CN111138542A - 双特异性抗体及其用途 - Google Patents
双特异性抗体及其用途 Download PDFInfo
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- CN111138542A CN111138542A CN201910915568.9A CN201910915568A CN111138542A CN 111138542 A CN111138542 A CN 111138542A CN 201910915568 A CN201910915568 A CN 201910915568A CN 111138542 A CN111138542 A CN 111138542A
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Abstract
Description
Claims (28)
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Application Number | Priority Date | Filing Date | Title |
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CN201811294887 | 2018-11-01 | ||
CN2018112948874 | 2018-11-01 |
Publications (2)
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CN111138542A true CN111138542A (zh) | 2020-05-12 |
CN111138542B CN111138542B (zh) | 2022-09-23 |
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Application Number | Title | Priority Date | Filing Date |
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CN201910915568.9A Active CN111138542B (zh) | 2018-11-01 | 2019-09-26 | 双特异性抗体及其用途 |
CN201980071433.7A Active CN112955461B (zh) | 2018-11-01 | 2019-10-28 | 针对Her2和CD3的同源二聚体型双特异性抗体及其用途 |
CN201911033163.9A Active CN111138544B (zh) | 2018-11-01 | 2019-10-28 | 针对Her2和CD3的同源二聚体型双特异性抗体及其用途 |
CN201980071461.9A Active CN112996810B (zh) | 2018-11-01 | 2019-10-29 | 针对cd20和cd3的双特异性抗体及其用途 |
CN201911036797.XA Active CN111138545B (zh) | 2018-11-01 | 2019-10-29 | 针对cd20和cd3的双特异性抗体及其用途 |
CN201980071467.6A Active CN112996817B (zh) | 2018-11-01 | 2019-10-31 | 同源二聚体型双特异性抗体及其制备方法和用途 |
CN202211069993.9A Pending CN115819607A (zh) | 2018-11-01 | 2019-10-31 | 同源二聚体型双特异性抗体及其制备方法和用途 |
CN201911056250.6A Active CN111138547B (zh) | 2018-11-01 | 2019-10-31 | 针对cd19和cd3的同源二聚体型双特异性抗体及其制备方法和用途 |
CN201980071466.1A Active CN112996807B (zh) | 2018-11-01 | 2019-10-31 | 针对cd19和cd3的同源二聚体型双特异性抗体及其制备方法和用途 |
CN201911054536.0A Active CN111138546B (zh) | 2018-11-01 | 2019-10-31 | 同源二聚体型双特异性抗体及其制备方法和用途 |
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CN201911033163.9A Active CN111138544B (zh) | 2018-11-01 | 2019-10-28 | 针对Her2和CD3的同源二聚体型双特异性抗体及其用途 |
CN201980071461.9A Active CN112996810B (zh) | 2018-11-01 | 2019-10-29 | 针对cd20和cd3的双特异性抗体及其用途 |
CN201911036797.XA Active CN111138545B (zh) | 2018-11-01 | 2019-10-29 | 针对cd20和cd3的双特异性抗体及其用途 |
CN201980071467.6A Active CN112996817B (zh) | 2018-11-01 | 2019-10-31 | 同源二聚体型双特异性抗体及其制备方法和用途 |
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US20230357446A1 (en) | 2022-04-11 | 2023-11-09 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for universal tumor cell killing |
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WO2023218027A1 (en) * | 2022-05-12 | 2023-11-16 | Amgen Research (Munich) Gmbh | Multichain multitargeting bispecific antigen-binding molecules of increased selectivity |
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WO2024027793A1 (en) * | 2022-08-05 | 2024-02-08 | I-Mab Biopharma (Hangzhou) Co., Ltd. | Bispecific antibodies targeting ifnar1 and blys |
CN116143934B (zh) * | 2023-03-21 | 2023-07-25 | 诺赛联合(北京)生物医学科技有限公司 | 一种干细胞外泌体提取试剂盒及其应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090252683A1 (en) * | 2005-10-11 | 2009-10-08 | Micromet Ag | Composition Comprising Cross-Species-Sepecific Antibodies and uses Thereof |
CN105358570A (zh) * | 2013-03-14 | 2016-02-24 | 美国安进公司 | 含有非糖基化Fc的多肽 |
CN106279418A (zh) * | 2011-05-27 | 2017-01-04 | 葛兰素集团有限公司 | Bcma(cd269/tnfrsf17)结合蛋白 |
US20170218077A1 (en) * | 2016-02-03 | 2017-08-03 | Amgen Research (Munich) Gmbh | Bcma and cd3 bispecific t cell engaging antibody constructs |
