CN110869024A - 多生物剂及其使用方法 - Google Patents

多生物剂及其使用方法 Download PDF

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Publication number
CN110869024A
CN110869024A CN201880037509.XA CN201880037509A CN110869024A CN 110869024 A CN110869024 A CN 110869024A CN 201880037509 A CN201880037509 A CN 201880037509A CN 110869024 A CN110869024 A CN 110869024A
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Prior art keywords
acyl group
acid
alcohol
acyl
group
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CN201880037509.XA
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Chinese (zh)
Inventor
J.P.小凯西
D.贝里
A.卡斯特罗
S.J.泰勒
F.E.马萨里
J.普劳富特
E.博加特
T.F.布里格斯
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Flagship Entrepreneurship And Innovation Co 5
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Flagship Entrepreneurship And Innovation Co 5
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112979464A (zh) * 2020-12-28 2021-06-18 中国农业科学院农产品加工研究所 白藜芦醇共轭亚油酸酯及其制备方法
CN114957004A (zh) * 2022-05-20 2022-08-30 上海远志昌浦生物科技有限公司 一种(r)-3-羟基丁酸-(r)-羟基丁酯及其中间体的合成方法和应用
CN115417865A (zh) * 2022-09-20 2022-12-02 上海予君生物科技发展有限公司 一种依拉地平中间体的制备工艺
CN116194090A (zh) * 2020-09-25 2023-05-30 Cj第一制糖株式会社 包含芪类化合物的抗球虫组合物及其用途
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CN119530194A (zh) * 2024-12-09 2025-02-28 北京胜元优奇生物科技有限公司 一种端粒酶及其在抗衰老中的用途

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210016407A (ko) 2018-06-05 2021-02-15 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 대사 장애 및 비알코올성 지방 간 질환의 치료를 위한 활성제 및 그 사용 방법
JP2021528385A (ja) 2018-06-05 2021-10-21 フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド 自己免疫障害を治療するためのアシル化活性剤およびその使用方法
JP2021535092A (ja) 2018-08-13 2021-12-16 フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド 結合体およびその使用方法
WO2020106454A2 (en) * 2018-11-07 2020-05-28 Regents Of The University Of Minnesota Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction
AU2019392784A1 (en) * 2018-12-06 2021-06-10 Flagship Pioneering Innovations V, Inc. Monomethyl fumarate-carrier conjugates and methods of their use
CN113993833B (zh) * 2019-06-12 2024-05-10 凯托利皮克斯治疗有限责任公司 酰基封端的3-羟基羧酸及其盐和酯的生产方法
KR20220119464A (ko) * 2019-12-26 2022-08-29 스미또모 가가꾸 가부시키가이샤 점착제 조성물
WO2021141959A1 (en) 2020-01-10 2021-07-15 Pacira Pharmaceuticals, Inc. Treatment of pain by administration of sustained-release liposomal anesthetic compositions
US20230080593A1 (en) 2020-01-10 2023-03-16 Pacira Pharmaceuticals, Inc. Treatment of pain by subarachnoid administration of sustained-release liposomal anesthetic compositions
JP7737231B2 (ja) * 2020-03-31 2025-09-10 大阪瓦斯株式会社 ジオール化合物およびその重合体ならびにそれらの製造方法
US10738077B1 (en) * 2020-04-09 2020-08-11 Shaanxi University Of Science And Technology Hydroxytyrosol ursodeoxycholic acid ester with antioxidant activity and a method of preparing the same
MY198026A (en) * 2020-11-06 2023-07-26 Stellar Biomolecular Res Gmbh Parenteral nutrition formulation and methods of preparation thereof
AU2020476040B2 (en) * 2020-11-06 2024-05-23 Stellar Biomolecular Research Gmbh Parenteral nutrition formulation and methods of preparation thereof
WO2022140580A1 (en) * 2020-12-24 2022-06-30 Orn Almarsson Xanthophyll derivatives
US11918688B2 (en) 2021-01-11 2024-03-05 Pacira Pharmaceuticals, Inc. Treatment of hip pain with sustained-release liposomal anesthetic compositions
WO2022197899A2 (en) 2021-03-19 2022-09-22 Pacira Pharmaceuticals, Inc. Treatment of pain in pediatric patients by administration of sustained-release liposomal anesthetic compositions
CN113045416B (zh) * 2021-03-23 2023-08-18 南京纽邦生物科技有限公司 一种(r)-3-羟基丁酰-(r)-3-羟基丁酯的制备方法
CN113912743B (zh) * 2021-10-19 2023-07-18 山东善维免疫科技有限公司 淀粉-吲哚酸衍生物及其制备方法和应用
IL312317B2 (en) * 2021-11-12 2025-04-01 Arxada Ag Polyol-derived compounds
CA3238205A1 (en) 2021-11-12 2023-05-19 Rajaram Samant A synergistic composition for activating intracellular secondary messenger(camp) pathway
US11918565B1 (en) 2022-11-03 2024-03-05 Pacira Pharmaceuticals, Inc. Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions
US12226610B2 (en) 2022-11-03 2025-02-18 Pacira Pharmaceuticals, Inc. Treatment of pain associated with total knee arthroplasty with sustained-release liposomal anesthetic compositions
KR20240123157A (ko) * 2023-02-06 2024-08-13 주식회사 카파바이오사이언스 폴리아민이 결합된 아스코르브산 유도체 및 그 제조방법
WO2024204847A1 (ja) * 2023-03-30 2024-10-03 三井化学株式会社 アミド化合物
WO2025038998A1 (en) * 2023-08-17 2025-02-20 University Of Wyoming Materials and methods for inhibiting, preventing, and dispersing biofilms
FR3153997A1 (fr) * 2023-10-13 2025-04-18 L'oreal Utilisation cosmétique d'au moins l’urolithine B sur une peau sensible
WO2025078645A1 (en) * 2023-10-13 2025-04-17 L'oreal Cosmetic use of at least urolithin b or c on a sensitive skin

