CN110753692A - 作为h-pgds抑制剂的化学化合物 - Google Patents

作为h-pgds抑制剂的化学化合物 Download PDF

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Publication number
CN110753692A
CN110753692A CN201880039565.7A CN201880039565A CN110753692A CN 110753692 A CN110753692 A CN 110753692A CN 201880039565 A CN201880039565 A CN 201880039565A CN 110753692 A CN110753692 A CN 110753692A
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CN
China
Prior art keywords
alkyl
naphthalene
carboxamide
substituted
mmol
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Pending
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CN201880039565.7A
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English (en)
Chinese (zh)
Inventor
D.N.迪顿
B.G.希勒
M.A.扬曼
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GlaxoSmithKline Intellectual Property Development Ltd
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GlaxoSmithKline Intellectual Property Development Ltd
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Publication of CN110753692A publication Critical patent/CN110753692A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201880039565.7A 2017-06-13 2018-06-11 作为h-pgds抑制剂的化学化合物 Pending CN110753692A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762518779P 2017-06-13 2017-06-13
US62/518,779 2017-06-13
US201762522869P 2017-06-21 2017-06-21
US62/522,869 2017-06-21
PCT/IB2018/054206 WO2018229629A1 (en) 2017-06-13 2018-06-11 Chemical compounds as h-pgds inhibitors

Publications (1)

Publication Number Publication Date
CN110753692A true CN110753692A (zh) 2020-02-04

Family

ID=62948277

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880039565.7A Pending CN110753692A (zh) 2017-06-13 2018-06-11 作为h-pgds抑制剂的化学化合物

Country Status (9)

Country Link
US (1) US11149035B2 (https=)
EP (1) EP3638672A1 (https=)
JP (1) JP2020523367A (https=)
CN (1) CN110753692A (https=)
BR (1) BR112019026452A2 (https=)
CA (1) CA3066979A1 (https=)
TW (1) TW201908311A (https=)
UY (1) UY37764A (https=)
WO (1) WO2018229629A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3085293A1 (en) * 2017-12-13 2019-06-20 Glaxosmithkline Intellectual Property Development Limited Fused pyridines which act as inhibitors of h-pgds
JP2022506850A (ja) * 2018-11-08 2022-01-17 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド 化学化合物
CN109651241B (zh) * 2018-12-27 2021-02-09 上海毕得医药科技股份有限公司 一种4-溴-6-氯烟醛的合成方法
WO2021256569A1 (ja) 2020-06-19 2021-12-23 佐藤製薬株式会社 Ｈ－ｐｇｄｓを阻害する縮環化合物
CN112430632B (zh) * 2020-11-18 2022-09-13 上海合全药物研发有限公司 2-((反式)-4-氨基环己烷基)异丙醇的制备方法
MX2023005747A (es) 2020-11-18 2023-07-28 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos.
CA3240926A1 (en) 2021-12-17 2023-06-22 Sato Pharmaceutical Co., Ltd. Azaindole derivative inhibiting h-pgds

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WO2009153720A1 (en) * 2008-06-18 2009-12-23 Pfizer Limited Nicotinamide derivatives
AU2011208139A1 (en) * 2010-01-22 2012-08-02 Taiho Pharmaceutical Co., Ltd. Piperazine compound having a PGDS inhibitory effect
EP2487175A1 (en) * 2009-10-06 2012-08-15 Kyowa Hakko Kirin Co., Ltd. Pharmaceutical product containing aromatic heterocyclic compound
EP2661265A1 (en) * 2010-12-23 2013-11-13 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators

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US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
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US7868204B2 (en) 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
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WO2004014377A1 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc 4-hydroxyquinoline derivatives as matrix metalloproteinase inhibitors
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CA2725481A1 (en) * 2008-06-18 2009-12-23 Pfizer Limited Nicotinamide derivatives
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EA027809B1 (ru) 2012-07-27 2017-09-29 Биоген Айдек Ма Инк. Соединения, которые являются s1p-модулирующими агентами и/или atx-модулирующими агентами
US10005720B2 (en) 2013-04-05 2018-06-26 North Carolina Central University Compounds useful for the treatment of metabolic disorders and synthesis of the same
RU2685234C1 (ru) 2013-12-09 2019-04-17 Юсб Байофарма Спрл Конденсированные бициклические гетероароматические производные в качестве модуляторов активности tnf
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CN108430992A (zh) * 2015-12-17 2018-08-21 阿斯特克斯医疗公司 作为h-pgds抑制剂的喹啉-3-甲酰胺
US10898469B2 (en) * 2016-02-26 2021-01-26 Sumitomo Dainippon Pharma Co., Ltd. Imidazolylamide derivative
JOP20190072A1 (ar) * 2016-10-13 2019-04-07 Glaxosmithkline Ip Dev Ltd مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
CA3085293A1 (en) * 2017-12-13 2019-06-20 Glaxosmithkline Intellectual Property Development Limited Fused pyridines which act as inhibitors of h-pgds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005094805A1 (ja) * 2004-04-01 2005-10-13 Institute Of Medicinal Molecular Design. Inc. イミン誘導体及びアミド誘導体
WO2009153720A1 (en) * 2008-06-18 2009-12-23 Pfizer Limited Nicotinamide derivatives
EP2487175A1 (en) * 2009-10-06 2012-08-15 Kyowa Hakko Kirin Co., Ltd. Pharmaceutical product containing aromatic heterocyclic compound
AU2011208139A1 (en) * 2010-01-22 2012-08-02 Taiho Pharmaceutical Co., Ltd. Piperazine compound having a PGDS inhibitory effect
EP2661265A1 (en) * 2010-12-23 2013-11-13 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators

Also Published As

Publication number Publication date
EP3638672A1 (en) 2020-04-22
US20200123152A1 (en) 2020-04-23
JP2020523367A (ja) 2020-08-06
US11149035B2 (en) 2021-10-19
UY37764A (es) 2019-01-02
CA3066979A1 (en) 2018-12-20
TW201908311A (zh) 2019-03-01
BR112019026452A2 (pt) 2020-07-14
WO2018229629A1 (en) 2018-12-20

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