CN111011401A - Mosquito killing medicament and preparation process thereof - Google Patents
Mosquito killing medicament and preparation process thereof Download PDFInfo
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- CN111011401A CN111011401A CN201911176321.6A CN201911176321A CN111011401A CN 111011401 A CN111011401 A CN 111011401A CN 201911176321 A CN201911176321 A CN 201911176321A CN 111011401 A CN111011401 A CN 111011401A
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- A—HUMAN NECESSITIES
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/28—Myrtaceae [Myrtle family], e.g. teatree or clove
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention relates to a mosquito killing medicament and a preparation process thereof, relates to the technical field of mosquito killing medicaments, and specifically comprises the following components in percentage by mass: 1-3% of clove, 2-7% of mint, 0.5-3% of perilla leaf, 3-5% of honeysuckle, 3-6% of evening primrose, 2-5% of mozzie buster, 4-7% of lavender, 5-8% of mugwort, 5-10% of alternanthera philoxeroides, 2-4% of sweet wormwood oil, 3-5% of anophelifuge, 8-12% of ethanol and the balance of water. The invention can kill mosquito effectively and has no harm to human body by using the plant mosquito killing component.
Description
Technical Field
The invention relates to the technical field of mosquito killing medicines, in particular to a mosquito killing medicament and a preparation process thereof.
Background
In summer, mosquitoes are abused, except that the mosquitoes directly bite and suck blood and disturb sleep, more serious diseases are transmitted, the mosquitoes can transmit the diseases to more than 7 billion people all over the world every year, and the diseases are infected by 2 billions of people who are dead in malaria due to mosquito transmission among 200 to 300 million people. The mosquito control method mainly comprises environmental control, physical control, chemical control and biological control, wherein the chemical control mainly utilizes the mosquito killing medicament to play a role in killing mosquitoes, and the mosquito killing medicament is convenient to use, quick in effect taking, strong in effect and suitable for large-scale application, so that the mosquito killing medicament is more and more widely applied. The mosquito killing agent should be developed towards the goals of high efficiency, low toxicity, no pollution and no damage to ecological environment.
Nowadays, many people have insufficient understanding on the harm of mosquito killing medicaments, and think that the mosquito killing medicaments are fragrant, have no unpleasant irritating peculiar smell and have no toxicity, and actually, excessive indoor spraying is very harmful to the old, the weak and the children. The main components of the current mosquito killing medicament are pyrethrins, such as tetramethrin, permethrin, organic solvents and the like, and when ventilation is poor, the use is excessive, and the concentration is too high, the damage to a human body can be caused, particularly, severe stimulation can be caused to respiratory tracts, and allergic cough and asthma are caused. Therefore, it is required to prepare a mosquito-killing medicament which has the effects of killing mosquitoes with high efficiency and is harmless to human bodies.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a mosquito killing medicament which has the effects of killing mosquitoes efficiently and is harmless to human bodies; the second purpose of the invention is to provide a preparation process of the mosquito killing medicament.
The above object of the present invention is achieved by the following technical solutions: the mosquito killing medicament specifically comprises the following components in percentage by mass: 1-3% of clove, 2-7% of mint, 0.5-3% of perilla leaf, 3-5% of honeysuckle, 3-6% of evening primrose, 2-5% of mozzie buster, 4-7% of lavender, 5-8% of mugwort, 5-10% of alternanthera philoxeroides, 2-4% of sweet wormwood oil, 3-5% of anophelifuge, 8-12% of ethanol and the balance of water.
By adopting the technical scheme, the clove, the perilla leaf, the honeysuckle and the evening primrose have fragrant fragrance and have irritation to mosquitoes, so that the mosquito killing and repelling effect can be achieved, and the smell is harmless to human bodies. The mint contains easy-to-disperse mint oil, menthol, menthone and the like, the components can achieve the effects of repelling and killing mosquitoes, are harmless to human bodies, have no pungent smell, are sprayed indoors, are easy to diffuse uniformly, and can ensure that the mosquito killing and repelling effects of all parts in the room are consistent. The mozzie buster can give off fresh and elegant lemon fragrance and has the effects of repelling mosquitoes, purifying air, and sterilizing.