CN107286248A (zh) * | 2016-08-19 | 2017-10-24 | 安源医药科技(上海)有限公司 | 高糖基化人生长激素融合蛋白及其制备方法与用途 |
CN108350076A (zh) * | 2015-08-17 | 2018-07-31 | 詹森药业有限公司 | 抗-bcma抗体,结合bcma和cd3的双特异性抗原结合分子及其用途 |
Family Cites Families (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US926A (en) | 1838-09-17 | Machine for threshing and winnowing grain | ||
US8034A (en) | 1851-04-08 | Cooking-stove | ||
US3522A (en) | 1844-04-04 | richard son | ||
US530A (en) | 1837-12-20 | Threshing-machine | ||
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4818679A (en) | 1985-02-19 | 1989-04-04 | The Trustees Of Columbia University In The City Of New York | Method for recovering mutant cells |
US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
DE3785186T2 (de) | 1986-09-02 | 1993-07-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2 Inc | Geänderte antikörper. |
GB8905669D0 (en) | 1989-03-13 | 1989-04-26 | Celltech Ltd | Modified antibodies |
US6750325B1 (en) | 1989-12-21 | 2004-06-15 | Celltech R&D Limited | CD3 specific recombinant antibody |
WO1992002551A1 (en) | 1990-08-02 | 1992-02-20 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
US5968509A (en) | 1990-10-05 | 1999-10-19 | Btp International Limited | Antibodies with binding affinity for the CD3 antigen |
GB9206422D0 (en) | 1992-03-24 | 1992-05-06 | Bolt Sarah L | Antibody preparation |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
WO1997043316A1 (en) | 1996-05-10 | 1997-11-20 | Beth Israel Deaconess Medical Center, Inc. | Physiologically active molecules with extended half-lives and methods of using same |
GB9815909D0 (en) | 1998-07-21 | 1998-09-16 | Btg Int Ltd | Antibody preparation |
ES2649037T3 (es) | 2000-12-12 | 2018-01-09 | Medimmune, Llc | Moléculas con semividas prolongadas, composiciones y usos de las mismas |
DE60124912T2 (de) * | 2001-09-14 | 2007-06-14 | Affimed Therapeutics Ag | Multimerische, einzelkettige, Tandem-Fv-Antikörper |
US7906118B2 (en) | 2005-04-06 | 2011-03-15 | Ibc Pharmaceuticals, Inc. | Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technology |
US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
US7993864B2 (en) | 2002-12-03 | 2011-08-09 | Ucb Pharma S.A. | Assay for identifying antibody producing cells |
GB0312481D0 (en) | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
DE602004030811D1 (de) | 2003-10-16 | 2011-02-10 | Micromet Ag | Multispezifische deimmunisierte cd3-bindende moleküle |
US20050176028A1 (en) | 2003-10-16 | 2005-08-11 | Robert Hofmeister | Deimmunized binding molecules to CD3 |
DK1753783T3 (en) | 2004-06-03 | 2014-11-17 | Novlmmune Sa | Anti-CD3 antibodies, and methods of use thereof |
US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
BRPI0517837A (pt) | 2004-11-12 | 2008-10-21 | Xencor Inc | variantes fc com ligação alterada a fcrn |
US8444973B2 (en) | 2005-02-15 | 2013-05-21 | Duke University | Anti-CD19 antibodies and uses in B cell disorders |
US10155816B2 (en) | 2005-11-28 | 2018-12-18 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
US9315578B2 (en) * | 2006-03-23 | 2016-04-19 | Tohoku Univeristy | High functional bispecific antibody |
TR201816277T4 (tr) | 2007-04-03 | 2018-11-21 | Amgen Res Munich Gmbh | Çapraz-tür-spesifik bağlama alanı. |
US20100183615A1 (en) | 2007-04-03 | 2010-07-22 | Micromet Ag | Cross-species-specific bispecific binders |
EP4098661A1 (en) | 2007-12-26 | 2022-12-07 | Xencor, Inc. | Fc variants with altered binding to fcrn |
CA2716882A1 (en) * | 2008-03-27 | 2009-10-01 | Zymogenetics, Inc. | Compositions and methods for inhibiting pdgfr-beta and vegf-a |