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
TW201242961A (en) * 2007-06-20 2012-11-01 Ironwood Pharmaceuticals Inc FAAH inhibitors
CN105407718A (zh) * 2013-06-04 2016-03-16 维奥姆生物科学有限公司 涂布的颗粒和包括其的组合物
US20160213702A1 (en) * 2015-01-26 2016-07-28 Kaleido Biosciences, Inc. Glycan therapeutics and related methods thereof
JP2016222612A (ja) * 2015-06-01 2016-12-28 昭和電工株式会社 化粧料または皮膚外用剤
US20170145044A1 (en) * 2015-11-24 2017-05-25 Theravance Biopharma R&D Ip, Llc Prodrugs of a JAK Inhibitor Compound for Treatment of Gastrointestinal Inflammatory Disease

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385938B1 (en) * 1986-12-23 1997-07-15 Tristrata Inc Method of using glycolic acid for treating wrinkles
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
DE19709787A1 (de) * 1997-03-11 1998-09-17 Bayer Ag Oligosaccaride und deren Derivate sowie ein chemo-enzymatisches Verfahren zu deren Herstellung
US6465463B1 (en) * 1999-09-08 2002-10-15 Nitromed, Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
WO2005000248A2 (en) * 2003-06-25 2005-01-06 Geron Corporation Compositions and methods for skin conditioning
US20040265345A1 (en) * 2003-06-30 2004-12-30 Perricone Nicholas V. Treatment of skin damage using acetyl carnitine and lipoic acid
BRPI0507384A (pt) * 2004-02-03 2007-07-10 Nippon Shinyaku Co Ltd pró-droga glicosìdica de ácido 5-aminossalicìlico
DE102005046237A1 (de) * 2005-09-28 2007-04-05 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Buttersäureester von Kohlenhydraten und Kohlenhydratpolyolen
US8026285B2 (en) 2007-09-04 2011-09-27 Bezwada Biomedical, Llc Control release of biologically active compounds from multi-armed oligomers
FR2923717B1 (fr) * 2007-11-15 2015-01-16 Caudalie Compositions de derives polyphenoliques stilbeniques et leurs applications pour lutter contre les pathologies et le veillissement des organismes vivants
FR2927801B1 (fr) * 2008-02-22 2010-03-05 Sederma Sa Composition cosmetique hydratante comprenant une combinaison d'homarine et d'erythritol
US8465788B2 (en) * 2008-08-18 2013-06-18 Bioactor B.V. Arabinoxylans for modulating the barrier function of the intestinal surface
SI3677252T1 (sl) * 2012-03-19 2024-02-29 Cidara Therapeutics, Inc. Sheme odmerjanja za spojine iz razreda ehinokandinov
US10899879B2 (en) 2014-08-13 2021-01-26 The Regents Of The University Of California Biodegradable trehalose glycopolymers

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
TW201242961A (en) * 2007-06-20 2012-11-01 Ironwood Pharmaceuticals Inc FAAH inhibitors
CN105407718A (zh) * 2013-06-04 2016-03-16 维奥姆生物科学有限公司 涂布的颗粒和包括其的组合物
US20160213702A1 (en) * 2015-01-26 2016-07-28 Kaleido Biosciences, Inc. Glycan therapeutics and related methods thereof
JP2016222612A (ja) * 2015-06-01 2016-12-28 昭和電工株式会社 化粧料または皮膚外用剤
US20170145044A1 (en) * 2015-11-24 2017-05-25 Theravance Biopharma R&D Ip, Llc Prodrugs of a JAK Inhibitor Compound for Treatment of Gastrointestinal Inflammatory Disease

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANDREW V. STACHULSKI ET AL.，: "Thiazolides as Novel Antiviral Agents: I. Inhibition of Hepatitis B Virus Replication", 《J MED CHEM.》 *
FEIFEI LI ET AL.，: "Synthesis, colon-targeted studies and pharmacological evaluation of an anti-ulcerative colitis drug 4-Aminosalicylic acid-b-O-glucoside", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》 *
Y.ZENGY.SHABALIN ET AL.,: "Synthesis of Aryl Azide Derivatives of UDP-GlcNAc and UDP-GalNAc and Their Use for the Affinity Labeling of Glycosyltransferases and the UDP-HexNAc Pyrophosphorylase", 《ANALYTICAL BIOCHEMISTRY》 *
次仁央宗等: "氨基水杨酸制剂的药理学与临床应用", 《临床药物治疗杂志》 *
郑家驹等: "氨基水杨酸制剂治疗溃疡性结肠炎的临床应用", 《现代消化及介入诊疗》 *

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CN112979464A (zh) * 2020-12-28 2021-06-18 中国农业科学院农产品加工研究所 白藜芦醇共轭亚油酸酯及其制备方法
CN114957004A (zh) * 2022-05-20 2022-08-30 上海远志昌浦生物科技有限公司 一种(r)-3-羟基丁酸-(r)-羟基丁酯及其中间体的合成方法和应用
CN115417865A (zh) * 2022-09-20 2022-12-02 上海予君生物科技发展有限公司 一种依拉地平中间体的制备工艺
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WO2025113500A1 (zh) * 2023-11-30 2025-06-05 上海市东方医院（同济大学附属东方医院） 吲哚丙酸在治疗自身免疫性肝损伤和肝硬化中的应用
CN119530194A (zh) * 2024-12-09 2025-02-28 北京胜元优奇生物科技有限公司 一种端粒酶及其在抗衰老中的用途

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