The lavender has aromatic smell, and mosquitoes do not like the aromatic smell, so that the lavender has a certain mosquito repelling effect and can increase the aromatic smell of the mosquito killing medicament when being added into the mosquito killing medicament. Substances such as eucalyptol and terpineol in the mugwort have good repellent activity on mosquitoes, can paralyze the mosquitoes and play a role in killing the mosquitoes; in addition, the mugwort has fragrant smell and has certain repellent effect on mosquitoes. The alligator alternanthera grows in ponds and ditches and is propagated in water in large quantity, certain harm is caused to water, and flavonoid glycoside, triterpenoid saponin and other components in the alligator alternanthera have a good effect on killing mosquitoes, so that the alligator alternanthera is developed and utilized as an additive component of a mosquito killing medicament, and not only can effectively repel mosquitoes, but also can change waste into valuables and reduce the damage of the alligator alternanthera to the ecological environment.
The principle of repelling mosquitoes by using anophelifuge ester is that the mosquitoes look for targets through olfactory system by using smells emitted by human body, such as two gases exhaled and smells emitted by skin, and the anophelifuge ester has the function of forming a barrier on the surface of human body, so that the emission of human body smells is isolated, the olfactory system of the mosquitoes is paralyzed, and the smell induction of the mosquitoes is interfered, so that the effect of repelling the mosquitoes is realized. When people are in the room, the mosquito killing agent is sprayed, which can not cause harm to the human body, and can prevent indoor mosquitoes from biting the skin of the human body.
Most of the components in the plant belong to organic matters which are insoluble or insoluble in water, ethanol belongs to an organic solvent, and the organic matters in the plant can be dissolved in the organic solvents and then diluted by adding water to prepare the mosquito killing medicament. The components added in the invention are all plants, so that the mosquito killer can effectively kill mosquitoes and is harmless to human bodies.
The present invention in a preferred example may be further configured to: the lavender is subjected to extraction treatment, and the extraction steps are as follows: 1) washing the lavender, drying the lavender, and crushing the dried lavender into 60-80 meshes of lavender powder; 2) lavender powder and absolute ethanol were mixed in a ratio of 1: 4-6, and soaking in a dark place for 24-48 hours; 3) after soaking, performing suction filtration, distilling and concentrating the filtrate at 60 ℃ under reduced pressure, and removing absolute ethyl alcohol to obtain lavender extract.
By adopting the technical scheme, the lavender is soaked in absolute ethyl alcohol and is subjected to reduced pressure distillation and concentration to prepare the lavender extracting solution, the whole lavender plant has aromatic smell, mosquitoes do not like the lavender extracting solution, the extracted lavender extracting solution has stronger aromatic smell, and the lavender extracting solution is added into the mosquito killing medicament, so that the mosquito killing medicament has a certain mosquito repelling effect and can increase the aromatic smell of the mosquito killing medicament.
The present invention in a preferred example may be further configured to: the mugwort is extracted and processed, and the extraction steps are as follows: 1) cleaning the dry mugwort, drying the mugwort when the surface of the sun-dried mugwort is anhydrous, further drying the mugwort, and crushing the dried mugwort into 60-80-mesh mugwort powder; 2) mixing mugwort powder and absolute ethyl alcohol according to a ratio of 1: uniformly mixing the materials according to the mass ratio of 6-10, and then sealing and soaking for 24-48 h; 3) filtering the soaking solution through gauze, and filtering the soaking solution by vacuum filtration; 4) evaporating the soak solution obtained in the step 3) to remove ethanol in the soak solution, so as to obtain the mugwort extract.
By adopting the technical scheme, the extracting solution of the mugwort extracted by ethanol mainly contains volatile oil, flavone, cineole, mushrooms, trace chemical elements and the like, wherein the cineole, terpineol and other substances have good repellent activity on mosquitoes, can paralyze mosquitoes and play a role in killing mosquitoes; in addition, the mugwort has fragrant smell and has certain repellent effect on mosquitoes.
