CN1120001C - 刺激阴道革兰氏阳性杆菌生长、增强阴道酸度的药剂和其用途 - Google Patents
刺激阴道革兰氏阳性杆菌生长、增强阴道酸度的药剂和其用途 Download PDFInfo
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- CN1120001C CN1120001C CN98809508A CN98809508A CN1120001C CN 1120001 C CN1120001 C CN 1120001C CN 98809508 A CN98809508 A CN 98809508A CN 98809508 A CN98809508 A CN 98809508A CN 1120001 C CN1120001 C CN 1120001C
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- positive bacillus
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- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Polymers CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 description 1
- YKQOSKADJPQZHB-YNWHQGOSSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1s)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Polymers CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O YKQOSKADJPQZHB-YNWHQGOSSA-N 0.000 description 1
- WTEVQBCEXWBHNA-YFHOEESVSA-N neral Chemical compound CC(C)=CCC\C(C)=C/C=O WTEVQBCEXWBHNA-YFHOEESVSA-N 0.000 description 1
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- 239000002674 ointment Substances 0.000 description 1
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- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 description 1
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- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (26)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN97122790.X | 1997-11-24 | ||
CN97122790 | 1997-11-24 |
Publications (2)
Publication Number | Publication Date |
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CN1271291A CN1271291A (zh) | 2000-10-25 |
CN1120001C true CN1120001C (zh) | 2003-09-03 |
Family
ID=5176887
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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CN98809507A Expired - Fee Related CN1120000C (zh) | 1997-11-24 | 1998-11-24 | 刺激阴道革兰氏阳性杆菌生长、增强阴道酸度的药剂和其用途 |
CN98809508A Expired - Fee Related CN1120001C (zh) | 1997-11-24 | 1998-11-24 | 刺激阴道革兰氏阳性杆菌生长、增强阴道酸度的药剂和其用途 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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CN98809507A Expired - Fee Related CN1120000C (zh) | 1997-11-24 | 1998-11-24 | 刺激阴道革兰氏阳性杆菌生长、增强阴道酸度的药剂和其用途 |
Country Status (7)
Country | Link |
---|---|
US (2) | US6632796B1 (zh) |
EP (2) | EP1072268B1 (zh) |
CN (2) | CN1120000C (zh) |
AT (2) | ATE304362T1 (zh) |
AU (2) | AU1223099A (zh) |
DE (2) | DE69831609T2 (zh) |
WO (2) | WO1999026635A1 (zh) |
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IT1306141B1 (it) * | 1999-05-17 | 2001-05-30 | Giampiero Valletta | Composizione per il trattamento del prurito uremico e di forme diprurito non riconducibili a lesioni organiche. |
US6964949B2 (en) * | 2000-05-24 | 2005-11-15 | Shanghai Jiao Da Onlly Co., Ltd. | Pharmaceutical compositions for promoting the growth of gram-positive bacilli and increasing the acidity in the vagina and the use thereof |
JP2002113041A (ja) * | 2000-10-11 | 2002-04-16 | Uni Charm Corp | 皮膚常在菌をコントロールする吸収性物品 |
US20030017207A1 (en) * | 2001-05-01 | 2003-01-23 | Lin Shun Y. | Compositions and methods for treating vulvovaginitis and vaginosis |
NZ515869A (en) | 2001-11-30 | 2003-09-26 | Med Chem Ingredients Ltd | Compositions and methods for animal treatment comprising gluco- and isomalto- oligosaccharides |
US6589216B1 (en) | 2002-02-20 | 2003-07-08 | Abbott Research Group, Inc. | Vaginal douches, vaginal douche applicators and methods of vaginal douching |
US8118789B2 (en) | 2002-02-20 | 2012-02-21 | Abbott Research Group, Inc. | Deodorizer devices and systems for controlling perspiration-related body odor |
US7270653B2 (en) | 2002-02-20 | 2007-09-18 | Abbott Research Group | Methods of treating abnormal biological conditions using metal oxides |
US20040126369A1 (en) * | 2002-12-30 | 2004-07-01 | Richard Payne | Delivery of peroxide-generating enzymes to the vaginal tract |
