CN111201245B - 化合物、组合物和方法 - Google Patents
化合物、组合物和方法 Download PDFInfo
- Publication number
- CN111201245B CN111201245B CN201880063335.4A CN201880063335A CN111201245B CN 111201245 B CN111201245 B CN 111201245B CN 201880063335 A CN201880063335 A CN 201880063335A CN 111201245 B CN111201245 B CN 111201245B
- Authority
- CN
- China
- Prior art keywords
- optionally substituted
- compound
- heterocyclyl
- alkyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762553750P | 2017-09-01 | 2017-09-01 | |
| US62/553,750 | 2017-09-01 | ||
| US201762609267P | 2017-12-21 | 2017-12-21 | |
| US62/609,267 | 2017-12-21 | ||
| US201862634721P | 2018-02-23 | 2018-02-23 | |
| US62/634,721 | 2018-02-23 | ||
| US201862697281P | 2018-07-12 | 2018-07-12 | |
| US62/697,281 | 2018-07-12 | ||
| PCT/US2018/049197 WO2019046779A1 (en) | 2017-09-01 | 2018-08-31 | COMPOUNDS, COMPOSITIONS AND METHODS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111201245A CN111201245A (zh) | 2020-05-26 |
| CN111201245B true CN111201245B (zh) | 2024-04-05 |
Family
ID=65526108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880063335.4A Active CN111201245B (zh) | 2017-09-01 | 2018-08-31 | 化合物、组合物和方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US12139478B2 (enExample) |
| EP (2) | EP4248965A3 (enExample) |
| JP (3) | JP7382308B2 (enExample) |
| CN (1) | CN111201245B (enExample) |
| CA (1) | CA3072057A1 (enExample) |
| DK (1) | DK3676297T3 (enExample) |
| ES (1) | ES2952994T3 (enExample) |
| FI (1) | FI3676297T3 (enExample) |
| HU (1) | HUE062446T2 (enExample) |
| MA (1) | MA50063A (enExample) |
| PL (1) | PL3676297T3 (enExample) |
| PT (1) | PT3676297T (enExample) |
| SI (1) | SI3676297T1 (enExample) |
| TW (1) | TW201920129A (enExample) |
| WO (1) | WO2019046779A1 (enExample) |
Families Citing this family (21)
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| MA49858A (fr) | 2017-08-09 | 2021-04-28 | Denali Therapeutics Inc | Composés, compositions et procédés |
| JP7382308B2 (ja) | 2017-09-01 | 2023-11-16 | デナリ セラピューティクス インコーポレイテッド | 化合物、組成物、及び、方法 |
| WO2019090088A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| EP3723762A4 (en) | 2017-12-13 | 2021-12-08 | Praxis Biotech LLC | STRESS INTEGRATED RESPONSE PATH INHIBITORS |
| WO2019236710A1 (en) | 2018-06-05 | 2019-12-12 | Praxis Biotech LLC | Inhibitors of integrated stress response pathway |
| TWI771621B (zh) | 2018-10-11 | 2022-07-21 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
| CA3129609A1 (en) | 2019-02-13 | 2020-08-20 | Denali Therapeutics Inc. | Eukaryotic initiation factor 2b modulators |
| EP3924341A4 (en) | 2019-02-13 | 2022-11-02 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| KR20220004105A (ko) * | 2019-04-23 | 2022-01-11 | 에보텍 인터내셔널 게엠베하 | 통합 스트레스 반응 경로의 조절제 |
| EA202192900A1 (ru) * | 2019-04-23 | 2022-03-18 | Эвотек Интернешнл Гмбх | Модуляторы пути интегрированной реакции на стресс |
| AU2020264485A1 (en) * | 2019-04-30 | 2021-12-02 | Abbvie Inc. | Substituted cycloalkyls as modulators of the integrated stress pathway |
| CN114466654A (zh) | 2019-06-12 | 2022-05-10 | 普拉西斯生物技术有限责任公司 | 整合应激反应通路调节剂 |
| KR20220133252A (ko) | 2020-01-28 | 2022-10-04 | 에보텍 인터내셔널 게엠베하 | 통합 스트레스 반응 경로의 조절자 |
| US12441720B2 (en) | 2020-03-11 | 2025-10-14 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
| MX2023004677A (es) * | 2020-10-22 | 2023-05-24 | Evotec Int Gmbh | Moduladores de la via de respuesta integrada al estres. |
| CN116761803A (zh) * | 2020-10-22 | 2023-09-15 | 埃沃特克国际有限责任公司 | 整合应激反应途径的调节剂 |
| LT4232154T (lt) * | 2020-10-22 | 2025-02-10 | Evotec International Gmbh | Integruoto streso atsako kelio moduliatoriai |
| KR20230110511A (ko) | 2020-10-22 | 2023-07-24 | 에보텍 인터내셔널 게엠베하 | 통합 스트레스 반응 경로의 조절제 |
| IL302440A (en) * | 2020-10-30 | 2023-06-01 | Calico Life Sciences Llc | Combined pressure pathway modulators |
| CN116768877A (zh) * | 2022-05-30 | 2023-09-19 | 中国药科大学 | Isr抑制剂及其制备方法和应用 |
| TW202440081A (zh) * | 2023-03-14 | 2024-10-16 | 美商人福醫藥美國公司 | σ-1受體拮抗劑及其應用 |
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| KR20220133252A (ko) | 2020-01-28 | 2022-10-04 | 에보텍 인터내셔널 게엠베하 | 통합 스트레스 반응 경로의 조절자 |
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| JP2020532506A (ja) | 2020-11-12 |
| EP4248965A2 (en) | 2023-09-27 |
| MA50063A (fr) | 2021-04-28 |
| US20200331900A1 (en) | 2020-10-22 |
| CN111201245A (zh) | 2020-05-26 |
| EP3676297A4 (en) | 2021-04-28 |
| ES2952994T3 (es) | 2023-11-07 |
| JP2023060020A (ja) | 2023-04-27 |
| DK3676297T3 (da) | 2023-08-14 |
| TW201920129A (zh) | 2019-06-01 |
| HUE062446T2 (hu) | 2023-11-28 |
| US12139478B2 (en) | 2024-11-12 |
| PL3676297T3 (pl) | 2023-12-11 |
| CA3072057A1 (en) | 2019-03-07 |
| FI3676297T3 (fi) | 2023-08-08 |
| PT3676297T (pt) | 2023-08-29 |
| EP3676297A1 (en) | 2020-07-08 |
| JP2024086819A (ja) | 2024-06-28 |
| EP3676297B1 (en) | 2023-05-17 |
| SI3676297T1 (sl) | 2023-12-29 |
| WO2019046779A1 (en) | 2019-03-07 |
| EP4248965A3 (en) | 2023-11-22 |
| JP7382308B2 (ja) | 2023-11-16 |
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