) | 2002-02-05 |
| JP2000514033A (ja) | 2000-10-24 |
| KR19980703245A (ko) | 1998-10-15 |
| KR100427623B1 (ko) | 2004-07-12 |
| WO1996029084A1 (fr) | 1996-09-26 |
| JP4002296B2 (ja) | 2007-10-31 |
| AU5141096A (en) | 1996-10-08 |
| CN1131556A (zh) | 1996-09-25 |
| EP0815868B1 (en) | 2002-02-06 |
| EP0815868A4 (en) | 1998-12-02 |
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