CN1106400C - 抗肿瘤吲哚并吡咯并咔唑衍生物 - Google Patents

抗肿瘤吲哚并吡咯并咔唑衍生物 Download PDF

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Publication number
CN1106400C
CN1106400C CN95193830A CN95193830A CN1106400C CN 1106400 C CN1106400 C CN 1106400C CN 95193830 A CN95193830 A CN 95193830A CN 95193830 A CN95193830 A CN 95193830A CN 1106400 C CN1106400 C CN 1106400C
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CN
China
Prior art keywords
formula
compound
expression
compound represented
ethyl acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN95193830A
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English (en)
Chinese (zh)
Other versions
CN1153518A (zh
Inventor
小尻胜久
近藤久雄
荒川浩治
大久保满
须田宽之
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MSD KK
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Banyu Phamaceutical Co Ltd
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Publication of CN1153518A publication Critical patent/CN1153518A/zh
Application granted granted Critical
Publication of CN1106400C publication Critical patent/CN1106400C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
    • C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CN95193830A 1994-05-09 1995-05-02 抗肿瘤吲哚并吡咯并咔唑衍生物 Expired - Fee Related CN1106400C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP119483/94 1994-05-09
JP119483/1994 1994-05-09
JP11948394 1994-05-09
JP145648/94 1994-06-03
JP145648/1994 1994-06-03
JP14564894 1994-06-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB021469482A Division CN1285605C (zh) 1994-05-09 1995-05-02 抗肿瘤吲哚并吡咯并咔唑衍生物

Publications (2)

Publication Number Publication Date
CN1153518A CN1153518A (zh) 1997-07-02
CN1106400C true CN1106400C (zh) 2003-04-23

Family

ID=26457215

Family Applications (2)

Application Number Title Priority Date Filing Date
CN95193830A Expired - Fee Related CN1106400C (zh) 1994-05-09 1995-05-02 抗肿瘤吲哚并吡咯并咔唑衍生物
CNB021469482A Expired - Fee Related CN1285605C (zh) 1994-05-09 1995-05-02 抗肿瘤吲哚并吡咯并咔唑衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB021469482A Expired - Fee Related CN1285605C (zh) 1994-05-09 1995-05-02 抗肿瘤吲哚并吡咯并咔唑衍生物

Country Status (14)

Country Link
EP (2) EP0760375B1 (enExample)
JP (1) JP3038921B2 (enExample)
KR (1) KR100312473B1 (enExample)
CN (2) CN1106400C (enExample)
AT (2) ATE255121T1 (enExample)
AU (1) AU683749B2 (enExample)
CA (1) CA2190007C (enExample)
CL (1) CL2004001117A1 (enExample)
DE (2) DE69532198T2 (enExample)
DK (2) DK0760375T3 (enExample)
ES (2) ES2230433T3 (enExample)
HK (1) HK1000890A1 (enExample)
PT (2) PT1264836E (enExample)
TW (1) TW313566B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101585861B (zh) * 2009-07-03 2012-10-24 复旦大学 N-糖基萘并咔唑化合物及其合成方法和应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1541582A1 (en) * 2002-08-23 2005-06-15 Banyu Pharmaceutical Co., Ltd. Process for producing indolopyrrolocarbazole derivative
WO2025082431A1 (zh) * 2023-10-18 2025-04-24 正大天晴药业集团股份有限公司 一种吲哚衍生物治疗头颈部肿瘤的用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018003A1 (fr) * 1990-05-11 1991-11-28 Banyu Pharmaceutical Co., Ltd. Derive antitumoral de be-13793c
WO1993011145A1 (en) * 1991-11-29 1993-06-10 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
WO1995034663A1 (en) * 1994-06-13 1995-12-21 Banyu Pharmaceutical Co., Ltd. Gene coding for glycosyltransferase and use thereof
AU3086495A (en) * 1994-08-02 1996-03-04 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018003A1 (fr) * 1990-05-11 1991-11-28 Banyu Pharmaceutical Co., Ltd. Derive antitumoral de be-13793c
WO1993011145A1 (en) * 1991-11-29 1993-06-10 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101585861B (zh) * 2009-07-03 2012-10-24 复旦大学 N-糖基萘并咔唑化合物及其合成方法和应用

Also Published As

Publication number Publication date
DK0760375T3 (da) 2003-12-29
PT760375E (pt) 2004-04-30
ATE255121T1 (de) 2003-12-15
HK1000890A1 (en) 2004-01-09
ES2206501T3 (es) 2004-05-16
PT1264836E (pt) 2005-02-28
CA2190007A1 (en) 1995-11-16
CL2004001117A1 (es) 2005-04-22
EP1264836A1 (en) 2002-12-11
ES2230433T3 (es) 2005-05-01
CA2190007C (en) 2003-04-15
DE69533833T2 (de) 2005-12-15
DE69532198D1 (de) 2004-01-08
JP3038921B2 (ja) 2000-05-08
EP0760375A4 (en) 2002-03-27
CN1285605C (zh) 2006-11-22
KR970702869A (ko) 1997-06-10
DE69532198T2 (de) 2004-08-26
CN1153518A (zh) 1997-07-02
AU683749B2 (en) 1997-11-20
DK1264836T3 (da) 2005-03-07
CN1513865A (zh) 2004-07-21
ATE283863T1 (de) 2004-12-15
EP0760375B1 (en) 2003-11-26
DE69533833D1 (de) 2005-01-05
TW313566B (enExample) 1997-08-21
HK1067948A1 (en) 2005-04-22
KR100312473B1 (ko) 2002-06-24
EP1264836B1 (en) 2004-12-01
AU2353595A (en) 1995-11-29
EP0760375A1 (en) 1997-03-05

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20030423

Termination date: 20100502