CN112754980A - Toothpaste with antibacterial effect and preparation method thereof - Google Patents
Toothpaste with antibacterial effect and preparation method thereof Download PDFInfo
- Publication number
- CN112754980A CN112754980A CN202110218160.3A CN202110218160A CN112754980A CN 112754980 A CN112754980 A CN 112754980A CN 202110218160 A CN202110218160 A CN 202110218160A CN 112754980 A CN112754980 A CN 112754980A
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- CN
- China
- Prior art keywords
- toothpaste
- extract
- antibacterial effect
- sodium
- deionized water
- Prior art date
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- 239000000606 toothpaste Substances 0.000 title claims abstract description 60
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 58
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title abstract description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 73
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 40
- 239000000843 powder Substances 0.000 claims abstract description 38
- 239000008367 deionised water Substances 0.000 claims abstract description 37
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
- 244000248349 Citrus limon Species 0.000 claims abstract description 34
- 235000005979 Citrus limon Nutrition 0.000 claims abstract description 34
- 240000004638 Dendrobium nobile Species 0.000 claims abstract description 25
- HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 claims abstract description 24
- 229940079841 sodium copper chlorophyllin Drugs 0.000 claims abstract description 24
- 235000013758 sodium copper chlorophyllin Nutrition 0.000 claims abstract description 24
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 22
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 21
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 21
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 21
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 21
- 239000004299 sodium benzoate Substances 0.000 claims abstract description 21
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 21
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 21
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 21
- 229940078499 tricalcium phosphate Drugs 0.000 claims abstract description 21
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims abstract description 21
- 235000019731 tricalcium phosphate Nutrition 0.000 claims abstract description 21
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 241001116742 Drynaria Species 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 85
- 238000001914 filtration Methods 0.000 claims description 24
- 239000000243 solution Substances 0.000 claims description 24
- 239000011259 mixed solution Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 17
- 229940036811 bone meal Drugs 0.000 claims description 16
- 239000002374 bone meal Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 16
- 238000005520 cutting process Methods 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 8
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- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 8
- 229960003885 sodium benzoate Drugs 0.000 claims description 8
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 8
- 241001523681 Dendrobium Species 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 14
- 230000002087 whitening effect Effects 0.000 abstract description 8
- 235000011187 glycerol Nutrition 0.000 description 22
- 235000019441 ethanol Nutrition 0.000 description 21
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 16
- 241000894006 Bacteria Species 0.000 description 9
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 8
- 229930003268 Vitamin C Natural products 0.000 description 8
- 210000000214 mouth Anatomy 0.000 description 8
- 235000019154 vitamin C Nutrition 0.000 description 8
- 239000011718 vitamin C Substances 0.000 description 8
- 238000007710 freezing Methods 0.000 description 7
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- 230000001954 sterilising effect Effects 0.000 description 7
- 238000001291 vacuum drying Methods 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 2
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- 238000001514 detection method Methods 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
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- 210000004261 periodontium Anatomy 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
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- 230000008439 repair process Effects 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000034619 Gingival inflammation Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241000605862 Porphyromonas gingivalis Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- 241000223229 Trichophyton rubrum Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Abstract
The invention provides toothpaste with antibacterial effect and a preparation method thereof, wherein the toothpaste with antibacterial effect comprises the following raw materials in percentage by weight: 10-30% of dendrobium nobile extract, 1-1.5% of sodium carboxymethylcellulose, 2-4% of sodium dodecyl sulfate, 30-50% of glycerol, 20-25% of calcium carbonate, 5-10% of tricalcium phosphate, 0.1-0.3% of orange powder, 0.2-0.6% of sodium benzoate, 0.1-0.3% of sodium copper chlorophyllin, 0.4-0.8% of drynaria powder, 0.5-4% of lemon extract and the balance of deionized water. The invention also comprises a preparation method of the toothpaste with antibacterial effect. The toothpaste has a strong antibacterial effect, has the effects of whitening, resisting decayed teeth and the like, and effectively solves the problems of limited antibacterial effect, single function and the like in the prior art.
