CN1116281C - 丙烯酰取代的偏端霉素衍生物,其制备方法,及其作为抗肿瘤和抗病毒剂的应用 - Google Patents
丙烯酰取代的偏端霉素衍生物,其制备方法,及其作为抗肿瘤和抗病毒剂的应用 Download PDFInfo
- Publication number
- CN1116281C CN1116281C CN97196737A CN97196737A CN1116281C CN 1116281 C CN1116281 C CN 1116281C CN 97196737 A CN97196737 A CN 97196737A CN 97196737 A CN97196737 A CN 97196737A CN 1116281 C CN1116281 C CN 1116281C
- Authority
- CN
- China
- Prior art keywords
- methyl
- pyrroles
- formamido group
- group
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (7)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9615692.2 | 1996-07-25 | ||
GBGB9615692.2A GB9615692D0 (en) | 1996-07-25 | 1996-07-25 | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1226232A CN1226232A (zh) | 1999-08-18 |
CN1116281C true CN1116281C (zh) | 2003-07-30 |
Family
ID=10797527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN97196737A Expired - Fee Related CN1116281C (zh) | 1996-07-25 | 1997-07-10 | 丙烯酰取代的偏端霉素衍生物,其制备方法,及其作为抗肿瘤和抗病毒剂的应用 |
Country Status (27)
Country | Link |
---|---|
US (2) | US6482920B1 (zh) |
EP (1) | EP0915845B1 (zh) |
JP (1) | JP4312264B2 (zh) |
KR (1) | KR100408538B1 (zh) |
CN (1) | CN1116281C (zh) |
AR (1) | AR007997A1 (zh) |
AT (1) | ATE205476T1 (zh) |
AU (1) | AU724511B2 (zh) |
BR (1) | BR9710717A (zh) |
CA (1) | CA2260060C (zh) |
DE (1) | DE69706690T2 (zh) |
DK (1) | DK0915845T3 (zh) |
EA (1) | EA001863B1 (zh) |
ES (1) | ES2164366T3 (zh) |
GB (1) | GB9615692D0 (zh) |
HK (1) | HK1020948A1 (zh) |
HU (1) | HU224635B1 (zh) |
IL (1) | IL127689A (zh) |
MY (1) | MY124103A (zh) |
NO (1) | NO310817B1 (zh) |
NZ (1) | NZ334082A (zh) |
PL (1) | PL199865B1 (zh) |
PT (1) | PT915845E (zh) |
TW (1) | TW360652B (zh) |
UA (1) | UA61922C2 (zh) |
WO (1) | WO1998004524A1 (zh) |
ZA (1) | ZA976549B (zh) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9806689D0 (en) * | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents |
GB9928703D0 (en) * | 1999-12-03 | 2000-02-02 | Pharmacia & Upjohn Spa | Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents |
US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
PE20011277A1 (es) * | 2000-04-14 | 2002-01-07 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis |
GB0011059D0 (en) * | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
GB0015446D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
GB0015447D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
GB0015444D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors |
GB0016447D0 (en) | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
GB0017852D0 (en) * | 2000-07-20 | 2000-09-06 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
US6576612B1 (en) * | 2000-10-02 | 2003-06-10 | Pharmacia Italia S.P.A. | Antitumor therapy comprising distamycin derivatives |
GB0029004D0 (en) * | 2000-11-28 | 2001-01-10 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
EP1470119A4 (en) * | 2001-06-13 | 2005-10-19 | Genesoft Pharmaceuticals Inc | BENZOTHIOPHENE COMPOUNDS WITH ANTI-INFECTIOUS ACTIVITY |
US6969592B2 (en) | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
RU2328306C2 (ru) * | 2002-01-02 | 2008-07-10 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л., | Комбинированная противоопухолевая терапия замещенными производными акрилоилдистамицина и ингибиторами протеинкиназ (серин-/треонинкиназы) |
ES2299692T3 (es) * | 2002-04-02 | 2008-06-01 | Nerviano Medical Sciences S.R.L. | Terapia combinada contra tumores que comprende derivados de distmicina acriloil sustituido y radioterapia. |
MX2018001517A (es) * | 2015-08-06 | 2018-06-19 | Ube Industries | Derivados sustituidos de guanidina. |
GB202114032D0 (en) * | 2021-09-30 | 2021-11-17 | Univ Strathclyde | Antivirals |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2178036A (en) * | 1985-07-16 | 1987-02-04 | Erba Farmitalia | Poly-4-aminopyrrole-2-carboxamido derivatives and process for their preparation |
