ZA976549B - Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents. - Google Patents

Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents.

Info

Publication number
ZA976549B
ZA976549B ZA9706549A ZA976549A ZA976549B ZA 976549 B ZA976549 B ZA 976549B ZA 9706549 A ZA9706549 A ZA 9706549A ZA 976549 A ZA976549 A ZA 976549A ZA 976549 B ZA976549 B ZA 976549B
Authority
ZA
South Africa
Prior art keywords
antitumor
preparing
antiviral agents
distamycin derivatives
acryloyl substituted
Prior art date
Application number
ZA9706549A
Other languages
English (en)
Inventor
Paolo Cozzi
Italo Beria
Giovanni Biasoli
Marina Caldarelli
Laura Capolongo
Cristina Franzetti
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of ZA976549B publication Critical patent/ZA976549B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA9706549A 1996-07-25 1997-07-23 Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents. ZA976549B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9615692.2A GB9615692D0 (en) 1996-07-25 1996-07-25 Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Publications (1)

Publication Number Publication Date
ZA976549B true ZA976549B (en) 1998-02-03

Family

ID=10797527

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9706549A ZA976549B (en) 1996-07-25 1997-07-23 Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents.

Country Status (27)

Country Link
US (2) US6482920B1 (xx)
EP (1) EP0915845B1 (xx)
JP (1) JP4312264B2 (xx)
KR (1) KR100408538B1 (xx)
CN (1) CN1116281C (xx)
AR (1) AR007997A1 (xx)
AT (1) ATE205476T1 (xx)
AU (1) AU724511B2 (xx)
BR (1) BR9710717A (xx)
CA (1) CA2260060C (xx)
DE (1) DE69706690T2 (xx)
DK (1) DK0915845T3 (xx)
EA (1) EA001863B1 (xx)
ES (1) ES2164366T3 (xx)
GB (1) GB9615692D0 (xx)
HK (1) HK1020948A1 (xx)
HU (1) HU224635B1 (xx)
IL (1) IL127689A (xx)
MY (1) MY124103A (xx)
NO (1) NO310817B1 (xx)
NZ (1) NZ334082A (xx)
PL (1) PL199865B1 (xx)
PT (1) PT915845E (xx)
TW (1) TW360652B (xx)
UA (1) UA61922C2 (xx)
WO (1) WO1998004524A1 (xx)
ZA (1) ZA976549B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9806689D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9928703D0 (en) * 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
PE20011277A1 (es) * 2000-04-14 2002-01-07 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
GB0011059D0 (en) * 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
GB0017852D0 (en) * 2000-07-20 2000-09-06 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives
GB0029004D0 (en) * 2000-11-28 2001-01-10 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
JP2005505508A (ja) * 2001-06-13 2005-02-24 ジーンソフト ファーマシューティカルズ インコーポレイテッド 抗感染活性を有するベンゾチオフェン化合物
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
MXPA04006543A (es) * 2002-01-02 2004-10-04 Pharmacia Italia Spa Terapia combinada contra tumores, que comprende derivados de acriloildistamicina sustituida e inhibidores de serina/treonina cinasa.
KR100968657B1 (ko) * 2002-04-02 2010-07-06 네르비아노 메디칼 사이언시스 에스.알.엘. 치환된 아크릴로일 디스타마이신 유도체 및 방사선요법을포함하는 조합 종양 치료법
CA2994924A1 (en) 2015-08-06 2017-02-09 Ube Industries, Ltd. Substituted guanidine derivatives
GB202114032D0 (en) * 2021-09-30 2021-11-17 Univ Strathclyde Antivirals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE468642B (sv) * 1985-07-16 1993-02-22 Erba Farmitalia Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives

Also Published As

Publication number Publication date
CN1226232A (zh) 1999-08-18
NO990246D0 (no) 1999-01-20
GB9615692D0 (en) 1996-09-04
AU724511B2 (en) 2000-09-21
US20030023031A1 (en) 2003-01-30
NO310817B1 (no) 2001-09-03
CA2260060A1 (en) 1998-02-05
IL127689A0 (en) 1999-10-28
ATE205476T1 (de) 2001-09-15
AR007997A1 (es) 1999-11-24
JP2000515164A (ja) 2000-11-14
CA2260060C (en) 2007-01-30
CN1116281C (zh) 2003-07-30
MY124103A (en) 2006-06-30
NZ334082A (en) 1999-08-30
KR100408538B1 (ko) 2004-01-13
WO1998004524A1 (en) 1998-02-05
HUP9903253A2 (hu) 2000-02-28
ES2164366T3 (es) 2002-02-16
HK1020948A1 (en) 2000-05-26
AU4009897A (en) 1998-02-20
TW360652B (en) 1999-06-11
DK0915845T3 (da) 2002-01-07
EA199900163A1 (ru) 1999-08-26
DE69706690T2 (de) 2002-06-20
PT915845E (pt) 2002-03-28
DE69706690D1 (de) 2001-10-18
EP0915845B1 (en) 2001-09-12
EP0915845A1 (en) 1999-05-19
KR20000029448A (ko) 2000-05-25
PL331344A1 (en) 1999-07-05
US6482920B1 (en) 2002-11-19
HUP9903253A3 (en) 2002-01-28
BR9710717A (pt) 1999-08-17
EA001863B1 (ru) 2001-10-22
UA61922C2 (uk) 2003-12-15
NO990246L (no) 1999-01-20
HU224635B1 (hu) 2005-12-28
JP4312264B2 (ja) 2009-08-12
PL199865B1 (pl) 2008-11-28
IL127689A (en) 2003-07-31

Similar Documents

Publication Publication Date Title
AU5121698A (en) Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9823873D0 (en) 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents
ZA200201511B (en) 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents.
MXPA02001497A (es) Derivados de 3-(5)-ureido-pirazol, procedimiento para su preparacion y sus uso como agentes antitumorales.
AU1596097A (en) Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
ZA976549B (en) Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents.
ZA945655B (en) 1-Benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one derivatives
ZA9711317B (en) Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them.
ZA973883B (en) Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents.
AU3415499A (en) Acryloyl derivatives analogous to distamycin, process for preparing them, and their use as antitumor agents
ZA976329B (en) Substituted pyrazolylpyrazole derivatives, process for their preparation, and their use as herbicides.
SI0863139T1 (en) Benzoxazindione derivatives, process for their preparation and their use
HUP9902883A3 (en) Bis/acridinecarboxamide/ and bis/phenazinecarboxamide/ derivatives as antitumour agents, preparation and use thereof
AU2306595A (en) Dihydrodibenzo(de,h)isoquinolines derivatives and their use as anti-cancer agents
GB9602163D0 (en) Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9613987D0 (en) Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
SI1064281T1 (sl) Benzoheterociklicni distamicinski derivati, postopek za njihovo pripravo in njihova uporaba kot protitumorska sredstva