TW201920129A - 化合物、組合物及方法 - Google Patents

化合物、組合物及方法 Download PDF

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Publication number
TW201920129A
TW201920129A TW107130678A TW107130678A TW201920129A TW 201920129 A TW201920129 A TW 201920129A TW 107130678 A TW107130678 A TW 107130678A TW 107130678 A TW107130678 A TW 107130678A TW 201920129 A TW201920129 A TW 201920129A
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TW
Taiwan
Prior art keywords
alkyl
independently
group
halo
cycloalkyl
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TW107130678A
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English (en)
Chinese (zh)
Inventor
羅伯特 A 二世 奎格
安東尼 A 艾斯特達
健文 馮
卡特琳娜 W 萊克薩
邁可森 歐希波夫
札克利 K 史溫利
強維爾 迪 文森 費達戈
Original Assignee
美商戴納立製藥公司
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Application filed by 美商戴納立製藥公司 filed Critical 美商戴納立製藥公司
Publication of TW201920129A publication Critical patent/TW201920129A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
TW107130678A 2017-09-01 2018-08-31 化合物、組合物及方法 TW201920129A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201762553750P 2017-09-01 2017-09-01
US62/553,750 2017-09-01
US201762609267P 2017-12-21 2017-12-21
US62/609,267 2017-12-21
US201862634721P 2018-02-23 2018-02-23
US62/634,721 2018-02-23
US201862697281P 2018-07-12 2018-07-12
US62/697,281 2018-07-12

Publications (1)

Publication Number Publication Date
TW201920129A true TW201920129A (zh) 2019-06-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW107130678A TW201920129A (zh) 2017-09-01 2018-08-31 化合物、組合物及方法

Country Status (15)

Country Link
US (1) US12139478B2 (enExample)
EP (2) EP3676297B1 (enExample)
JP (3) JP7382308B2 (enExample)
CN (1) CN111201245B (enExample)
CA (1) CA3072057A1 (enExample)
DK (1) DK3676297T3 (enExample)
ES (1) ES2952994T3 (enExample)
FI (1) FI3676297T3 (enExample)
HU (1) HUE062446T2 (enExample)
MA (1) MA50063A (enExample)
PL (1) PL3676297T3 (enExample)
PT (1) PT3676297T (enExample)
SI (1) SI3676297T1 (enExample)
TW (1) TW201920129A (enExample)
WO (1) WO2019046779A1 (enExample)

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JP2023517944A (ja) * 2020-03-11 2023-04-27 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 統合的ストレス応答経路の調節因子
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CN116761803A (zh) * 2020-10-22 2023-09-15 埃沃特克国际有限责任公司 整合应激反应途径的调节剂
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EP4237413A1 (en) * 2020-10-30 2023-09-06 Calico Life Sciences LLC Modulators of the integrated stress pathway
CN116768877A (zh) * 2022-05-30 2023-09-19 中国药科大学 Isr抑制剂及其制备方法和应用
TW202440081A (zh) * 2023-03-14 2024-10-16 美商人福醫藥美國公司 σ-1受體拮抗劑及其應用

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Also Published As

Publication number Publication date
US20200331900A1 (en) 2020-10-22
MA50063A (fr) 2021-04-28
PT3676297T (pt) 2023-08-29
EP3676297A1 (en) 2020-07-08
PL3676297T3 (pl) 2023-12-11
CA3072057A1 (en) 2019-03-07
JP7382308B2 (ja) 2023-11-16
EP3676297B1 (en) 2023-05-17
FI3676297T3 (fi) 2023-08-08
EP4248965A2 (en) 2023-09-27
HUE062446T2 (hu) 2023-11-28
SI3676297T1 (sl) 2023-12-29
CN111201245A (zh) 2020-05-26
JP2023060020A (ja) 2023-04-27
JP2020532506A (ja) 2020-11-12
US12139478B2 (en) 2024-11-12
DK3676297T3 (da) 2023-08-14
EP4248965A3 (en) 2023-11-22
CN111201245B (zh) 2024-04-05
ES2952994T3 (es) 2023-11-07
JP2024086819A (ja) 2024-06-28
EP3676297A4 (en) 2021-04-28
WO2019046779A1 (en) 2019-03-07

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