CN110582509A - 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 - Google Patents

使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 Download PDF

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Publication number
CN110582509A
CN110582509A CN201880008928.0A CN201880008928A CN110582509A CN 110582509 A CN110582509 A CN 110582509A CN 201880008928 A CN201880008928 A CN 201880008928A CN 110582509 A CN110582509 A CN 110582509A
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antigen
membrane protein
domain
cell
chimeric membrane
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B·恩格斯
B·W·格兰达
C·吉马雷斯
A·洛
M·拉莫内斯
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Novartis AG
University of Pennsylvania Penn
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Novartis AG
University of Pennsylvania Penn
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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CN201880008928.0A 2017-01-31 2018-01-31 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 Pending CN110582509A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762452601P 2017-01-31 2017-01-31
US62/452,601 2017-01-31
PCT/US2018/016139 WO2018144535A1 (en) 2017-01-31 2018-01-31 Treatment of cancer using chimeric t cell receptor proteins having multiple specificities

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US (1) US20190375815A1 (https=)
EP (1) EP3577134A1 (https=)
JP (2) JP2020506700A (https=)
CN (1) CN110582509A (https=)
WO (1) WO2018144535A1 (https=)

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CN111484563A (zh) * 2020-04-30 2020-08-04 徐州医科大学附属医院 一种抗cd38嵌合抗原受体及其应用
CN113980136A (zh) * 2020-07-27 2022-01-28 中国科学院分子细胞科学卓越创新中心 一种包含具有Y/F突变的CD3ε胞内区的嵌合抗原受体及其用途
CN113980137A (zh) * 2020-07-27 2022-01-28 中国科学院分子细胞科学卓越创新中心 一种包含CD3ε胞内碱性氨基酸富集区基序的嵌合抗原受体及其用途
CN113980138A (zh) * 2021-08-11 2022-01-28 卡瑞济(北京)生命科技有限公司 EphA2嵌合抗原受体以及其用途
CN115776991A (zh) * 2020-05-07 2023-03-10 华夏英泰（北京）生物技术有限公司 改进的t细胞受体-共刺激分子嵌合物
CN115806625A (zh) * 2021-09-15 2023-03-17 广州百暨基因科技有限公司 T细胞限定表达的嵌合抗原受体及其应用
CN116041545A (zh) * 2022-12-12 2023-05-02 南方医科大学 一种靶向荧光素或生物素的通用型car及其应用
CN116478929A (zh) * 2023-04-07 2023-07-25 上海科棋药业科技有限公司 靶向bcma和cd19的双特异性car-t细胞
CN116724052A (zh) * 2020-08-20 2023-09-08 A2生物治疗股份有限公司 用于治疗ceacam阳性癌症的组合物和方法
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