CN112279867B - 一种头孢哌酮钠的制备方法 - Google Patents
一种头孢哌酮钠的制备方法 Download PDFInfo
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- CN112279867B CN112279867B CN202011017449.0A CN202011017449A CN112279867B CN 112279867 B CN112279867 B CN 112279867B CN 202011017449 A CN202011017449 A CN 202011017449A CN 112279867 B CN112279867 B CN 112279867B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
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- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Description
批号 | 对比例3 | 对比例4 | 对比例5 |
丙酮溶解用量/ml | 100 | 50 | 50 |
碳酸氢钠用量/g | 7.5 | 6.2 | 6.3 |
纯化水用量/ml | 15 | 10 | 13 |
丙酮流加速度/ml/min | 2 | 6 | 2 |
收率/% | 92.9 | 92.1 | 92.7 |
Claims (9)
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CN112279867A CN112279867A (zh) | 2021-01-29 |
CN112279867B true CN112279867B (zh) | 2021-10-12 |
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CN114621254A (zh) * | 2022-03-07 | 2022-06-14 | 苏州东瑞制药有限公司 | 一种头孢哌酮钠的制备方法 |
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CN102372729B (zh) * | 2011-12-14 | 2014-09-24 | 哈药集团制药总厂 | 一种合成头孢哌酮钠化合物的新方法 |
CN104650115A (zh) * | 2015-01-22 | 2015-05-27 | 杭州长典医药科技有限公司 | 头孢哌酮钠及其复方特种超细粉体制剂与制备方法 |
CN104644640B (zh) * | 2015-01-27 | 2016-06-08 | 华北制药河北华民药业有限责任公司 | 一种注射用头孢哌酮钠舒巴坦钠粉针的制备方法 |
CN105440057B (zh) * | 2015-11-25 | 2017-10-17 | 华北制药河北华民药业有限责任公司 | 一种制备头孢哌酮钠的方法 |
CN106309448A (zh) * | 2016-08-24 | 2017-01-11 | 南昌立健药业有限公司 | 一种新型注射用头孢哌酮钠舒巴坦钠药物组合物 |
CA3074733C (en) * | 2017-09-06 | 2022-06-21 | Tepha, Inc. | Calendered surgical meshes comprising polyhydroxyalkanoates |
CN109293680B (zh) * | 2018-09-26 | 2020-06-16 | 华北制药河北华民药业有限责任公司 | 一种头孢哌酮酸的制备方法 |
CN109796470B (zh) * | 2019-01-23 | 2020-07-10 | 华北制药河北华民药业有限责任公司 | 一种高纯度头孢哌酮钠微粉的制备方法 |
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Inventor after: Ren Feng Inventor after: He Jiao Inventor after: Jia Quan Inventor after: Yin Lixin Inventor after: Zhang Tao Inventor after: Tian Hongnian Inventor after: Zhang Jianli Inventor after: Wei Baojun Inventor after: Liu Shubin Inventor after: Yang Mengde Inventor before: Ren Feng Inventor before: Jia Quan Inventor before: Tian Hongnian Inventor before: Zhang Jianli Inventor before: Wei Baojun Inventor before: Liu Shubin Inventor before: Yang Mengde Inventor before: He Jiao |
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