The present invention in a preferred example may be further configured to: the mosquito killing medicament also comprises 1-3% of chitosan.
By adopting the technical scheme, the mosquito is sweet, and the chitosan is added into the mosquito killing medicament to attract the mosquito, so that the mosquito is killed.
The present invention in a preferred example may be further configured to: the preparation method of the extracting solution comprises the following steps: 1) cleaning the alternanthera philoxeroides, drying in the shade, drying in an oven at 50-65 ℃, and crushing into alternanthera philoxeroides powder of 40-60 meshes; 2) mixing the alternanthera philoxeroides powder with absolute ethyl alcohol according to the weight ratio of 1: 5-8, and soaking in a sealed condition for 24-48 hours; 3) transferring the mixture obtained in the step 2) into a distillation container, connecting a steam distillation device, and distilling for 4-6 h at the temperature of 60-70 ℃; 4) cooling the extracting solution obtained in the step 3), filtering filter residues, and carrying out reduced pressure distillation and concentration on the filtrate at the temperature of 60 ℃ to obtain the alligator alternanthera extracting solution.
By adopting the technical scheme, the alternanthera philoxeroides is crushed and then soaked, so that the alternanthera philoxeroides can be fully soaked, the alternanthera philoxeroides mainly contains flavonoid glycoside, triterpenoid saponin, organic acid, phenolic components, coumarin, sugar and garcinia cambogia, the components can be dissolved in absolute ethyl alcohol, and the organic components can be soaked out through soaking in the absolute ethyl alcohol, so that the mosquito killing effect is achieved.
The present invention in a preferred example may be further configured to: the mass ratio of the lavender to the mugwort to the alternanthera philoxeroides is 1: 1.3: 1.6.
by adopting the technical scheme, the prepared mosquito-killing medicament has the best mosquito-killing effect under the condition of the proportion of lavender, mugwort and alternanthera philoxeroides.
The present invention in a preferred example may be further configured to: the ethanol is 75wt% ethanol solution.
By adopting the technical scheme, the 75% ethanol solution can be used for disinfection, and the human skin can not be damaged when the ethanol solution is directly contacted with the human skin.
The second aim of the invention is realized by the following technical scheme: a preparation process of a mosquito-killing medicament,
the method specifically comprises the following steps:
step 1, weighing clove, mint, perilla leaf, honeysuckle, folium artemisiae argyi, evening primrose and mozzie buster according to the formula ratio, removing impurities attached to the leaves, cleaning, drying and crushing for later use;
step 2, mixing the mixture crushed in the step 1 with water according to a mass ratio of 1: 5-8, soaking for 24-48 hours in a dark place, and turning over for several times in the soaking process to ensure that the mixture can be fully soaked;
step 3, filtering filter residues after soaking, adding active carbon into the filtrate for decoloring, removing the active carbon after decoloring, and distilling and concentrating the filtrate at 65 ℃ under reduced pressure to obtain a mixed extract;
and 4, adding the mixed extracting solution, the lavender extracting solution, the artemisia argyi extracting solution, the alternanthera philoxeroides extracting solution and the anophelifuge into the ethanol according to the formula amount, uniformly stirring, then adding the water according to the formula amount, finally adding the chitosan, uniformly stirring, and canning.
By adopting the technical scheme, the components in the mixed extracting solution, the lavender extracting solution, the artemisia argyi extracting solution and the alternanthera philoxeroides extracting solution can be dissolved in ethanol, are uniformly mixed with the ethanol firstly, and are diluted into the mosquito killing medicament by adding water, and the mosquito killing medicament adopts plant components, so that the mosquito killing medicament can kill mosquitoes effectively and is harmless to human bodies.
