CN110914300A - 使用ps靶向抗体与免疫肿瘤学药剂治疗癌症的方法 - Google Patents

使用ps靶向抗体与免疫肿瘤学药剂治疗癌症的方法 Download PDF

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CN110914300A
CN110914300A CN201880023312.0A CN201880023312A CN110914300A CN 110914300 A CN110914300 A CN 110914300A CN 201880023312 A CN201880023312 A CN 201880023312A CN 110914300 A CN110914300 A CN 110914300A
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antibody molecule
antibody
cancer
composition
antibodies
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J.S.肖恩
N.L.卡林特里斯
M.唐
A.F.多尔
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Ankang Leji Co Ltd
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Ankang Leji Co Ltd
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1761—Apoptosis related proteins, e.g. Apoptotic protease-activating factor-1 (APAF-1), Bax, Bax-inhibitory protein(s)(BI; bax-I), Myeloid cell leukemia associated protein (MCL-1), Inhibitor of apoptosis [IAP] or Bcl-2
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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CN201880023312.0A 2017-04-03 2018-04-02 使用ps靶向抗体与免疫肿瘤学药剂治疗癌症的方法 Pending CN110914300A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762481064P 2017-04-03 2017-04-03
US62/481,064 2017-04-03
US201762507545P 2017-05-17 2017-05-17
US62/507,545 2017-05-17
PCT/US2018/025724 WO2018187227A1 (en) 2017-04-03 2018-04-02 Methods for treating cancer using ps-targeting antibodies with immuno-oncology agents

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CN110914300A true CN110914300A (zh) 2020-03-24

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CN201880023312.0A Pending CN110914300A (zh) 2017-04-03 2018-04-02 使用ps靶向抗体与免疫肿瘤学药剂治疗癌症的方法

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US (1) US11571459B2 (https=)
EP (1) EP3606960A1 (https=)
JP (1) JP2020515637A (https=)
KR (1) KR20200020662A (https=)
CN (1) CN110914300A (https=)
AU (1) AU2018249493A1 (https=)
CA (1) CA3055769A1 (https=)
MX (1) MX2019011858A (https=)
WO (1) WO2018187227A1 (https=)

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CN112921091A (zh) * 2021-03-16 2021-06-08 南京先声医学检验有限公司 Flt3基因突变在预测非小细胞肺癌患者对免疫检查点抑制剂疗法敏感性中的应用
CN114288399A (zh) * 2022-01-20 2022-04-08 武汉科技大学 一种嵌合抗原受体联合抗肿瘤药物组合物及其应用
CN114743593A (zh) * 2022-06-13 2022-07-12 北京橡鑫生物科技有限公司 一种基于尿液进行前列腺癌早期筛查模型的构建方法、筛查模型及试剂盒
CN115239156A (zh) * 2022-07-27 2022-10-25 广东省科学院广州地理研究所 城镇化指标对水系结构的影响警示方法

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JP2021502100A (ja) 2017-11-08 2021-01-28 ゼンコア インコーポレイテッド 新規抗ｐｄ−１配列を用いた二重特異性および単一特異性抗体
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KR20210033947A (ko) * 2018-06-01 2021-03-29 예일 유니버시티 스테로이드 호르몬-관련된 질환 또는 장애를 치료하기 위한 조성물 및 방법
KR20210030411A (ko) * 2018-07-10 2021-03-17 사노피 Cd38 및 tgf-베타를 표적으로 하는 암에 대한 병용 요법
KR102948775B1 (ko) * 2018-11-20 2026-04-03 스타파마 피티와이 리미티드 치료 덴드리머
CN114269376A (zh) * 2019-05-03 2022-04-01 豪夫迈·罗氏有限公司 用抗pd-l1抗体治疗癌症的方法
CN114126648A (zh) * 2019-05-31 2022-03-01 Alx肿瘤生物技术公司 用SIRPα Fc融合体组合免疫检查点抑制剂治疗癌症的方法
CN111053900B (zh) * 2019-11-19 2022-05-03 南京大学射阳高新技术研究院 一种靶向肿瘤、提高放疗敏感性的血小板载药体系及其制备方法
ES3014683T3 (en) * 2020-03-13 2025-04-24 Univ Texas Sequential treatment of cancers using 6-thio-dg and checkpoint inhibitors
US20230314438A1 (en) * 2020-04-03 2023-10-05 University Of Cincinnati Secreted phosphorylated heat shock protein-70 as a biomarker for treating and diagnosing cancer
TW202535468A (zh) * 2020-05-12 2025-09-16 瑞典商阿斯特捷利康公司 使用免疫檢查點抑制劑抗體治療癌症之方法和組合
CA3187944A1 (en) 2020-06-22 2021-12-30 Ngm Biopharmaceuticals, Inc. Lair-1-binding agents and methods of use thereof
EP4351593A4 (en) * 2021-06-07 2025-09-03 Cocytus Ltd USE OF DEATH LIGANDS ON HEMATOPOIETIC STEM AND PROGENITOR CELLS AND MESENCHYMAL STROMAL CELLS FOR CANCER THERAPY
CN113409949B (zh) * 2021-06-26 2022-09-02 南方医科大学南方医院 基于器官转移谱的非小细胞肺癌免疫检查点抑制治疗疗效的预测模型的构建方法及其应用
CN113933517B (zh) * 2021-10-09 2024-02-09 武汉金域医学检验所有限公司 一种检测t细胞对灭活疫苗敏感性的方法
CN114574447B (zh) * 2022-03-10 2023-10-20 中国海洋大学 Her2靶向的增强型抗肿瘤nk细胞、其制备方法及其应用
CN114793959B (zh) * 2022-05-06 2023-03-14 昆明市水产科学研究所 一种提高产后亲鱼成活率的银白鱼人工繁殖方法

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