WO2004110461A1 (en) * | 2003-06-13 | 2004-12-23 | Idh Holding Aps | Treatment of symptoms associated with bacterial vaginosis |
US8309103B2 (en) * | 2004-01-22 | 2012-11-13 | Alparis, S.A. De C.V. | Association of fluconazole-tinidazole for the treatment of vaginal infections, its composition, preparation process and usage |
US7276486B2 (en) * | 2004-03-15 | 2007-10-02 | Kimberly-Clark Worldwide, Inc. | Compositions for vaginal treatment |
US20050244402A1 (en) * | 2004-04-30 | 2005-11-03 | Villanueva Julie M | Absorption of pain-causing agents |
US20060093675A1 (en) * | 2004-10-29 | 2006-05-04 | Mathew Ebmeier | Intravaginal treatment of vaginal infections with metronidazole compositions |
US7619008B2 (en) * | 2004-11-12 | 2009-11-17 | Kimberly-Clark Worldwide, Inc. | Xylitol for treatment of vaginal infections |
US20060217443A1 (en) * | 2005-03-28 | 2006-09-28 | Kimberly-Clark Worldwide, Inc. | Method for preventing and/or treating vaginal and vulval infections |
US20060223765A1 (en) * | 2005-03-30 | 2006-10-05 | Kimberly-Clark Worldwide, Inc. | Method for inhibiting and/or treating vaginal infection |
CN101175503B (zh) * | 2005-04-27 | 2012-12-12 | 深圳福诺生物技术有限公司 | 一种调节并保持阴道菌群和阴道酸度正常的组合物与方法 |
US7786176B2 (en) | 2005-07-29 | 2010-08-31 | Kimberly-Clark Worldwide, Inc. | Vaginal treatment composition containing xylitol |
US7801502B2 (en) * | 2006-12-18 | 2010-09-21 | Aai Corporation | Method for implementing continuous radio frequency (RF) alignment in advanced electronic warfare (EW) signal stimulation systems |
BRPI1006902A2 (pt) | 2009-01-23 | 2016-02-16 | Aziende Chimiche Riunte Angelini Francesco A C R A F S P A | formulação farmacêutica ou alimentícia de liberação controlada, processo para a produção de uma forma farmacêutica ou alimentícia, sistema de liberação controlada, e, uso de um sistema de liberação controlada |
KR101133723B1 (ko) * | 2009-10-19 | 2012-04-09 | 최원석 | 소금 및 당을 유효성분으로 함유하는 질염 예방 및 치료용 조성물 및 이의 용도 |
US8409628B2 (en) | 2010-02-04 | 2013-04-02 | Penguin IP Holdings, Inc. | Methods and compositions for oxygenation of skin to treat skin disorders |
EP2489408A1 (de) | 2011-01-13 | 2012-08-22 | Michael Tchirikov | Aminosäurezusammensetzung und deren Verwendung zur Behandlung von fetaler Wachstumsrestriktion (IUGR) und zur parenteralen Ernährung von extrem Frühgeborenen |
CN103110973A (zh) * | 2013-01-24 | 2013-05-22 | 量子高科(中国)生物股份有限公司 | 保护生殖道微生态健康平衡的方法 |
SG11201607600TA (en) * | 2014-03-13 | 2016-10-28 | Singapore Ze&Z Internat Pte Ltd | Vaginal composition and use thereof |
CN104825946A (zh) * | 2015-04-10 | 2015-08-12 | 付秀花 | 一种洁阴洗液及其制备方法 |
US11129896B2 (en) * | 2015-07-20 | 2021-09-28 | Trilogic Pharma Llc | Topical formulations and treatments |
KR102587444B1 (ko) | 2015-09-29 | 2023-10-11 | 킴벌리-클라크 월드와이드, 인크. | 미생물총의 건강한 균형을 유지하기 위한 상승 조성물 |
WO2017180174A1 (en) | 2016-04-15 | 2017-10-19 | Fairhaven Health, Llc | Compositions and methods for maintaining or enhancing homeostasis or function of female lower reproductive tract |
RU2748651C2 (ru) | 2017-02-28 | 2021-05-28 | Кимберли-Кларк Ворлдвайд, Инк. | Синергическая композиция для сохранения здорового баланса микрофлоры |
CN109771434A (zh) * | 2019-03-07 | 2019-05-21 | 江西鼎中科技有限公司 | 一种治疗阴道炎的蔗糖和低聚木糖凝胶 |
GB202018068D0 (en) | 2020-11-17 | 2020-12-30 | Ucl Business Ltd | Pharmaceutical composition |
CN112451472A (zh) * | 2020-11-27 | 2021-03-09 | 江苏威克斯医疗科技有限公司 | 一种调节阴道微生态的组合物及其制备方法 |
EP4324465A1 (en) * | 2022-08-15 | 2024-02-21 | Gedea Biotech AB | Compounds for use in the treatment of a microbial infection in the urogenital system |
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GB1390803A (en) * | 1972-07-18 | 1975-04-16 | Wootton L W | Medicinal tampons and compositions containing lactulose |
IT1172185B (it) * | 1981-12-21 | 1987-06-18 | Serono Ist Farm | Composizione particolarmente per la vande vaginali |
