JP7316936B2 - Stingアゴニストとしての環状ジヌクレオチド - Google Patents

Stingアゴニストとしての環状ジヌクレオチド Download PDF

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JP7316936B2
JP7316936B2 JP2019528031A JP2019528031A JP7316936B2 JP 7316936 B2 JP7316936 B2 JP 7316936B2 JP 2019528031 A JP2019528031 A JP 2019528031A JP 2019528031 A JP2019528031 A JP 2019528031A JP 7316936 B2 JP7316936 B2 JP 7316936B2
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JP2020500862A (ja
JP2020500862A5 (https=
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シー. ビグナン,ギルス
コノリー,ピーター
パトリック エドワーズ,ジェームス
エマニュエル,スチュアート
ラケール,シルヴィー
ルー,ティエンバオ
リヒター,マーク
ベイゲルマン,レオニード
クマール タティコンダ,サンソッシュ
ワン,グアンイ
ゾン,ミンホン
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ヤンセン バイオテツク,インコーポレーテツド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2019528031A 2016-11-25 2017-11-21 Stingアゴニストとしての環状ジヌクレオチド Active JP7316936B2 (ja)

Priority Applications (1)

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JP2022082784A JP2022110131A (ja) 2016-11-25 2022-05-20 Stingアゴニストとしての環状ジヌクレオチド

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662426350P 2016-11-25 2016-11-25
US62/426,350 2016-11-25
US201762502983P 2017-05-08 2017-05-08
US62/502,983 2017-05-08
US201762555232P 2017-09-07 2017-09-07
US62/555,232 2017-09-07
PCT/US2017/062901 WO2018098203A1 (en) 2016-11-25 2017-11-21 Cyclic dinucleotides as sting agonists

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JP2022082784A Division JP2022110131A (ja) 2016-11-25 2022-05-20 Stingアゴニストとしての環状ジヌクレオチド

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JP2020500862A JP2020500862A (ja) 2020-01-16
JP2020500862A5 JP2020500862A5 (https=) 2021-01-07
JP7316936B2 true JP7316936B2 (ja) 2023-07-28

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JP2022082784A Pending JP2022110131A (ja) 2016-11-25 2022-05-20 Stingアゴニストとしての環状ジヌクレオチド

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US (2) US11472830B2 (https=)
EP (1) EP3544989A1 (https=)
JP (2) JP7316936B2 (https=)
KR (1) KR20190085107A (https=)
CN (1) CN110291096A (https=)
AU (1) AU2017365158B2 (https=)
BR (1) BR112019010606A2 (https=)
CA (1) CA3044693A1 (https=)
JO (1) JOP20170188A1 (https=)
MX (1) MX2019006082A (https=)
TW (1) TW201831192A (https=)
UY (1) UY37495A (https=)
WO (1) WO2018098203A1 (https=)

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CN110291096A (zh) 2019-09-27
JP2022110131A (ja) 2022-07-28
US20180162899A1 (en) 2018-06-14
CA3044693A1 (en) 2018-05-31
UY37495A (es) 2018-05-31
JOP20170188A1 (ar) 2019-01-30
JP2020500862A (ja) 2020-01-16
EP3544989A1 (en) 2019-10-02
AU2017365158B2 (en) 2022-02-17
US20230144627A1 (en) 2023-05-11
WO2018098203A1 (en) 2018-05-31
TW201831192A (zh) 2018-09-01
BR112019010606A2 (pt) 2019-09-17
AU2017365158A1 (en) 2019-06-06
KR20190085107A (ko) 2019-07-17
MX2019006082A (es) 2019-11-12
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