CN104055705A - Plant mosquito repellent - Google Patents
Plant mosquito repellent Download PDFInfo
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- CN104055705A CN104055705A CN201410312623.2A CN201410312623A CN104055705A CN 104055705 A CN104055705 A CN 104055705A CN 201410312623 A CN201410312623 A CN 201410312623A CN 104055705 A CN104055705 A CN 104055705A
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- mosquito repellent
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- herba artemisiae
- plant mosquito
- repellent product
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Abstract
The invention relates to the technical field of mosquito repellent products, in particular to plant mosquito repellent based on artemisia annuae oil. The artemisia annuae oil of the plant mosquito repellent serves as the effective constituent, the artemisia annuae oil is a remaining residue obtained when artemisinin is extracted from artemisia annuae, and the content of the artemisinin is lower than 1%. According to the plant mosquito repellent, the artemisia annuae oil which is the remaining residue obtained when the artemisinin is extracted from the artemisia annuae is sufficiently developed and utilized, and the plant mosquito repellent has the good mosquito repellent effect.
Description
Technical field
The present invention relates to plant mosquito repellent product technical field, be specifically related to the plant anophelifuge formula based on Herba Artemisiae Annuae oil.
Background technology
Herba Artemisiae Annuae is feverfew Herba Artemisiae annuae aerial parts, has clearing away summer-heat, removes steaming, malaria function.Herba Artemisiae Annuae main component arteannuin is a kind of sesquiterpene lactones, has the features such as efficient, quick-acting, low toxicity, safety in treatment aspect dangerous encephalic malaria, is also the new antimalarial agent of the unique acquisition international recognition of China so far.
But, the research according to prior art to Herba Artemisiae Annuae extract, main active still relates to arteannuin mostly; Remaining residue---Herba Artemisiae Annuae oil after extraction arteannuin, is conventionally used as fuel and burns or bury as garbage, not yet can be utilized effectively.
More existing plant extracts are for the report of anophelifuge, as Fruticose Breyniae Leaf and Twig's extract, leaf of Herba Rosmarini Officinalis prepared product etc.Citronella oil, Oleum Santali albi, Oleum Menthae Rotundifoliae and rutaceae quintessence oil etc. are made anophelifuge incense, and adult mosquito is had to the very strong prevention effect of sucking blood, and can reach the effect of anophelifuge and environmental protection.
Summary of the invention
The present invention is intended to make full use of Herba Artemisiae Annuae and extracts the residual residue after arteannuin, to obtaining the composition with good anophelifuge activity.
The invention provides a kind of plant mosquito repellent product, comprise that Herba Artemisiae Annuae oil is as effective ingredient, described Herba Artemisiae Annuae oil is the residual residue that Herba Artemisiae Annuae extracts arteannuin, and the content of arteannuin is lower than 1%.
In some embodiment, described plant mosquito repellent product also comprises Flos Daturae extract, Cortex Phellodendri extract, Flos Caryophylli extract, Fructus clausenae lansii extract, Radix Sophorae Flavescentis extract.
In some embodiment, described plant mosquito repellent product is paste, and comprises chitosan, carbomer, polyvinyl alcohol, polyvinylpyrrolidone, methylated vegetable oil.
In some embodiment, in described plant mosquito repellent product, the mass fraction of Herba Artemisiae Annuae oil is 15-25%.
In some embodiment, in described plant mosquito repellent product, the mass fraction of each composition is:
The present invention fully develops the residual residue Herba Artemisiae Annuae oil of Herba Artemisiae Annuae extraction arteannuin, utilizes its anophelifuge activity, and preparation plant mosquito repellent product, obtains the plant mosquito repellent product formula with good repelling effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
Extracting arteannuin from Herba Artemisiae Annuae is that prior art is known, and its residual residue is Herba Artemisiae Annuae oil, and in Herba Artemisiae Annuae oil, the content of arteannuin is lower, for example, generally lower than 1% (weight), and is generally used as fuel burning or buries as garbage.
