CN110691852A - Alk、ret和ros融合物的多重pcr检测 - Google Patents
Alk、ret和ros融合物的多重pcr检测 Download PDFInfo
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- CN110691852A CN110691852A CN201880035309.0A CN201880035309A CN110691852A CN 110691852 A CN110691852 A CN 110691852A CN 201880035309 A CN201880035309 A CN 201880035309A CN 110691852 A CN110691852 A CN 110691852A
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12Q1/6851—Quantitative amplification
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
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- C12Q2600/112—Disease subtyping, staging or classification
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- C12Q2600/118—Prognosis of disease development
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- C12Q2600/156—Polymorphic or mutational markers
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
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- Hospice & Palliative Care (AREA)
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762513226P | 2017-05-31 | 2017-05-31 | |
| US62/513226 | 2017-05-31 | ||
| PCT/EP2018/064172 WO2018220004A1 (en) | 2017-05-31 | 2018-05-30 | Multiplex pcr detection of alk, ret, and ros fusions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110691852A true CN110691852A (zh) | 2020-01-14 |
Family
ID=62567625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880035309.0A Pending CN110691852A (zh) | 2017-05-31 | 2018-05-30 | Alk、ret和ros融合物的多重pcr检测 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11505830B2 (enExample) |
| EP (1) | EP3631011B1 (enExample) |
| JP (2) | JP2020521440A (enExample) |
| CN (1) | CN110691852A (enExample) |
| AU (1) | AU2018277210B2 (enExample) |
| CA (1) | CA3059119C (enExample) |
| ES (1) | ES2883934T3 (enExample) |
| WO (1) | WO2018220004A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112029857A (zh) * | 2020-08-14 | 2020-12-04 | 上海真固生物科技有限公司 | 一种引物组合物及用于融合基因检测的试剂 |
| CN115466788A (zh) * | 2022-06-28 | 2022-12-13 | 湖南圣洲生物科技有限公司 | 引物探针组合、试剂盒及其检测人alk、ros1基因融合的方法 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3059119C (en) | 2017-05-31 | 2024-01-23 | F. Hoffman-La Roche Ag | Multiplex pcr detection of alk, ret, and ros fusions |
| CN109837275B (zh) * | 2019-01-08 | 2022-09-06 | 大连医科大学附属第二医院 | 一种融合基因阳性对照标准品的制备方法 |
| CN111718994A (zh) * | 2019-03-22 | 2020-09-29 | 广州金域医学检验中心有限公司 | 肿瘤融合基因靶向检测探针、试剂盒及应用 |
| CN110964830A (zh) * | 2019-12-31 | 2020-04-07 | 中山大学达安基因股份有限公司 | 多重检测ros1基因突变的试剂盒及方法 |
| CN117144016A (zh) * | 2023-10-27 | 2023-12-01 | 神州医疗科技股份有限公司 | 一种用于外周血循环肿瘤rna中检测ret融合基因的引物探针、试剂盒及检测系统 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101466721A (zh) * | 2007-04-13 | 2009-06-24 | 细胞信号技术公司 | 在人实体瘤中的基因缺损和突变体alk激酶 |
| CN104818320A (zh) * | 2014-12-03 | 2015-08-05 | 厦门艾德生物医药科技有限公司 | 一次性检测肺癌多重基因的引物、探针、检测体系和试剂盒 |
| CN105102635A (zh) * | 2013-03-15 | 2015-11-25 | 生命技术公司 | 肺癌的分类和可行性指数 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455170A (en) | 1986-08-22 | 1995-10-03 | Hoffmann-La Roche Inc. | Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05 |
| JP4943585B2 (ja) * | 1999-02-18 | 2012-05-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 発光マーカーとして用いるためのサリチルアミド−ランタニド錯体 |
| CA2405687A1 (en) * | 2000-04-05 | 2001-10-18 | Molecular Staging, Inc. | Process for allele discrimation utilizing primer extension |
| US7385043B1 (en) | 2003-04-30 | 2008-06-10 | The Public Health Research Institute Of The City Of New York, Inc. | Homogeneous multiplex screening assays and kits |
| ES2561406T3 (es) * | 2006-04-14 | 2016-02-26 | Cell Signaling Technology, Inc. | Defectos de genes y quinasa ALK mutante en tumores sólidos humanos |
