BR112020005856A2 - uso de uma composição contendo benzoato para tratar encefalopatia da glicina - Google Patents
uso de uma composição contendo benzoato para tratar encefalopatia da glicina Download PDFInfo
- Publication number
- BR112020005856A2 BR112020005856A2 BR112020005856-4A BR112020005856A BR112020005856A2 BR 112020005856 A2 BR112020005856 A2 BR 112020005856A2 BR 112020005856 A BR112020005856 A BR 112020005856A BR 112020005856 A2 BR112020005856 A2 BR 112020005856A2
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- BR
- Brazil
- Prior art keywords
- patient
- glyceryl
- formulation
- pharmaceutical composition
- tribenzoate
- Prior art date
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- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- CKQVRZJOMJRTOY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CKQVRZJOMJRTOY-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000003340 retarding agent Substances 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762569251P | 2017-10-06 | 2017-10-06 | |
| US62/569,251 | 2017-10-06 | ||
| PCT/US2018/052879 WO2019070478A1 (en) | 2017-10-06 | 2018-09-26 | USE OF A BENZOATE-CONTAINING COMPOSITION FOR TREATING GLYCINIC ENCEPHALOPATHY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112020005856A2 true BR112020005856A2 (pt) | 2020-09-29 |
Family
ID=65994915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112020005856-4A BR112020005856A2 (pt) | 2017-10-06 | 2018-09-26 | uso de uma composição contendo benzoato para tratar encefalopatia da glicina |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11304923B2 (https=) |
| EP (1) | EP3691630A4 (https=) |
| JP (1) | JP2020536098A (https=) |
| KR (1) | KR20200065012A (https=) |
| CN (1) | CN111212637A (https=) |
| AU (2) | AU2018345244A1 (https=) |
| BR (1) | BR112020005856A2 (https=) |
| CA (1) | CA3078609A1 (https=) |
| EA (1) | EA202090666A1 (https=) |
| WO (1) | WO2019070478A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020176432A1 (en) * | 2019-02-25 | 2020-09-03 | Rush University Medical Center | Compositions including cinnamic acid and methods of use thereof |
| AU2020315331A1 (en) | 2019-07-16 | 2022-02-03 | Rush University Medical Center | Use of a benzoate containing composition to treat neurodegenerative disorders |
| CN116390761A (zh) | 2020-10-28 | 2023-07-04 | 拉什大学医学中心 | 肉桂酸苄酯组合物在治疗甘氨酸脑病和尿素循环障碍中的应用 |
| CA3205005A1 (en) * | 2020-12-16 | 2022-06-23 | Rush University Medical Center | Administration of glycerol tribenzoate and glycerol phenylbutyrate for treatment of neurodegenerative and urea cycle disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2864161A1 (en) * | 2012-02-10 | 2013-08-15 | Whitehead Institute For Biomedical Research | Inhibition of the glycine cleavage system for treatment of cancer |
| JP6836905B2 (ja) * | 2014-01-17 | 2021-03-03 | ラッシュ・ユニバーシティ・メディカル・センター | 尿素サイクル障害及び神経変性障害におけるベンゾエート含有組成物の使用 |
-
2018
- 2018-09-26 EP EP18865150.9A patent/EP3691630A4/en active Pending
- 2018-09-26 KR KR1020207011606A patent/KR20200065012A/ko not_active Ceased
- 2018-09-26 EA EA202090666A patent/EA202090666A1/ru unknown
- 2018-09-26 WO PCT/US2018/052879 patent/WO2019070478A1/en not_active Ceased
- 2018-09-26 BR BR112020005856-4A patent/BR112020005856A2/pt not_active IP Right Cessation
- 2018-09-26 CN CN201880063022.9A patent/CN111212637A/zh active Pending
- 2018-09-26 JP JP2020519254A patent/JP2020536098A/ja active Pending
- 2018-09-26 AU AU2018345244A patent/AU2018345244A1/en not_active Abandoned
- 2018-09-26 CA CA3078609A patent/CA3078609A1/en active Pending
- 2018-09-26 US US16/648,422 patent/US11304923B2/en active Active
-
2022
- 2022-01-17 AU AU2022200277A patent/AU2022200277A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20200065012A (ko) | 2020-06-08 |
| CN111212637A (zh) | 2020-05-29 |
| EA202090666A1 (ru) | 2020-08-05 |
| US20200281884A1 (en) | 2020-09-10 |
| EP3691630A4 (en) | 2021-10-27 |
| US11304923B2 (en) | 2022-04-19 |
| CA3078609A1 (en) | 2019-04-11 |
| AU2018345244A1 (en) | 2020-04-02 |
| EP3691630A1 (en) | 2020-08-12 |
| AU2022200277A1 (en) | 2022-02-03 |
| JP2020536098A (ja) | 2020-12-10 |
| WO2019070478A1 (en) | 2019-04-11 |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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