Description
Technical Field
The invention belongs to the technical field of antibacterial toothpaste, and particularly relates to toothpaste with an antibacterial effect and a preparation method thereof.
Background
The oral environment is the most daily health problem in human life, with the continuous development of scientific technology, the continuous improvement and perfection of technological equipment, the successive appearance of various types of toothpaste and the continuous improvement of product quality and grade. Most of the diseases of teeth and periodontium are caused by oral hygiene problems, and people want to protect teeth, prevent tooth decay, and maintain the health of periodontium and gingival tissues through daily oral cleaning and nursing. Dental plaque is an ecological environment for metabolism and pathogenicity of bacteria on tooth surfaces, provides conditions for the action of the bacteria, and is also used for treating red and swollen gums caused by periodontitis and gingivitis and the like due to the action of the bacteria. Therefore, the toothpaste with the antibacterial effect is a product which is popular with consumers in the market and also provides health guarantee for the oral cavity of people. However, the existing toothpaste has limited antibacterial effect and single function, and cannot completely meet the use requirements of consumers on the toothpaste.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides the toothpaste with the antibacterial effect and the preparation method thereof, the toothpaste has the advantages of strong antibacterial effect, whitening, anti-caries and the like, and the problems of limited antibacterial effect, single function and the like in the prior art are effectively solved.
In order to achieve the purpose, the technical scheme adopted by the invention for solving the technical problems is as follows: the toothpaste with the antibacterial effect comprises the following raw materials in percentage by weight: 10-30% of dendrobium nobile extract, 1-1.5% of sodium carboxymethylcellulose, 2-4% of sodium dodecyl sulfate, 30-50% of glycerol, 20-25% of calcium carbonate, 5-10% of tricalcium phosphate, 0.1-0.3% of orange powder, 0.2-0.6% of sodium benzoate, 0.1-0.3% of sodium copper chlorophyllin, 0.4-0.8% of drynaria powder, 0.5-4% of lemon extract and the balance of deionized water.
Further, the toothpaste with the antibacterial effect comprises the following raw materials in percentage by weight: 20% of dendrobium stem extract, 1.3% of sodium carboxymethylcellulose, 3% of sodium dodecyl sulfate, 40% of glycerol, 22% of calcium carbonate, 7% of tricalcium phosphate, 0.2% of orange powder, 0.4% of sodium benzoate, 0.2% of sodium copper chlorophyllin, 0.6% of bone meal, 2% of lemon extract and the balance of deionized water.
Further, the dendrobium nobile lindl extract is prepared by the following method: placing herba Dendrobii and folium Menthae at a mass ratio of 1:1-2 in an extraction bottle, adding 70-80 vt% ethanol solution, sealing, soaking for 10-30min, reflux extracting for 20-40min, and filtering to obtain extractive solution; drying the extractive solution under reduced pressure to remove ethanol, and vacuum freeze drying to obtain herba Dendrobii extract.
Further, the mass volume ratio of the dendrobium nobile to the ethanol is 1: 7-9.
Further freezing at-90 deg.C to-70 deg.C until agglomeration, and vacuum drying for 1-2 hr.
Further, the lemon extract is prepared by the following method: removing seeds of fructus Citri Limoniae, cutting into pieces, squeezing to obtain juice, adding anhydrous ethanol and deionized water, ultrasonic extracting at room temperature for 20-30min, filtering, vacuum filtering, and freeze drying to obtain fructus Citri Limoniae extract.
Further, the mass ratio of the lemon to the absolute ethyl alcohol to the deionized water is 1:1-2: 2-4.
