CN111991360A - 一种银耳多糖口服片及其制备工艺 - Google Patents

一种银耳多糖口服片及其制备工艺 Download PDF

Info

Publication number
CN111991360A
CN111991360A CN202011160879.8A CN202011160879A CN111991360A CN 111991360 A CN111991360 A CN 111991360A CN 202011160879 A CN202011160879 A CN 202011160879A CN 111991360 A CN111991360 A CN 111991360A
Authority
CN
China
Prior art keywords
oral tablet
tremella
tremella polysaccharide
weight parts
oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202011160879.8A
Other languages
English (en)
Inventor
吕国军
陈立
耿少特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhangjiagang Industry Technology Research Institute Co ltd Dalian Institute Of Chemical Physics Chinese Academy Of Sciences
Original Assignee
Zhangjiagang Industry Technology Research Institute Co ltd Dalian Institute Of Chemical Physics Chinese Academy Of Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhangjiagang Industry Technology Research Institute Co ltd Dalian Institute Of Chemical Physics Chinese Academy Of Sciences filed Critical Zhangjiagang Industry Technology Research Institute Co ltd Dalian Institute Of Chemical Physics Chinese Academy Of Sciences
Priority to CN202011160879.8A priority Critical patent/CN111991360A/zh
Publication of CN111991360A publication Critical patent/CN111991360A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

本发明提供了一种银耳多糖的口服片及其制备工艺，本口服片采用直接压片法制备，包括以下组分：银耳粉、羧甲基淀粉钠、交联聚维酮、微粉硅胶、D‑甘露醇、水溶性膳食纤维和预胶化淀粉。本口服片能够在少量水中迅速膨胀分散，可在缺水条件下在口腔中分散或者咀嚼后服用，有利于老年及吞咽困难人群服用，方便服用，且具有良好的营养价值。

Description

一种银耳多糖口服片及其制备工艺
技术领域
本发明属于天然活性多糖加工领域，特别涉及采用直接压片法制备银耳多糖口服片。
技术背景
银耳多糖是银耳子实体中的主要成分，约占银耳干重的60-70%。银耳多糖是主要以α-（1→3）-D-甘露糖为主链的杂多糖，具有改善机体免疫功能及提升白细胞数量的作用，以及降血脂、降血糖、抗溃疡、抗氧化、抗肿瘤、改善记忆力等功效，具有较高的药用价值和食用价值。
我国银耳资源丰富，开发以银耳多糖为主要成分的高附加值保健食品，提高人们的身体素质和生活质量，具有很好的应用前景，目前市面上已开发出银耳糖浆、口服液等。相较液体制品，固体银耳多糖制品具有更好的稳定性、存储运输方便。目前固体口服银耳多糖制品主要是速食产品，食用时需要加水冲泡，无法直接食用。
发明内容
本发明为了解决即食银耳多糖的加工技术，提供了一种银耳多糖口服片及其制备工艺，使口服片的崩解时间更短，在缺水条件下在口腔中分散或者咀嚼后服用，有利于老年及吞咽困难人群服用。
本发明的技术方案如下：
一种银耳多糖的口服片，组成为：每100重量份银耳粉中，加入5-30重量份羧甲基淀粉钠，5-30重量份交联聚维酮，5-40重量份微粉硅胶，5-50重量份D-甘露醇，5-50重量份水溶性膳食纤维，5-50预胶化淀粉。
进一步地，所述的银耳粉粒径为300-500目。
进一步地，所述的每100重量份银耳粉中，加入的羧甲基淀粉钠优选10-25重量份，加入的交联聚维酮优选10-25重量份。
本发明还包括一种银耳多糖的口服片的制备工艺，具体为：将上述组分按一定比例混合均匀后，使用压片机压片，采用直接压片法制备。
本发明的优点有：制备的银耳多糖口服片具有很好的崩解性能，能够在少量水中迅速膨胀分散，无需额外加水冲服或者冲泡，可在缺水条件下在口腔中分散或者咀嚼后服用，储存和运输方便，稳定性好，含银耳和有膳食纤维，具有良好的营养价值。
具体实施方式
实施例1
Figure 129437DEST_PATH_IMAGE002
单冲压片机，8mm浅圆冲头，20 MPa压力下制得1000片，根据《中华人民共和国药典》四部通则0921崩解时限检查法加测口服片的崩解时间，制得的口服片崩解时间小于60s。
实施例2
Figure 46577DEST_PATH_IMAGE004
单冲压片机，9mm浅圆冲头，25 MPa压力下制得1000片，根据《中华人民共和国药典》四部通则0921崩解时限检查法加测口服片的崩解时间，制得的口服片崩解时间小于120s。
实施例3
Figure 826314DEST_PATH_IMAGE006
单冲压片机，9mm浅圆冲头，25 MPa压力下制得1000片，根据《中华人民共和国药典》四部通则0921崩解时限检查法加测口服片的崩解时间，制得的口服片崩解时间小于60s。
实施例4
Figure 221524DEST_PATH_IMAGE008
单冲压片机，9mm浅圆冲头，25 MPa压力下制得1000片，根据《中华人民共和国药典》四部通则0921崩解时限检查法加测口服片的崩解时间，制得的口服片崩解时间小于60s。

Claims (5)