In summary, the invention includes at least one of the following beneficial technical effects:
1. the added mosquito killing components are plant components, so that the mosquito killing effect can be guaranteed, the mosquito killing composition is harmless to human bodies, and the use safety is high;
2. the lavender is soaked in absolute ethyl alcohol and is subjected to reduced pressure distillation and concentration to prepare a lavender extracting solution, the whole lavender has aromatic smell, mosquitoes do not like the aromatic smell, the extracted lavender extracting solution has stronger aromatic smell, and the lavender extracting solution has a certain mosquito repelling effect and can increase the aromatic smell of a mosquito killing medicament when being added into the mosquito killing medicament;
3. the alligator alternanthera grows in ponds and ditches, and is propagated in water in large quantity, so that a certain harm is caused to water, and flavonoid glycoside, triterpenoid saponin and other components in the alligator alternanthera have a good effect on killing mosquitoes, so that the alligator alternanthera is developed and utilized as an additive component of a mosquito killing medicament, and not only can effectively repel mosquitoes, but also can change waste into valuables, and reduce the damage of the alligator alternanthera to the ecological environment;
4. the extracting solution of the mugwort extracted by ethanol mainly contains volatile oil, flavone, eudesmane, three mushrooms, trace chemical elements and the like, wherein substances such as the eudesmane, the terpineol and the like have good repellent activity on mosquitoes, can paralyze the mosquitoes and play a role in killing the mosquitoes; in addition, the mugwort has fragrant smell and has certain repellent effect on mosquitoes.
Detailed Description
The present invention will be described in further detail with reference to examples.
Example 1
Table 1 shows the components and the mass of a mosquito-killing agent of example 1
| Components | Percent by mass (%) | Components | Percent by mass (%) |
| Clove | 1 | Mugwort | 5 |
| Mint | 4 | Hollow lotus seed | 10 |
| Folium Perillae | 0.5 | Sweet wormwood oil | 2 |
| Honeysuckle flower | 4 | Mosquito repellent ester | 3 |
| Evening primrose | 3 | 75wt% ethanol | 10 |
| Culicifuge | 2 | Water (W) | 54.5 |
| Lavender | 5 |
Wherein, the lavender is subjected to extraction treatment, and the extraction steps are as follows: 1) washing lavender, drying, and crushing the dried lavender into 60-mesh lavender powder; 2) lavender powder and absolute ethanol were mixed in a ratio of 1: 4, uniformly mixing, and soaking in a dark place for 24 hours; 3) after soaking, performing suction filtration, distilling and concentrating the filtrate at 60 ℃ under reduced pressure, and removing absolute ethyl alcohol to obtain lavender extract.
The mugwort is extracted and processed, and the extraction steps are as follows: 1) cleaning dry folium Artemisiae Argyi, drying in the sun when there is no water on the surface of the dried folium Artemisiae Argyi, further oven drying, and pulverizing into 60 mesh folium Artemisiae Argyi powder; 2) mixing mugwort powder and absolute ethyl alcohol according to a ratio of 1: 6, uniformly mixing, and then sealing and soaking for 24 hours; 3) filtering the soaking solution through gauze, and filtering the soaking solution by vacuum filtration; 4) evaporating the soak solution obtained in the step 3) to remove ethanol in the soak solution, so as to obtain the mugwort extract.
The alligator alternanthera is subjected to extraction treatment, and the extraction steps are as follows: 1) cleaning the alternanthera philoxeroides, drying in the shade, drying in an oven at 50 ℃, and crushing into alternanthera philoxeroides powder of 40 meshes; 2) mixing the alternanthera philoxeroides powder with absolute ethyl alcohol according to the weight ratio of 1: 5, uniformly mixing, and soaking for 24 hours in a sealing manner; 3) transferring the mixture obtained in the step 2) into a distillation container, connecting a steam distillation device, and distilling for 6h at 60 ℃; 4) cooling the extracting solution obtained in the step 3), filtering filter residues, and carrying out reduced pressure distillation and concentration on the filtrate at the temperature of 60 ℃ to obtain the alligator alternanthera extracting solution.
