CN112165930A - 口腔用组合物 - Google Patents
口腔用组合物 Download PDFInfo
- Publication number
- CN112165930A CN112165930A CN201980035567.3A CN201980035567A CN112165930A CN 112165930 A CN112165930 A CN 112165930A CN 201980035567 A CN201980035567 A CN 201980035567A CN 112165930 A CN112165930 A CN 112165930A
- Authority
- CN
- China
- Prior art keywords
- copper
- oral composition
- feeling
- component
- glutarate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 64
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229910052802 copper Inorganic materials 0.000 claims abstract description 21
- 239000010949 copper Substances 0.000 claims abstract description 21
- 150000001875 compounds Chemical class 0.000 claims abstract description 18
- 206010006326 Breath odour Diseases 0.000 claims abstract description 15
- 208000032139 Halitosis Diseases 0.000 claims abstract description 14
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000551 dentifrice Substances 0.000 claims description 18
- CTMTYSVTTGVYAW-FRRDWIJNSA-N 5-[(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl]oxy-5-oxopentanoic acid Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)CCCC(O)=O CTMTYSVTTGVYAW-FRRDWIJNSA-N 0.000 claims description 10
- 150000001879 copper Chemical class 0.000 claims description 7
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims description 6
- 229910001431 copper ion Inorganic materials 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims description 5
- IVFWZYOGAYVLRF-UHFFFAOYSA-N bis(5-methyl-2-propan-2-ylcyclohexyl) pentanedioate Chemical compound CC(C)C1CCC(C)CC1OC(=O)CCCC(=O)OC1C(C(C)C)CCC(C)C1 IVFWZYOGAYVLRF-UHFFFAOYSA-N 0.000 claims description 5
- 229940108925 copper gluconate Drugs 0.000 claims description 5
- HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 claims description 4
- 229940079841 sodium copper chlorophyllin Drugs 0.000 claims description 4
- 235000013758 sodium copper chlorophyllin Nutrition 0.000 claims description 4
- 229940079721 copper chloride Drugs 0.000 claims description 3
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 3
- 229960000355 copper sulfate Drugs 0.000 claims description 3
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims description 3
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 3
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 31
- 230000001629 suppression Effects 0.000 abstract description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
- 208000025371 Taste disease Diseases 0.000 description 11
- 235000019656 metallic taste Nutrition 0.000 description 11
- 238000009472 formulation Methods 0.000 description 8
- 239000011230 binding agent Substances 0.000 description 7
- 239000000377 silicon dioxide Substances 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- BXOCHUWSGYYSFW-HVWOQQCMSA-N spilanthol Chemical compound C\C=C\C=C/CC\C=C\C(=O)NCC(C)C BXOCHUWSGYYSFW-HVWOQQCMSA-N 0.000 description 6
- 239000003945 anionic surfactant Substances 0.000 description 5
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 5
- 239000006071 cream Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000035807 sensation Effects 0.000 description 5
- 235000019615 sensations Nutrition 0.000 description 5
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 5
- 239000004711 α-olefin Substances 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 239000003082 abrasive agent Substances 0.000 description 4
- -1 alkali metal salt Chemical class 0.000 description 4
- 150000008051 alkyl sulfates Chemical class 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 4
- 239000001506 calcium phosphate Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 3
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 3
- BXOCHUWSGYYSFW-UHFFFAOYSA-N all-trans spilanthol Natural products CC=CC=CCCC=CC(=O)NCC(C)C BXOCHUWSGYYSFW-UHFFFAOYSA-N 0.000 description 3
- 229960002504 capsaicin Drugs 0.000 description 3
- 230000008602 contraction Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 210000004195 gingiva Anatomy 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
- 235000019477 peppermint oil Nutrition 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- 150000005846 sugar alcohols Chemical class 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 239000000811 xylitol Substances 0.000 description 3
- 235000010447 xylitol Nutrition 0.000 description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
- 229960002675 xylitol Drugs 0.000 description 3
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 2
- 150000000083 (-)-menthol derivatives Chemical class 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 2
- 239000005749 Copper compound Substances 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VUNOFAIHSALQQH-UHFFFAOYSA-N Ethyl menthane carboxamide Chemical compound CCNC(=O)C1CC(C)CCC1C(C)C VUNOFAIHSALQQH-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 229960000458 allantoin Drugs 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 229940011037 anethole Drugs 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 235000017663 capsaicin Nutrition 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- JOZKFWLRHCDGJA-UHFFFAOYSA-N citronellol acetate Chemical compound CC(=O)OCCC(C)CCC=C(C)C JOZKFWLRHCDGJA-UHFFFAOYSA-N 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- 150000001880 copper compounds Chemical class 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 230000007721 medicinal effect Effects 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 2
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 2
- 235000012141 vanillin Nutrition 0.000 description 2
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- KRLBLPBPZSSIGH-CSKARUKUSA-N (6e)-3,7-dimethylnona-1,6-dien-3-ol Chemical compound CC\C(C)=C\CCC(C)(O)C=C KRLBLPBPZSSIGH-CSKARUKUSA-N 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- WUOACPNHFRMFPN-SECBINFHSA-N (S)-(-)-alpha-terpineol Chemical compound CC1=CC[C@@H](C(C)(C)O)CC1 WUOACPNHFRMFPN-SECBINFHSA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- MDVYIGJINBYKOM-UHFFFAOYSA-N 3-[[5-Methyl-2-(1-methylethyl)cyclohexyl]oxy]-1,2-propanediol Chemical compound CC(C)C1CCC(C)CC1OCC(O)CO MDVYIGJINBYKOM-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 244000037364 Cinnamomum aromaticum Species 0.000 description 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 1
- JOZKFWLRHCDGJA-LLVKDONJSA-N Citronellyl acetate Natural products CC(=O)OCC[C@H](C)CCC=C(C)C JOZKFWLRHCDGJA-LLVKDONJSA-N 0.000 description 1
- 235000019499 Citrus oil Nutrition 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 108010001682 Dextranase Proteins 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- 244000245214 Mentha canadensis Species 0.000 description 1
- 235000016278 Mentha canadensis Nutrition 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 125000004442 acylamino group Chemical group 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- OVKDFILSBMEKLT-UHFFFAOYSA-N alpha-Terpineol Natural products CC(=C)C1(O)CCC(C)=CC1 OVKDFILSBMEKLT-UHFFFAOYSA-N 0.000 description 1
- 229940088601 alpha-terpineol Drugs 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000010620 bay oil Substances 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 229960004217 benzyl alcohol Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229910000281 calcium bentonite Inorganic materials 0.000 description 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 239000010500 citrus oil Substances 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 230000035597 cooling sensation Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 229910000400 magnesium phosphate tribasic Inorganic materials 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000001683 mentha spicata herb oil Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229910000150 monocalcium phosphate Inorganic materials 0.000 description 1
- 235000019691 monocalcium phosphate Nutrition 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 231100000017 mucous membrane irritation Toxicity 0.000 description 1
- 239000008601 oleoresin Substances 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 239000001622 pimenta officinalis fruit oil Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000010668 rosemary oil Substances 0.000 description 1
- 229940058206 rosemary oil Drugs 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 239000010670 sage oil Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- RUTSRVMUIGMTHJ-UHFFFAOYSA-M sodium;tetradec-1-ene-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCC=CS([O-])(=O)=O RUTSRVMUIGMTHJ-UHFFFAOYSA-M 0.000 description 1
- CDGJVLFXHHVFFL-UHFFFAOYSA-M sodium;tetradecanoyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCC(=O)OS([O-])(=O)=O CDGJVLFXHHVFFL-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
本发明提供一种适宜用于口臭抑制的口腔用组合物，其混合有含铜化合物且通过牙龈的紧绷感而给予优异的实际效果感。口腔用组合物含有(A)含铜化合物和(B)戊二酸薄荷酯。
Description
技术领域
本发明涉及一种适宜用于口臭抑制的口腔用组合物，其中混合有含铜化合物，且通过牙龈的紧绷感而给予优异的实际效果感。
背景技术
以往，含铜化合物，例如水溶性铜盐，已知可用作引起口臭的物质的化学除臭剂，可与其他口臭抑制手段组合，或与唾液分泌促进剂并用而谋求提高效果(专利文献1：日本专利第3661741号公报)，但是其不一定是能够充分满足使用者实际感觉到的效果感的物质。此外，混合有铜盐的口腔用制剂有来自于铜的令人不愉快的金属味、伴随着刺激的独特的收敛感影响口腔用制剂的使用感的情形。
对于上述课题，申请人提出如下方案：通过苯甲醇与木糖醇或赤藓糖醇，抑制由铜带来的金属味、收敛感并改善适口性(专利文献2：WO2016/93279)。此外，有人提出如下方案：将通过将并用甜菜碱型两性表面活性剂与木糖醇等特定的糖醇、并与铜化合物组合而混合的口腔用组合物，尤其制备成凝胶剂而涂布，从而兼具抑制来自于铜化合物的苦味和粘膜刺激与赋予牙龈充分的收敛感(专利文献3：WO2010/113688)。
此外，作为铜盐的令人不愉快的味道的掩蔽技术，人们提出了：L-薄荷脑衍生物和N-乙基-对薄荷烷-3-甲酰胺的组合(专利文献4：日本特开2003-137755号公报)；通用香料的油树脂、柑桔油的活用(专利文献5：日本特开平01-153622号公报)；尿囊素与非离子性表面活性剂的并用(专利文献6：日本特开2010-189358号公报)是有效的。
可是，近年来，虽然提供有具有各种药效的口腔用制剂，但是，从与继续使用相关且也可以期待进一步提高效果的角度考虑，除了实际的药效之外，还可以赋予使用者能够满意地实际感受到该效果的实际效果感是重要的。含铜化合物发挥效果的口臭多为牙龈等牙周问题所引起的口臭的情况，牙龈感觉到实际效果感这样的情况可期待作为口臭抑制的效果容易被使用者意识到且赋予高满足感。上述专利文献3中，利用铜的收敛感而提高赋予牙龈收敛感效果，但牙龈中的实际效果感方面尚有改善的余地。
现有技术文献
专利文献
专利文献1：日本专利第3661741号公报
专利文献2：WO2016/93279
专利文献3：WO2010/113688
专利文献4：日本特开2003-137755号公报
专利文献5：日本特开平01-153622号公报
专利文献6：日本特开2010-189358号公报
发明内容
发明所要解决的课题
鉴于上述情况完成本发明，目的在于提供一种口腔用组合物，其混合有含铜化合物且通过牙龈的紧绷感而给予优异的实际效果感。
解决课题的手段
本发明人为了达到上述目的，进行了深入研究，结果发现：在混合有(A)含铜化合物的口腔用组合物中混合(B)戊二酸薄荷酯时，可抑制来自于(A)成分的令人不愉快的金属味、收敛感，而且，强烈感觉到牙龈的紧绷感，通过该紧绷感可以满意地赋予优异的实际效果感、尤其是口臭抑制的实际效果感，至完成了本发明。
混合有含铜化合物的口腔用组合物中，含铜化合物引起的收敛感的抑制，同时具有对牙龈实际效果感降低的倾向。但是，本发明中，在(A)成分中并用(B)成分时，两者特异性地相互作用，(A)成分引起的收敛感被抑制，且即使收敛感被抑制，作为对牙龈的实际效果感也可得到高紧绷感。即，由于该牙龈的紧绷感，可赋予健康地改善牙龈、抑制口臭的感觉。然后，由此，通过牙龈的紧绷感赋予(A)成分带来的实际效果感、尤其是口臭抑制的实际效果感，使用者通过在易于意识到实际效果感的牙龈感受到的感觉而可赋予高满足感。
在该情况时，缺少(A)成分而仅混合(B)成分时，几乎感觉不到牙龈的紧绷感(后述的比较例3)，此外，缺少(B)成分时，即使混合有(A)成分，进一步地，即使混合有温感剂千日菊酰胺(spilanthol)、辣椒素(capsaicin)或者已知作为冷感剂、清凉化剂等的L-薄荷脑衍生物即3-L-薄荷氧基丙烷-1,2-二醇、N-乙基-对薄荷烷-3-甲酰胺，也有几乎感觉不到牙龈的紧绷感(后述的比较例2、4～7)、收敛感等不被抑制的情况，作用效果差。与此相对地，本发明的含有(A)和(B)成分的口腔用组合物(后述的实施例)，可充分地感觉到牙龈的紧绷感，也几乎感觉不到金属味和收敛感。
因而，本发明提供下述的口腔用组合物。
〔1〕一种口腔用组合物，其含有
(A)含铜化合物，和
(B)戊二酸薄荷酯。
〔2〕根据〔1〕所述的口腔用组合物，其中，(A)含铜化合物为选自葡萄糖酸铜，硫酸铜、氯化铜、叶绿素铜钠和乙酸铜中的1种或2种以上的水溶性铜盐。
〔3〕根据〔1〕或〔2〕所述的口腔用组合物，其中，(B)戊二酸薄荷酯为戊二酸单薄荷酯和戊二酸二薄荷酯的混合物。
〔4〕根据〔3〕所述的口腔用组合物，其中，戊二酸单薄荷酯和戊二酸二薄荷酯的混合比例，以质量比计，为1：9～9：1。
〔5〕根据〔1〕～〔4〕中任一项所述的口腔用组合物，其中，表示作为(A)成分的以铜离子计的含量与(B)成分的含量的比率的(A)/(B)，以质量比计，为0.0001～20。
〔6〕根据〔1〕～〔5〕中任一项所述的口腔用组合物，其中，所述口腔用组合物含有以铜离子计0.0001～0.1质量％的(A)成分、0.0001～2质量％的(B)成分。
〔7〕根据〔1〕～〔6〕中任一项所述的口腔用组合物，其中，所述口腔用组合物还含有表面活性剂。
〔8〕根据〔1〕～〔7〕中任一项所述的口腔用组合物，其中，所述口腔用组合物为洁齿剂组合物。
〔9〕根据〔1〕～〔8〕中任一项所述的口腔用组合物，其中，所述口腔用组合物为口臭抑制用。
发明效果
根据本发明可以提供一种口腔用组合物，其混合有含铜化合物且通过牙龈的紧绷感而给予优异的实际效果感，味道等使用感也良好。该口腔用组合物的由含铜化合物引起的口臭抑制的效果高，可适宜用作口臭抑制用。
具体实施方式
以下，进一步地详细地叙述本发明。本发明的口腔用组合物含有(A)含铜化合物、(B)戊二酸薄荷酯。
(A)含铜化合物可以使用具有口臭抑制作用、可以用作口腔用的水溶性铜盐。可列举例如葡萄糖酸铜、硫酸铜、氯化铜、叶绿素铜钠、乙酸铜等，其中，优选葡萄糖酸铜、叶绿素铜钠，更优选葡萄糖酸铜。
以铜离子计，(A)含铜化合物的混合量优选为组合物整体的0.0001～0.1％(质量％，以下相同)，更优选为0.001～0.1％，特别优选为0.005～0.1％。该混合量为0.0001％以上时，可得到充分的赋予牙龈紧绷感的效果。该混合量为0.1％以下时，可充分地抑制金属味和收敛性。
已知(B)戊二酸薄荷酯作为冷却剂、清凉感赋予剂，但是，在本发明中，与(A)成分并用时，(B)成分作为牙龈的紧绷感赋予剂发挥作用，还发挥抑制来自于(A)成分的令人不愉快的金属味和收敛感的作用。
作为戊二酸薄荷酯，可列举例如戊二酸单薄荷酯、戊二酸二薄荷酯。它们可以单独使用1种，尤其从赋予牙龈紧绷感的角度考虑，更优选戊二酸单薄荷酯和戊二酸二薄荷酯的混合物。
此处，混合戊二酸单薄荷酯和戊二酸二薄荷酯时，两者的混合比例(戊二酸单薄荷酯：戊二酸二薄荷酯)，以质量比计，优选为1：9～9：1，更优选为1：1～9：1，特别优选为3：2～3：1。混合比例在上述范围内时，可以赋予充分的牙龈的紧绷感，实际效果感优异。
(B)戊二酸薄荷酯的混合量优选为组合物整体的0.0001～2％，更优选为0.001～2％，特别优选为0.005～1％。该混合量为0.0001％以上时，可充分地赋予牙龈的紧绷感。该混合量为2％以下时，可抑制来自于(B)成分的刺激，此外，可以充分地维持牙龈的紧绷感。
本发明中，表示(A)成分的含量(以铜离子计的含量)和(B)成分的含量的比率的(A)/(B)，以质量比计，优选为0.0001～20，更优选为0.001～10，特别优选为0.01～3。上述比率在该范围内时，牙龈的紧绷感赋予效果足够优异，此外，可充分地抑制金属味和收敛感。
本发明的口腔用组合物尤其可制备为洁齿剂组合物，例如可制备为膏状洁齿剂、液状洁齿剂、湿粉状洁齿剂(tooth wet-powder)等，特别优选膏状洁齿剂。此外，除了上述成分之外，根据需要，可在不损害本发明效果的范围内混合其他公知成分，可以在这些混合成分中添加水而按照通常的方法制备。作为可以混合的任意成分，具体而言，可列举：研磨剂、增稠剂、粘结剂、表面活性剂、甜味剂、防腐剂、(B)成分以外的香料、pH调节剂、(A)成分以外的药效成分等。
研磨剂可列举例如：沉淀二氧化硅、硅酸铝、硅酸锆、钛结合性二氧化硅等二氧化硅系研磨剂；磷酸二钙2水合盐或无水合物、磷酸一钙、磷酸三钙、焦磷酸钙等磷酸钙系研磨剂；碳酸钙等碳酸钙系研磨剂、氢氧化钙、氢氧化铝、磷酸三镁、碳酸镁、硫酸钙、膨润土、羟基磷灰石，可以混合它们中的1种或2种以上。在它们之中，从牙龈的紧绷感赋予的角度考虑，特别优选沉淀二氧化硅、硅酸铝、硅酸锆、钛结合性二氧化硅等以硅酸盐为主成分的二氧化硅系研磨剂。这些研磨剂的混合量，优选为组合物整体的8～70％。
增稠剂可列举：甘油、丙二醇等多元醇；山梨糖醇、木糖醇等糖醇。增稠剂的混合量优选为组合物整体的5～50％，特别优选为20～45％。
粘结剂可以适宜有机粘结剂、无机粘结剂。例如，有机粘结剂可列举黄原胶等胶类；卡拉胶、羧甲基纤维素钠、甲基纤维素等纤维素衍生物。无机粘结剂可列举增稠性二氧化硅、硅酸铝等。它们可以使用1种或2种以上。粘结剂的混合量优选组合物整体的1.4～10％，特别优选1.4～8％。
表面活性剂可列举阴离子型表面活性剂、非离子型表面活性剂、两性表面活性剂，特别优选阴离子型表面活性剂。
例如，阴离子型表面活性剂可列举月桂基硫酸钠等烷基硫酸盐；α-烯烃磺酸盐；N-酰基牛磺酸盐；酰基肌氨酸盐；酰基氨基酸盐。其中，从牙龈的紧绷感赋予的角度考虑，优选起泡性、泡沫质量良好的含有磺酸基的阴离子型表面活性剂，更优选烷基硫酸盐、α-烯烃磺酸盐。作为上述盐，可列举钠盐、钾盐、铵盐等，特别优选钠盐。
烷基硫酸盐优选烷基的碳原子数为12～14的烷基硫酸盐，可列举月桂基硫酸钠、肉豆蔻酰硫酸钠等。
α-烯烃磺酸盐优选碳原子数14～16的α-烯烃磺酸的钠、钾等碱金属盐，特别是碳原子数14的α-烯烃磺酸盐，尤其是钠盐(通用名；十四碳烯磺酸钠)良好。
这些表面活性剂可以单独使用1种，也可组合2种以上使用。
表面活性剂、尤其是阴离子型表面活性剂的混合量优选为组合物整体的0.6～2.5％，特别优选为1～2.5％。
作为甜味剂，可列举糖精钠等。
防腐剂可列举对羟基苯甲酸酯、苯甲酸钠等。
