CA3072057A1 - Small molecule modulators of eukaryotic initiation factor 2b - Google Patents
Small molecule modulators of eukaryotic initiation factor 2b Download PDFInfo
- Publication number
- CA3072057A1 CA3072057A1 CA3072057A CA3072057A CA3072057A1 CA 3072057 A1 CA3072057 A1 CA 3072057A1 CA 3072057 A CA3072057 A CA 3072057A CA 3072057 A CA3072057 A CA 3072057A CA 3072057 A1 CA3072057 A1 CA 3072057A1
- Authority
- CA
- Canada
- Prior art keywords
- optionally substituted
- alkyl
- heterocyclyl
- halo
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762553750P | 2017-09-01 | 2017-09-01 | |
| US62/553,750 | 2017-09-01 | ||
| US201762609267P | 2017-12-21 | 2017-12-21 | |
| US62/609,267 | 2017-12-21 | ||
| US201862634721P | 2018-02-23 | 2018-02-23 | |
| US62/634,721 | 2018-02-23 | ||
| US201862697281P | 2018-07-12 | 2018-07-12 | |
| US62/697,281 | 2018-07-12 | ||
| PCT/US2018/049197 WO2019046779A1 (en) | 2017-09-01 | 2018-08-31 | COMPOUNDS, COMPOSITIONS AND METHODS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3072057A1 true CA3072057A1 (en) | 2019-03-07 |
Family
ID=65526108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3072057A Pending CA3072057A1 (en) | 2017-09-01 | 2018-08-31 | Small molecule modulators of eukaryotic initiation factor 2b |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US12139478B2 (enExample) |
| EP (2) | EP3676297B1 (enExample) |
| JP (3) | JP7382308B2 (enExample) |
| CN (1) | CN111201245B (enExample) |
| CA (1) | CA3072057A1 (enExample) |
| DK (1) | DK3676297T3 (enExample) |
| ES (1) | ES2952994T3 (enExample) |
| FI (1) | FI3676297T3 (enExample) |
| HU (1) | HUE062446T2 (enExample) |
| MA (1) | MA50063A (enExample) |
| PL (1) | PL3676297T3 (enExample) |
| PT (1) | PT3676297T (enExample) |
| SI (1) | SI3676297T1 (enExample) |
| TW (1) | TW201920129A (enExample) |
| WO (1) | WO2019046779A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118239938A (zh) | 2017-08-09 | 2024-06-25 | 戴纳立制药公司 | 化合物、组合物及方法 |
| EP3676297B1 (en) | 2017-09-01 | 2023-05-17 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| JP2021501785A (ja) | 2017-11-02 | 2021-01-21 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤 |
| MX2020006115A (es) | 2017-12-13 | 2020-11-09 | Praxis Biotech LLC | Inhibidores de la vía de respuesta al estrés integrada. |
| AU2019282253A1 (en) | 2018-06-05 | 2020-11-26 | Altos Labs, Inc. | Inhibitors of integrated stress response pathway |
| TWI877863B (zh) | 2018-10-11 | 2025-03-21 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
| CA3129609A1 (en) | 2019-02-13 | 2020-08-20 | Denali Therapeutics Inc. | Eukaryotic initiation factor 2b modulators |
| WO2020167994A1 (en) | 2019-02-13 | 2020-08-20 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| US12258338B2 (en) * | 2019-04-23 | 2025-03-25 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
| US20220213078A1 (en) * | 2019-04-23 | 2022-07-07 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
| TW202106679A (zh) * | 2019-04-30 | 2021-02-16 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之調節劑 |
| CA3142748A1 (en) | 2019-06-12 | 2020-12-17 | Praxis Biotech LLC | Modulators of integrated stress response pathway |
| AU2021213289A1 (en) | 2020-01-28 | 2022-07-07 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
| JP2023517944A (ja) * | 2020-03-11 | 2023-04-27 | エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 統合的ストレス応答経路の調節因子 |
| LT4232154T (lt) | 2020-10-22 | 2025-02-10 | Evotec International Gmbh | Integruoto streso atsako kelio moduliatoriai |
| WO2022084446A1 (en) | 2020-10-22 | 2022-04-28 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
| CN116761803A (zh) * | 2020-10-22 | 2023-09-15 | 埃沃特克国际有限责任公司 | 整合应激反应途径的调节剂 |
| JP2023546226A (ja) * | 2020-10-22 | 2023-11-01 | エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 統合ストレス応答経路のモジュレーター |
| TW202233580A (zh) * | 2020-10-30 | 2022-09-01 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之調節劑 |
| CN116768877A (zh) * | 2022-05-30 | 2023-09-19 | 中国药科大学 | Isr抑制剂及其制备方法和应用 |
| TW202440081A (zh) * | 2023-03-14 | 2024-10-16 | 美商人福醫藥美國公司 | σ-1受體拮抗劑及其應用 |
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| CN118239938A (zh) | 2017-08-09 | 2024-06-25 | 戴纳立制药公司 | 化合物、组合物及方法 |
