CN111417622A - 用于治疗与nlrp活性相关的病症的磺胺类及其组合物 - Google Patents

用于治疗与nlrp活性相关的病症的磺胺类及其组合物 Download PDF

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CN111417622A
CN111417622A CN201880077068.6A CN201880077068A CN111417622A CN 111417622 A CN111417622 A CN 111417622A CN 201880077068 A CN201880077068 A CN 201880077068A CN 111417622 A CN111417622 A CN 111417622A
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alkyl
aryl
membered
radical
alkoxy
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S·文卡特拉曼
S·古什
W·R·鲁什
沈东明
J·卡茨
H·M·塞德尔
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Novartis AG
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Novartis Inflammasome Research Inc
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    • C07D498/04—Ortho-condensed systems
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/04—Ortho-condensed systems

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  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
CN201880077068.6A 2017-10-17 2018-10-12 用于治疗与nlrp活性相关的病症的磺胺类及其组合物 Pending CN111417622A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762573562P 2017-10-17 2017-10-17
US62/573,562 2017-10-17
PCT/US2018/055576 WO2019079119A1 (en) 2017-10-17 2018-10-12 SULFONAMIDES AND ASSOCIATED COMPOSITIONS FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

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CN111417622A true CN111417622A (zh) 2020-07-14

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US (1) US11718631B2 (https=)
EP (1) EP3697758B1 (https=)
JP (1) JP7157804B2 (https=)
CN (1) CN111417622A (https=)
ES (1) ES2927851T3 (https=)
WO (1) WO2019079119A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114133345A (zh) * 2020-12-17 2022-03-04 顺毅宜昌化工有限公司 一种2-氯磺酰基-4-甲磺酰胺甲基苯甲酸甲酯的制备方法
WO2022237781A1 (zh) * 2021-05-10 2022-11-17 成都百裕制药股份有限公司 酰胺衍生物及其应用
WO2023078127A1 (zh) * 2021-11-03 2023-05-11 中国药科大学 大环磺酰胺类化合物及其制备方法和医药用途

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA49903A (fr) 2017-08-15 2020-06-24 Inflazome Ltd Sulfonylureés et sulfonylthioureés en tant qu'inhibiteurs de nlrp3
EP3759090A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
EP3759078A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
WO2019166627A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
US11530200B2 (en) 2018-03-02 2022-12-20 Inflazome Limited Compounds
JP2021529186A (ja) * 2018-07-03 2021-10-28 ノバルティス アーゲー Ｎｌｒｐ調節剤
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
KR20210053910A (ko) 2018-08-15 2021-05-12 인플라좀 리미티드 신규한 설폰아마이드유레아 화합물
GB201819083D0 (en) 2018-11-23 2019-01-09 Inflazome Ltd Novel compounds
GB201905265D0 (en) 2019-04-12 2019-05-29 Inflazome Ltd Inflammasome inhibition
EP3986879B1 (en) 2019-06-21 2024-10-02 AC Immune SA Fused 1,2-thiazoles and 1,2-thiazines which act as nlrp3 modulators
KR20220064364A (ko) 2019-07-17 2022-05-18 조마젠 바이오사이언시즈 엘티디 다발성 경화증(ms)의 치료를 위한 nlpr3 조절제로서의 n-((1,2,3,5,6,7-헥사하이드로-s-인다센-4-일)카바모일)-4,5,6,7-테트라하이드로벤조푸란-2-설폰아미드 유도체 및 관련 화합물
EP3999179A1 (en) 2019-07-17 2022-05-25 Zomagen Biosciences Ltd Nlrp3 modulators
WO2021032588A1 (en) 2019-08-16 2021-02-25 Inflazome Limited Macrocyclic sulfonylamide derivatives useful as nlrp3 inhibitors
US20220289692A1 (en) 2019-09-06 2022-09-15 Inflazome Limited Nlrp3 inhibitors
CN114641287A (zh) * 2019-11-07 2022-06-17 英夫拉索姆有限公司 神经退行性病症的治疗和预防
JP7392169B2 (ja) * 2019-11-12 2023-12-05 成都百裕制薬股▲ふん▼有限公司 アミド誘導体及びその調製方法並びに医薬における応用
PH12022552447A1 (en) 2020-03-16 2024-01-03 Zomagen Biosciences Ltd Nlrp3 modulators
AU2021257619A1 (en) 2020-04-15 2022-12-15 Janssen Pharmaceutica Nv Pyrazolo[1,5-d][1,2,4]triazine-5(4H)-acetamides as inhibitors of the NLRP3 inflammasome pathway
CN115485026A (zh) 2020-04-15 2022-12-16 詹森药业有限公司 Nlrp3炎体途径抑制剂吡唑并[1，2-d][1，2，4]三嗪-2-基-乙酰胺
EP4139312A1 (en) 2020-04-23 2023-03-01 JANSSEN Pharmaceutica NV Tricyclic compounds as inhibitors of nlrp3
MX2022013637A (es) 2020-04-30 2022-11-16 Janssen Pharmaceutica Nv Nuevos compuestos de triazinoindol.
US20230202989A1 (en) 2020-05-28 2023-06-29 Janssen Pharmaceutica Nv Compounds
AU2021291065B2 (en) 2020-06-19 2025-06-26 Ac Immune Sa Dihydrooxazole and thiourea or urea derivatives modulating the nlrp3 inflammasome pathway
US12577211B2 (en) 2020-06-29 2026-03-17 Bacainn Biotherapeutics, Ltd. Probenecid compounds for the treatment of inflammasome-mediated lung disease
WO2022023907A1 (en) 2020-07-31 2022-02-03 Novartis Ag Methods of selecting and treating patients at elevated risk of major adverse cardiac events
EP3974415A1 (en) 2020-09-24 2022-03-30 Janssen Pharmaceutica NV Nlrp3 modulators
CN116194445A (zh) 2020-09-24 2023-05-30 詹森药业有限公司 新化合物
CN116964052A (zh) 2021-03-04 2023-10-27 詹森药业有限公司 调节nlrp3的4-氨基-6-氧代-哒嗪衍生物
JP2024508017A (ja) 2021-03-04 2024-02-21 ヤンセン ファーマシューティカ エヌ．ベー． Ｎｌｒｐ３を調節する４－アルコキシ－６－オキソ－ピリダジン誘導体
US11932630B2 (en) 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
KR20240029027A (ko) 2021-07-01 2024-03-05 얀센 파마슈티카 엔브이 5-옥소-피리도[2,3-d]피리다진-6(5H)-일 아세트아미드
CN118541366A (zh) 2021-12-22 2024-08-23 Ac免疫有限公司 二氢噁唑衍生物化合物
US20250109154A1 (en) * 2022-01-27 2025-04-03 The University Of Tokyo Lysophosphatidylserine analogue, and lysophosphatidylserine analogue-containing phamaceutical composition for treating or preventing fibrosis
WO2023158824A1 (en) * 2022-02-21 2023-08-24 Viva Star Biosciences (Suzhou) Co., Ltd. Novel bicyclic substituted sulfonylurea compounds as inhibitors of interleukin- 1 activity
EP4554945A1 (en) 2022-07-14 2025-05-21 AC Immune SA Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway
GEAP202516743A (en) 2022-09-23 2025-08-11 Merck Sharp & Dohme Llc Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
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AR134646A1 (es) 2023-12-14 2026-02-04 Merck Sharp & Dohme Llc Derivados de indazol útiles como inhibidores de la proteína 3 del receptor similar a nod
US20250223290A1 (en) 2023-12-14 2025-07-10 Merck Sharp & Dohme Llc Azaindazole derivatives useful as inhibitors of nod-like receptor protein 3
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WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies
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WO2025163069A1 (en) 2024-01-31 2025-08-07 Ac Immune Sa Novel compounds
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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0513533A2 (de) * 1991-04-26 1992-11-19 Bayer Ag Heterocyclisch substituierte Phenylessigsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
CN1337953A (zh) * 1998-12-24 2002-02-27 卡罗生物股份公司 新的甲状腺受体配位体及方法ⅱ
CN1894231A (zh) * 2003-10-16 2007-01-10 阿斯特兰德英国有限公司 作为ep4受体拮抗剂的呋喃衍生物
WO2009080835A1 (en) * 2007-12-24 2009-07-02 Karo Bio Ab Thyromimetric compounds in treatment of disease related to sonic hedgehog signalling
CN103159674A (zh) * 2013-04-03 2013-06-19 苏州安诺生物医药技术有限公司 2-苯烷酰胺类化合物及其制备方法、药物组合物和用途
CN103172547A (zh) * 2011-12-20 2013-06-26 天津市国际生物医药联合研究院 磺酰胺衍生物的制备及其应用
WO2017129897A1 (fr) * 2016-01-25 2017-08-03 Galderma Research & Development Inhibiteurs nlrp3 pour le traitement des pathologies cutanées inflammatoires

