CN110678180A - 治疗癌症的液体剂型 - Google Patents

治疗癌症的液体剂型 Download PDF

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Publication number
CN110678180A
CN110678180A CN201880035207.9A CN201880035207A CN110678180A CN 110678180 A CN110678180 A CN 110678180A CN 201880035207 A CN201880035207 A CN 201880035207A CN 110678180 A CN110678180 A CN 110678180A
Authority
CN
China
Prior art keywords
compound
malate
pharmaceutically acceptable
less
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880035207.9A
Other languages
English (en)
Chinese (zh)
Inventor
K·沙
G·施瓦布
S·莱西
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exerie Exis Co
Original Assignee
Exerie Exis Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exerie Exis Co filed Critical Exerie Exis Co
Publication of CN110678180A publication Critical patent/CN110678180A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201880035207.9A 2017-06-09 2018-06-08 治疗癌症的液体剂型 Pending CN110678180A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762517736P 2017-06-09 2017-06-09
US62/517,736 2017-06-09
US201762520768P 2017-06-16 2017-06-16
US62/520,768 2017-06-16
PCT/US2018/036703 WO2018227119A1 (en) 2017-06-09 2018-06-08 Liquid dosage forms to treat cancer

Publications (1)

Publication Number Publication Date
CN110678180A true CN110678180A (zh) 2020-01-10

Family

ID=62779087

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880035207.9A Pending CN110678180A (zh) 2017-06-09 2018-06-08 治疗癌症的液体剂型

Country Status (10)

Country Link
US (3) US11504362B2 (https=)
EP (1) EP3634413A1 (https=)
JP (1) JP7249962B2 (https=)
KR (1) KR102647794B1 (https=)
CN (1) CN110678180A (https=)
AU (1) AU2018279834B2 (https=)
CA (1) CA3065560A1 (https=)
MX (1) MX2019014298A (https=)
UA (1) UA126402C2 (https=)
WO (1) WO2018227119A1 (https=)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
JP2014505109A (ja) * 2011-02-10 2014-02-27 エクセリクシス， インク． キノリン化合物およびそのような化合物を含有する医薬組成物の調製方法
EP3634413A1 (en) 2017-06-09 2020-04-15 Exelixis, Inc. Liquid dosage forms to treat cancer
UA128476C2 (uk) 2018-01-26 2024-07-24 Екселіксіс, Інк. Сполуки для лікування кіназозалежних розладів
CN113292537B (zh) 2018-06-15 2024-04-05 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物
TW202444365A (zh) 2023-01-31 2024-11-16 漢達生技醫藥股份有限公司 改良之卡博替尼組合物及其使用方法

Citations (2)

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US20120070368A1 (en) * 2010-04-16 2012-03-22 Exelixis, Inc. Methods of Using C-Met Modulators
CN106715397A (zh) * 2014-07-31 2017-05-24 埃克塞里艾克西斯公司 制备氟‑18标记的卡博替尼及其类似物的方法

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US6136846A (en) 1999-10-25 2000-10-24 Supergen, Inc. Formulation for paclitaxel
PT2213661E (pt) 2003-09-26 2011-12-15 Exelixis Inc Moduladores de c-met e métodos de uso
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
WO2008083319A1 (en) 2006-12-29 2008-07-10 Il Yang Pharmaceutical Company, Ltd. Solid state forms of enantiopure ilaprazole
SG173014A1 (en) * 2009-01-16 2011-08-29 Exelixis Inc Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quin0lin-4-yl] oxy}phenyl)-n' - (4 -fluorophenyl) cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer
UA111342C2 (uk) 2010-10-29 2016-04-25 Троікаа Фармасьютікалс Лімітед Назальні композиції вітаміну b12
KR20140025496A (ko) 2011-05-02 2014-03-04 엑셀리시스, 인코포레이티드 암 및 뼈 암 통증의 치료방법
GEP201606523B (en) * 2011-09-22 2016-08-10 Exelixis Inc Method for treating osteoporosis
ITRM20120331A1 (it) 2012-07-12 2014-01-13 Guidotti & C Spa Labor Composizioni pediatriche orali liquide contenenti nepadutant.
BR112015001838B1 (pt) 2012-07-27 2022-10-25 Izumi Technology, Llc Composição de inibidor de efluxo
KR102354963B1 (ko) 2014-02-14 2022-01-21 엑셀리시스, 인코포레이티드 N-｛4-[(6,7-다이메톡시퀴놀린-4-일)옥시]페닐｝-n'-(4-플루오로페닐) 사이클로프로판-1,1-다이카복스아마이드의 결정질 고체 형태, 제조 방법 및 사용 방법
IL248408B (en) 2014-04-25 2022-06-01 Exelixis Inc A method for treating adenocarcinoma of the lungs
EP3634413A1 (en) 2017-06-09 2020-04-15 Exelixis, Inc. Liquid dosage forms to treat cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120070368A1 (en) * 2010-04-16 2012-03-22 Exelixis, Inc. Methods of Using C-Met Modulators
CN106715397A (zh) * 2014-07-31 2017-05-24 埃克塞里艾克西斯公司 制备氟‑18标记的卡博替尼及其类似物的方法

Non-Patent Citations (6)

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FRAUKE BENTZIEN等: "In Vitro and in vivo Activity of Cabozantinib (XL184),an inhibitor of RET,MET,and VEGFR2,in a Model of Medullary Thyroid Cancer", 《THYROID.》 *
QIUHONG YANG等: "Cabozantinib Loaded DSPE-PEG2000 Micelles as Delivery System: Formulation, Characterization and Cytotoxicity Evaluation", 《BAOJ PHARM SCI.》 *
R. KURZROCK等: "Activity of XL184(Cabozantinib), an oral Tyrosine Kinase Inhibitor, in Patients With Medullary Thyroid Cancer", 《JOURNAL OF CLINICAL ONCOLOGY》 *
STEVEN LACY等: "Metabolism and Disposition of Cabozantinib in Healthy Male Volunteers and Pharmacologic Characterization of Its Major Metabolites", 《DRUG METABOLISM AND DISPOSITION》 *
方亮: "《药用高分子材料学》", 31 August 2015, 中国医药科技出版社 *

Also Published As

Publication number Publication date
EP3634413A1 (en) 2020-04-15
US20240307367A1 (en) 2024-09-19
WO2018227119A1 (en) 2018-12-13
AU2018279834B2 (en) 2024-05-23
KR20200014903A (ko) 2020-02-11
JP7249962B2 (ja) 2023-03-31
UA126402C2 (uk) 2022-09-28
JP2020523317A (ja) 2020-08-06
US12016854B2 (en) 2024-06-25
KR102647794B1 (ko) 2024-03-15
US20200268737A1 (en) 2020-08-27
AU2018279834A1 (en) 2020-01-16
MX2019014298A (es) 2020-02-03
CA3065560A1 (en) 2018-12-13
US20230301978A1 (en) 2023-09-28
US11504362B2 (en) 2022-11-22
BR112019025110A2 (pt) 2020-09-01

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