The preparation method of the toothpaste with the antibacterial effect comprises the following steps:
(1) dissolving herba Dendrobii extract with deionized water, adding sodium carboxymethylcellulose and fructus Citri Limoniae extract, standing at 2-5 deg.C for 10-15 hr until completely dissolved to obtain mixed solution;
(2) adding sodium dodecyl sulfate, glycerol, orange powder, sodium benzoate, sodium copper chlorophyllin and bone meal powder into the mixed solution obtained in the step (1), stirring for 0.5-2h under the condition of 600r/min for 400-.
In summary, the invention has the following advantages:
1. the toothpaste obtained by the invention has a strong antibacterial effect, can repair defects on the surface of teeth, has the effects of whitening, resisting decayed teeth, resisting sensitivity, preventing dental ulcer, freshening breath and the like, is simple and easy to control in preparation process, effectively solves the problems of limited antibacterial effect, single function and the like in the prior art, can meet the use requirements of consumers, and is convenient to popularize and use.
2. The dendrobium nobile lindl in the raw materials for preparation contains rich alkaloid and polysaccharide substances, the alkaloid has strong anti-inflammatory and antibacterial effects, and can dissipate blood stasis, stop bleeding, reduce swelling and relieve pain, and the polysaccharide has the effect of enhancing the immune function of the oral cavity, so that the gum can be effectively protected; and the dendrobium nobile lindl contains a large amount of mucus, has certain nourishing and anti-aging effects on the oral cavity and the gum surface, and can also prevent gum sensitivity and bleeding. The orange powder has the effects of clearing heat and reducing internal heat, can relieve gingival inflammation, contains rich vitamin C, supplements nutrient substances for gingiva, and has the effects of whitening and removing tooth stains. The lemon extract contains lemon essential oil, citric acid and sodium citrate, rich nutrient substances of the lemon extract can provide better supplement for gum, the lemon extract also contains a large amount of vitamin C, the vitamin C and the orange powder play roles of whitening and removing tooth stains together, harmful bacteria in an oral cavity can be killed, and the lemon extract and the orange powder can prevent the occurrence of oral ulcer and keep fresh breath after being added into toothpaste for a long time. The bone fragment tonic powder is a traditional Chinese medicine component with an antibacterial effect, has good histocompatibility, promotes osteoblast proliferation activity, and promotes calcium and phosphorus deposition, thereby promoting bone fracture healing and improving bone density; and the tricalcium phosphate can ensure that the rhizoma drynariae is uniformly distributed in the toothpaste, promotes the adhesion and regeneration of gingival cells, has the antibacterial effect, repairs the defects around teeth, and has better functions of resisting decayed teeth and whitening.
3. The sodium dodecyl sulfate is used as a foaming agent, and the foaming is uniform; the glycerin has the advantages of superior moisturizing effect, mildness to oral cavity and gum, no stimulation, fine and rich foam, and capability of thoroughly removing oil stain in the deep part of the gum to ensure that the gum is moist, glossy and elastic; besides the amazing cleaning power, the cleaning agent can not damage the oral cavity and the gum at all because the glycerin contained in the cleaning agent can clean dirt and simultaneously form a protective film together with vitamin C, thereby achieving the effect of protecting the gum and the oral cavity; meanwhile, as the vitamin C is easy to oxidize, the film formed by the glycerol can also play a role in protection and prevent the oxidation. Calcium carbonate and tricalcium phosphate are also used as abrasives, have an abrasive cleaning effect on dirt on the gum surface, and can also provide a calcium source for repairing tooth defects. The sodium copper chlorophyllin has high stability, can remove free radicals on the surfaces of oral cavity and gum, has an antioxidation effect, can act synergistically with glycerin, plays a role in protecting easily-oxidized components such as vitamin C in the toothpaste, ensures the normal exertion of the efficacy and prevents failure; meanwhile, the sodium copper chlorophyllin also has the effects of inhibiting the activity of oral odor causing bacteria, refreshing breath, resisting inflammation, stopping bleeding and the like.
