CN110996984A - 脂糖肽可裂解衍生物及其用途 - Google Patents

脂糖肽可裂解衍生物及其用途 Download PDF

Info

Publication number
CN110996984A
CN110996984A CN201880048300.3A CN201880048300A CN110996984A CN 110996984 A CN110996984 A CN 110996984A CN 201880048300 A CN201880048300 A CN 201880048300A CN 110996984 A CN110996984 A CN 110996984A
Authority
CN
China
Prior art keywords
infection
compound
pharmaceutically acceptable
acceptable salt
glycopeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880048300.3A
Other languages
English (en)
Chinese (zh)
Inventor
瑞恩·赫克勒
D·科尼切克
A·普朗特
V·马利宁
W·珀金斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Insmed Inc
Original Assignee
Insmed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insmed Inc filed Critical Insmed Inc
Publication of CN110996984A publication Critical patent/CN110996984A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201880048300.3A 2017-05-22 2018-05-22 脂糖肽可裂解衍生物及其用途 Pending CN110996984A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762509378P 2017-05-22 2017-05-22
US62/509,378 2017-05-22
US201762518280P 2017-06-12 2017-06-12
US62/518,280 2017-06-12
US201762560413P 2017-09-19 2017-09-19
US62/560,413 2017-09-19
PCT/US2018/033963 WO2018217808A1 (en) 2017-05-22 2018-05-22 Lipo-glycopeptide cleavable derivatives and uses thereof

Publications (1)

Publication Number Publication Date
CN110996984A true CN110996984A (zh) 2020-04-10

Family

ID=64395938

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201880048300.3A Pending CN110996984A (zh) 2017-05-22 2018-05-22 脂糖肽可裂解衍生物及其用途
CN201880047233.3A Active CN110891590B (zh) 2017-05-22 2018-05-22 糖肽衍生物化合物及其用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201880047233.3A Active CN110891590B (zh) 2017-05-22 2018-05-22 糖肽衍生物化合物及其用途

Country Status (11)

Country Link
US (3) US11071769B2 (cg-RX-API-DMAC7.html)
EP (2) EP3630154A4 (cg-RX-API-DMAC7.html)
JP (2) JP7165146B2 (cg-RX-API-DMAC7.html)
KR (2) KR102661786B1 (cg-RX-API-DMAC7.html)
CN (2) CN110996984A (cg-RX-API-DMAC7.html)
AU (2) AU2018271873B2 (cg-RX-API-DMAC7.html)
BR (2) BR112019024549A2 (cg-RX-API-DMAC7.html)
GB (2) GB2577420B (cg-RX-API-DMAC7.html)
IL (2) IL270686B (cg-RX-API-DMAC7.html)
NZ (2) NZ758836A (cg-RX-API-DMAC7.html)
WO (2) WO2018217800A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110891590A (zh) * 2017-05-22 2020-03-17 英斯麦德公司 糖肽衍生物化合物及其用途

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0811530B1 (pt) 2007-05-14 2019-01-02 Research Foundation Of State Univ Of New York composição compreendendo indutor(es) de resposta fisiológica à dispersão ácido decanóico, superfície, solução, método ex vivo de tratamento ou inibição da formação de um biofilme sobre uma superfície
NL2023883B1 (en) * 2019-09-24 2021-04-26 Univ Leiden Antibiotic compounds
US11793808B2 (en) 2021-02-22 2023-10-24 Mannkind Corp. Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them
WO2023094994A1 (en) * 2021-11-24 2023-06-01 Cumberland Pharmaceuticals Inc Methods for the prevention or treatment of anthrax infection