EP0458370B1 (en) * | 1985-02-08 | 1995-09-13 | Daicel Chemical Industries, Ltd. | Fermentation to d-lactic acid |
JPS61227777A (ja) * | 1985-04-02 | 1986-10-09 | Showa Sangyo Kk | ビフイズス菌生育活性剤 |
US5266329A (en) * | 1985-10-31 | 1993-11-30 | Kv Pharmaceutical Company | Vaginal delivery system |
SE8603338D0 (sv) * | 1986-08-07 | 1986-08-07 | Bjorn Andersch | Medel for behandling av tillstand i slidan |
US4837154A (en) * | 1987-01-14 | 1989-06-06 | Wisconsin Alumni Research Foundation | Selective growth medium for isolation of Mobiluncus from vaginal fluid |
DK505488D0 (da) * | 1987-12-21 | 1988-09-09 | Bar Shalom Daniel | Middel og anvendelse af samme |
US5211971A (en) * | 1989-10-23 | 1993-05-18 | Unilever Patent Holdings B.V. | Lactic acid bacteria cultures supported on an expanded cereal for preparing flavor or aroma material |
ATE214592T1 (de) * | 1990-12-21 | 2002-04-15 | Felice Bombart | Wässrige vaginaldusche und deren anwendung |
US5573765A (en) * | 1991-02-19 | 1996-11-12 | Mark S. Reinhard | Composition and method for treatment of vaginal yeast infections |
FR2678166B1 (fr) * | 1991-06-27 | 1993-10-22 | Bioeurope | Compositions cosmetiques contenant des glucooligosaccharides. |
SE9200199L (sv) * | 1992-01-24 | 1993-07-25 | Rune Soeremark | Farmaceutisk komposition och dess anvaendning |
HU212426B (en) * | 1992-07-22 | 1996-06-28 | Vepex Kft | Process for producing bioactive pharmaceutical compositions |
IT1255488B (it) * | 1992-08-04 | 1995-11-06 | Angelini Francesco Ist Ricerca | Polisaccaridi del glicogeno |
CN1039087C (zh) * | 1993-12-29 | 1998-07-15 | 昆明宏达实业有限总公司 | 妇科病治疗保健外用药物 |
DE19503423A1 (de) * | 1995-02-03 | 1996-08-08 | Beiersdorf Ag | Antiadhäsive Wirkstoffe |
JPH11504049A (ja) * | 1996-02-14 | 1999-04-06 | ザ、プロクター、エンド、ギャンブル、カンパニー | ツツジ科の植物種より由来する物質および乳酸バクテリア成長因子を含む泌尿生殖器および腸の疾患用の組成物 |
US6165997A (en) * | 1997-11-20 | 2000-12-26 | Statens Serum Institut | Phospholipids having antimicrobial activity with or without the presence of antimicrobials |
-
1998
- 1998-11-24 AU AU12230/99A patent/AU1223099A/en not_active Abandoned
- 1998-11-24 WO PCT/CN1998/000277 patent/WO1999026635A1/zh active IP Right Grant
- 1998-11-24 AT AT98955312T patent/ATE304362T1/de not_active IP Right Cessation
- 1998-11-24 DE DE69831609T patent/DE69831609T2/de not_active Expired - Lifetime
- 1998-11-24 EP EP98955312A patent/EP1072268B1/en not_active Expired - Lifetime
- 1998-11-24 DE DE69831878T patent/DE69831878D1/de not_active Expired - Fee Related
- 1998-11-24 CN CN98809507A patent/CN1120000C/zh not_active Expired - Fee Related
- 1998-11-24 EP EP98955313A patent/EP1072269B1/en not_active Expired - Lifetime
- 1998-11-24 WO PCT/CN1998/000278 patent/WO1999026636A1/zh active IP Right Grant
- 1998-11-24 AT AT98955313T patent/ATE306274T1/de not_active IP Right Cessation
- 1998-11-24 AU AU12231/99A patent/AU1223199A/en not_active Abandoned
- 1998-11-24 CN CN98809508A patent/CN1120001C/zh not_active Expired - Fee Related
-
2000
- 2000-05-24 US US09/577,858 patent/US6632796B1/en not_active Expired - Fee Related
- 2000-05-24 US US09/578,177 patent/US6440949B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1072268A4 (en) | 2003-09-03 |
EP1072269A4 (en) | 2003-08-27 |
WO1999026636A1 (fr) | 1999-06-03 |
ATE306274T1 (de) | 2005-10-15 |
EP1072269A1 (en) | 2001-01-31 |
DE69831609D1 (de) | 2005-10-20 |
CN1120000C (zh) | 2003-09-03 |
US6440949B1 (en) | 2002-08-27 |
US6632796B1 (en) | 2003-10-14 |
EP1072268B1 (en) | 2005-09-14 |
CN1271290A (zh) | 2000-10-25 |
DE69831878D1 (de) | 2006-02-23 |
EP1072268A1 (en) | 2001-01-31 |
EP1072269B1 (en) | 2005-10-12 |
WO1999026635A1 (fr) | 1999-06-03 |
ATE304362T1 (de) | 2005-09-15 |
DE69831609T2 (de) | 2006-02-02 |
CN1271291A (zh) | 2000-10-25 |
AU1223199A (en) | 1999-06-15 |
AU1223099A (en) | 1999-06-15 |
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