| US8735074B2 (en) * | 2009-08-28 | 2014-05-27 | Asuragen, Inc. | MiRNA biomarkers of lung disease |
| US9109259B2 (en) * | 2010-06-22 | 2015-08-18 | Japanese Foundation For Cancer Research | Detection method for novel ROS1 fusions |
| EP2599878A4 (en) * | 2010-07-26 | 2014-02-12 | Astellas Pharma Inc | NEW METHOD FOR DETECTING FUSED BODIES RET |
| US20130059762A1 (en) * | 2011-04-28 | 2013-03-07 | Life Technologies Corporation | Methods and compositions for multiplex pcr |
| US20130237442A1 (en) * | 2012-03-07 | 2013-09-12 | University Of Miami | Methods and Compositions for Diagnosis of Non-Viable Early Pregnancy |
| WO2014150300A2 (en) | 2013-03-15 | 2014-09-25 | Abbott Molecular Inc. | Method for amplification and assay of rna fusion gene variants, method of distinguishing same and related primers, probes, and kits |
| US10072298B2 (en) | 2013-04-17 | 2018-09-11 | Life Technologies Corporation | Gene fusions and gene variants associated with cancer |
| EP3825421B1 (en) | 2014-03-25 | 2022-06-22 | Quest Diagnostics Investments Incorporated | Detection of gene fusions by intragenic differential expression (ide) using average cycle thresholds |
| CN106414768B (zh) | 2014-03-27 | 2020-05-29 | 生命技术公司 | 与癌症相关的基因融合体和基因变异体 |
| BR112016024672A2 (pt) | 2014-04-25 | 2021-02-02 | Exelixis, Inc | método para o tratamento de adenocarcinoma de pulmão |
| CN107532209A (zh) * | 2015-04-17 | 2018-01-02 | 豪夫迈·罗氏有限公司 | 检测基因融合的多重pcr |
| CA3059119C (en) | 2017-05-31 | 2024-01-23 | F. Hoffman-La Roche Ag | Multiplex pcr detection of alk, ret, and ros fusions |
-
2018
- 2018-05-30 CA CA3059119A patent/CA3059119C/en active Active
- 2018-05-30 JP JP2019559727A patent/JP2020521440A/ja active Pending
- 2018-05-30 WO PCT/EP2018/064172 patent/WO2018220004A1/en not_active Ceased
- 2018-05-30 US US15/993,375 patent/US11505830B2/en active Active
- 2018-05-30 CN CN201880035309.0A patent/CN110691852A/zh active Pending
- 2018-05-30 EP EP18730279.9A patent/EP3631011B1/en active Active
- 2018-05-30 ES ES18730279T patent/ES2883934T3/es active Active
- 2018-05-30 AU AU2018277210A patent/AU2018277210B2/en active Active
-
2022
- 2022-10-06 US US17/961,200 patent/US20230121541A1/en active Pending
-
2023
- 2023-12-07 JP JP2023206878A patent/JP2024019433A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101466721A (zh) * | 2007-04-13 | 2009-06-24 | 细胞信号技术公司 | 在人实体瘤中的基因缺损和突变体alk激酶 |
| CN105102635A (zh) * | 2013-03-15 | 2015-11-25 | 生命技术公司 | 肺癌的分类和可行性指数 |
| CN104818320A (zh) * | 2014-12-03 | 2015-08-05 | 厦门艾德生物医药科技有限公司 | 一次性检测肺癌多重基因的引物、探针、检测体系和试剂盒 |
Non-Patent Citations (1)
| Title |
|---|
| MARUJA E LIRA等: "A single-tube multiplexed assay for detecting ALK, ROS1, and RET fusions in lung cancer" * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112029857A (zh) * | 2020-08-14 | 2020-12-04 | 上海真固生物科技有限公司 | 一种引物组合物及用于融合基因检测的试剂 |
| CN115466788A (zh) * | 2022-06-28 | 2022-12-13 | 湖南圣洲生物科技有限公司 | 引物探针组合、试剂盒及其检测人alk、ros1基因融合的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3059119A1 (en) | 2018-12-06 |
| CA3059119C (en) | 2024-01-23 |
| AU2018277210B2 (en) | 2024-03-28 |
| EP3631011B1 (en) | 2021-06-23 |
| JP2020521440A (ja) | 2020-07-27 |
| ES2883934T3 (es) | 2021-12-09 |
| JP2024019433A (ja) | 2024-02-09 |
| US20180346994A1 (en) | 2018-12-06 |
| US11505830B2 (en) | 2022-11-22 |
| EP3631011A1 (en) | 2020-04-08 |
| WO2018220004A1 (en) | 2018-12-06 |
| US20230121541A1 (en) | 2023-04-20 |
| AU2018277210A1 (en) | 2019-10-17 |
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