CN110291096A - 环状二核苷酸作为sting激动剂 - Google Patents

环状二核苷酸作为sting激动剂 Download PDF

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Publication number
CN110291096A
CN110291096A CN201780084645.XA CN201780084645A CN110291096A CN 110291096 A CN110291096 A CN 110291096A CN 201780084645 A CN201780084645 A CN 201780084645A CN 110291096 A CN110291096 A CN 110291096A
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compound
mmol
added
cancer
mixture
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Chinese (zh)
Inventor
G.C.比格南
P.肯诺利
J.P.爱德华兹
S.伊曼纽尔
S.拉克瑞
T.鲁
M.瑞施特
L.贝格曼
S.K.泰缇肯达
王广义
M.钟
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Janssen Biotech Inc
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Janssen Biotech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201780084645.XA 2016-11-25 2017-11-21 环状二核苷酸作为sting激动剂 Pending CN110291096A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662426350P 2016-11-25 2016-11-25
US62/426350 2016-11-25
US201762502983P 2017-05-08 2017-05-08
US62/502983 2017-05-08
US201762555232P 2017-09-07 2017-09-07
US62/555232 2017-09-07
PCT/US2017/062901 WO2018098203A1 (en) 2016-11-25 2017-11-21 Cyclic dinucleotides as sting agonists

Publications (1)

Publication Number Publication Date
CN110291096A true CN110291096A (zh) 2019-09-27

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CN201780084645.XA Pending CN110291096A (zh) 2016-11-25 2017-11-21 环状二核苷酸作为sting激动剂

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US (2) US11472830B2 (https=)
EP (1) EP3544989A1 (https=)
JP (2) JP7316936B2 (https=)
KR (1) KR20190085107A (https=)
CN (1) CN110291096A (https=)
AU (1) AU2017365158B2 (https=)
BR (1) BR112019010606A2 (https=)
CA (1) CA3044693A1 (https=)
JO (1) JOP20170188A1 (https=)
MX (1) MX2019006082A (https=)
TW (1) TW201831192A (https=)
UY (1) UY37495A (https=)
WO (1) WO2018098203A1 (https=)

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CN110234403A (zh) * 2017-01-27 2019-09-13 詹森生物科技公司 作为sting激动剂的环状二核苷酸
CN110234404A (zh) * 2017-01-27 2019-09-13 詹森生物科技公司 作为sting激动剂的环状二核苷酸

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CN110234404A (zh) * 2017-01-27 2019-09-13 詹森生物科技公司 作为sting激动剂的环状二核苷酸

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JP2022110131A (ja) 2022-07-28
US20180162899A1 (en) 2018-06-14
CA3044693A1 (en) 2018-05-31
UY37495A (es) 2018-05-31
JP7316936B2 (ja) 2023-07-28
JOP20170188A1 (ar) 2019-01-30
JP2020500862A (ja) 2020-01-16
EP3544989A1 (en) 2019-10-02
AU2017365158B2 (en) 2022-02-17
US20230144627A1 (en) 2023-05-11
WO2018098203A1 (en) 2018-05-31
TW201831192A (zh) 2018-09-01
BR112019010606A2 (pt) 2019-09-17
AU2017365158A1 (en) 2019-06-06
KR20190085107A (ko) 2019-07-17
MX2019006082A (es) 2019-11-12
US11472830B2 (en) 2022-10-18

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