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273727A2 (en) * 1986-12-30 1988-07-06 Smithkline Beecham Corporation Glycosylated glycopeptides
CN1315961A (zh) * 1998-12-23 2001-10-03 先进医药公司 糖肽衍生物或含有它们的药物组合物
US20040242505A1 (en) * 2003-05-27 2004-12-02 Kone Kaniga Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
US20050171010A1 (en) * 1998-02-20 2005-08-04 Qi-Qi Chen Novel antibacterial agents
CN101959849A (zh) * 2007-12-26 2011-01-26 利德治疗公司 作为抗菌剂的新型半合成糖肽
CN103717231A (zh) * 2011-05-19 2014-04-09 萨瓦拉股份有限公司 干粉万古霉素组合物以及相关方法
CN104884047A (zh) * 2012-11-29 2015-09-02 英斯梅德股份有限公司 稳定的万古霉素制剂
CN105085636A (zh) * 2014-05-19 2015-11-25 中国医学科学院药物研究所 一类万古霉素衍生物、其制备方法及其在抗菌方面的应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639433A (en) 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
PT101450B (pt) 1994-02-02 1999-11-30 Hovione Produtos Farmaceuticos Novo dispositivo para inalacao
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
WO1998029141A1 (en) 1996-12-31 1998-07-09 Inhale Therapeutic Systems, Inc. Processes for spray drying solutions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes
JP2001517692A (ja) 1997-09-29 2001-10-09 インヘール セラピューティック システムズ， インコーポレイテッド ネブライザにおける使用のための安定化調製物
WO1999016420A1 (en) 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in nebulizers
CA2319495A1 (en) * 1998-06-08 1999-12-16 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
UA73924C2 (en) 1998-10-09 2005-10-17 Nektar Therapeutics Device for delivering active agent formulation to lungs of human patient
DE60041610D1 (de) 1999-05-28 2009-04-02 Nektar Therapeutics Gerät zum Abgeben von abgemessenen Mengen von Medikamente beinhaltendem Aerosol
US6606992B1 (en) 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
US6586008B1 (en) 1999-08-25 2003-07-01 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles during spray drying
WO2001057071A2 (en) 2000-02-04 2001-08-09 Advanced Medicine, Inc. Glycopeptide derivatives having antibiotic activity
AU3818001A (en) 2000-02-11 2001-08-20 Lilly Co Eli Selective n-acylation of a82846 glycopeptide analogs
US7442388B2 (en) 2000-05-10 2008-10-28 Weers Jeffry G Phospholipid-based powders for drug delivery
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
TWI312785B (en) * 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
WO2004044222A2 (en) * 2002-11-12 2004-05-27 Enzon Pharmaceuticals, Inc. Polymeric prodrugs of vancomycin
TWI342312B (en) * 2003-10-22 2011-05-21 Theravance Inc Hydrochloride salts of a glycopeptide phosphonate derivative
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
BRPI0817311A2 (pt) * 2007-09-25 2015-03-17 Novartis Ag Tratamento de doenças pulmonares com medicamentos em aerossol tais como a vancomicina
JP5855829B2 (ja) * 2007-10-23 2016-02-09 インスメッド， インコーポレイテッド リポソーム化バンコマイシン製剤
WO2010048340A2 (en) * 2008-10-24 2010-04-29 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
GB2465863A (en) * 2008-12-05 2010-06-09 Lead Therapeutics Inc Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
AU2010229721A1 (en) * 2009-03-26 2011-10-06 Pulmatrix, Inc. Methods for treating and preventing pneumonia and ventilator-associated tracheobronchitis
PL2424559T3 (pl) * 2009-04-28 2024-07-29 Melinta Therapeutics, Llc Sposoby leczenia zakażeń bakteryjnych z zastosowaniem orytawancyny
US9572774B2 (en) 2011-05-19 2017-02-21 Savara Inc. Dry powder vancomycin compositions and associated methods
US9879049B2 (en) 2011-08-05 2018-01-30 The Scripps Research Institute Glycopeptide antibiotic analogs effective against vancomycin-resistant bacterial strains
HRP20220158T1 (hr) * 2012-05-21 2022-04-15 Insmed Incorporated Sustavi za liječenje plućnih infekcija
GB201402267D0 (en) * 2014-02-10 2014-03-26 Cambridge Entpr Ltd Antibacterial agents
US10577395B2 (en) 2014-07-10 2020-03-03 The Scripps Research Institute N-(hydrophobe-substituted) vancosaminyl [Ψ-[C(=NH) NH] Tpg4] vancomycin and [Ψ-[CH2NH]Tpg4] vancomycin
CN107325159A (zh) 2016-04-29 2017-11-07 中国科学院上海药物研究所 一类万古霉素衍生物、其制备方法、药物组合物和用途
WO2018008197A1 (ja) 2016-07-07 2018-01-11 日東電工株式会社 反射層および蛍光体層付光半導体素子
CA3042039C (en) 2016-10-31 2023-09-26 The Scripps Research Institute Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability
KR102661786B1 (ko) * 2017-05-22 2024-04-26 인스메드 인코포레이티드 글리코펩티드 유도체 화합물 및 이의 용도