The inventor finds in practice, and this residual residue Herba Artemisiae Annuae oil has certain repelling effect, and to people, animal all without irritated, or other toxic and side effects, therefore can be used as effective ingredient for plant mosquito repellent product.
Particularly, such plant mosquito repellent product based on Herba Artemisiae Annuae oil is carried out to acute toxicity testing, result shows: according to acute toxicity analytical standard in " sterile products independent trials program and method ", this series products belongs to actual nontoxic level.
On this basis, to Herba Artemisiae Annuae oil, the application in anophelifuge conducts in-depth research inventor, and find, when composite with Flos Daturae extract, Cortex Phellodendri extract, Flos Caryophylli extract, Fructus clausenae lansii extract, Radix Sophorae Flavescentis extract, the plant mosquito repellent product obtaining has compared with Herba Artemisiae Annuae oil, the anophelifuge activity of enhancing.
Further, the inventor finds, when composite with chitosan, carbomer, polyvinyl alcohol, polyvinylpyrrolidone, methylated vegetable oil, can obtain the paste plant mosquito repellent product with slow release effect.
In a kind of preferable case of the present invention, the mass fraction of the each composition of plant mosquito repellent product is: Herba Artemisiae Annuae oil 15-25%, Flos Daturae extract 10-15%, Cortex Phellodendri extract 10-15%, Flos Caryophylli extract 10-15%, Fructus clausenae lansii extract 10-15%, Radix Sophorae Flavescentis extract 10-15%, chitosan 2-5%, carbomer 2-5%, polyvinyl alcohol 2-5%, polyvinylpyrrolidone 2-5%, methylated vegetable oil 5-10%.
Plant mosquito repellent product of the present invention has no stimulation to skin.Rat baring skin allergic experiment result shows, does not find the anaphylaxis of rat local skin.
Walk quickly and keep away experiment: select 3 and the qualified tester of above attack (before experiment and duration of test should not be drunk, tea or coffee, should not use the product containing essence class), the skin area that respectively draws 50mm × 50mm at its both hands back, every hands is pressed 15mg/cm
2consumption, weigh in the balance and get 0.375g or 1.5mg/cm
2weigh in the balance and get 0.0375g and evenly smear repellent product to be measured, mosquito is provided by Disease Control and Prevention Center of Liaoning Province the required examination of this experiment.
Expose 40mm × 40mm skin wherein, tightly cover remainder.Another hands is blank.Smear repellent product 2h, hands is stretched into and is placed with 2min in the mosquito cage that attack is qualified, observe and have or not mosquito to come to stop to fall to sucking blood.
Test once every 1h afterwards, make repellent product failure as long as have a mosquito to come to suck blood to sentence.Record the effective protecting time (h) of repellent product.
Each contrast hands first does contrast test, and the examination worm that attack is qualified can continue test, and examination worm attack is defective to be needed to change qualified examination worm and test.
Embodiment
Herba Artemisiae Annuae oil is that Herba Artemisiae Annuae extracts the residual residue of arteannuin, after testing wherein the content of arteannuin lower than 1% (weight).Flos Daturae, Cortex Phellodendri, Flos Caryophylli, Radix Sophorae Flavescentis, Fructus clausenae lansii extract, preparation in the following way: Soxhlet is extracted (90 DEG C), and extracting molten product is ethyl acetate, and ratio is 10g:200mL ethyl acetate, extract 5 hours, distilling under reduced pressure extracting solution is to the dry extract that is.
embodiment 1:plant mosquito repellent product composition is Herba Artemisiae Annuae oil 25%, Flos Daturae extract 15%, Cortex Phellodendri extract 10%, Flos Caryophylli extract 10%, Fructus clausenae lansii extract 10%, chitosan 5%, carbomer 5%, polyvinyl alcohol 5%, polyvinylpyrrolidone 5%, methylated vegetable oil 10%.