Detailed Description
Example 1
The toothpaste with the antibacterial effect comprises the following raw materials in percentage by weight: 10% of dendrobium stem extract, 1% of sodium carboxymethylcellulose, 2% of sodium dodecyl sulfate, 30% of glycerol, 20% of calcium carbonate, 5% of tricalcium phosphate, 0.1% of orange powder, 0.2% of sodium benzoate, 0.1% of sodium copper chlorophyllin, 0.4% of bone meal, 0.5% of lemon extract and the balance of deionized water.
The dendrobium nobile lindl extract is prepared by the following method: placing herba Dendrobii and folium Menthae at a mass ratio of 1:1 in an extraction bottle, adding 70 vt% ethanol solution, sealing and soaking for 10min, reflux-extracting for 20min, and filtering to obtain extractive solution; drying the extractive solution under reduced pressure to remove ethanol, and vacuum freeze drying to obtain herba Dendrobii extract. Wherein the mass volume ratio of the dendrobium nobile to the ethanol is 1: 7; freezing at-90 deg.C to block, and vacuum drying for 1 h.
The lemon extract is prepared by the following method: removing seeds of fructus Citri Limoniae, cutting into pieces, squeezing to obtain juice, adding anhydrous ethanol and deionized water, ultrasonic extracting at room temperature for 20min, filtering, vacuum filtering, and freeze drying to obtain fructus Citri Limoniae extract. Wherein the mass ratio of the lemon to the absolute ethyl alcohol to the deionized water is 1:1: 2.
The preparation method of the toothpaste with the antibacterial effect comprises the following steps:
(1) dissolving herba Dendrobii extract with deionized water, adding sodium carboxymethylcellulose and fructus Citri Limoniae extract, standing at 2 deg.C for 10 hr to dissolve completely to obtain mixed solution;
(2) and (2) adding sodium dodecyl sulfate, glycerol, orange powder, sodium benzoate, sodium copper chlorophyllin and bone meal powder into the mixed solution obtained in the step (1), stirring for 0.5h at the speed of 400r/min, then adding calcium carbonate and tricalcium phosphate, stirring for 20h at the speed of 300r/min, and sterilizing to obtain the toothpaste with the antibacterial effect.
Example 2
The toothpaste with the antibacterial effect comprises the following raw materials in percentage by weight: 15% of dendrobium stem extract, 1.1% of sodium carboxymethylcellulose, 3% of sodium dodecyl sulfate, 35% of glycerol, 21% of calcium carbonate, 6% of tricalcium phosphate, 0.2% of orange powder, 0.3% of sodium benzoate, 0.2% of sodium copper chlorophyllin, 0.5% of bone meal, 1% of lemon extract and the balance of deionized water.
The dendrobium nobile lindl extract is prepared by the following method: placing herba Dendrobii and folium Menthae at a mass ratio of 1:1 in an extraction bottle, adding 75 vt% ethanol solution, sealing and soaking for 15min, reflux-extracting for 25min, and filtering to obtain extractive solution; drying the extractive solution under reduced pressure to remove ethanol, and vacuum freeze drying to obtain herba Dendrobii extract. Wherein the mass volume ratio of the dendrobium nobile to the ethanol is 1: 8; freezing at-85 deg.C to block, and vacuum drying for 1 h.
The lemon extract is prepared by the following method: removing seeds of fructus Citri Limoniae, cutting into pieces, squeezing to obtain juice, adding anhydrous ethanol and deionized water, ultrasonic extracting at room temperature for 20min, filtering, vacuum filtering, and freeze drying to obtain fructus Citri Limoniae extract. Wherein the mass ratio of the lemon to the absolute ethyl alcohol to the deionized water is 1:1: 3.