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273727A2 (en) * 1986-12-30 1988-07-06 Smithkline Beecham Corporation Glycosylated glycopeptides
US20050171010A1 (en) * 1998-02-20 2005-08-04 Qi-Qi Chen Novel antibacterial agents
CN1315961A (zh) * 1998-12-23 2001-10-03 先进医药公司 糖肽衍生物或含有它们的药物组合物
US20040242505A1 (en) * 2003-05-27 2004-12-02 Kone Kaniga Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
CN101959849A (zh) * 2007-12-26 2011-01-26 利德治疗公司 作为抗菌剂的新型半合成糖肽
CN103717231A (zh) * 2011-05-19 2014-04-09 萨瓦拉股份有限公司 干粉万古霉素组合物以及相关方法
CN104884047A (zh) * 2012-11-29 2015-09-02 英斯梅德股份有限公司 稳定的万古霉素制剂
CN105085636A (zh) * 2014-05-19 2015-11-25 中国医学科学院药物研究所 一类万古霉素衍生物、其制备方法及其在抗菌方面的应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DANIEL D. LONG，等: "Exploring the Positional Attachment of Glycopeptide/ β-lactam Heterodimers" *
T. I. NICAS,等: "ctivity of Glycopeptides against Vancomycin-Resistant Gram-Positive Bacteria" *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110891590A (zh) * 2017-05-22 2020-03-17 英斯麦德公司 糖肽衍生物化合物及其用途

Also Published As

Publication number Publication date
BR112019024549A2 (pt) 2020-06-09
EP3630154A1 (en) 2020-04-08
GB2577419B (en) 2022-08-17
US20220133843A1 (en) 2022-05-05
EP3630154A4 (en) 2021-03-10
KR102661790B1 (ko) 2024-04-26
GB201917675D0 (en) 2020-01-15
KR102661786B1 (ko) 2024-04-26
NZ758839A (en) 2025-08-29
GB201917677D0 (en) 2020-01-15
KR20200026803A (ko) 2020-03-11
IL270685A (cg-RX-API-DMAC7.html) 2019-12-31
CN110891590B (zh) 2023-07-18
IL270685B (en) 2022-09-01
CA3062567A1 (en) 2018-11-29
US20200368312A1 (en) 2020-11-26
IL270686B (en) 2022-09-01
AU2018273887A1 (en) 2019-11-28
EP3634464A4 (en) 2021-04-07
JP2020520986A (ja) 2020-07-16
WO2018217808A1 (en) 2018-11-29
IL270686A (cg-RX-API-DMAC7.html) 2019-12-31
AU2018271873B2 (en) 2023-11-02
WO2018217800A1 (en) 2018-11-29
GB2577420A (en) 2020-03-25
CN110891590A (zh) 2020-03-17
EP3634464A1 (en) 2020-04-15
NZ758836A (en) 2025-11-28
JP7210476B2 (ja) 2023-01-23
CA3062570A1 (en) 2018-11-29
US11071769B2 (en) 2021-07-27
AU2018273887B2 (en) 2022-09-08
AU2018271873A1 (en) 2019-11-28
JP2020520987A (ja) 2020-07-16
GB2577420B (en) 2022-07-06
BR112019024472A2 (pt) 2020-06-16
US11857597B2 (en) 2024-01-02
US20200155640A1 (en) 2020-05-21
JP7165146B2 (ja) 2022-11-02
GB2577419A (en) 2020-03-25
KR20200027922A (ko) 2020-03-13

Similar Documents

Publication Publication Date Title
US11857597B2 (en) Lipo-glycopeptide cleavable derivatives and uses thereof
CN101222927B (zh) 气溶胶化的氟喹诺酮类药物及其应用
KR100958235B1 (ko) 아미노글리코시드의 폐 전달
JP2008503586A (ja) アンフォテリシンｂを含む組成物、方法、およびシステム
KR102345084B1 (ko) 매크롤라이드계 항균제의 나노미립자를 함유하는 수성 현탁액제
US20220024980A1 (en) Lipo-glycopeptide cleavable derivatives and uses thereof
CA3062570C (en) Lipo-glycopeptide cleavable derivatives and uses thereof
CA3217735A1 (en) Methods for treating a pulmonary disease with an alk-5 (tgf beta r1) inhibitor
WO2022198009A1 (en) Dry powder compositions of glycopeptide derivative compounds and methods of use thereof
US20210388028A1 (en) Glycopeptide derivative compounds and uses thereof
CA3062567C (en) Glycopeptide derivative compounds and uses thereof
US12226474B2 (en) Methods and compositions for treating infections
Kwong et al. Co-spray drying of cannabidiol and vancomycin combination powder formulations for the treatment of methicillin-resistant Staphylococcus aureus respiratory infections
US20250135028A1 (en) Tunable polymeric nanoparticles for targeted and sustained delivery of glycopeptide antibiotics

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20200410

WD01 Invention patent application deemed withdrawn after publication