Under express the plant mosquito repellent product (1.5mg/cm of Herba Artemisiae Annuae oil, embodiment 1
2) walk quickly and keep away and test contrast:
embodiment 2:plant mosquito repellent product composition is Herba Artemisiae Annuae oil 15%, Flos Daturae extract 15%, Cortex Phellodendri extract 15%, Flos Caryophylli extract 15%, Fructus clausenae lansii extract 15%, chitosan 3%, carbomer 3%, polyvinyl alcohol 4%, polyvinylpyrrolidone 5%, methylated vegetable oil 10%.
Under express the plant mosquito repellent product (1.5mg/cm of Herba Artemisiae Annuae oil, embodiment 2
2) walk quickly and keep away and test contrast:
embodiment 3:plant mosquito repellent product composition is Herba Artemisiae Annuae oil 20%, Flos Daturae extract 10%, Cortex Phellodendri extract 14%, Flos Caryophylli extract 15%, Fructus clausenae lansii extract 15%, chitosan 4%, carbomer 4%, polyvinyl alcohol 4%, polyvinylpyrrolidone 4%, methylated vegetable oil 10%.
Under express the plant mosquito repellent product (1.5mg/cm of Herba Artemisiae Annuae oil, embodiment 2
2) walk quickly and keep away and test contrast:
Judge that according to repellent product indoor pharmacodynamic test and evaluation criterion (GB/T13917.9-2009) the application's plant mosquito repellent product has good slow release effect, mosquito repelling effect is approached to B level, and successful is better than the former medicine of Herba Artemisiae Annuae oil.
The above specific embodiment of the invention, does not form limiting the scope of the present invention.Various other corresponding changes and distortion that any technical conceive according to the present invention has been done, all should be included in the protection domain of the claims in the present invention.
Claims (5)
1. a kind of plant mosquito repellent product, is characterized in that, comprises that Herba Artemisiae Annuae oil is as effective ingredient, and described Herba Artemisiae Annuae oil is the residual residue that Herba Artemisiae Annuae extracts arteannuin, and the content of arteannuin is lower than 1% (weight).
2. plant mosquito repellent product as claimed in claim 1, is characterized in that, also comprises Flos Daturae extract, Cortex Phellodendri extract, Flos Caryophylli extract, Fructus clausenae lansii extract, Radix Sophorae Flavescentis extract.
3. plant mosquito repellent product as claimed in claim 2, is characterized in that, described plant mosquito repellent product is paste, and comprises chitosan, carbomer, polyvinyl alcohol, polyvinylpyrrolidone, methylated vegetable oil.
4. plant mosquito repellent product as claimed any one in claims 1 to 3, is characterized in that, the mass fraction of described Herba Artemisiae Annuae oil is 15-25%.
