ATE255121T1 - Antitumor-indolopyrolocarbazolderivat - Google Patents
Antitumor-indolopyrolocarbazolderivatInfo
- Publication number
- ATE255121T1 ATE255121T1 AT95917506T AT95917506T ATE255121T1 AT E255121 T1 ATE255121 T1 AT E255121T1 AT 95917506 T AT95917506 T AT 95917506T AT 95917506 T AT95917506 T AT 95917506T AT E255121 T1 ATE255121 T1 AT E255121T1
- Authority
- AT
- Austria
- Prior art keywords
- antitumor
- indolopyrolocarbazole
- derivative
- compounds
- chem
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
- C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11948394 | 1994-05-09 | ||
| JP14564894 | 1994-06-03 | ||
| PCT/JP1995/000868 WO1995030682A1 (en) | 1994-05-09 | 1995-05-02 | Antitumor indolopyprolocarbazole derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE255121T1 true ATE255121T1 (de) | 2003-12-15 |
Family
ID=26457215
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95917506T ATE255121T1 (de) | 1994-05-09 | 1995-05-02 | Antitumor-indolopyrolocarbazolderivat |
| AT02018235T ATE283863T1 (de) | 1994-05-09 | 1995-05-02 | Verfahren zur herstellung von indolopyrrolocarbazol-derivaten |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02018235T ATE283863T1 (de) | 1994-05-09 | 1995-05-02 | Verfahren zur herstellung von indolopyrrolocarbazol-derivaten |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP0760375B1 (enExample) |
| JP (1) | JP3038921B2 (enExample) |
| KR (1) | KR100312473B1 (enExample) |
| CN (2) | CN1106400C (enExample) |
| AT (2) | ATE255121T1 (enExample) |
| AU (1) | AU683749B2 (enExample) |
| CA (1) | CA2190007C (enExample) |
| CL (1) | CL2004001117A1 (enExample) |
| DE (2) | DE69532198T2 (enExample) |
| DK (2) | DK0760375T3 (enExample) |
| ES (2) | ES2230433T3 (enExample) |
| HK (1) | HK1000890A1 (enExample) |
| PT (2) | PT1264836E (enExample) |
| TW (1) | TW313566B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1541582A1 (en) * | 2002-08-23 | 2005-06-15 | Banyu Pharmaceutical Co., Ltd. | Process for producing indolopyrrolocarbazole derivative |
| CN101585861B (zh) * | 2009-07-03 | 2012-10-24 | 复旦大学 | N-糖基萘并咔唑化合物及其合成方法和应用 |
| WO2025082431A1 (zh) * | 2023-10-18 | 2025-04-24 | 正大天晴药业集团股份有限公司 | 一种吲哚衍生物治疗头颈部肿瘤的用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2015996C (en) * | 1989-05-05 | 2001-08-28 | Hartmut Osswald | Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals |
| EP0528030B1 (en) * | 1990-05-11 | 1997-09-17 | Banyu Pharmaceutical Co., Ltd. | Antitumor be-13793c derivative |
| NZ245203A (en) | 1991-11-29 | 1997-07-27 | Banyu Pharma Co Ltd | 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates |
| JP3603322B2 (ja) * | 1992-12-14 | 2004-12-22 | 萬有製薬株式会社 | インドロピロロカルバゾール誘導体の製造法 |
| WO1995034663A1 (en) * | 1994-06-13 | 1995-12-21 | Banyu Pharmaceutical Co., Ltd. | Gene coding for glycosyltransferase and use thereof |
| AU3086495A (en) * | 1994-08-02 | 1996-03-04 | Banyu Pharmaceutical Co., Ltd. | Antitumor indolopyrrolocarbazoles |
-
1995
- 1995-05-02 ES ES02018235T patent/ES2230433T3/es not_active Expired - Lifetime
- 1995-05-02 CA CA002190007A patent/CA2190007C/en not_active Expired - Fee Related
- 1995-05-02 DK DK95917506T patent/DK0760375T3/da active
- 1995-05-02 PT PT02018235T patent/PT1264836E/pt unknown
- 1995-05-02 DE DE69532198T patent/DE69532198T2/de not_active Expired - Fee Related
- 1995-05-02 HK HK97102485A patent/HK1000890A1/xx not_active IP Right Cessation
- 1995-05-02 KR KR1019960706296A patent/KR100312473B1/ko not_active Expired - Fee Related
- 1995-05-02 JP JP7528838A patent/JP3038921B2/ja not_active Expired - Fee Related
- 1995-05-02 EP EP95917506A patent/EP0760375B1/en not_active Expired - Lifetime
- 1995-05-02 ES ES95917506T patent/ES2206501T3/es not_active Expired - Lifetime
- 1995-05-02 CN CN95193830A patent/CN1106400C/zh not_active Expired - Fee Related
- 1995-05-02 DK DK02018235T patent/DK1264836T3/da active
- 1995-05-02 PT PT95917506T patent/PT760375E/pt unknown
- 1995-05-02 AU AU23535/95A patent/AU683749B2/en not_active Ceased
- 1995-05-02 EP EP02018235A patent/EP1264836B1/en not_active Expired - Lifetime
- 1995-05-02 AT AT95917506T patent/ATE255121T1/de not_active IP Right Cessation
- 1995-05-02 AT AT02018235T patent/ATE283863T1/de not_active IP Right Cessation
- 1995-05-02 CN CNB021469482A patent/CN1285605C/zh not_active Expired - Fee Related
- 1995-05-02 DE DE69533833T patent/DE69533833T2/de not_active Expired - Fee Related
- 1995-05-23 TW TW084105169A patent/TW313566B/zh not_active IP Right Cessation
-
2004
- 2004-05-18 CL CL200401117A patent/CL2004001117A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0760375T3 (da) | 2003-12-29 |
| PT760375E (pt) | 2004-04-30 |
| CN1106400C (zh) | 2003-04-23 |
| HK1000890A1 (en) | 2004-01-09 |
| ES2206501T3 (es) | 2004-05-16 |
| PT1264836E (pt) | 2005-02-28 |
| CA2190007A1 (en) | 1995-11-16 |
| CL2004001117A1 (es) | 2005-04-22 |
| EP1264836A1 (en) | 2002-12-11 |
| ES2230433T3 (es) | 2005-05-01 |
| CA2190007C (en) | 2003-04-15 |
| DE69533833T2 (de) | 2005-12-15 |
| DE69532198D1 (de) | 2004-01-08 |
| JP3038921B2 (ja) | 2000-05-08 |
| EP0760375A4 (en) | 2002-03-27 |
| CN1285605C (zh) | 2006-11-22 |
| KR970702869A (ko) | 1997-06-10 |
| DE69532198T2 (de) | 2004-08-26 |
| CN1153518A (zh) | 1997-07-02 |
| AU683749B2 (en) | 1997-11-20 |
| DK1264836T3 (da) | 2005-03-07 |
| CN1513865A (zh) | 2004-07-21 |
| ATE283863T1 (de) | 2004-12-15 |
| EP0760375B1 (en) | 2003-11-26 |
| DE69533833D1 (de) | 2005-01-05 |
| TW313566B (enExample) | 1997-08-21 |
| HK1067948A1 (en) | 2005-04-22 |
| KR100312473B1 (ko) | 2002-06-24 |
| EP1264836B1 (en) | 2004-12-01 |
| AU2353595A (en) | 1995-11-29 |
| EP0760375A1 (en) | 1997-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0760375 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |