CN112135613A - 激酶抑制剂化合物和组合物及使用方法 - Google Patents

激酶抑制剂化合物和组合物及使用方法 Download PDF

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Publication number
CN112135613A
CN112135613A CN201980032475.XA CN201980032475A CN112135613A CN 112135613 A CN112135613 A CN 112135613A CN 201980032475 A CN201980032475 A CN 201980032475A CN 112135613 A CN112135613 A CN 112135613A
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compound
methyl
group
nmr
subject
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Chinese (zh)
Inventor
K·库玛
P·王
R·桑切斯
A·G·奥卡尼亚
A·斯图尔特
R·戴维塔
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Icahn School of Medicine at Mount Sinai
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Icahn School of Medicine at Mount Sinai
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980032475.XA 2018-03-20 2019-03-20 激酶抑制剂化合物和组合物及使用方法 Pending CN112135613A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862645560P 2018-03-20 2018-03-20
US62/645,560 2018-03-20
PCT/US2019/023206 WO2019183245A1 (en) 2018-03-20 2019-03-20 Kinase inhibitor compounds and compositions and methods of use

Publications (1)

Publication Number Publication Date
CN112135613A true CN112135613A (zh) 2020-12-25

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CN201980032475.XA Pending CN112135613A (zh) 2018-03-20 2019-03-20 激酶抑制剂化合物和组合物及使用方法

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US (2) US11866427B2 (https=)
EP (1) EP3768267B1 (https=)
JP (1) JP2021518413A (https=)
CN (1) CN112135613A (https=)
AU (1) AU2019240065A1 (https=)
CA (1) CA3093340A1 (https=)
ES (1) ES3038913T3 (https=)
WO (1) WO2019183245A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114907346A (zh) * 2022-05-19 2022-08-16 暨南大学 一种生物碱类化合物、提取物及其在制备具有抗呼吸道合胞病毒作用的产品中的应用
CN114984195A (zh) * 2022-04-29 2022-09-02 上海中医药大学 脂肪膜相关蛋白及其相关编码基因和片段的新用途
CN115322089A (zh) * 2022-07-18 2022-11-11 中国农业科学院烟草研究所(中国烟草总公司青州烟草研究所) 一种覆盆子酮半抗原、人工抗原及其制备方法、抗体和应用
WO2023123834A1 (zh) * 2021-12-28 2023-07-06 大连医科大学附属第一医院 Norharman在制备预防或治疗急性胰腺炎药物中的应用
CN116509853A (zh) * 2023-06-12 2023-08-01 新疆医科大学第一附属医院 去氢骆驼蓬碱衍生物在改善器官纤维化中的应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019100062A1 (en) 2017-11-20 2019-05-23 Ichan School Of Medicine At Mount Sinai Kinase inhibitor compounds and compositions and methods of use
WO2019136320A1 (en) 2018-01-05 2019-07-11 Icahn School Of Medicine At Mount Sinai Method of increasing proliferation of pancreatic beta cells, treatment method, and composition
CN112135613A (zh) 2018-03-20 2020-12-25 西奈山伊坎医学院 激酶抑制剂化合物和组合物及使用方法
CN115466312B (zh) * 2021-06-10 2025-10-31 首都医科大学 抑制侵袭和迁移的1-咪唑-β-咔啉-3-甲酰-RGDV、其制备和应用
WO2024178504A1 (en) * 2023-02-27 2024-09-06 Enveric Biosciences Canada Inc. Tri-halo-alkoxy-substituted tryptamine derivatives and methods of using
US11802129B1 (en) 2023-03-20 2023-10-31 King Faisal University Pyrido[3,4-b]indol-1-one compounds as anticancer agents
US11773092B1 (en) 2023-03-27 2023-10-03 King Faisal University Pyrido[3,4-b]indol-1-one compounds as antibacterial agents
WO2025122509A1 (en) * 2023-12-04 2025-06-12 Poviva Corp Compositions and methods for treating diabetes

Citations (4)

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WO2012024433A2 (en) * 2010-08-17 2012-02-23 Translational Genomics Research Institute Compounds that inhibit tau phosphorylation
CN102977096A (zh) * 2012-12-07 2013-03-20 中国药科大学 具有靶向特性的去氢骆驼蓬碱衍生物的抗肿瘤前药
WO2015011331A1 (es) * 2013-07-25 2015-01-29 Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz (Fibhulp) Uso de compuestos derivados de sales de piridazino[1',6':1,2]pirido[3,4-b]indolinio y piridazino[3,2-b]benzimidazolio como agentes antiinflamatorios
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