US20100260668A1 (en) * | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
TWI667257B (zh) * | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
CA2815363C (en) * | 2010-10-22 | 2020-07-14 | Seattle Genetics, Inc. | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the pi3k-akt mtor pathway |
WO2012066058A1 (en) * | 2010-11-16 | 2012-05-24 | Boehringer Ingelheim International Gmbh | Agents and methods for treating diseases that correlate with bcma expression |
WO2012130831A1 (en) * | 2011-03-29 | 2012-10-04 | Roche Glycart Ag | Antibody fc variants |
UA116192C2 (uk) * | 2011-08-23 | 2018-02-26 | Рош Глікарт Аг | Активуюча т-клітини біоспецифічна антигензв'язуюча молекула |
TW201817744A (zh) * | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之FcRn結合域的治療性抗原結合分子 |
TWI679212B (zh) * | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對bcma之e3以及cd3的結合分子 |
ES2751386T3 (es) | 2011-12-21 | 2020-03-31 | Amgen Inc | Polipéptidos Fc variantes con unión potenciada al receptor de Fc neonatal |
CN104144949B (zh) * | 2011-12-22 | 2016-08-31 | 财团法人生物技术开发中心 | 双特异性t细胞活化剂抗体 |
WO2014028560A2 (en) * | 2012-08-14 | 2014-02-20 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
US9701759B2 (en) * | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
AR095374A1 (es) * | 2013-03-15 | 2015-10-14 | Amgen Res (Munich) Gmbh | Moléculas de unión para bcma y cd3 |
US9288361B2 (en) | 2013-06-06 | 2016-03-15 | Open Text S.A. | Systems, methods and computer program products for fax delivery and maintenance |
CA2917886A1 (en) * | 2013-07-12 | 2015-01-15 | Zymeworks Inc. | Bispecific cd3 and cd19 antigen binding constructs |
GB201317928D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Molecule |
CN104744592B (zh) * | 2013-12-27 | 2019-08-06 | 北京韩美药品有限公司 | 抗HER2-抗CD3 scFv双特异四价抗体 |
JPWO2015146438A1 (ja) * | 2014-03-26 | 2017-04-13 | 国立大学法人東北大学 | ヒト上皮増殖因子受容体を標的とした二重特異性抗体 |
CN104558192B (zh) * | 2015-01-21 | 2018-12-28 | 武汉友芝友生物制药有限公司 | 一种双特异性抗体her2xcd3的构建及应用 |
EP3172236B1 (en) * | 2014-07-25 | 2020-09-30 | Memorial Sloan Kettering Cancer Center | Bispecific her2 and cd3 binding molecules |
NZ730348A (en) * | 2014-09-26 | 2024-03-22 | Macrogenics Inc | Bi-specific monovalent diabodies that are capable of binding cd19 and cd3, and uses thereof |
WO2016105450A2 (en) * | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Trispecific antibodies |
CN104558193B (zh) * | 2015-01-21 | 2019-01-11 | 武汉友芝友生物制药有限公司 | 一种靶向鼠t淋巴细胞cd3和人肿瘤抗原her2的双特异性抗体制备方法及应用 |
CN104558191B (zh) * | 2015-01-21 | 2020-08-21 | 武汉友芝友生物制药有限公司 | 一种双特异性抗体cd20×cd3的构建及应用 |
CN104829728B (zh) * | 2015-01-21 | 2019-03-12 | 武汉友芝友生物制药有限公司 | 一种双特异性抗体her2xcd3的构建及应用 |
EP3256494A4 (en) | 2015-02-10 | 2018-12-05 | Minerva Biotechnologies Corporation | Humanized anti-muc1* antibodies |
US10711054B2 (en) * | 2015-03-16 | 2020-07-14 | Helmholtz Zentrum München—Deutsches Forschungszentrum fur Gesundheit und umwelt (GmbH) | Trispecific binding molecules for treating HBV infection and associated conditions |
CN104829729B (zh) * | 2015-04-03 | 2018-08-14 | 复旦大学 | 一种携带抗Her2/CD3双特异性功能蛋白的人T细胞制备 |
CA2980827A1 (en) * | 2015-05-20 | 2016-11-24 | Amgen Research (Munich) Gmbh | B-cell depletion as a diagnostic marker |
US20180171017A1 (en) * | 2015-06-05 | 2018-06-21 | Chugai Seiyaku Kabushiki Kaisha | Combined use of immune activators |
TW202346349A (zh) * | 2015-07-31 | 2023-12-01 | 德商安美基研究(慕尼黑)公司 | Dll3及cd3抗體構築體 |
ES2883240T3 (es) * | 2015-08-03 | 2021-12-07 | Cafa Therapeutics Ltd | Anticuerpo contra glipicano-3 y aplicación del mismo |