| EP3676297B1 (en) | 2017-09-01 | 2023-05-17 | Denali Therapeutics Inc. | Compounds, compositions and methods |
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| JP7184889B2 (ja) | 2017-11-02 | 2022-12-06 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤 |
| JP7307057B2 (ja) | 2017-11-02 | 2023-07-11 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤 |
| UY37956A (es) | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| IL274367B2 (en) | 2017-11-02 | 2023-10-01 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| JP2021501785A (ja) | 2017-11-02 | 2021-01-21 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤 |
| SG11202004009TA (en) | 2017-11-02 | 2020-05-28 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
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| WO2020031107A1 (en) | 2018-08-08 | 2020-02-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds |
| TWI877863B (zh) | 2018-10-11 | 2025-03-21 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
| WO2020167994A1 (en) | 2019-02-13 | 2020-08-20 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| CA3129609A1 (en) | 2019-02-13 | 2020-08-20 | Denali Therapeutics Inc. | Eukaryotic initiation factor 2b modulators |
| US20220177456A1 (en) | 2019-03-06 | 2022-06-09 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| US12258338B2 (en) | 2019-04-23 | 2025-03-25 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
| TW202106679A (zh) | 2019-04-30 | 2021-02-16 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之調節劑 |
| US20210363136A1 (en) | 2019-04-30 | 2021-11-25 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| AU2021213289A1 (en) | 2020-01-28 | 2022-07-07 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
| EP4263488A4 (en) | 2020-12-18 | 2024-11-27 | Denali Therapeutics Inc. | SOLID FORMS OF A CONNECTION |
| US20250376432A1 (en) | 2022-06-23 | 2025-12-11 | Denali Therapeutics Inc. | Process for preparing modulators of eukaryotic initiation factor 2b |
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2018
- 2018-08-31 EP EP18850713.1A patent/EP3676297B1/en active Active
- 2018-08-31 CN CN201880063335.4A patent/CN111201245B/zh active Active
- 2018-08-31 JP JP2020511347A patent/JP7382308B2/ja active Active
- 2018-08-31 CA CA3072057A patent/CA3072057A1/en active Pending
- 2018-08-31 EP EP23173466.6A patent/EP4248965A3/en active Pending
- 2018-08-31 SI SI201830964T patent/SI3676297T1/sl unknown
- 2018-08-31 FI FIEP18850713.1T patent/FI3676297T3/fi active
- 2018-08-31 WO PCT/US2018/049197 patent/WO2019046779A1/en not_active Ceased
- 2018-08-31 MA MA050063A patent/MA50063A/fr unknown
- 2018-08-31 PL PL18850713.1T patent/PL3676297T3/pl unknown
- 2018-08-31 US US16/643,168 patent/US12139478B2/en active Active
- 2018-08-31 HU HUE18850713A patent/HUE062446T2/hu unknown
- 2018-08-31 DK DK18850713.1T patent/DK3676297T3/da active
- 2018-08-31 TW TW107130678A patent/TW201920129A/zh unknown
- 2018-08-31 PT PT188507131T patent/PT3676297T/pt unknown
- 2018-08-31 ES ES18850713T patent/ES2952994T3/es active Active
-
2023
- 2023-02-28 JP JP2023030214A patent/JP2023060020A/ja active Pending
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2024
- 2024-04-08 JP JP2024062313A patent/JP2024086819A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US12139478B2 (en) | 2024-11-12 |
| HUE062446T2 (hu) | 2023-11-28 |
| EP3676297B1 (en) | 2023-05-17 |
| SI3676297T1 (sl) | 2023-12-29 |
| EP3676297A4 (en) | 2021-04-28 |
| ES2952994T3 (es) | 2023-11-07 |
| PT3676297T (pt) | 2023-08-29 |
| FI3676297T3 (fi) | 2023-08-08 |
| CN111201245B (zh) | 2024-04-05 |
| TW201920129A (zh) | 2019-06-01 |
| CN111201245A (zh) | 2020-05-26 |
| PL3676297T3 (pl) | 2023-12-11 |
| JP2024086819A (ja) | 2024-06-28 |
| EP4248965A3 (en) | 2023-11-22 |
| US20200331900A1 (en) | 2020-10-22 |
| JP2023060020A (ja) | 2023-04-27 |
| EP3676297A1 (en) | 2020-07-08 |
| WO2019046779A1 (en) | 2019-03-07 |
| JP2020532506A (ja) | 2020-11-12 |
| EP4248965A2 (en) | 2023-09-27 |
| JP7382308B2 (ja) | 2023-11-16 |
| DK3676297T3 (da) | 2023-08-14 |
| MA50063A (fr) | 2021-04-28 |
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