The preparation process of the mosquito killing medicament specifically comprises the following steps:
step 1, weighing clove, mint, perilla leaf, honeysuckle, folium artemisiae argyi, evening primrose and mozzie buster according to the formula ratio, removing impurities attached to the leaves, cleaning, drying and crushing for later use;
step 2, mixing the mixture crushed in the step 1 with water according to a mass ratio of 1: 5, soaking the mixture for 24-48 hours in a dark place, and turning the mixture for several times in the soaking process to fully soak the mixture;
step 3, filtering filter residues after soaking, adding active carbon into the filtrate for decoloring, removing the active carbon after decoloring, and distilling and concentrating the filtrate at 65 ℃ under reduced pressure to obtain a mixed extract;
and 4, adding the mixed extracting solution, the lavender extracting solution, the artemisia argyi extracting solution, the alternanthera philoxeroides extracting solution and the anophelifuge into the ethanol according to the formula amount, uniformly stirring, then adding the water according to the formula amount, finally adding the chitosan, uniformly stirring, and canning.
Example 2
Table 2 shows the components and the mass of a mosquito-killing agent of example 2
| Components | Percent by mass (%) | Components | Percent by mass (%) |
| Clove | 2 | Mugwort | 6 |
| Mint | 2 | Hollow lotus seed | 5 |
| Folium Perillae | 1 | Sweet wormwood oil | 3 |
| Honeysuckle flower | 3 | Mosquito repellent ester | 4 |
| Evening primrose | 4 | 75wt% ethanol | 12 |
| Culicifuge | 3 | Water (W) | 51 |
| Lavender | 4 |
Wherein, the lavender is subjected to extraction treatment, and the extraction steps are as follows: 1) washing lavender, drying, and crushing the dried lavender into 70-mesh lavender powder; 2) lavender powder and absolute ethanol were mixed in a ratio of 1: 5, uniformly mixing, and soaking in a dark place for 36 hours; 3) after soaking, performing suction filtration, distilling and concentrating the filtrate at 60 ℃ under reduced pressure, and removing absolute ethyl alcohol to obtain lavender extract.
The mugwort is extracted and processed, and the extraction steps are as follows: 1) cleaning dry folium Artemisiae Argyi, drying in the sun when there is no water on the surface of the dried folium Artemisiae Argyi, further oven drying, and pulverizing into 70 mesh folium Artemisiae Argyi powder; 2) mixing mugwort powder and absolute ethyl alcohol according to a ratio of 1: 8, uniformly mixing the components in a mass ratio, and then sealing and soaking the mixture for 48 hours; 3) filtering the soaking solution through gauze, and filtering the soaking solution by vacuum filtration; 4) evaporating the soak solution obtained in the step 3) to remove ethanol in the soak solution, so as to obtain the mugwort extract.
The alligator alternanthera is subjected to extraction treatment, and the extraction steps are as follows: 1) cleaning the alternanthera philoxeroides, drying in the shade, drying in an oven at 65 ℃, and crushing into alternanthera philoxeroides powder of 40 meshes; 2) mixing the alternanthera philoxeroides powder with absolute ethyl alcohol according to the weight ratio of 1: 8, uniformly mixing, and soaking in a sealed manner for 36 hours; 3) transferring the mixture obtained in the step 2) into a distillation container, connecting a steam distillation device, and distilling for 4h at 70 ℃; 4) cooling the extracting solution obtained in the step 3), filtering filter residues, and carrying out reduced pressure distillation and concentration on the filtrate at the temperature of 60 ℃ to obtain the alligator alternanthera extracting solution.
The preparation process of the mosquito killing medicament specifically comprises the following steps:
step 1, weighing clove, mint, perilla leaf, honeysuckle, folium artemisiae argyi, evening primrose and mozzie buster according to the formula ratio, removing impurities attached to the leaves, cleaning, drying and crushing for later use;
step 2, mixing the mixture crushed in the step 1 with water according to a mass ratio of 1: 7, soaking the mixture in a dark place for 24-48 hours, and turning the mixture for several times in the soaking process to fully soak the mixture;
step 3, filtering filter residues after soaking, adding active carbon into the filtrate for decoloring, removing the active carbon after decoloring, and distilling and concentrating the filtrate at 65 ℃ under reduced pressure to obtain a mixed extract;
and 4, adding the mixed extracting solution, the lavender extracting solution, the artemisia argyi extracting solution, the alternanthera philoxeroides extracting solution and the anophelifuge into the ethanol according to the formula amount, uniformly stirring, then adding the water according to the formula amount, finally adding the chitosan, uniformly stirring, and canning.