KR101851380B1 (ko) * | 2015-10-12 | 2018-04-23 | 아주대학교산학협력단 | 효모접합을 이용한 항체 ch3 도메인 이종이중체 돌연변이쌍 제조 방법 및 이에 의하여 제조된 ch3 돌연변이체 쌍 |
CN108474793A (zh) * | 2015-10-30 | 2018-08-31 | 葛兰素史密斯克莱知识产权发展有限公司 | 预后方法 |
WO2017106684A2 (en) | 2015-12-17 | 2017-06-22 | Janssen Biotech, Inc. | Antibodies specifically binding hla-dr and their uses |
CA3018382A1 (en) * | 2016-03-29 | 2017-10-05 | University Of Southern California | Chimeric antigen receptors targeting cancer |
EP3464370A1 (en) * | 2016-06-01 | 2019-04-10 | Xencor, Inc. | Bispecific antibodies that bind cd20 and cd3 for use in the treatment of lymphoma |
KR20190053835A (ko) * | 2016-06-21 | 2019-05-20 | 테네오바이오, 인코포레이티드 | Cd3 결합 항체 |
WO2018035084A1 (en) * | 2016-08-16 | 2018-02-22 | Epimab Biotherapeutics, Inc. | Monovalent asymmetric tandem fab bispecific antibodies |
CN107759694B (zh) * | 2016-08-19 | 2023-01-13 | 安源医药科技(上海)有限公司 | 双特异性抗体及其制备方法与用途 |
CN106117370B (zh) * | 2016-08-19 | 2017-05-17 | 安源医药科技(上海)有限公司 | 高糖基化Exendin‑4及其类似物的融合蛋白、其制备方法和用途 |
CN110225924B (zh) | 2017-01-25 | 2024-04-02 | 免疫医疗有限公司 | 松弛素融合多肽及其用途 |
US11046768B2 (en) * | 2017-01-27 | 2021-06-29 | Memorial Sloan Kettering Cancer Center | Bispecific HER2 and CD3 binding molecules |
CA3051484A1 (en) * | 2017-01-27 | 2018-08-02 | Memorial Sloan Kettering Cancer Center | Bispecific her2 and cd3 binding molecules |
SG11201907753TA (en) * | 2017-02-24 | 2019-09-27 | Macrogenics Inc | Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof |
CN108623689B (zh) * | 2017-03-15 | 2020-10-16 | 宜明昂科生物医药技术(上海)有限公司 | 新型重组双功能融合蛋白及其制备方法和用途 |
US20200095323A1 (en) * | 2017-03-20 | 2020-03-26 | The General Hospital Corporation | MITIGATING Fc-Fc RECEPTOR INTERACTIONS IN CANCER IMMUNOTHERAPY |
MY200973A (en) * | 2017-04-11 | 2024-01-26 | Inhibrx Inc | Multispecific Polypeptide Constructs Having Constrained Cd3 Binding And Methods Of Using The Same |
CN107501412A (zh) * | 2017-10-11 | 2017-12-22 | 深圳精准医疗科技有限公司 | 突变型双特异性抗体及其应用 |
WO2019222428A1 (en) * | 2018-05-16 | 2019-11-21 | Arbele Limited | Composition of bispecific antibodies and method of use thereof |
-
2019
- 2019-09-26 BR BR112021008486-0A patent/BR112021008486A2/pt unknown
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-
2021
- 2021-04-30 CL CL2021001143A patent/CL2021001143A1/es unknown
- 2021-05-27 CO CONC2021/0006970A patent/CO2021006970A2/es unknown
- 2021-05-31 ZA ZA2021/03717A patent/ZA202103717B/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090252683A1 (en) * | 2005-10-11 | 2009-10-08 | Micromet Ag | Composition Comprising Cross-Species-Sepecific Antibodies and uses Thereof |
CN106279418A (zh) * | 2011-05-27 | 2017-01-04 | 葛兰素集团有限公司 | Bcma(cd269/tnfrsf17)结合蛋白 |
CN105358570A (zh) * | 2013-03-14 | 2016-02-24 | 美国安进公司 | 含有非糖基化Fc的多肽 |
CN108350076A (zh) * | 2015-08-17 | 2018-07-31 | 詹森药业有限公司 | 抗-bcma抗体,结合bcma和cd3的双特异性抗原结合分子及其用途 |
US20170218077A1 (en) * | 2016-02-03 | 2017-08-03 | Amgen Research (Munich) Gmbh | Bcma and cd3 bispecific t cell engaging antibody constructs |
CN107286248A (zh) * | 2016-08-19 | 2017-10-24 | 安源医药科技(上海)有限公司 | 高糖基化人生长激素融合蛋白及其制备方法与用途 |
Non-Patent Citations (3)
Title |
---|
ANJA SECKINGER等: "Target Expression, Generation, Preclinical Activity, and Pharmacokinetics of the BCMA-T Cell Bispecific Antibody EM801 for Multiple Myeloma Treatment", 《CANCER CELL》 * |
JEAND.WILSON等: "《哈里逊内科学 第12版》", 30 June 1994, 人民卫生出版社 * |
姚文兵主编: "双特异性抗体", 《生物技术制药概论》 * |
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WO2022156739A1 (zh) * | 2021-01-20 | 2022-07-28 | 江苏恒瑞医药股份有限公司 | 特异性结合bcma和cd3的抗原结合分子及其医药用途 |
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