The preparation method of the toothpaste with the antibacterial effect comprises the following steps:
(1) dissolving herba Dendrobii extract with deionized water, adding sodium carboxymethylcellulose and fructus Citri Limoniae extract, standing at 3 deg.C for 12 hr to dissolve completely to obtain mixed solution;
(2) and (2) adding sodium dodecyl sulfate, glycerol, orange powder, sodium benzoate, sodium copper chlorophyllin and bone meal powder into the mixed solution obtained in the step (1), stirring for 1h at the speed of 450r/min, then adding calcium carbonate and tricalcium phosphate, stirring for 22h at the speed of 400r/min, and sterilizing to obtain the toothpaste with the antibacterial effect.
Example 3
The toothpaste with the antibacterial effect comprises the following raw materials in percentage by weight: 20% of dendrobium stem extract, 1.3% of sodium carboxymethylcellulose, 3% of sodium dodecyl sulfate, 40% of glycerol, 23% of calcium carbonate, 7% of tricalcium phosphate, 0.2% of orange powder, 0.4% of sodium benzoate, 0.2% of sodium copper chlorophyllin, 0.6% of bone meal, 2% of lemon extract and the balance of deionized water.
The dendrobium nobile lindl extract is prepared by the following method: placing herba Dendrobii and folium Menthae at a mass ratio of 1:1 in an extraction bottle, adding 70 vt% ethanol solution, sealing, soaking for 20min, reflux extracting for 30min, and filtering to obtain extractive solution; drying the extractive solution under reduced pressure to remove ethanol, and vacuum freeze drying to obtain herba Dendrobii extract. Wherein the mass volume ratio of the dendrobium nobile to the ethanol is 1: 8; freezing at-80 deg.C to agglomerate, and vacuum drying for 1 hr.
The lemon extract is prepared by the following method: removing seeds of fructus Citri Limoniae, cutting into pieces, squeezing to obtain juice, adding anhydrous ethanol and deionized water, ultrasonic extracting at room temperature for 25min, filtering, vacuum filtering, and freeze drying to obtain fructus Citri Limoniae extract. Wherein the mass ratio of the lemon to the absolute ethyl alcohol to the deionized water is 1:1: 3.
The preparation method of the toothpaste with the antibacterial effect comprises the following steps:
(1) dissolving herba Dendrobii extract with deionized water, adding sodium carboxymethylcellulose and fructus Citri Limoniae extract, standing at 3 deg.C for 13 hr to dissolve completely to obtain mixed solution;
(2) and (2) adding sodium dodecyl sulfate, glycerol, orange powder, sodium benzoate, sodium copper chlorophyllin and bone meal powder into the mixed solution obtained in the step (1), stirring for 1h at the speed of 500r/min, then adding calcium carbonate and tricalcium phosphate, stirring for 23h at the speed of 500r/min, and sterilizing to obtain the toothpaste with the antibacterial effect.
Example 4
The toothpaste with the antibacterial effect comprises the following raw materials in percentage by weight: 23% of dendrobium nobile extract, 1.3% of sodium carboxymethylcellulose, 3% of sodium dodecyl sulfate, 35% of glycerol, 20% of calcium carbonate, 6% of tricalcium phosphate, 0.3% of orange powder, 0.5% of sodium benzoate, 0.5% of sodium copper chlorophyllin, 0.7% of bone meal, 3% of lemon extract and the balance of deionized water.
The dendrobium nobile lindl extract is prepared by the following method: placing herba Dendrobii and folium Menthae at a mass ratio of 1:1 in an extraction bottle, adding 750 vt% ethanol solution, sealing and soaking for 30min, reflux-extracting for 40min, and filtering to obtain extractive solution; drying the extractive solution under reduced pressure to remove ethanol, and vacuum freeze drying to obtain herba Dendrobii extract. Wherein the mass volume ratio of the dendrobium nobile to the ethanol is 1: 9; freezing at-70 deg.C to agglomerate, and vacuum drying for 2 hr.
The lemon extract is prepared by the following method: removing seeds of fructus Citri Limoniae, cutting into pieces, squeezing to obtain juice, adding anhydrous ethanol and deionized water, ultrasonic extracting at room temperature for 30min, filtering, vacuum filtering, and freeze drying to obtain fructus Citri Limoniae extract. Wherein the mass ratio of the lemon to the absolute ethyl alcohol to the deionized water is 1:2: 4.
