JP2020522514A - マルチバイオティック剤及びその使用方法 - Google Patents

マルチバイオティック剤及びその使用方法 Download PDF

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JP2020522514A
JP2020522514A JP2019566683A JP2019566683A JP2020522514A JP 2020522514 A JP2020522514 A JP 2020522514A JP 2019566683 A JP2019566683 A JP 2019566683A JP 2019566683 A JP2019566683 A JP 2019566683A JP 2020522514 A JP2020522514 A JP 2020522514A
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acyl
acid
core
alcohol
multibiotic
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JP2020522514A5 (enExample
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ジョン パトリック ジュニア ケイシー，
ジョン パトリック ジュニア ケイシー，
デイビッド ベリー，
デイビッド ベリー，
アルフレド カストロ，
アルフレド カストロ，
スティーブン ジェイ． テイラー，
スティーブン ジェイ． テイラー，
フェルディナンド イー． マッサリ，
フェルディナンド イー． マッサリ，
ジョン プラウドフット，
ジョン プラウドフット，
イライジャ ボガート，
イライジャ ボガート，
ティモシー エフ． ブリッグス，
ティモシー エフ． ブリッグス，
Original Assignee
フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド
フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024537552A (ja) * 2021-10-19 2024-10-10 山東善維免疫科技有限公司 デンプン－インドールカルボン酸誘導体及びその製造方法並びに使用
JP2024541228A (ja) * 2021-11-12 2024-11-08 アークサーダ・アクチェンゲゼルシャフト ポリオール由来の化合物

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210016407A (ko) 2018-06-05 2021-02-15 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 대사 장애 및 비알코올성 지방 간 질환의 치료를 위한 활성제 및 그 사용 방법
JP2021528385A (ja) 2018-06-05 2021-10-21 フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド 自己免疫障害を治療するためのアシル化活性剤およびその使用方法
JP2021535092A (ja) 2018-08-13 2021-12-16 フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド 結合体およびその使用方法
WO2020106454A2 (en) * 2018-11-07 2020-05-28 Regents Of The University Of Minnesota Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction
AU2019392784A1 (en) * 2018-12-06 2021-06-10 Flagship Pioneering Innovations V, Inc. Monomethyl fumarate-carrier conjugates and methods of their use
CN113993833B (zh) * 2019-06-12 2024-05-10 凯托利皮克斯治疗有限责任公司 酰基封端的3-羟基羧酸及其盐和酯的生产方法
KR20220119464A (ko) * 2019-12-26 2022-08-29 스미또모 가가꾸 가부시키가이샤 점착제 조성물
WO2021141959A1 (en) 2020-01-10 2021-07-15 Pacira Pharmaceuticals, Inc. Treatment of pain by administration of sustained-release liposomal anesthetic compositions
US20230080593A1 (en) 2020-01-10 2023-03-16 Pacira Pharmaceuticals, Inc. Treatment of pain by subarachnoid administration of sustained-release liposomal anesthetic compositions
JP7737231B2 (ja) * 2020-03-31 2025-09-10 大阪瓦斯株式会社 ジオール化合物およびその重合体ならびにそれらの製造方法
US10738077B1 (en) * 2020-04-09 2020-08-11 Shaanxi University Of Science And Technology Hydroxytyrosol ursodeoxycholic acid ester with antioxidant activity and a method of preparing the same
KR102718991B1 (ko) * 2020-09-25 2024-10-16 씨제이제일제당 (주) 스틸벤계 화합물을 포함하는 항콕시듐증 조성물 및 이의 용도
MY198026A (en) * 2020-11-06 2023-07-26 Stellar Biomolecular Res Gmbh Parenteral nutrition formulation and methods of preparation thereof
AU2020476040B2 (en) * 2020-11-06 2024-05-23 Stellar Biomolecular Research Gmbh Parenteral nutrition formulation and methods of preparation thereof
WO2022140580A1 (en) * 2020-12-24 2022-06-30 Orn Almarsson Xanthophyll derivatives
CN112979464B (zh) * 2020-12-28 2022-02-11 中国农业科学院农产品加工研究所 白藜芦醇共轭亚油酸酯及其制备方法
US11918688B2 (en) 2021-01-11 2024-03-05 Pacira Pharmaceuticals, Inc. Treatment of hip pain with sustained-release liposomal anesthetic compositions
WO2022197899A2 (en) 2021-03-19 2022-09-22 Pacira Pharmaceuticals, Inc. Treatment of pain in pediatric patients by administration of sustained-release liposomal anesthetic compositions
CN113045416B (zh) * 2021-03-23 2023-08-18 南京纽邦生物科技有限公司 一种(r)-3-羟基丁酰-(r)-3-羟基丁酯的制备方法
CA3238205A1 (en) 2021-11-12 2023-05-19 Rajaram Samant A synergistic composition for activating intracellular secondary messenger(camp) pathway
CN114957004A (zh) * 2022-05-20 2022-08-30 上海远志昌浦生物科技有限公司 一种(r)-3-羟基丁酸-(r)-羟基丁酯及其中间体的合成方法和应用
CN115417865A (zh) * 2022-09-20 2022-12-02 上海予君生物科技发展有限公司 一种依拉地平中间体的制备工艺
US11918565B1 (en) 2022-11-03 2024-03-05 Pacira Pharmaceuticals, Inc. Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions
US12226610B2 (en) 2022-11-03 2025-02-18 Pacira Pharmaceuticals, Inc. Treatment of pain associated with total knee arthroplasty with sustained-release liposomal anesthetic compositions
KR20240123157A (ko) * 2023-02-06 2024-08-13 주식회사 카파바이오사이언스 폴리아민이 결합된 아스코르브산 유도체 및 그 제조방법
WO2024204847A1 (ja) * 2023-03-30 2024-10-03 三井化学株式会社 アミド化合物
WO2025038998A1 (en) * 2023-08-17 2025-02-20 University Of Wyoming Materials and methods for inhibiting, preventing, and dispersing biofilms
FR3153997A1 (fr) * 2023-10-13 2025-04-18 L'oreal Utilisation cosmétique d'au moins l’urolithine B sur une peau sensible
WO2025078645A1 (en) * 2023-10-13 2025-04-17 L'oreal Cosmetic use of at least urolithin b or c on a sensitive skin
CN117919232B (zh) * 2023-11-30 2024-10-25 上海市东方医院（同济大学附属东方医院） 吲哚丙酸在治疗肝硬化以及免疫性肝损伤的应用
CN119530194B (zh) * 2024-12-09 2025-06-17 纽柏抗衰老国际医生集团(广州)有限公司 一种端粒酶及其在抗衰老中的用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998040390A2 (de) * 1997-03-11 1998-09-17 Bayer Aktiengesellschaft Oligosaccharide und deren derivate sowie ein chemo-enzymatisches verfahren zu deren herstellung