1.一种银耳多糖的口服片，其特征在于：口服片的组分为：银耳粉、羧甲基淀粉钠、交联聚维酮、微粉硅胶、D-甘露醇、水溶性膳食纤维、预胶化淀粉。
2.根据权利要求1所述的银耳多糖的口服片，其特征在于：所述口服片的组分为：每100重量份银耳粉中，加入5-30重量份羧甲基淀粉钠，5-30重量份交联聚维酮，5-40重量份微粉硅胶，5-50重量份D-甘露醇，5-50重量份水溶性膳食纤维，5-50预胶化淀粉。
3.根据权利要求2所述的银耳多糖的口服片，其特征在于：每100重量份银耳粉中，加入的羧甲基淀粉钠10-25重量份，加入的交联聚维酮10-25重量份。
4.根据权利要求1所述的银耳多糖的口服，其特征在于：所述的银耳粉粒径为300-500目。
5.权利要求1或2或3所述的银耳多糖的口服片的制备工艺，其特征在于：将所述组分按一定比例混合均匀后，使用压片机压片，采用直接压片法制备。
CN202011160879.8A 2020-10-27 2020-10-27 一种银耳多糖口服片及其制备工艺 Pending CN111991360A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011160879.8A CN111991360A (zh) 2020-10-27 2020-10-27 一种银耳多糖口服片及其制备工艺

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202011160879.8A CN111991360A (zh) 2020-10-27 2020-10-27 一种银耳多糖口服片及其制备工艺

Publications (1)

Publication Number Publication Date
CN111991360A true CN111991360A (zh) 2020-11-27

Family

ID=73475229

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202011160879.8A Pending CN111991360A (zh) 2020-10-27 2020-10-27 一种银耳多糖口服片及其制备工艺

Country Status (1)

Country Link
CN (1) CN111991360A (zh)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1698638A (zh) * 2004-05-17 2005-11-23 北京扬新科技有限公司 灯盏花素口腔崩解片及制备方法
CN1778824A (zh) * 2004-11-25 2006-05-31 中国医学科学院放射医学研究所 几种均一体银耳多糖及其提取方法和以该化合物为活性成分的药物组合物
CN102318835A (zh) * 2011-08-31 2012-01-18 石家庄中硕药业集团有限公司 一种减少骨质流失的组合物及其制备方法
CN104621550A (zh) * 2015-03-17 2015-05-20 成都大学 银耳咀嚼片及其制备方法
CN110558565A (zh) * 2019-10-14 2019-12-13 中华全国供销合作总社昆明食用菌研究所 一种金耳多糖咀嚼片及其制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1698638A (zh) * 2004-05-17 2005-11-23 北京扬新科技有限公司 灯盏花素口腔崩解片及制备方法
CN1778824A (zh) * 2004-11-25 2006-05-31 中国医学科学院放射医学研究所 几种均一体银耳多糖及其提取方法和以该化合物为活性成分的药物组合物
CN102318835A (zh) * 2011-08-31 2012-01-18 石家庄中硕药业集团有限公司 一种减少骨质流失的组合物及其制备方法
CN104621550A (zh) * 2015-03-17 2015-05-20 成都大学 银耳咀嚼片及其制备方法
CN110558565A (zh) * 2019-10-14 2019-12-13 中华全国供销合作总社昆明食用菌研究所 一种金耳多糖咀嚼片及其制备方法

Similar Documents

Publication Publication Date Title
CN1663573B (zh) 一种稳定安全的微生态制剂及其制备方法和用途
CN101530207B (zh) 一种枸杞营养咀嚼片及其制备方法
CN101700094B (zh) 一种低糖食用菌菇脯的制备方法
CN101317666A (zh) 高效复合膳食纤维素及其制备方法
CN101849919A (zh) 口腔崩解型n-乙酰基葡萄糖胺片剂及其制造方法
CN105286021A (zh) 一种维生素c咀嚼片及其制备方法
CN104644609A (zh) 一种功能性咀嚼型软胶囊皮
CN107303280A (zh) 黄秋葵咀嚼片组合物及其制备方法
CN105661512A (zh) 一种水果酵素颗粒及其制备工艺
JP6045238B2 (ja) 増粘多糖類を含む錠剤
CN106723015A (zh) 一种具有抗疲劳和抗氧化功能的保健食品及其制备工艺
CN103766571A (zh) 一种含水苏糖的玛咖压片糖果和玛咖片
WO2018077275A1 (zh) 一种保护视力的组合物及其制备方法
CN109892662A (zh) 一种清肠轻身竹笋清香膳食纤维珍珠丸/膏
CN105725218A (zh) 竹笋膳食纤维口嚼片及其制备方法
CN108782934A (zh) 一种富含南瓜籽油的功能性压片糖果及其制备方法
CN104137992B (zh) 一种降血糖保健食品及其制备方法
CN111991360A (zh) 一种银耳多糖口服片及其制备工艺
CN107929489A (zh) 一种对胃粘膜损伤具有保护作用的组合物及其中药制剂、应用
CN107929393A (zh) 壳寡糖润喉口腔压片及其制备方法
CN106822097A (zh) 一种用于减肥的含奥利司他的药物组合物
CN107822132B (zh) 一种含玉米黄质、磷脂酰丝氨酸的即食枸杞子及制备方法
Nautyal et al. FDA-Approved Natural Disintrgrant for Fast Dissolving Tablets
CN111466579A (zh) 一种益生菌菊粉片剂及其制备方法
CN105166926A (zh) 一种野生番石榴降糖抗氧化口服片及制备方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20201127

WD01 Invention patent application deemed withdrawn after publication