ATE205476T1 - Acryloyl-substituierte distamycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als antitumor- und antivirale mittel - Google Patents

Acryloyl-substituierte distamycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als antitumor- und antivirale mittel

Info

Publication number
ATE205476T1
ATE205476T1 AT97937474T AT97937474T ATE205476T1 AT E205476 T1 ATE205476 T1 AT E205476T1 AT 97937474 T AT97937474 T AT 97937474T AT 97937474 T AT97937474 T AT 97937474T AT E205476 T1 ATE205476 T1 AT E205476T1
Authority
AT
Austria
Prior art keywords
acryloyl
antitumor
production
antiviral agents
distamycin derivatives
Prior art date
Application number
AT97937474T
Other languages
English (en)
Inventor
Paolo Cozzi
Italo Beria
Giovanni Biasoli
Marina Caldarelli
Laura Capolongo
Cristina Franzetti
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Application granted granted Critical
Publication of ATE205476T1 publication Critical patent/ATE205476T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT97937474T 1996-07-25 1997-07-10 Acryloyl-substituierte distamycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als antitumor- und antivirale mittel ATE205476T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9615692.2A GB9615692D0 (en) 1996-07-25 1996-07-25 Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
PCT/EP1997/003719 WO1998004524A1 (en) 1996-07-25 1997-07-10 Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Publications (1)

Publication Number Publication Date
ATE205476T1 true ATE205476T1 (de) 2001-09-15

Family

ID=10797527

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97937474T ATE205476T1 (de) 1996-07-25 1997-07-10 Acryloyl-substituierte distamycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als antitumor- und antivirale mittel

Country Status (27)

Country Link
US (2) US6482920B1 (de)
EP (1) EP0915845B1 (de)
JP (1) JP4312264B2 (de)
KR (1) KR100408538B1 (de)
CN (1) CN1116281C (de)
AR (1) AR007997A1 (de)
AT (1) ATE205476T1 (de)
AU (1) AU724511B2 (de)
BR (1) BR9710717A (de)
CA (1) CA2260060C (de)
DE (1) DE69706690T2 (de)
DK (1) DK0915845T3 (de)
EA (1) EA001863B1 (de)
ES (1) ES2164366T3 (de)
GB (1) GB9615692D0 (de)
HK (1) HK1020948A1 (de)
HU (1) HU224635B1 (de)
IL (1) IL127689A (de)
MY (1) MY124103A (de)
NO (1) NO310817B1 (de)
NZ (1) NZ334082A (de)
PL (1) PL199865B1 (de)
PT (1) PT915845E (de)
TW (1) TW360652B (de)
UA (1) UA61922C2 (de)
WO (1) WO1998004524A1 (de)
ZA (1) ZA976549B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9806689D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9928703D0 (en) * 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
PA8515201A1 (es) * 2000-04-14 2002-10-24 Agouron Pharma Compuestos y composiciones antipicornavirales; sus usos farmaceuticos y los materiales para su sintesis
GB0011059D0 (en) * 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
GB0017852D0 (en) * 2000-07-20 2000-09-06 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives
GB0029004D0 (en) * 2000-11-28 2001-01-10 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US6825228B2 (en) * 2001-06-13 2004-11-30 Genesoft Pharmaceuticals, Inc. Benzothiophene compounds having antiinfective activity
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
KR20040078118A (ko) * 2002-01-02 2004-09-08 파마시아 이탈리아 에스.피.에이. 치환된 아크릴로일 디스타마이신 유도체 및 단백질 키나제(세린/트레오닌 키나제) 저해제를 포함하는 항종양 조합요법
CA2481005C (en) * 2002-04-02 2009-06-09 Pharmacia Italia S.P.A. Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy
RU2733951C9 (ru) * 2015-08-06 2020-12-22 Убе Индастриз, Лтд. Замещенные производные гуанидина
GB202114032D0 (en) * 2021-09-30 2021-11-17 Univ Strathclyde Antivirals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387013B (de) * 1985-07-16 1988-11-25 Erba Farmitalia Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives

Also Published As

Publication number Publication date
AU4009897A (en) 1998-02-20
NO310817B1 (no) 2001-09-03
NO990246D0 (no) 1999-01-20
BR9710717A (pt) 1999-08-17
AR007997A1 (es) 1999-11-24
DK0915845T3 (da) 2002-01-07
IL127689A (en) 2003-07-31
KR100408538B1 (ko) 2004-01-13
IL127689A0 (en) 1999-10-28
EP0915845A1 (de) 1999-05-19
PL331344A1 (en) 1999-07-05
MY124103A (en) 2006-06-30
HK1020948A1 (en) 2000-05-26
HU224635B1 (hu) 2005-12-28
CA2260060A1 (en) 1998-02-05
CN1116281C (zh) 2003-07-30
CA2260060C (en) 2007-01-30
HUP9903253A2 (hu) 2000-02-28
CN1226232A (zh) 1999-08-18
JP2000515164A (ja) 2000-11-14
EP0915845B1 (de) 2001-09-12
US6482920B1 (en) 2002-11-19
TW360652B (en) 1999-06-11
EA001863B1 (ru) 2001-10-22
ES2164366T3 (es) 2002-02-16
ZA976549B (en) 1998-02-03
UA61922C2 (uk) 2003-12-15
PL199865B1 (pl) 2008-11-28
KR20000029448A (ko) 2000-05-25
US20030023031A1 (en) 2003-01-30
NZ334082A (en) 1999-08-30
EA199900163A1 (ru) 1999-08-26
GB9615692D0 (en) 1996-09-04
JP4312264B2 (ja) 2009-08-12
HUP9903253A3 (en) 2002-01-28
NO990246L (no) 1999-01-20
DE69706690T2 (de) 2002-06-20
AU724511B2 (en) 2000-09-21
DE69706690D1 (de) 2001-10-18
WO1998004524A1 (en) 1998-02-05
PT915845E (pt) 2002-03-28

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