CN112279867A - 一种头孢哌酮钠的制备方法 - Google Patents
一种头孢哌酮钠的制备方法 Download PDFInfo
- Publication number
- CN112279867A CN112279867A CN202011017449.0A CN202011017449A CN112279867A CN 112279867 A CN112279867 A CN 112279867A CN 202011017449 A CN202011017449 A CN 202011017449A CN 112279867 A CN112279867 A CN 112279867A
- Authority
- CN
- China
- Prior art keywords
- cefoperazone
- acetone
- temperature
- preparing
- controlling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Abstract
Description
批号 | 对比例3 | 对比例4 | 对比例5 |
丙酮溶解用量/ml | 100 | 50 | 50 |
碳酸氢钠用量/g | 7.5 | 6.2 | 6.3 |
纯化水用量/ml | 15 | 10 | 13 |
丙酮流加速度/ml/min | 2 | 6 | 2 |
收率/% | 92.9 | 92.1 | 92.7 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011017449.0A CN112279867B (zh) | 2020-09-24 | 2020-09-24 | 一种头孢哌酮钠的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011017449.0A CN112279867B (zh) | 2020-09-24 | 2020-09-24 | 一种头孢哌酮钠的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN112279867A true CN112279867A (zh) | 2021-01-29 |
CN112279867B CN112279867B (zh) | 2021-10-12 |
Family
ID=74422924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011017449.0A Active CN112279867B (zh) | 2020-09-24 | 2020-09-24 | 一种头孢哌酮钠的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112279867B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114621254A (zh) * | 2022-03-07 | 2022-06-14 | 苏州东瑞制药有限公司 | 一种头孢哌酮钠的制备方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102372729A (zh) * | 2011-12-14 | 2012-03-14 | 哈药集团制药总厂 | 一种合成头孢哌酮钠化合物的新方法 |
CN104650115A (zh) * | 2015-01-22 | 2015-05-27 | 杭州长典医药科技有限公司 | 头孢哌酮钠及其复方特种超细粉体制剂与制备方法 |
CN104644640A (zh) * | 2015-01-27 | 2015-05-27 | 华北制药河北华民药业有限责任公司 | 一种注射用头孢哌酮钠舒巴坦钠粉针的制备方法 |
CN105440057A (zh) * | 2015-11-25 | 2016-03-30 | 华北制药河北华民药业有限责任公司 | 一种制备头孢哌酮钠的方法 |
CN106309448A (zh) * | 2016-08-24 | 2017-01-11 | 南昌立健药业有限公司 | 一种新型注射用头孢哌酮钠舒巴坦钠药物组合物 |
CN109293680A (zh) * | 2018-09-26 | 2019-02-01 | 华北制药河北华民药业有限责任公司 | 一种头孢哌酮酸的制备方法 |
WO2019050936A1 (en) * | 2017-09-06 | 2019-03-14 | Tepha, Inc. | CALANDERATED SURGICAL TRELLIS COMPRISING POLYHYDROXYALKANOATES |
CN109796470A (zh) * | 2019-01-23 | 2019-05-24 | 华北制药河北华民药业有限责任公司 | 一种高纯度头孢哌酮钠微粉的制备方法 |
-
2020
- 2020-09-24 CN CN202011017449.0A patent/CN112279867B/zh active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102372729A (zh) * | 2011-12-14 | 2012-03-14 | 哈药集团制药总厂 | 一种合成头孢哌酮钠化合物的新方法 |
CN104650115A (zh) * | 2015-01-22 | 2015-05-27 | 杭州长典医药科技有限公司 | 头孢哌酮钠及其复方特种超细粉体制剂与制备方法 |
CN104644640A (zh) * | 2015-01-27 | 2015-05-27 | 华北制药河北华民药业有限责任公司 | 一种注射用头孢哌酮钠舒巴坦钠粉针的制备方法 |