The preparation method of the toothpaste with the antibacterial effect comprises the following steps:
(1) dissolving herba Dendrobii extract with deionized water, adding sodium carboxymethylcellulose and fructus Citri Limoniae extract, standing at 5 deg.C for 15 hr to dissolve completely to obtain mixed solution;
(2) and (2) adding sodium dodecyl sulfate, glycerol, orange powder, sodium benzoate, sodium copper chlorophyllin and bone meal powder into the mixed solution obtained in the step (1), stirring for 2 hours at the speed of 600r/min, then adding calcium carbonate and tricalcium phosphate, stirring for 25 hours at the speed of 600r/min, and sterilizing to obtain the toothpaste with the antibacterial effect.
Comparative example 1
The toothpaste with the antibacterial effect comprises the following raw materials in percentage by weight: 1.3% of sodium carboxymethylcellulose, 3% of sodium dodecyl sulfate, 40% of glycerol, 23% of calcium carbonate, 7% of tricalcium phosphate, 0.2% of orange powder, 0.4% of sodium benzoate, 0.2% of sodium copper chlorophyllin, 0.6% of bone meal powder, 2% of lemon extract and the balance of deionized water.
The lemon extract is prepared by the following method: removing seeds of fructus Citri Limoniae, cutting into pieces, squeezing to obtain juice, adding anhydrous ethanol and deionized water, ultrasonic extracting at room temperature for 25min, filtering, vacuum filtering, and freeze drying to obtain fructus Citri Limoniae extract. Wherein the mass ratio of the lemon to the absolute ethyl alcohol to the deionized water is 1:1: 3.
The preparation method of the toothpaste with the antibacterial effect comprises the following steps:
(1) adding sodium carboxymethylcellulose and fructus Citri Limoniae extract into deionized water, standing at 3 deg.C for 13 hr until completely dissolved to obtain mixed solution;
(2) and (2) adding sodium dodecyl sulfate, glycerol, orange powder, sodium benzoate, sodium copper chlorophyllin and bone meal powder into the mixed solution obtained in the step (1), stirring for 1h at the speed of 500r/min, then adding calcium carbonate and tricalcium phosphate, stirring for 23h at the speed of 500r/min, and sterilizing to obtain the toothpaste with the antibacterial effect.
Comparative example 2
The toothpaste with the antibacterial effect comprises the following raw materials in percentage by weight: 20% of dendrobium nobile extract, 1.3% of sodium carboxymethylcellulose, 3% of sodium dodecyl sulfate, 40% of glycerol, 23% of calcium carbonate, 7% of tricalcium phosphate, 0.2% of orange powder, 0.4% of sodium benzoate, 0.2% of sodium copper chlorophyllin, 2% of lemon extract and the balance of deionized water.
The dendrobium nobile lindl extract is prepared by the following method: placing herba Dendrobii and folium Menthae at a mass ratio of 1:1 in an extraction bottle, adding 70 vt% ethanol solution, sealing, soaking for 20min, reflux extracting for 30min, and filtering to obtain extractive solution; drying the extractive solution under reduced pressure to remove ethanol, and vacuum freeze drying to obtain herba Dendrobii extract. Wherein the mass volume ratio of the dendrobium nobile to the ethanol is 1: 8; freezing at-80 deg.C to agglomerate, and vacuum drying for 1 hr.
The lemon extract is prepared by the following method: removing seeds of fructus Citri Limoniae, cutting into pieces, squeezing to obtain juice, adding anhydrous ethanol and deionized water, ultrasonic extracting at room temperature for 25min, filtering, vacuum filtering, and freeze drying to obtain fructus Citri Limoniae extract. Wherein the mass ratio of the lemon to the absolute ethyl alcohol to the deionized water is 1:1: 3.