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1270565E (pt) * 1997-01-29 2004-09-30 Pfizer Furano-2-sulfonamida 4-substituida e sua utilizacao na preparacao de derivados de sulfonilureia
AU7447500A (en) 1999-09-30 2001-04-30 Mitsubishi Chemical Corporation Acylsulfonamide derivatives
MXPA04001253A (es) * 2001-08-09 2004-06-03 Ono Pharmaceutical Co Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo.
US11447460B2 (en) * 2016-04-18 2022-09-20 Novartis Ag Compounds and compositions for treating conditions associated with NLRP activity

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0513533A2 (de) * 1991-04-26 1992-11-19 Bayer Ag Heterocyclisch substituierte Phenylessigsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
CN1337953A (zh) * 1998-12-24 2002-02-27 卡罗生物股份公司 新的甲状腺受体配位体及方法ⅱ
CN1894231A (zh) * 2003-10-16 2007-01-10 阿斯特兰德英国有限公司 作为ep4受体拮抗剂的呋喃衍生物
WO2009080835A1 (en) * 2007-12-24 2009-07-02 Karo Bio Ab Thyromimetric compounds in treatment of disease related to sonic hedgehog signalling
CN103172547A (zh) * 2011-12-20 2013-06-26 天津市国际生物医药联合研究院 磺酰胺衍生物的制备及其应用
CN103159674A (zh) * 2013-04-03 2013-06-19 苏州安诺生物医药技术有限公司 2-苯烷酰胺类化合物及其制备方法、药物组合物和用途
WO2017129897A1 (fr) * 2016-01-25 2017-08-03 Galderma Research & Development Inhibiteurs nlrp3 pour le traitement des pathologies cutanées inflammatoires

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ACS: "RN 1625968-73-1、1394694-20-2等", 《STN REGISTRY》 *
MARCELO ACTIS 等: "Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *
YIN LUO等: "Metronidazole acid acyl sulfonamide: A novel class of anticancer agents and potential EGFR tyrosine kinase inhibitors", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114133345A (zh) * 2020-12-17 2022-03-04 顺毅宜昌化工有限公司 一种2-氯磺酰基-4-甲磺酰胺甲基苯甲酸甲酯的制备方法
WO2022237781A1 (zh) * 2021-05-10 2022-11-17 成都百裕制药股份有限公司 酰胺衍生物及其应用
WO2023078127A1 (zh) * 2021-11-03 2023-05-11 中国药科大学 大环磺酰胺类化合物及其制备方法和医药用途

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