CN111875665A - 用于细胞破碎和/或回收生物分子的微粒 - Google Patents

用于细胞破碎和/或回收生物分子的微粒 Download PDF

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Publication number
CN111875665A
CN111875665A CN202010556781.8A CN202010556781A CN111875665A CN 111875665 A CN111875665 A CN 111875665A CN 202010556781 A CN202010556781 A CN 202010556781A CN 111875665 A CN111875665 A CN 111875665A
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cell
microparticles
cells
biomolecules
resin
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Chinese (zh)
Inventor
R·哈恩
A·章格鲍尔
A·特列菲洛夫
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Boehringer Ingelheim RCV GmbH and Co KG
Sandoz AG
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Boehringer Ingelheim RCV GmbH and Co KG
Sandoz AG
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/16Organic material
    • B01J39/18Macromolecular compounds
    • B01J39/20Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361Ion-exchange
    • B01D15/362Cation-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361Ion-exchange
    • B01D15/363Anion-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/04Processes using organic exchangers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/04Processes using organic exchangers
    • B01J39/05Processes using organic exchangers in the strongly acidic form
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/04Processes using organic exchangers
    • B01J39/07Processes using organic exchangers in the weakly acidic form
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26Cation exchangers for chromatographic processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/04Processes using organic exchangers
    • B01J41/05Processes using organic exchangers in the strongly basic form
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/04Processes using organic exchangers
    • B01J41/07Processes using organic exchangers in the weakly basic form
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/08Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/12Macromolecular compounds
    • B01J41/14Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20Anion exchangers for chromatographic processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00Ion-exchange processes in general; Apparatus therefor
    • B01J47/02Column or bed processes
    • B01J47/04Mixed-bed processes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/18Ion-exchange chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/101Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0089Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
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    • C12Y115/00Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001Superoxide dismutase (1.15.1.1)

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  • Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
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  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202010556781.8A 2013-08-23 2014-08-25 用于细胞破碎和/或回收生物分子的微粒 Pending CN111875665A (zh)

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Application Number Priority Date Filing Date Title
EP13181540.9 2013-08-23
EP13181540 2013-08-23
EP13181537.5 2013-08-23
EP13181537 2013-08-23
CN201480058620.9A CN105683210B (zh) 2013-08-23 2014-08-25 用于细胞破碎和/或回收生物分子的微粒

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CN201480058100.8A Expired - Fee Related CN105764914B (zh) 2013-08-23 2014-08-25 新型吸附性组合物及其用途
CN201480058620.9A Expired - Fee Related CN105683210B (zh) 2013-08-23 2014-08-25 用于细胞破碎和/或回收生物分子的微粒
CN202010556781.8A Pending CN111875665A (zh) 2013-08-23 2014-08-25 用于细胞破碎和/或回收生物分子的微粒

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CN201480058620.9A Expired - Fee Related CN105683210B (zh) 2013-08-23 2014-08-25 用于细胞破碎和/或回收生物分子的微粒

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US (3) US10076749B2 (enExample)
EP (2) EP3036250A1 (enExample)
JP (3) JP2016530271A (enExample)
KR (2) KR20160065092A (enExample)
CN (3) CN105764914B (enExample)
AU (2) AU2014310479B2 (enExample)
CA (2) CA2919288A1 (enExample)
SG (3) SG11201600275PA (enExample)
WO (2) WO2015025063A1 (enExample)

Cited By (1)

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CN115404235A (zh) * 2022-09-16 2022-11-29 广东海天创新技术有限公司 酱醪中微生物总dna的提取方法