The preparation method of the toothpaste with the antibacterial effect comprises the following steps:
(1) dissolving herba Dendrobii extract with deionized water, adding sodium carboxymethylcellulose and fructus Citri Limoniae extract, standing at 3 deg.C for 13 hr to dissolve completely to obtain mixed solution;
(2) and (2) adding sodium dodecyl sulfate, glycerin, orange powder, sodium benzoate and sodium copper chlorophyllin into the mixed solution obtained in the step (1), stirring for 1h at the speed of 500r/min, then adding calcium carbonate and tricalcium phosphate, stirring for 23h at the speed of 500r/min, and sterilizing to obtain the toothpaste with the antibacterial effect.
Comparative example 3
The toothpaste with the antibacterial effect comprises the following raw materials in percentage by weight: 20% of dendrobium stem extract, 1.3% of sodium carboxymethylcellulose, 3% of sodium dodecyl sulfate, 40% of glycerol, 23% of calcium carbonate, 7% of tricalcium phosphate, 0.2% of orange powder, 0.4% of sodium benzoate, 0.2% of sodium copper chlorophyllin, 0.6% of bone meal, and the balance of deionized water.
The dendrobium nobile lindl extract is prepared by the following method: placing herba Dendrobii and folium Menthae at a mass ratio of 1:1 in an extraction bottle, adding 70 vt% ethanol solution, sealing, soaking for 20min, reflux extracting for 30min, and filtering to obtain extractive solution; drying the extractive solution under reduced pressure to remove ethanol, and vacuum freeze drying to obtain herba Dendrobii extract. Wherein the mass volume ratio of the dendrobium nobile to the ethanol is 1: 8; freezing at-80 deg.C to agglomerate, and vacuum drying for 1 hr.
The preparation method of the toothpaste with the antibacterial effect comprises the following steps:
(1) dissolving herba Dendrobii extract with deionized water, adding sodium carboxymethylcellulose, standing at 3 deg.C for 13 hr until completely dissolved to obtain mixed solution;
(2) and (2) adding sodium dodecyl sulfate, glycerol, orange powder, sodium benzoate, sodium copper chlorophyllin and bone meal powder into the mixed solution obtained in the step (1), stirring for 1h at the speed of 500r/min, then adding calcium carbonate and tricalcium phosphate, stirring for 23h at the speed of 500r/min, and sterilizing to obtain the toothpaste with the antibacterial effect.
Experimental example 1
The toothpastes obtained in examples 1 to 4 and comparative examples 1 to 3 were subjected to bacteriostatic experiments on various bacteria (streptococcus mutans, porphyromonas gingivalis, staphylococcus aureus, trichophyton rubrum and escherichia coli), and then tested in a bacteriostatic ring to determine whether there is any residual bacteria, and the results are shown in table 1. In table 1, Y indicates detection, and N indicates non-detection.
TABLE 1 results of bacteriostatic experiments
As can be seen from Table 1, the toothpaste obtained by the invention has the advantages that corresponding strains are detected after experiments, which shows that the toothpaste has a good antibacterial effect, can inhibit the growth of various oral harmful bacteria, and protect the oral environment. The toothpaste is probably related to the raw material components of dendrobium nobile, drynaria rhizome, lemon extract and the like in the toothpaste, and has stronger inhibition effect on various bacteria.
Experimental example 2
140 subjects were randomly selected and divided into 7 groups of 20 persons, and the plaque index and the Schiff cold air sensitivity index of the subjects were checked and recorded, and then each group was brushed 2 times a day with 1g each time and 5min each time using the toothpastes obtained in examples 1 to 4 and comparative examples 1 to 3, and after 4 weeks, the plaque index and the Schiff cold air sensitivity index of the subjects were recorded again, and the results thereof are shown in table 2.
TABLE 2 test results
As can be seen from table 2, the toothpaste with antibacterial effect provided by the invention can reduce the plaque index and Schiff cold air sensitivity index, and has the effects of tooth whitening, anti-sensitivity and the like; the orange powder, the lemon extract and the like in the raw materials of the toothpaste contain a large amount of vitamin C, so that the toothpaste has the effects of whitening and removing tooth stains, and meanwhile, glycerin and the vitamin C can form a protective film on the surface of teeth and have the protective effects of dendrobium nobile, sodium copper chlorophyllin and the like, so that the anti-sensitivity degree of the teeth is improved, and the teeth are protected comprehensively.
While the present invention has been described in detail with reference to the specific embodiments thereof, it should not be construed as limited by the scope of the present patent. Various modifications and changes may be made by those skilled in the art without inventive step within the scope of the appended claims.
Claims (8)
1. The toothpaste with the antibacterial effect is characterized by comprising the following raw materials in percentage by weight: 10-30% of dendrobium nobile extract, 1-1.5% of sodium carboxymethylcellulose, 2-4% of sodium dodecyl sulfate, 30-50% of glycerol, 20-25% of calcium carbonate, 5-10% of tricalcium phosphate, 0.1-0.3% of orange powder, 0.2-0.6% of sodium benzoate, 0.1-0.3% of sodium copper chlorophyllin, 0.4-0.8% of drynaria powder, 0.5-4% of lemon extract and the balance of deionized water.
2. The toothpaste with antibacterial effect according to claim 1, comprising the following raw materials in percentage by weight: 20% of dendrobium stem extract, 1.3% of sodium carboxymethylcellulose, 3% of sodium dodecyl sulfate, 40% of glycerol, 22% of calcium carbonate, 7% of tricalcium phosphate, 0.2% of orange powder, 0.4% of sodium benzoate, 0.2% of sodium copper chlorophyllin, 0.6% of bone meal, 2% of lemon extract and the balance of deionized water.
3. The toothpaste having an antibacterial effect according to claim 1 or 2, wherein the dendrobium nobile extract is prepared by the following method: placing herba Dendrobii and folium Menthae at a mass ratio of 1:1-2 in an extraction bottle, adding 70-80 vt% ethanol solution, sealing, soaking for 10-30min, reflux extracting for 20-40min, and filtering to obtain extractive solution; drying the extractive solution under reduced pressure to remove ethanol, and vacuum freeze drying to obtain herba Dendrobii extract.
4. The toothpaste having antibacterial effect according to claim 3, wherein the mass volume ratio of Dendrobium nobile to ethanol is 1: 7-9.
5. The toothpaste having antibacterial effect according to claim 3, wherein the toothpaste is frozen to be agglomerated at a temperature of-90 ℃ to-70 ℃ and vacuum-dried for 1 to 2 hours.
6. The toothpaste having antibacterial effect according to claim 1 or 2, wherein said lemon extract is prepared by the following method: removing seeds of fructus Citri Limoniae, cutting into pieces, squeezing to obtain juice, adding anhydrous ethanol and deionized water, ultrasonic extracting at room temperature for 20-30min, filtering, vacuum filtering, and freeze drying to obtain fructus Citri Limoniae extract.
7. The toothpaste having antibacterial effect according to claim 1, wherein the mass ratio of the lemon, the anhydrous ethanol and the deionized water is 1:1-2: 2-4.
8. A method of preparing a toothpaste having an antibacterial effect according to any one of claims 1 to 7, comprising the steps of:
(1) dissolving herba Dendrobii extract with deionized water, adding sodium carboxymethylcellulose and fructus Citri Limoniae extract, standing at 2-5 deg.C for 10-15 hr until completely dissolved to obtain mixed solution;
(2) adding sodium dodecyl sulfate, glycerol, orange powder, sodium benzoate, sodium copper chlorophyllin and bone meal powder into the mixed solution obtained in the step (1), stirring for 0.5-2h under the condition of 600r/min for 400-.
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Application publication date: 20210507 |