CN111212637A - 含苯甲酸酯的组合物治疗甘氨酸脑病的用途 - Google Patents

含苯甲酸酯的组合物治疗甘氨酸脑病的用途 Download PDF

Info

Publication number
CN111212637A
CN111212637A CN201880063022.9A CN201880063022A CN111212637A CN 111212637 A CN111212637 A CN 111212637A CN 201880063022 A CN201880063022 A CN 201880063022A CN 111212637 A CN111212637 A CN 111212637A
Authority
CN
China
Prior art keywords
patient
pharmaceutical composition
glycerol
effective amount
formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880063022.9A
Other languages
English (en)
Chinese (zh)
Inventor
卡利帕达·帕汉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rush University Medical Center
Original Assignee
Rush University Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rush University Medical Center filed Critical Rush University Medical Center
Publication of CN111212637A publication Critical patent/CN111212637A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201880063022.9A 2017-10-06 2018-09-26 含苯甲酸酯的组合物治疗甘氨酸脑病的用途 Pending CN111212637A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762569251P 2017-10-06 2017-10-06
US62/569,251 2017-10-06
PCT/US2018/052879 WO2019070478A1 (en) 2017-10-06 2018-09-26 USE OF A BENZOATE-CONTAINING COMPOSITION FOR TREATING GLYCINIC ENCEPHALOPATHY

Publications (1)

Publication Number Publication Date
CN111212637A true CN111212637A (zh) 2020-05-29

Family

ID=65994915

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880063022.9A Pending CN111212637A (zh) 2017-10-06 2018-09-26 含苯甲酸酯的组合物治疗甘氨酸脑病的用途

Country Status (10)

Country Link
US (1) US11304923B2 (https=)
EP (1) EP3691630A4 (https=)
JP (1) JP2020536098A (https=)
KR (1) KR20200065012A (https=)
CN (1) CN111212637A (https=)
AU (2) AU2018345244A1 (https=)
BR (1) BR112020005856A2 (https=)
CA (1) CA3078609A1 (https=)
EA (1) EA202090666A1 (https=)
WO (1) WO2019070478A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116600798A (zh) * 2020-12-16 2023-08-15 拉什大学医学中心 三苯甲酸甘油酯和苯丁酸甘油酯的给予用于治疗神经退行性疾病和尿素循环障碍

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020176432A1 (en) * 2019-02-25 2020-09-03 Rush University Medical Center Compositions including cinnamic acid and methods of use thereof
AU2020315331A1 (en) 2019-07-16 2022-02-03 Rush University Medical Center Use of a benzoate containing composition to treat neurodegenerative disorders
CN116390761A (zh) 2020-10-28 2023-07-04 拉什大学医学中心 肉桂酸苄酯组合物在治疗甘氨酸脑病和尿素循环障碍中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150011611A1 (en) * 2012-02-10 2015-01-08 Whitehead Institute For Biomedical Research Inhibition of the glycine cleavage system for treatment of cancer
US20160331714A1 (en) * 2014-01-17 2016-11-17 Rush University Medical Center The use of a benzoate containing composition in urea cycle disorders and neurodegenerative disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150011611A1 (en) * 2012-02-10 2015-01-08 Whitehead Institute For Biomedical Research Inhibition of the glycine cleavage system for treatment of cancer
US20160331714A1 (en) * 2014-01-17 2016-11-17 Rush University Medical Center The use of a benzoate containing composition in urea cycle disorders and neurodegenerative disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHRISTOFFEL PETRUS STEPHANUS BADENHORST: "A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids", 《DRUG METABOLISM REVIEWS》 *
JENNICA L. ZARO: "Lipid-based drug carriers for prodrugs to enhance drug delivery", 《THE AAPS JOURNA》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116600798A (zh) * 2020-12-16 2023-08-15 拉什大学医学中心 三苯甲酸甘油酯和苯丁酸甘油酯的给予用于治疗神经退行性疾病和尿素循环障碍

Also Published As

Publication number Publication date
KR20200065012A (ko) 2020-06-08
EA202090666A1 (ru) 2020-08-05
US20200281884A1 (en) 2020-09-10
EP3691630A4 (en) 2021-10-27
US11304923B2 (en) 2022-04-19
CA3078609A1 (en) 2019-04-11
AU2018345244A1 (en) 2020-04-02
BR112020005856A2 (pt) 2020-09-29
EP3691630A1 (en) 2020-08-12
AU2022200277A1 (en) 2022-02-03
JP2020536098A (ja) 2020-12-10
WO2019070478A1 (en) 2019-04-11

Similar Documents

Publication Publication Date Title
AU2022200277A1 (en) The use of a benzoate containing composition to treat glycine encephalopathy
US12478598B2 (en) Compositions including cinnamic acid and methods of use thereof
CN106573029B (zh) 用于治疗睡眠障碍的缬草根提取物和薰衣草油的组合物
US20230255910A1 (en) Use of a cinnamein composition for the treatment of glycine encephalopathy and urea cycle disorders
JP2024041898A (ja) 高用量の放出調節フペルジン製剤の使用
JP5523663B2 (ja) 歯根−歯周組織形成促進用医薬組成物
JP7206223B2 (ja) パーキンソン病の予防および／または支持治療処置のための物質
AU2018270505B2 (en) Modified release pharmaceutical compositions of huperzine and methods of using the same
CA3216699A1 (en) Blood carnitine-increasing agent
JP7335954B2 (ja) 白頭翁サポニンｂ４の抗急性痛風性関節炎の医薬における用途
US20240100008A1 (en) Administration of glycerol tribenzoate and glycerol phenylbutyrate for treatment of neurodegenerative and urea cycle disorders
US20140212478A1 (en) Method for preventing and/or treating periodontal disease
US12514842B2 (en) Use of a benzoate containing composition to treat neurodegenerative disorders
EP4104847B1 (en) Crocus sativus and probiotics for the treatment of depressive disorder and coprostasis
HK40075156A (en) Inhalation dosage forms of glycerol tribenzoate and/or glycerol dibenzoate for use in the treatment of huntington's disease
HK40075156B (en) Inhalation dosage forms of glycerol tribenzoate and/or glycerol dibenzoate for use in the treatment of huntington's disease
CN107951872B (zh) 一种治疗糖尿病的口服药物组合物
CN120732846A (zh) 吲哚乙酸在制备预防或治疗高血压产品中的用途
CN106138031A (zh) 桑辛素c在制备用于治疗糖尿病的药物中的应用
CN107595863A (zh) 一种用于降低血糖血脂的药物复方制剂及其用途

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20200529

RJ01 Rejection of invention patent application after publication