UA61922C2 - Акрилоїлзаміщенa похідна дистаміцину, спосіб її одержання (варіанти) та фармацевтична композиція на її основі - Google Patents
Акрилоїлзаміщенa похідна дистаміцину, спосіб її одержання (варіанти) та фармацевтична композиція на її основі Download PDFInfo
- Publication number
- UA61922C2 UA61922C2 UA99021068A UA99021068A UA61922C2 UA 61922 C2 UA61922 C2 UA 61922C2 UA 99021068 A UA99021068 A UA 99021068A UA 99021068 A UA99021068 A UA 99021068A UA 61922 C2 UA61922 C2 UA 61922C2
- Authority
- UA
- Ukraine
- Prior art keywords
- methyl
- carboxamido
- pyrrole
- bromoacrylamido
- propion
- Prior art date
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- UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical class CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims description 19
- 239000002246 antineoplastic agent Substances 0.000 title abstract description 10
- 239000003443 antiviral agent Substances 0.000 title abstract description 5
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 title abstract 2
- 230000000118 anti-neoplastic effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 91
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 27
- 239000001257 hydrogen Substances 0.000 claims abstract description 27
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 20
- 150000003839 salts Chemical class 0.000 claims abstract description 18
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 10
- 150000002367 halogens Chemical class 0.000 claims abstract description 10
- 150000002431 hydrogen Chemical class 0.000 claims abstract description 6
- -1 pyrrole-2-carboxamido Chemical group 0.000 claims description 30
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 26
- RLZPCFQNZGINRP-UHFFFAOYSA-N n'-hydroxypropanimidamide Chemical compound CCC(N)=NO RLZPCFQNZGINRP-UHFFFAOYSA-N 0.000 claims description 15
- 229940080818 propionamide Drugs 0.000 claims description 15
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims description 14
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- 230000003993 interaction Effects 0.000 claims description 11
- 206010028980 Neoplasm Diseases 0.000 claims description 9
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9615692.2A GB9615692D0 (en) | 1996-07-25 | 1996-07-25 | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
| PCT/EP1997/003719 WO1998004524A1 (en) | 1996-07-25 | 1997-07-10 | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA61922C2 true UA61922C2 (uk) | 2003-12-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA99021068A UA61922C2 (uk) | 1996-07-25 | 1997-10-07 | Акрилоїлзаміщенa похідна дистаміцину, спосіб її одержання (варіанти) та фармацевтична композиція на її основі |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US6482920B1 (zh) |
| EP (1) | EP0915845B1 (zh) |
| JP (1) | JP4312264B2 (zh) |
| KR (1) | KR100408538B1 (zh) |
| CN (1) | CN1116281C (zh) |
| AR (1) | AR007997A1 (zh) |
| AT (1) | ATE205476T1 (zh) |
| AU (1) | AU724511B2 (zh) |
| BR (1) | BR9710717A (zh) |
| CA (1) | CA2260060C (zh) |
| DE (1) | DE69706690T2 (zh) |
| DK (1) | DK0915845T3 (zh) |
| EA (1) | EA001863B1 (zh) |
| ES (1) | ES2164366T3 (zh) |
| GB (1) | GB9615692D0 (zh) |
| HK (1) | HK1020948A1 (zh) |
| HU (1) | HU224635B1 (zh) |
| IL (1) | IL127689A (zh) |
| MY (1) | MY124103A (zh) |
| NO (1) | NO310817B1 (zh) |
| NZ (1) | NZ334082A (zh) |
| PL (1) | PL199865B1 (zh) |
| PT (1) | PT915845E (zh) |
| TW (1) | TW360652B (zh) |
| UA (1) | UA61922C2 (zh) |
| WO (1) | WO1998004524A1 (zh) |
| ZA (1) | ZA976549B (zh) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9806689D0 (en) * | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents |
| GB9928703D0 (en) * | 1999-12-03 | 2000-02-02 | Pharmacia & Upjohn Spa | Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents |
| US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
| PE20011277A1 (es) * | 2000-04-14 | 2002-01-07 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis |
| GB0011059D0 (en) * | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
| GB0015446D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
| GB0015447D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| GB0015444D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors |
| GB0016447D0 (en) | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| GB0017852D0 (en) * | 2000-07-20 | 2000-09-06 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| US6576612B1 (en) * | 2000-10-02 | 2003-06-10 | Pharmacia Italia S.P.A. | Antitumor therapy comprising distamycin derivatives |
| GB0029004D0 (en) * | 2000-11-28 | 2001-01-10 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| JP2005505508A (ja) * | 2001-06-13 | 2005-02-24 | ジーンソフト ファーマシューティカルズ インコーポレイテッド | 抗感染活性を有するベンゾチオフェン化合物 |
| US6969592B2 (en) | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
| MXPA04006543A (es) * | 2002-01-02 | 2004-10-04 | Pharmacia Italia Spa | Terapia combinada contra tumores, que comprende derivados de acriloildistamicina sustituida e inhibidores de serina/treonina cinasa. |
| KR100968657B1 (ko) * | 2002-04-02 | 2010-07-06 | 네르비아노 메디칼 사이언시스 에스.알.엘. | 치환된 아크릴로일 디스타마이신 유도체 및 방사선요법을포함하는 조합 종양 치료법 |
| CA2994924A1 (en) | 2015-08-06 | 2017-02-09 | Ube Industries, Ltd. | Substituted guanidine derivatives |
| GB202114032D0 (en) * | 2021-09-30 | 2021-11-17 | Univ Strathclyde | Antivirals |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE468642B (sv) * | 1985-07-16 | 1993-02-22 | Erba Farmitalia | Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition |
| GB8612218D0 (en) * | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
| GB8906709D0 (en) * | 1989-03-23 | 1989-05-10 | Creighton Andrew M | Acryloyl substituted pyrrole derivatives |
-
1996
- 1996-07-25 GB GBGB9615692.2A patent/GB9615692D0/en active Pending
-
1997
- 1997-07-10 BR BR9710717A patent/BR9710717A/pt not_active IP Right Cessation
- 1997-07-10 IL IL12768997A patent/IL127689A/xx not_active IP Right Cessation
- 1997-07-10 DE DE69706690T patent/DE69706690T2/de not_active Expired - Lifetime
- 1997-07-10 AU AU40098/97A patent/AU724511B2/en not_active Ceased
- 1997-07-10 WO PCT/EP1997/003719 patent/WO1998004524A1/en active IP Right Grant
- 1997-07-10 EP EP97937474A patent/EP0915845B1/en not_active Expired - Lifetime
- 1997-07-10 CN CN97196737A patent/CN1116281C/zh not_active Expired - Fee Related
- 1997-07-10 AT AT97937474T patent/ATE205476T1/de active
- 1997-07-10 PT PT97937474T patent/PT915845E/pt unknown
- 1997-07-10 NZ NZ334082A patent/NZ334082A/xx not_active IP Right Cessation
- 1997-07-10 EA EA199900163A patent/EA001863B1/ru not_active IP Right Cessation
- 1997-07-10 JP JP50842898A patent/JP4312264B2/ja not_active Expired - Fee Related
- 1997-07-10 PL PL331344A patent/PL199865B1/pl unknown
- 1997-07-10 KR KR10-1999-7000409A patent/KR100408538B1/ko not_active IP Right Cessation
- 1997-07-10 US US09/147,573 patent/US6482920B1/en not_active Expired - Lifetime
- 1997-07-10 DK DK97937474T patent/DK0915845T3/da active
- 1997-07-10 CA CA002260060A patent/CA2260060C/en not_active Expired - Fee Related
- 1997-07-10 ES ES97937474T patent/ES2164366T3/es not_active Expired - Lifetime
- 1997-07-10 HU HU9903253A patent/HU224635B1/hu not_active IP Right Cessation
- 1997-07-18 TW TW086110294A patent/TW360652B/zh not_active IP Right Cessation
- 1997-07-23 ZA ZA9706549A patent/ZA976549B/xx unknown
- 1997-07-25 AR ARP970103377A patent/AR007997A1/es active IP Right Grant
- 1997-07-25 MY MYPI97003389A patent/MY124103A/en unknown
- 1997-10-07 UA UA99021068A patent/UA61922C2/uk unknown
-
1999
- 1999-01-20 NO NO19990246A patent/NO310817B1/no not_active IP Right Cessation
- 1999-12-22 HK HK99106034A patent/HK1020948A1/xx not_active IP Right Cessation
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2002
- 2002-07-17 US US10/196,363 patent/US20030023031A1/en not_active Abandoned
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