Example 3
Table 3 shows the components and the mass of a mosquito-killing agent of example 3
| Components | Percent by mass (%) | Components | Percent by mass (%) |
| Clove | 3 | Mugwort | 7 |
| Mint | 7 | Hollow lotus seed | 8 |
| Folium Perillae | 3 | Sweet wormwood oil | 4 |
| Honeysuckle flower | 5 | Mosquito repellent ester | 5 |
| Evening primrose | 6 | 75wt% ethanol | 8 |
| Culicifuge | 5 | Water (W) | 32 |
| Lavender | 7 |
Wherein, the lavender is subjected to extraction treatment, and the extraction steps are as follows: 1) washing lavender, drying, and crushing the dried lavender into 70-mesh lavender powder; 2) lavender powder and absolute ethanol were mixed in a ratio of 1: 6, uniformly mixing, and soaking in a dark place for 48 hours; 3) after soaking, performing suction filtration, distilling and concentrating the filtrate at 60 ℃ under reduced pressure, and removing absolute ethyl alcohol to obtain lavender extract.
The mugwort is extracted and processed, and the extraction steps are as follows: 1) cleaning dry folium Artemisiae Argyi, drying in the sun when there is no water on the surface of the dried folium Artemisiae Argyi, further oven drying, and pulverizing into 80 mesh folium Artemisiae Argyi powder; 2) mixing mugwort powder and absolute ethyl alcohol according to a ratio of 1: 10, and then soaking for 36 hours in a sealing manner; 3) filtering the soaking solution through gauze, and filtering the soaking solution by vacuum filtration; 4) evaporating the soak solution obtained in the step 3) to remove ethanol in the soak solution, so as to obtain the mugwort extract.
The alligator alternanthera is subjected to extraction treatment, and the extraction steps are as follows: 1) cleaning the alternanthera philoxeroides, drying in the shade, drying in an oven at 60 ℃, and crushing into 50-mesh alternanthera philoxeroides powder; 2) mixing the alternanthera philoxeroides powder with absolute ethyl alcohol according to the weight ratio of 1: 8, uniformly mixing, and soaking in a sealed manner for 48 hours; 3) transferring the mixture obtained in the step 2) into a distillation container, connecting a steam distillation device, and distilling for 5h at 65 ℃; 4) cooling the extracting solution obtained in the step 3), filtering filter residues, and carrying out reduced pressure distillation and concentration on the filtrate at the temperature of 60 ℃ to obtain the alligator alternanthera extracting solution.
The preparation process of the mosquito killing medicament specifically comprises the following steps:
step 1, weighing clove, mint, perilla leaf, honeysuckle, folium artemisiae argyi, evening primrose and mozzie buster according to the formula ratio, removing impurities attached to the leaves, cleaning, drying and crushing for later use;
step 2, mixing the mixture crushed in the step 1 with water according to a mass ratio of 1: 8, soaking the mixture for 24-48 hours in a dark place, and turning the mixture for several times in the soaking process to fully soak the mixture;
step 3, filtering filter residues after soaking, adding active carbon into the filtrate for decoloring, removing the active carbon after decoloring, and distilling and concentrating the filtrate at 65 ℃ under reduced pressure to obtain a mixed extract;
and 4, adding the mixed extracting solution, the lavender extracting solution, the artemisia argyi extracting solution, the alternanthera philoxeroides extracting solution and the anophelifuge into the ethanol according to the formula amount, uniformly stirring, then adding the water according to the formula amount, finally adding the chitosan, uniformly stirring, and canning.