香料可列举公知的香料，例如薄荷脑、茴香脑、香芹酮、丁香酚、柠檬烯、正癸醇、香茅醇、α-松油醇、乙酸香茅酯、桉叶素、芳樟醇、乙基芳樟醇、香兰素(vanillin)、百里香酚、留兰香油、胡椒薄荷油、柠檬油、橙油、鼠尾草油、迷迭香油、桂皮油、多香果油、桂叶油、紫苏油、冬青油、丁香油、桉叶油。
pH调节剂可列举盐酸、氢氧化钠、氢氧化钾、磷酸氢二钠、磷酸二氢钠等无机化合物。
任意的药效成分，可列举例如葡聚糖酶(dextranase)等酶；氨甲环酸、ε-氨基己酸、尿囊素氯羟基铝等抗炎剂；维生素类等细胞激活剂；异丙基甲基苯酚、西吡氯铵、苯扎氯铵等杀菌剂；沸石等牙结石预防剂；维生素E等血液循环促进剂。另外，对于药效成分的混合量，可在不损害本发明效果的范围内取有效量。
实施例
以下，示出实施例和比较例、配方例，具体地说明本发明，但本发明并不限定于下述实施例。另外，除非有特殊说明，否则下述的例中，％均表示质量％。
[实施例、比较例]
使用下述的表1、2所示的戊二酸薄荷酯1～5和香料A，制备各例的洁齿剂组合物(膏状洁齿剂)，根据下述方法进行评价。
[表1]
[表2]
| 成分 | 香料A |
| 胡椒薄荷油 | 20 |
| 胡椒薄荷油萜烯10％馏分 | 20 |
| 日本薄荷 | 20 |
| 薄荷脑 | 30 |
| 茴香脑 | 5 |
| 乙醇 | 5 |
| 合计 | 100％ |
评价方法
按照通常的方法制备后述的表5～7所示组成的膏状洁齿剂，使用这些膏状洁齿剂，10名受试者(专业评价员)按照通常的方法刷牙，对刷牙后的牙龈紧绷感的有无，刷牙过程中的来自于铜盐的金属味(金属味的有无)、收敛感(收敛感的有无)进行感官评价，按照表3、4所示的评价基准进行判定。结果一并记于表5～7。
[表3]
[表4]
[表5]
[表6]
[表7]
从表5结果可知：单独混合(A)成分或(B)成分时，几乎感觉不到牙龈的紧绷感(比较例2、3)，此外，即使将千日菊酰胺、辣椒素、L-薄荷脑衍生物中的任一种与(A)成分并用，在不混合(B)成分时，也几乎感觉不到牙龈的紧绷感(比较例4～7)。与此相对地，从表6、7的结果可知：并用、混合本发明的(A)和(B)成分的膏状洁齿剂(实施例1～11)可以充分地感觉到牙龈的紧绷感，此外，确认到金属味和收敛感得到抑制，使用感良好。这些实施例的膏状洁齿剂的口臭抑制效果优异，同时其效果感优异，是满足感高的膏状洁齿剂。
配方例如下述所示。使用与上述相同的原料，同样地制备配方例的膏状洁齿剂进行评价时，可以充分地感觉到牙龈的紧绷感高，此外，使用时的金属味和收敛感得到抑制，使用感良好。
[配方例1](膏状洁齿剂)
[配方例2](膏状洁齿剂)
[配方例3](膏状洁齿剂)
[配方例4](膏状洁齿剂)
[配方例5](膏状洁齿剂)
Claims (9)
1.一种口腔用组合物，其特征在于，含有
(A)含铜化合物，和
(B)戊二酸薄荷酯。
2.根据权利要求1所述的口腔用组合物，其中，(A)含铜化合物为选自葡萄糖酸铜、硫酸铜、氯化铜、叶绿素铜钠和乙酸铜中的1种或2种以上的水溶性铜盐。
3.根据权利要求1或2所述的口腔用组合物，其中，(B)戊二酸薄荷酯为戊二酸单薄荷酯和戊二酸二薄荷酯的混合物。
4.根据权利要求3所述的口腔用组合物，其中，戊二酸单薄荷酯和戊二酸二薄荷酯的混合比例，以质量比计，为1：9～9：1。
5.根据权利要求1～4中任一项所述的口腔用组合物，其中，(A)成分的以铜离子计的含量与(B)成分含量的比率(A)/(B)，以质量比计，为0.0001～20。
6.根据权利要求1～5中任一项所述的口腔用组合物，其中，所述口腔用组合物含有以铜离子计为0.0001～0.1质量％的(A)成分、0.0001～2质量％的(B)成分。
7.根据权利要求1～6中任一项所述的口腔用组合物，其中，所述口腔用组合物还含有表面活性剂。
8.根据权利要求1～7中任一项所述的口腔用组合物，其中，所述口腔用组合物为洁齿剂组合物。
9.根据权利要求1～8中任一项所述的口腔用组合物，其中，所述口腔用组合物为口臭抑制用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018102421 | 2018-05-29 | ||
| JP2018-102421 | 2018-05-29 | ||
| PCT/JP2019/021058 WO2019230710A1 (ja) | 2018-05-29 | 2019-05-28 | 口腔用組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112165930A true CN112165930A (zh) | 2021-01-01 |
Family
ID=68697067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980035567.3A Pending CN112165930A (zh) | 2018-05-29 | 2019-05-28 | 口腔用组合物 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP7347416B2 (zh) |
| KR (1) | KR20210013686A (zh) |
| CN (1) | CN112165930A (zh) |
| WO (1) | WO2019230710A1 (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003137755A (ja) * | 2001-11-02 | 2003-05-14 | Lion Corp | 口腔用組成物 |
| CN105142419A (zh) * | 2013-04-24 | 2015-12-09 | 博费蒂·迈·麦勒有限公司 | 具有长效清新感的咀嚼胶及其制备方法 |
| CN105452430A (zh) * | 2013-09-13 | 2016-03-30 | 长谷川香料株式会社 | 降低了杂味的清凉感持续剂 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2580648B2 (ja) | 1987-12-11 | 1997-02-12 | ライオン株式会社 | 口腔用組成物 |
