CN110237157A - A kind of Chinese herbal and crude drugs preparations and preparation method thereof for treating influenza - Google Patents
A kind of Chinese herbal and crude drugs preparations and preparation method thereof for treating influenza Download PDFInfo
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Abstract
The present invention discloses a kind of Chinese herbal and crude drugs preparations and preparation method thereof for treating influenza, belongs to tcm field.The Chinese herbal and crude drugs preparations are made of 10-15 parts of houttuynia extract, 10-15 parts of Baical Skullcap root P.E, 10-15 parts of dandelion extract, 8-15 parts of rheum officinale, 5-10 parts of radix bupleuri, 5-10 parts of Fructus Forsythiae, 5-10 parts of ivory-white chirita herb, 5-10 parts of Randia cochinchinensis, 8-15 parts of dayflower, 8-15 parts of oriental wormwood, 10-30 parts of honey and 1-5 parts of bamboo rat oil.Preparation method be by rheum officinale, radix bupleuri, Fructus Forsythiae, ivory-white chirita herb, Randia cochinchinensis, dayflower and oriental wormwood after decocting twice, mix decocting liquid, after adding houttuynia extract, dandelion extract and Baical Skullcap root P.E mixing, the honey tempered is poured into again, side bevelling is stirred at circumference, after mixing up, it is uniform agglomerating, then rubbing adds a little bamboo rat oil and ball to obtain the final product.The formula of the invention is reasonable, and preparation method is simple, safe without toxic side effect, and drug residue free has no drug resistance, and bioavilability is high, has remarkable result to the treatment of influenza.
Description
Technical field
The present invention relates to tcm fields, and in particular to a kind of Chinese herbal and crude drugs preparations and preparation method thereof for treating influenza.
Background technique
Influenza (abbreviation influenza) be acute respiratory infection caused by influenza virus and a kind of infectiousness it is strong,
The fast disease of spread speed, high-incidence in all over the world, especially autumn and winter, clinical symptoms show as anxious high fever, whole body
Pain, significant respiratory symptom out of strength and slight, caused complication and the phenomena of mortality are very serious.The disease is by influenza disease
Poison causes, and can be divided into first (A), second (B), the third (C) three type, and Alphavirus antigenic variation frequent occurrence, infectiousness is big, propagates fast
Speed, easily occurs a wide range of popular, main through the air droplet, interpersonal contact or connects with contaminated article
Touching is propagated, therefore has the characteristics that infectiousness is strong, route of transmission is not easy to control, spread speed is fast, spread scope is wide.Influenza is easily simultaneously
Pneumonia, myocarditis, septicemia, meningitis etc. are sent out, will lead to multiple organ failure when serious and lethal.According to statistics, it is annual I
State is because of about 200,000 people of unnatural death number caused by influenza.
Chinese herbal medicine is China's tradition the most and naturally occurring medicinal material, and source resource is extremely abundant, price is relatively low
It is honest and clean, containing there are many natural chemical component and nutritional ingredients, such as tannin, saponin, alkaloid, organic acid, vitamin, mineral
Matter, microelement etc., these ingredients are in addition to having the effects that antibacterial, antiviral, anti-inflammatory and heat-clearing, additionally it is possible to improve immunization machine
Can, improve production performance, extra-nutrition and without side-effects etc., Chinese herbal and crude drugs preparations in terms of treat influenza with certain advantage,
Especially influenza virus is also easy to produce drug resistance, therefore, develop effect it is good, without drug resistance, it is without side-effects, be convenient for carrying and take
The drug for treating influenza is still the expectation of people.
Summary of the invention
Present invention aim to address problems of the prior art, provide a kind of formula rationally, curative effect is obvious, preparation
Method is simply and without side-effects, and can effectively cure the Chinese herbal and crude drugs preparations of influenza.
Raw material of the invention is all from Chinese herbal medicine, and science is configured to a kind of Chinese herbal and crude drugs preparations for treating influenza, this Chinese herbal medicine
Preparation has antibacterial, antiviral, anti-inflammatory, heat-clearing and raising immunity of organisms and other effects, and especially this pill is drug
Concentrate is made with extract formulation, not only there is decoction easily to absorb, quick characteristic, but also possess pill drug effect and hold
Long, save medicinal material, it is easy to carry with take the characteristics of, be treat influenza good medicine.
Purpose to realize the present invention, used technical solution are as follows:
A kind of Chinese herbal and crude drugs preparations for treating influenza, are made of following raw material: houttuynia extract, dandelion extract, radix scutellariae mention
Take object, rheum officinale, radix bupleuri, Fructus Forsythiae, ivory-white chirita herb, Randia cochinchinensis, dayflower, oriental wormwood, honey and bamboo rat oil.
Preferably, it is composed of the following parts by weight: 10-15 parts of houttuynia extract, Baical Skullcap root P.E 10-15
Part, 10-15 parts of dandelion extract, 8-15 parts of rheum officinale, 5-10 parts of radix bupleuri, 5-10 parts of Fructus Forsythiae, 5-10 parts of ivory-white chirita herb, Randia cochinchinensis 5-
10 parts, 8-15 parts of dayflower, 8-15 parts of oriental wormwood, 5-20 parts of honey and 1-5 parts of bamboo rat oil.