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385938B1 (en) * 1986-12-23 1997-07-15 Tristrata Inc Method of using glycolic acid for treating wrinkles
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US6465463B1 (en) * 1999-09-08 2002-10-15 Nitromed, Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
WO2005000248A2 (en) * 2003-06-25 2005-01-06 Geron Corporation Compositions and methods for skin conditioning
US20040265345A1 (en) * 2003-06-30 2004-12-30 Perricone Nicholas V. Treatment of skin damage using acetyl carnitine and lipoic acid
BRPI0507384A (pt) * 2004-02-03 2007-07-10 Nippon Shinyaku Co Ltd pró-droga glicosìdica de ácido 5-aminossalicìlico
DE102005046237A1 (de) * 2005-09-28 2007-04-05 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Buttersäureester von Kohlenhydraten und Kohlenhydratpolyolen
TW201242961A (en) * 2007-06-20 2012-11-01 Ironwood Pharmaceuticals Inc FAAH inhibitors
US8026285B2 (en) 2007-09-04 2011-09-27 Bezwada Biomedical, Llc Control release of biologically active compounds from multi-armed oligomers
FR2923717B1 (fr) * 2007-11-15 2015-01-16 Caudalie Compositions de derives polyphenoliques stilbeniques et leurs applications pour lutter contre les pathologies et le veillissement des organismes vivants
FR2927801B1 (fr) * 2008-02-22 2010-03-05 Sederma Sa Composition cosmetique hydratante comprenant une combinaison d'homarine et d'erythritol
US8465788B2 (en) * 2008-08-18 2013-06-18 Bioactor B.V. Arabinoxylans for modulating the barrier function of the intestinal surface
SI3677252T1 (sl) * 2012-03-19 2024-02-29 Cidara Therapeutics, Inc. Sheme odmerjanja za spojine iz razreda ehinokandinov
US20160128944A1 (en) * 2013-06-04 2016-05-12 Vyome Biosciences Pvt. Ltd. Coated particles and compositions comprising same
US10899879B2 (en) 2014-08-13 2021-01-26 The Regents Of The University Of California Biodegradable trehalose glycopolymers
US9492473B2 (en) * 2015-01-26 2016-11-15 Kaleido Biosciences, Inc. Glycan therapeutics and related methods thereof
JP2016222612A (ja) * 2015-06-01 2016-12-28 昭和電工株式会社 化粧料または皮膚外用剤
UA121270C2 (uk) * 2015-11-24 2020-04-27 Тереванс Байофарма Ар Енд Ді Айпі, Елелсі Проліки jak-інгібуючої сполуки для лікування запального захворювання шлунково-кишкового тракту

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998040390A2 (de) * 1997-03-11 1998-09-17 Bayer Aktiengesellschaft Oligosaccharide und deren derivate sowie ein chemo-enzymatisches verfahren zu deren herstellung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIOORG. MED. CHEM. LETT., vol. 19, JPN6022026342, 2009, pages 1939 - 1943, ISSN: 0004977247 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024537552A (ja) * 2021-10-19 2024-10-10 山東善維免疫科技有限公司 デンプン－インドールカルボン酸誘導体及びその製造方法並びに使用
JP2024541228A (ja) * 2021-11-12 2024-11-08 アークサーダ・アクチェンゲゼルシャフト ポリオール由来の化合物

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