JP7249962B2 - がんを治療するための液体剤形 - Google Patents

がんを治療するための液体剤形 Download PDF

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JP7249962B2
JP7249962B2 JP2019567635A JP2019567635A JP7249962B2 JP 7249962 B2 JP7249962 B2 JP 7249962B2 JP 2019567635 A JP2019567635 A JP 2019567635A JP 2019567635 A JP2019567635 A JP 2019567635A JP 7249962 B2 JP7249962 B2 JP 7249962B2
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compound
malate
pharmaceutically acceptable
acceptable salt
dose
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Japanese (ja)
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JP2020523317A5 (https=
JP2020523317A (ja
Inventor
カリード シャー，
ギセラ シュワブ，
スティーブン レイシー，
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エグゼリクシス， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2019567635A 2017-06-09 2018-06-08 がんを治療するための液体剤形 Active JP7249962B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762517736P 2017-06-09 2017-06-09
US62/517,736 2017-06-09
US201762520768P 2017-06-16 2017-06-16
US62/520,768 2017-06-16
PCT/US2018/036703 WO2018227119A1 (en) 2017-06-09 2018-06-08 Liquid dosage forms to treat cancer

Publications (3)

Publication Number Publication Date
JP2020523317A JP2020523317A (ja) 2020-08-06
JP2020523317A5 JP2020523317A5 (https=) 2021-07-26
JP7249962B2 true JP7249962B2 (ja) 2023-03-31

Family

ID=62779087

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019567635A Active JP7249962B2 (ja) 2017-06-09 2018-06-08 がんを治療するための液体剤形

Country Status (10)

Country Link
US (3) US11504362B2 (https=)
EP (1) EP3634413A1 (https=)
JP (1) JP7249962B2 (https=)
KR (1) KR102647794B1 (https=)
CN (1) CN110678180A (https=)
AU (1) AU2018279834B2 (https=)
CA (1) CA3065560A1 (https=)
MX (1) MX2019014298A (https=)
UA (1) UA126402C2 (https=)
WO (1) WO2018227119A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014505109A (ja) * 2011-02-10 2014-02-27 エクセリクシス， インク． キノリン化合物およびそのような化合物を含有する医薬組成物の調製方法
EP3634413A1 (en) 2017-06-09 2020-04-15 Exelixis, Inc. Liquid dosage forms to treat cancer
UA128476C2 (uk) 2018-01-26 2024-07-24 Екселіксіс, Інк. Сполуки для лікування кіназозалежних розладів
CN113292537B (zh) 2018-06-15 2024-04-05 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物
TW202444365A (zh) 2023-01-31 2024-11-16 漢達生技醫藥股份有限公司 改良之卡博替尼組合物及其使用方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003512416A (ja) 1999-10-25 2003-04-02 スーパージェン インコーポレイテッド パクリタクセル用の新規且つ改善された組成物
JP2005343897A (ja) 2004-06-02 2005-12-15 Cordis Corp Ｃａｄ治療のためのタキサンの注入可能な配合物
JP2013540805A (ja) 2010-10-29 2013-11-07 トロイカ ファーマスーティカルズ リミテッド ビタミンｂ１２の鼻内用組成物
JP2014513129A (ja) 2011-05-02 2014-05-29 エクセリクシス， インク． 癌および骨癌疼痛の治療方法
JP2015523400A (ja) 2012-07-27 2015-08-13 バント，アントニウス，マルティヌス ガステーブ 排出阻害剤およびこれを用いる治療法

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
PT2213661E (pt) 2003-09-26 2011-12-15 Exelixis Inc Moduladores de c-met e métodos de uso
WO2008083319A1 (en) 2006-12-29 2008-07-10 Il Yang Pharmaceutical Company, Ltd. Solid state forms of enantiopure ilaprazole
SG173014A1 (en) * 2009-01-16 2011-08-29 Exelixis Inc Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quin0lin-4-yl] oxy}phenyl)-n' - (4 -fluorophenyl) cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer
US20120070368A1 (en) * 2010-04-16 2012-03-22 Exelixis, Inc. Methods of Using C-Met Modulators
GEP201606523B (en) * 2011-09-22 2016-08-10 Exelixis Inc Method for treating osteoporosis
ITRM20120331A1 (it) 2012-07-12 2014-01-13 Guidotti & C Spa Labor Composizioni pediatriche orali liquide contenenti nepadutant.
KR102354963B1 (ko) 2014-02-14 2022-01-21 엑셀리시스, 인코포레이티드 N-｛4-[(6,7-다이메톡시퀴놀린-4-일)옥시]페닐｝-n'-(4-플루오로페닐) 사이클로프로판-1,1-다이카복스아마이드의 결정질 고체 형태, 제조 방법 및 사용 방법
IL248408B (en) 2014-04-25 2022-06-01 Exelixis Inc A method for treating adenocarcinoma of the lungs
ES2929888T3 (es) * 2014-07-31 2022-12-02 Exelixis Inc Procedimiento para preparar cabozantinib marcado con flúor 18 y sus análogos
EP3634413A1 (en) 2017-06-09 2020-04-15 Exelixis, Inc. Liquid dosage forms to treat cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003512416A (ja) 1999-10-25 2003-04-02 スーパージェン インコーポレイテッド パクリタクセル用の新規且つ改善された組成物
JP2005343897A (ja) 2004-06-02 2005-12-15 Cordis Corp Ｃａｄ治療のためのタキサンの注入可能な配合物
JP2013540805A (ja) 2010-10-29 2013-11-07 トロイカ ファーマスーティカルズ リミテッド ビタミンｂ１２の鼻内用組成物
JP2014513129A (ja) 2011-05-02 2014-05-29 エクセリクシス， インク． 癌および骨癌疼痛の治療方法
JP2015523400A (ja) 2012-07-27 2015-08-13 バント，アントニウス，マルティヌス ガステーブ 排出阻害剤およびこれを用いる治療法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DRUG METABOLISM AND DISPOSITION，2015年，43(8)，pp.1190 - 1207
JOURNAL OF CLINICAL ONCOLOGY，2011年，29(19)，pp.2660 - 2666

Also Published As

Publication number Publication date
EP3634413A1 (en) 2020-04-15
US20240307367A1 (en) 2024-09-19
WO2018227119A1 (en) 2018-12-13
AU2018279834B2 (en) 2024-05-23
KR20200014903A (ko) 2020-02-11
CN110678180A (zh) 2020-01-10
UA126402C2 (uk) 2022-09-28
JP2020523317A (ja) 2020-08-06
US12016854B2 (en) 2024-06-25
KR102647794B1 (ko) 2024-03-15
US20200268737A1 (en) 2020-08-27
AU2018279834A1 (en) 2020-01-16
MX2019014298A (es) 2020-02-03
CA3065560A1 (en) 2018-12-13
US20230301978A1 (en) 2023-09-28
US11504362B2 (en) 2022-11-22
BR112019025110A2 (pt) 2020-09-01

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