Example 4
Table 4 shows the components and the mass of a mosquito-killing agent of example 4
| Components | Percent by mass (%) | Components | Percent by mass (%) |
| Clove | 3 | Mugwort | 8 |
| Mint | 3 | Hollow lotus seed | 7 |
| Folium Perillae | 2.5 | Sweet wormwood oil | 2 |
| Honeysuckle flower | 5 | Mosquito repellent ester | 3 |
| Evening primrose | 5 | 75wt% ethanol | 10 |
| Culicifuge | 4 | Water (W) | 39.5 |
| Lavender | 6 | Chitosan | 3 |
Wherein, the lavender is subjected to extraction treatment, and the extraction steps are the same as those of the embodiment 3.
The mugwort is extracted and processed in the same way as in example 3.
The extraction process of alternanthera philoxeroides is the same as that in example 3.
The preparation process of the mosquito killing medicament is the same as that of example 3.
Example 5
Table 5 shows the components and the mass of a mosquito-killing agent of example 5
| Components | Percent by mass (%) | Components | Percent by mass (%) |
| Clove | 1 | Mugwort | 7 |
| Mint | 6 | Hollow lotus seed | 9 |
| Folium Perillae | 1.5 | Sweet wormwood oil | 3 |
| Honeysuckle flower | 3 | Mosquito repellent ester | 4 |
| Evening primrose | 3 | 75wt% ethanol | 12 |
| Culicifuge | 3 | Water (W) | 42.5 |
| Lavender | 4 | Chitosan | 1 |
Wherein, the lavender is subjected to extraction treatment, and the extraction steps are the same as those of the embodiment 3.
The mugwort was subjected to extraction treatment as in example 3.
The extraction process of alternanthera philoxeroides is the same as that in example 3.
The preparation process of the mosquito killing medicament is the same as that of example 3.
Example 6
Table 6 shows the components and the mass of a mosquito-killing agent of example 6
| Components | Percent by mass (%) | Components | Percent by mass (%) |
| Clove | 2 | Mugwort | 6.5 |
| Mint | 5 | Hollow lotus seed | 8 |
| Folium Perillae | 2 | Sweet wormwood oil | 4 |
| Honeysuckle flower | 4 | Mosquito repellent ester | 5 |
| Evening primrose | 4 | 75wt% ethanol | 10 |
| Culicifuge | 3 | Water (W) | 39.5 |
| Lavender | 5 | Chitosan | 2 |
Wherein, the lavender is subjected to extraction treatment, and the extraction steps are the same as those of the embodiment 3.
The mugwort was subjected to extraction treatment as in example 3.
The extraction process of alternanthera philoxeroides is the same as that in example 3.
The preparation process of the mosquito killing medicament is the same as that of example 3.
Comparative example 1
A mosquito-killing agent differing from example 6 in that lavender was not included, the water content was 44.5% by mass, and the rest was the same as example 6.
Comparative example 2
A mosquito-killing agent differing from example 6 in that it contained no mugwort and water in a mass percentage of 46% and the rest was the same as example 6.
Comparative example 3
A mosquito-killing agent is different from that of example 6 in that it does not include alternanthera philoxeroides, and the mass percentage of water is 47.5%, and the rest is the same as example 6.
The mosquito killing medicaments prepared in examples 1 to 6 and comparative examples 1 to 3 are used for mosquito killing experiments, and the mosquito killing experiments are specifically carried out by taking 100 culex pipiens pallens, adult insects at 3 weeks old and 50 males and females respectively as experimental objects; placing experimental mosquitoes in a 1m multiplied by 1m square box, spraying 2mL of mosquito killing agent into the square box, observing and recording the death number and time of the experimental mosquitoes; the blank control is the same condition, and no mosquito killing agent is sprayed.
Table 7 shows the results of mosquito eradication experiments
According to the mosquito killing experiment result, the mosquito killing medicament prepared in the embodiment has the advantages that the death number of mosquitoes reaches more than 90 within 6 hours, and is higher than that of the comparative example, so that the synergistic mosquito killing effect among lavender, mugwort and alternanthera philoxeroides is better.
The present embodiment is only for explaining the present invention, and not for limiting the present invention, and those skilled in the art can make modifications without inventive contribution to the present embodiment as needed after reading the present specification, but all of which are protected by patent law within the scope of the claims of the present invention.
