CN112094347A - 具有针对T细胞受体beta恒定区的抗原结合域的嵌合抗原受体(CAR) - Google Patents

具有针对T细胞受体beta恒定区的抗原结合域的嵌合抗原受体(CAR) Download PDF

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CN112094347A
CN112094347A CN202010858243.4A CN202010858243A CN112094347A CN 112094347 A CN112094347 A CN 112094347A CN 202010858243 A CN202010858243 A CN 202010858243A CN 112094347 A CN112094347 A CN 112094347A
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M.普勒
P.马乔西亚
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Autolus Ltd
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Autolus Ltd
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Priority claimed from GB201403905A external-priority patent/GB201403905D0/en
Priority claimed from GB201416908A external-priority patent/GB201416908D0/en
Application filed by Autolus Ltd filed Critical Autolus Ltd
Publication of CN112094347A publication Critical patent/CN112094347A/zh
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    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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CN202010858243.4A 2014-03-05 2015-03-05 具有针对T细胞受体beta恒定区的抗原结合域的嵌合抗原受体(CAR) Pending CN112094347A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB201403905A GB201403905D0 (en) 2014-03-05 2014-03-05 Method
GB1403905.1 2014-03-05
GB201416908A GB201416908D0 (en) 2014-09-25 2014-09-25 Method
GB1416908.0 2014-09-25
CN201580011306.XA CN106068276B (zh) 2014-03-05 2015-03-05 具有针对T细胞受体beta恒定区的抗原结合域的嵌合抗原受体(CAR)

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CN201580011306.XA Division CN106068276B (zh) 2014-03-05 2015-03-05 具有针对T细胞受体beta恒定区的抗原结合域的嵌合抗原受体(CAR)

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CN112094347A true CN112094347A (zh) 2020-12-18

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CN202010859460.5A Pending CN112094353A (zh) 2014-03-05 2015-03-05 具有针对T细胞受体beta恒定区的抗原结合域的嵌合抗原受体(CAR)
CN202410891896.0A Pending CN118852462A (zh) 2014-03-05 2015-03-05 具有针对T细胞受体beta恒定区的抗原结合域的嵌合抗原受体(CAR)
CN202010858243.4A Pending CN112094347A (zh) 2014-03-05 2015-03-05 具有针对T细胞受体beta恒定区的抗原结合域的嵌合抗原受体(CAR)
CN201580011306.XA Active CN106068276B (zh) 2014-03-05 2015-03-05 具有针对T细胞受体beta恒定区的抗原结合域的嵌合抗原受体(CAR)

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CN202410891896.0A Pending CN118852462A (zh) 2014-03-05 2015-03-05 具有针对T细胞受体beta恒定区的抗原结合域的嵌合抗原受体(CAR)

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US (2) US20170066827A1 (enExample)
EP (3) EP3241561B1 (enExample)
JP (5) JP6767872B2 (enExample)
KR (3) KR102235202B1 (enExample)
CN (4) CN112094353A (enExample)
AU (3) AU2015225944B2 (enExample)
BR (1) BR112016020304B1 (enExample)
CA (1) CA2940564C (enExample)
CL (4) CL2016002195A1 (enExample)
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ES (2) ES2758173T3 (enExample)
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IL (3) IL278878B (enExample)
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