| JP3661741B2 (ja) | 1997-12-24 | 2005-06-22 | ライオン株式会社 | 口臭抑制用口腔用組成物 |
| US6365215B1 (en) * | 2000-11-09 | 2002-04-02 | International Flavors & Fragrances Inc. | Oral sensory perception-affecting compositions containing dimethyl sulfoxide, complexes thereof and salts thereof |
| CA2749133C (en) * | 2009-01-15 | 2016-08-30 | Kraft Foods Global Brands Llc | Compositions and methods for the treatment of throat discomfort |
| JP5672651B2 (ja) | 2009-02-20 | 2015-02-18 | ライオン株式会社 | 洗口剤組成物 |
| CN102365077B (zh) | 2009-03-30 | 2013-10-16 | 狮王株式会社 | 口腔用组合物 |
| EP3043653A1 (en) * | 2013-09-12 | 2016-07-20 | Intercontinental Great Brands LLC | Chewing gum composition comprising a micro-encapsulated flavour in a matrix comprising protein |
| WO2016093279A1 (ja) | 2014-12-12 | 2016-06-16 | ライオン株式会社 | 口腔用組成物 |
-
2019
- 2019-05-28 KR KR1020207027931A patent/KR20210013686A/ko not_active Application Discontinuation
- 2019-05-28 WO PCT/JP2019/021058 patent/WO2019230710A1/ja active Application Filing
- 2019-05-28 CN CN201980035567.3A patent/CN112165930A/zh active Pending
- 2019-05-28 JP JP2020522206A patent/JP7347416B2/ja active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003137755A (ja) * | 2001-11-02 | 2003-05-14 | Lion Corp | 口腔用組成物 |
| CN105142419A (zh) * | 2013-04-24 | 2015-12-09 | 博费蒂·迈·麦勒有限公司 | 具有长效清新感的咀嚼胶及其制备方法 |
| CN105452430A (zh) * | 2013-09-13 | 2016-03-30 | 长谷川香料株式会社 | 降低了杂味的清凉感持续剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2019230710A1 (ja) | 2021-06-24 |
| KR20210013686A (ko) | 2021-02-05 |
| JP7347416B2 (ja) | 2023-09-20 |
| WO2019230710A1 (ja) | 2019-12-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5251350B2 (ja) | 歯磨組成物 | |
| JP2022000420A (ja) | 口腔用組成物 | |
| WO2022131147A1 (ja) | 口腔用組成物 | |
| JP2020011951A (ja) | 口腔用組成物 | |
| JP2019116442A (ja) | 歯磨剤組成物 | |
| JP5729291B2 (ja) | 口腔用組成物 | |
| JP5825088B2 (ja) | 液体口腔用組成物 | |
| JP6610208B2 (ja) | 口腔用組成物 | |
| CN111902125B (zh) | 口腔用组合物及α-烯烃磺酸盐的苦味改进剂 | |
| CN112165930A (zh) | 口腔用组合物 | |
| JP7347916B2 (ja) | 歯磨剤組成物 | |
| JP7172028B2 (ja) | 口腔用組成物 | |
| JP6825339B2 (ja) | 口腔用組成物 | |
| JPWO2018043717A1 (ja) | 口腔用組成物 | |
| JP7172392B2 (ja) | 口腔用組成物 | |
| JP7403736B2 (ja) | 口腔用組成物 | |
| CN110691581B (zh) | 洁齿剂组合物 | |
| CN110621292B (zh) | 洁齿剂组合物 | |
| WO2021015091A1 (ja) | 口腔用組成物及び歯茎へのマッサージ実感付与剤 | |
| JP2023005325A (ja) | 口腔用組成物 | |
| JP6439425B2 (ja) | 液体口腔用組成物 | |
| JP2022093971A (ja) | 口腔用組成物 | |
| JP2023005324A (ja) | 口腔用組成物 | |
| CN116669680A (zh) | 口腔用组合物 | |
| JP2023060592A (ja) | 口腔用組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210101 |
|
| RJ01 | Rejection of invention patent application after publication |