Claims (8)
1. A mosquito killing medicament, which is characterized in that: the paint specifically comprises the following components in percentage by mass: 1-3% of clove, 2-7% of mint, 0.5-3% of perilla leaf, 3-5% of honeysuckle, 3-6% of evening primrose, 2-5% of mozzie buster, 4-7% of lavender, 5-8% of mugwort, 5-10% of alternanthera philoxeroides, 2-4% of sweet wormwood oil, 3-5% of anophelifuge, 8-12% of ethanol and the balance of water.
2. A mosquito eradication agent according to claim 1, wherein: the lavender is subjected to extraction treatment, and the extraction steps are as follows: 1) washing the lavender, drying the lavender, and crushing the dried lavender into 60-80 meshes of lavender powder; 2) lavender powder and absolute ethanol were mixed in a ratio of 1: 4-6, and soaking in a dark place for 24-48 hours; 3) after soaking, performing suction filtration, distilling and concentrating the filtrate at 60 ℃ under reduced pressure, and removing absolute ethyl alcohol to obtain lavender extract.
3. A mosquito eradication agent according to claim 1, wherein: the mugwort is extracted and processed, and the extraction steps are as follows: 1) cleaning the dry mugwort, drying the mugwort when the surface of the sun-dried mugwort is anhydrous, further drying the mugwort, and crushing the dried mugwort into 60-80-mesh mugwort powder; 2) mixing mugwort powder and absolute ethyl alcohol according to a ratio of 1: uniformly mixing the materials according to the mass ratio of 6-10, and then sealing and soaking for 24-48 h; 3) filtering the soaking solution through gauze, and filtering the soaking solution by vacuum filtration; 4) evaporating the soak solution obtained in the step 3) to remove ethanol in the soak solution, so as to obtain the mugwort extract.
4. A mosquito eradication agent according to claim 1, wherein: the mosquito killing medicament also comprises 1-3% of chitosan.
5. A mosquito eradication agent according to claim 1, wherein: the preparation method of the extracting solution comprises the following steps: 1) cleaning the alternanthera philoxeroides, drying in the shade, drying in an oven at 50-65 ℃, and crushing into alternanthera philoxeroides powder of 40-60 meshes; 2) mixing the alternanthera philoxeroides powder with absolute ethyl alcohol according to the weight ratio of 1: 5-8, and soaking in a sealed condition for 24-48 hours; 3) transferring the mixture obtained in the step 2) into a distillation container, connecting a steam distillation device, and distilling for 4-6 h at the temperature of 60-70 ℃; 4) cooling the extracting solution obtained in the step 3), filtering filter residues, and carrying out reduced pressure distillation and concentration on the filtrate at the temperature of 60 ℃ to obtain the alligator alternanthera extracting solution.
6. A mosquito eradication agent according to claim 1, wherein: the mass ratio of the lavender to the mugwort to the alternanthera philoxeroides is 1: 1.3: 1.6.
7. a mosquito eradication agent according to claim 1, wherein: the ethanol is 75wt% ethanol solution.
8. A preparation process of a mosquito killing medicament is characterized by comprising the following steps: the method specifically comprises the following steps:
step 1, weighing clove, mint, perilla leaf, honeysuckle, folium artemisiae argyi, evening primrose and mozzie buster according to the formula amount to remove leaves
Cleaning impurities attached to the seeds, drying and crushing for later use;
step 2, mixing the mixture crushed in the step 1 with water according to a mass ratio of 1: 5-8, and soaking in a dark place
The mixture is stirred for several times in the soaking process for 24-48 hours, so that the mixture can be fully soaked;
step 3, filtering the filter residue after soaking, adding active carbon into the filtrate for decoloring, removing the active carbon after decoloring is finished, and filtering the filtrate
Distilling and concentrating under reduced pressure at 65 deg.C to obtain mixed extractive solution;
step 4, adding the mixed extracting solution, the lavender extracting solution, the artemisia argyi extracting solution, the alligator alternanthera extracting solution and the anophelifuge
Adding into ethanol, stirring, adding water, adding chitosan, stirring, and packaging.
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