EP0246868A1 (en) * | 1986-05-20 | 1987-11-25 | FARMITALIA CARLO ERBA S.r.l. | Site specific alkylating agents |
WO1990011277A1 (en) * | 1989-03-23 | 1990-10-04 | Farmitalia Carlo Erba S.R.L. | Acryloyl substituted pyrrole derivatives |
-
1996
- 1996-07-25 GB GBGB9615692.2A patent/GB9615692D0/en active Pending
-
1997
- 1997-07-10 DK DK97937474T patent/DK0915845T3/da active
- 1997-07-10 KR KR10-1999-7000409A patent/KR100408538B1/ko not_active IP Right Cessation
- 1997-07-10 AU AU40098/97A patent/AU724511B2/en not_active Ceased
- 1997-07-10 HU HU9903253A patent/HU224635B1/hu not_active IP Right Cessation
- 1997-07-10 WO PCT/EP1997/003719 patent/WO1998004524A1/en active IP Right Grant
- 1997-07-10 EP EP97937474A patent/EP0915845B1/en not_active Expired - Lifetime
- 1997-07-10 PL PL331344A patent/PL199865B1/pl unknown
- 1997-07-10 CN CN97196737A patent/CN1116281C/zh not_active Expired - Fee Related
- 1997-07-10 ES ES97937474T patent/ES2164366T3/es not_active Expired - Lifetime
- 1997-07-10 PT PT97937474T patent/PT915845E/pt unknown
- 1997-07-10 DE DE69706690T patent/DE69706690T2/de not_active Expired - Lifetime
- 1997-07-10 EA EA199900163A patent/EA001863B1/ru not_active IP Right Cessation
- 1997-07-10 CA CA002260060A patent/CA2260060C/en not_active Expired - Fee Related
- 1997-07-10 BR BR9710717A patent/BR9710717A/pt not_active IP Right Cessation
- 1997-07-10 NZ NZ334082A patent/NZ334082A/xx not_active IP Right Cessation
- 1997-07-10 US US09/147,573 patent/US6482920B1/en not_active Expired - Lifetime
- 1997-07-10 JP JP50842898A patent/JP4312264B2/ja not_active Expired - Fee Related
- 1997-07-10 AT AT97937474T patent/ATE205476T1/de active
- 1997-07-10 IL IL12768997A patent/IL127689A/xx not_active IP Right Cessation
- 1997-07-18 TW TW086110294A patent/TW360652B/zh not_active IP Right Cessation
- 1997-07-23 ZA ZA9706549A patent/ZA976549B/xx unknown
- 1997-07-25 AR ARP970103377A patent/AR007997A1/es active IP Right Grant
- 1997-07-25 MY MYPI97003389A patent/MY124103A/en unknown
- 1997-10-07 UA UA99021068A patent/UA61922C2/uk unknown
-
1999
- 1999-01-20 NO NO19990246A patent/NO310817B1/no not_active IP Right Cessation
- 1999-12-22 HK HK99106034A patent/HK1020948A1/xx not_active IP Right Cessation
-
2002
- 2002-07-17 US US10/196,363 patent/US20030023031A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2178036A (en) * | 1985-07-16 | 1987-02-04 | Erba Farmitalia | Poly-4-aminopyrrole-2-carboxamido derivatives and process for their preparation |
EP0246868A1 (en) * | 1986-05-20 | 1987-11-25 | FARMITALIA CARLO ERBA S.r.l. | Site specific alkylating agents |
WO1990011277A1 (en) * | 1989-03-23 | 1990-10-04 | Farmitalia Carlo Erba S.R.L. | Acryloyl substituted pyrrole derivatives |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: PHARMACIA ITALIA S.P.A. Free format text: FORMER OWNER: PHARMACIA + UPJOHN S.P.A. Effective date: 20020822 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20020822 Address after: Milan Italy Applicant after: Pharmacia & Up John S. P. A. Address before: Milan Italy Applicant before: The Upjohn Co. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: NERVIANO MEDICAL SCIENCES S R Free format text: FORMER OWNER: PHARMACIA ITALIA S.P.A. Effective date: 20061215 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20061215 Address after: Milan Italy Patentee after: Nerviano Medical Sciences SRL Address before: Milan Italy Patentee before: Pharmacia & Up John S. P. A. |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20030730 Termination date: 20160710 |
|
CF01 | Termination of patent right due to non-payment of annual fee |