5. plant mosquito repellent product as claimed in claim 4, is characterized in that, the mass fraction of each composition is:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410312623.2A CN104055705B (en) | 2014-07-02 | 2014-07-02 | A kind of plant anophelifuge |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410312623.2A CN104055705B (en) | 2014-07-02 | 2014-07-02 | A kind of plant anophelifuge |
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| CN104055705A true CN104055705A (en) | 2014-09-24 |
| CN104055705B CN104055705B (en) | 2016-08-31 |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104322571A (en) * | 2014-11-21 | 2015-02-04 | 沈阳化工研究院有限公司 | Plant-derived slow-release repellent composite, repellent and application |
| CN104365683A (en) * | 2014-11-21 | 2015-02-25 | 沈阳化工研究院有限公司 | Plant source slow-releasing mosquito repellent for animals as well as production method and application of plant source slow-releasing mosquito repellent for animals |
| CN106265168A (en) * | 2016-10-11 | 2017-01-04 | 济南大学 | A kind of preparation method of natural composite plant mosquito-driving liquid antibacterial, antipruritic |
| CN106511158A (en) * | 2016-11-07 | 2017-03-22 | 哈尔滨仟植生物科技有限公司 | Preparation and application of mosquito-repellent product prepared from natural plant extracts |
| CN106924117A (en) * | 2017-04-12 | 2017-07-07 | 惠州学院 | The washing product composition prepared with remaining artemisia annua residue after extraction qinghaosu |
| CN107518012A (en) * | 2017-09-06 | 2017-12-29 | 杨俊奇 | A kind of efficient mosquito repelling Chinese medicine compound prescription essential oil |
| CN108090316A (en) * | 2016-11-09 | 2018-05-29 | 成都彩虹电器（集团）股份有限公司 | A kind of spatial repellency product simulation field efficacy test method |
| CN109042766A (en) * | 2018-06-07 | 2018-12-21 | 周淑华 | A kind of Portable mosquito-dispelling bag |
| CN109875945A (en) * | 2019-04-12 | 2019-06-14 | 广东新南方青蒿药业股份有限公司 | Careless oil of a kind of sweet wormwood hundred and its preparation method and application |
| CN111011401A (en) * | 2019-11-26 | 2020-04-17 | 深圳市威必达有害生物防治有限公司 | Mosquito killing medicament and preparation process thereof |
| CN114917161A (en) * | 2022-06-07 | 2022-08-19 | 栾云鹏 | Composition for relieving itching and pain after mosquito bites and preparation method and application thereof |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104365683A (en) * | 2014-11-21 | 2015-02-25 | 沈阳化工研究院有限公司 | Plant source slow-releasing mosquito repellent for animals as well as production method and application of plant source slow-releasing mosquito repellent for animals |
| CN104365683B (en) * | 2014-11-21 | 2017-06-13 | 沈阳化工研究院有限公司 | A kind of plant source sustained release culicifuge for animals, its preparation method and application |
| CN104322571A (en) * | 2014-11-21 | 2015-02-04 | 沈阳化工研究院有限公司 | Plant-derived slow-release repellent composite, repellent and application |
| CN106265168A (en) * | 2016-10-11 | 2017-01-04 | 济南大学 | A kind of preparation method of natural composite plant mosquito-driving liquid antibacterial, antipruritic |
| CN106511158A (en) * | 2016-11-07 | 2017-03-22 | 哈尔滨仟植生物科技有限公司 | Preparation and application of mosquito-repellent product prepared from natural plant extracts |
| CN108090316A (en) * | 2016-11-09 | 2018-05-29 | 成都彩虹电器（集团）股份有限公司 | A kind of spatial repellency product simulation field efficacy test method |
| CN106924117B (en) * | 2017-04-12 | 2019-08-06 | 惠州学院 | With the washing product composition of artemisia annua residue preparation remaining after extraction qinghaosu |
| CN106924117A (en) * | 2017-04-12 | 2017-07-07 | 惠州学院 | The washing product composition prepared with remaining artemisia annua residue after extraction qinghaosu |
| CN107518012A (en) * | 2017-09-06 | 2017-12-29 | 杨俊奇 | A kind of efficient mosquito repelling Chinese medicine compound prescription essential oil |
| CN109042766A (en) * | 2018-06-07 | 2018-12-21 | 周淑华 | A kind of Portable mosquito-dispelling bag |
| CN109875945A (en) * | 2019-04-12 | 2019-06-14 | 广东新南方青蒿药业股份有限公司 | Careless oil of a kind of sweet wormwood hundred and its preparation method and application |
| CN111011401A (en) * | 2019-11-26 | 2020-04-17 | 深圳市威必达有害生物防治有限公司 | Mosquito killing medicament and preparation process thereof |
| CN114917161A (en) * | 2022-06-07 | 2022-08-19 | 栾云鹏 | Composition for relieving itching and pain after mosquito bites and preparation method and application thereof |
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| CN104055705B (en) | 2016-08-31 |
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