CN112996810A - 针对cd20和cd3的双特异性抗体及其用途 - Google Patents

针对cd20和cd3的双特异性抗体及其用途 Download PDF

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CN112996810A
CN112996810A CN201980071461.9A CN201980071461A CN112996810A CN 112996810 A CN112996810 A CN 112996810A CN 201980071461 A CN201980071461 A CN 201980071461A CN 112996810 A CN112996810 A CN 112996810A
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amino acid
sequence
bispecific antibody
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CN112996810B (zh
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李强
贾世香
马心鲁
崔雪原
张玉华
陈思
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Anyuan Pharmaceutical Technology Shanghai Co ltd
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Abstract

一种双特异性抗体，特异性结合免疫细胞的表面抗原CD3和肿瘤细胞表面的CD20抗原，并能够以高亲和力与人CD3结合并诱导T细胞增殖，介导肿瘤细胞杀伤作用。该双特异性抗体在体外测试可用于介导T细胞特异杀伤靶细胞，其构建方法简单，避免了异源双特异性抗体两组轻链与重链错配的可能性，从而降低了抗体纯化的难度，得到的抗体亲和力高，引起的细胞因子副作用小，安全性高。

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PCT国内申请，说明书已公开。

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  1. PCT国内申请，权利要求书已公开。
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