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AU2014310479B2 (en) * 2013-08-23 2020-01-30 Boehringer Ingelheim Rcv Gmbh & Co Kg Novel adsorbent composition and use thereof
US10626376B2 (en) * 2016-11-14 2020-04-21 St. Jude Children's Research Hospital Method for isolating and purifying adeno-associated virus particles using salt
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
KR101964242B1 (ko) * 2017-04-26 2019-04-01 한국과학기술원 복합 구조체를 이용한 진단 시스템 및 방법
CN108342382B (zh) * 2018-01-30 2020-12-15 广东海大畜牧兽医研究院有限公司 一种核酸快速提取方法及其试剂盒
CN109402112A (zh) * 2018-11-08 2019-03-01 华中农业大学 一种快速、低成本从鸡血中分离pcr模板的方法
CN110221010B (zh) * 2019-04-29 2021-12-14 贵州茅台酒股份有限公司 一种测定酱香型白酒大曲中吡喃酮类化合物的方法
JP7544339B2 (ja) * 2020-09-03 2024-09-03 日機装株式会社 被処理液の再生方法、被処理液の再生剤および被処理液の再生装置
US20220194791A1 (en) * 2020-12-22 2022-06-23 Tokyo Ohka Kogyo Co., Ltd. Method for producing aqueous solution of purified orthoperiodic acid, method for producing semiconductor device, and aqueous solution of orthoperiodic acid
CN112979352A (zh) * 2021-03-08 2021-06-18 亚太建设科技信息研究院有限公司 一种回收尿液中磷酸盐的方法
CN113337452A (zh) * 2021-04-19 2021-09-03 中国医学科学院医学生物学研究所 一种利用高密度cho-s细胞无血清培养表达制备双因子抗体的方法
WO2022260091A1 (ja) * 2021-06-10 2022-12-15 三菱ケミカル株式会社 合成吸着剤、抗体の精製方法及び抗体の製造方法
CN113607903B (zh) * 2021-07-30 2024-03-15 振德医疗用品股份有限公司 一种检测含有正电荷聚合物细菌内毒素的方法
CN115245814B (zh) * 2021-12-06 2023-08-11 青岛大学 一种由固废制备的固定床用吸附剂及其制备方法
WO2024132899A1 (en) * 2022-12-21 2024-06-27 Climeworks Ag Uses of amino sorbents for capturing of co2 from gas streams
CN116287077A (zh) * 2023-03-13 2023-06-23 山东至善硒生物科技有限公司 一种硒多肽的提取方法
CN118458887A (zh) * 2024-05-09 2024-08-09 中国科学院水生生物研究所 一种饮用水厂强化混凝除藻的方法
CN120330138B (zh) * 2025-06-20 2025-08-29 上海沐医医学生物工程有限公司 一种msc的培养基添加剂及其应用

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Publication number Priority date Publication date Assignee Title
CN115404235A (zh) * 2022-09-16 2022-11-29 广东海天创新技术有限公司 酱醪中微生物总dna的提取方法
CN115404235B (zh) * 2022-09-16 2025-06-13 广东海天创新技术有限公司 酱醪中微生物总dna的提取方法

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EP3036249A1 (en) 2016-06-29
CN105683210A (zh) 2016-06-15
EP3036249B1 (en) 2019-03-13
KR20160065093A (ko) 2016-06-08
AU2014310480B2 (en) 2020-03-05
CN105683210B (zh) 2020-07-14
CA2921883A1 (en) 2015-02-26
SG11201600574XA (en) 2016-02-26
CA2919288A1 (en) 2015-02-26
US20160200760A1 (en) 2016-07-14
WO2015025063A1 (en) 2015-02-26
JP2016530271A (ja) 2016-09-29
AU2014310480A1 (en) 2016-02-25
AU2014310479A1 (en) 2016-02-25
CN105764914A (zh) 2016-07-13
JP2020019799A (ja) 2020-02-06
CA2921883C (en) 2020-03-24
US10076749B2 (en) 2018-09-18
JP2016531128A (ja) 2016-10-06
US20160193598A1 (en) 2016-07-07
US10537887B2 (en) 2020-01-21
US20190046969A1 (en) 2019-02-14
SG11201600275PA (en) 2016-02-26
KR20160065092A (ko) 2016-06-08
AU2014310479B2 (en) 2020-01-30
EP3036250A1 (en) 2016-06-29
CN105764914B (zh) 2020-12-25
US10661264B2 (en) 2020-05-26
WO2015025062A1 (en) 2015-02-26
SG10201801371PA (en) 2018-04-27

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Application publication date: 20201103