CN110352247B - 用于增强基因表达的组合物和方法 - Google Patents

用于增强基因表达的组合物和方法 Download PDF

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CN110352247B
CN110352247B CN201780084622.9A CN201780084622A CN110352247B CN 110352247 B CN110352247 B CN 110352247B CN 201780084622 A CN201780084622 A CN 201780084622A CN 110352247 B CN110352247 B CN 110352247B
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nucleic acid
dlp
virus
sequence
rna
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CN110352247A (zh
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库尔特·艾弗·卡姆鲁德
温茂年
纳撒尼尔·斯蒂芬·王
詹森·德哈特
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Janssen Pharmaceuticals Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/10—Vectors comprising a special translation-regulating system regulates levels of translation
    • C12N2840/105—Vectors comprising a special translation-regulating system regulates levels of translation enhancing translation

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201780084622.9A 2016-12-05 2017-12-04 用于增强基因表达的组合物和方法 Active CN110352247B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662430250P 2016-12-05 2016-12-05
US62/430,250 2016-12-05
US201762486361P 2017-04-17 2017-04-17
US62/486,361 2017-04-17
US201762587954P 2017-11-17 2017-11-17
US62/587,954 2017-11-17
PCT/US2017/064561 WO2018106615A2 (en) 2016-12-05 2017-12-04 Compositions and methods for enhancing gene expression

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CN110352247A CN110352247A (zh) 2019-10-18
CN110352247B true CN110352247B (zh) 2024-06-28

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EP (1) EP3548625B1 (cg-RX-API-DMAC7.html)
JP (2) JP7788787B2 (cg-RX-API-DMAC7.html)
KR (1) KR102655641B1 (cg-RX-API-DMAC7.html)
CN (1) CN110352247B (cg-RX-API-DMAC7.html)
AU (1) AU2017372731B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019011661A2 (cg-RX-API-DMAC7.html)
CA (1) CA3045650A1 (cg-RX-API-DMAC7.html)
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