CN105440057A (zh) * | 2015-11-25 | 2016-03-30 | 华北制药河北华民药业有限责任公司 | 一种制备头孢哌酮钠的方法 |
CN106309448A (zh) * | 2016-08-24 | 2017-01-11 | 南昌立健药业有限公司 | 一种新型注射用头孢哌酮钠舒巴坦钠药物组合物 |
WO2019050936A1 (en) * | 2017-09-06 | 2019-03-14 | Tepha, Inc. | CALANDERATED SURGICAL TRELLIS COMPRISING POLYHYDROXYALKANOATES |
CN109293680A (zh) * | 2018-09-26 | 2019-02-01 | 华北制药河北华民药业有限责任公司 | 一种头孢哌酮酸的制备方法 |
CN109796470A (zh) * | 2019-01-23 | 2019-05-24 | 华北制药河北华民药业有限责任公司 | 一种高纯度头孢哌酮钠微粉的制备方法 |
Non-Patent Citations (1)
Title |
---|
贾全: "雾化吹干技术在头孢哌酮钠生产中的研究与应用", 《中国抗生素杂志》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114621254A (zh) * | 2022-03-07 | 2022-06-14 | 苏州东瑞制药有限公司 | 一种头孢哌酮钠的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN112279867B (zh) | 2021-10-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100506210C (zh) | 一种头孢替唑钠粉针及其合成方法 | |
CN103319502B (zh) | 一种磺苄西林钠的制备方法 | |
CN112279867B (zh) | 一种头孢哌酮钠的制备方法 | |
CN102993043B (zh) | 一种制备高纯度盐酸四环素的方法 | |
CN113365973B (zh) | 苯氧乙酸衍生物及利用其酶法制备青霉素v盐的方法 | |
CN112535666B (zh) | 一种高稳定性注射用头孢呋辛钠粉针制剂的制备方法 | |
KR101577488B1 (ko) | 세프디니르 산성 복염 화합물 및 제조방법 | |
CN104844625A (zh) | 头孢孟多酯钠的一种新晶型及其结晶制备方法 | |
CN112552167B (zh) | 葡萄糖酸钙的制备方法 | |
CN109776572B (zh) | 一种盐酸头孢吡肟的纯化方法 | |
CN109824700B (zh) | 一种头孢替坦二钠的制备方法 | |
CN112062779B (zh) | 一种舒巴坦钠的制备方法 | |
CN111961065A (zh) | 一种头孢氨苄连续结晶方法 | |
CN108440569B (zh) | 头孢曲松钠球形晶体的制备方法 | |
CN108586491B (zh) | 一种盐酸头孢他美酯的制备方法 | |
CN101585845A (zh) | 美洛西林的制备方法 | |
CN111116467A (zh) | 氯喹那多的制备方法 | |
CN109912625B (zh) | 一种降低头孢他啶杂质h的工艺方法 | |
CN114409677B (zh) | 高纯度头孢噻肟酸的制备方法 | |
CN108299470B (zh) | 一种头孢特仑新戊酯的制备方法 | |
CN110105374B (zh) | 一种粒度和晶习可控的苯乙酰-7-氨基-3-脱乙酰氧基头孢烷酸的结晶方法 | |
CN108707158B (zh) | 一种硫酸头孢匹罗的纯化方法 | |
CN107793432B (zh) | 头孢曲松钠粗盐的精制方法 | |
CN113968874B (zh) | 头孢克肟的精制方法 | |
CN111187255B (zh) | 右旋艾普拉唑钾盐的制备方法和右旋艾普拉唑的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information |
Inventor after: Ren Feng Inventor after: He Jiao Inventor after: Jia Quan Inventor after: Yin Lixin Inventor after: Zhang Tao Inventor after: Tian Hongnian Inventor after: Zhang Jianli Inventor after: Wei Baojun Inventor after: Liu Shubin Inventor after: Yang Mengde Inventor before: Ren Feng Inventor before: Jia Quan Inventor before: Tian Hongnian Inventor before: Zhang Jianli Inventor before: Wei Baojun Inventor before: Liu Shubin Inventor before: Yang Mengde Inventor before: He Jiao |
|
CB03 | Change of inventor or designer information | ||
GR01 | Patent grant | ||
GR01 | Patent grant |