Preferably, the extracting method of the houttuynia extract are as follows: after drying cordate houttuynia, clay into power, addition has
Solvent extraction, and extract liquor is purified and is obtained；
The organic solvent is the one or more of toluene, methylene chloride and butanol.
Preferably, the extracting method of the dandelion extract are as follows: after drying dandelion, clay into power, be added organic
Solvent extraction, and extract liquor is purified and is obtained；
The organic solvent is the one or more of toluene, methylene chloride and butanol.
Preferably, the extracting method of Baical Skullcap root P.E are as follows: it after drying radix scutellariae, clays into power, organic solvent extraction is added,
And extract liquor is purified and is obtained；
The organic solvent is the one or more of toluene, methylene chloride and butanol.
Preferably, the bamboo rat oil be artificial feeding the reasonable slaughter of hoarybamboo rat after take its leaf fat refining gained.
The present invention also provides a kind of a kind of Chinese herbal and crude drugs preparations preparation methods for treating influenza, including following step as previously discussed
It is rapid:
(1) each component is weighed respectively according to each raw material weight number；
(2) drinking water is added in rheum officinale, radix bupleuri, Fructus Forsythiae, ivory-white chirita herb, Randia cochinchinensis, dayflower and oriental wormwood, after impregnating 20-30 minutes,
It adds water and does not cross drug, casserole is placed on stove fire and is decocted, after boiling 40-50 minutes, medical fluid is poured out, obtain first time medicine
Liquid；Warm water is added in casserole, is carried out second and is decocted, after boiling 30 minutes, pours out medical fluid, mix with first time medical fluid,
After natural cooling, after decocting twice, decocting liquid is mixed；
(3) after adding houttuynia extract, dandelion extract and Baical Skullcap root P.E mixing, then the honey tempered is poured into,
Side bevelling is stirred at circumference, and after mixing up, the both hands for taking food-grade gloves are uniform agglomerating in basin, then rubbing, then plus
Upper a little bamboo rat oil and ball to get.
The present invention also provides a kind of a kind of Chinese herbal and crude drugs preparations application methods for treating influenza as previously discussed, press every time
100mg/5 kg bodyweight p, it is 3 times a day, continuous to use 4-7 days.
Additionally, the present invention provides a kind of Chinese herbal and crude drugs preparations for treating influenza and applies in the drug of preparation treatment influenza.
Preferably, the Chinese herbal and crude drugs preparations of the treatment influenza are paste.
(1) cordate houttuynia is the herbal medicine that Chinese Pharmacopoeia is included, and herbal medicine source is the drying overground part of saururaceae plant houttuynia cordata
Point.Cordate houttuynia acrid flavour, it is cold, it is distributed in lung channel.Energy is clearing heat and detoxicating, sore, promoting urination and removing dampness, clearing away heat to cure dysentery, stomach strengthening and digestion promoting are treated in detumescence, uses
Controlling real heat, heat toxin, damp evil, disease heat is pulmonary abscess, sore swollen toxin, hemorrhoidal hemorrhage, the retention of heat in the spleen and stomach etc. suffered from.Modern pharmacology tests table
Bright, this product has the effects that antibacterial, antiviral, raising immunity of organisms, diuresis.
(2) dandelion alias dandelion, Po Poding, Hua Hualang etc., composite family herbaceos perennial.Dandelion plant
In contain a variety of health-nutrition ingredients such as taraxol, taraxacin, choline, organic acid, synanthrin.Nature and flavor are sweet, slight bitter, tremble with fear.Return
Liver, stomach meridian.There are diuresis, laxative, removing jaundice subcutaneous ulcer, cholagogue and other effects.For treating heat toxin, carbuncle swells, sore, internal carbuncle, red eye, swell pain, wet
The puckery pain of heat, jaundice, dribbling urination, cold, fever, acute tonsillitis and acute bronchitis etc..
(3) radix scutellariae, alias Radix Scutellariae, tsuchikane tea root are lamiaceae labiatae scutellaria herbaceos perennials.The root of radix scutellariae enters
Medicine, it is bitter, cold in nature, there are antibacterial, anti-inflammatory this effect, it can heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention and other effects.Cure mainly warm
Disease, the infection of the upper respiratory tract, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, threatened abortion, hypertension, carbuncle swells furuncle
The diseases such as sore.The clinical antibiotic property of radix scutellariae is better than the coptis, and does not develop drug resistance.
(4) rheum officinale be the perennial plant of a variety of polygonaceae Rheums be collectively referred to as and the title of Chinese medicine.With attacking product
Stagnant, clearing away damp-heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances and other effects.Cure mainly accumulation of heat in chest ruffian, damp-heat dysentery, hot eyes and abscess of throat etc..
(5) radix bupleuri is the dry root of umbelliferae bupleurum or radix bupleuri scorzoneraefolii.It is bitter in taste, it is slightly cold.Return liver, gallbladder channel.Effect
For in inducing diaphoresis, soothing the liver, rising Yang.For cold, fever, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, sub-official prolapses, rectal prolapse.
(6) Fructus Forsythiae is Dicotyledoneae, twists colored mesh, Oleaceae, Forsythia Vahl machaka.There is the clearing heat and detoxicating, carbuncle that disappears to dissipate
Knot, dispelling wind and heat from the body effect.It opens and lets out dissipating bind, be persons particularly liable to develop skin infection's panacea；Light floating, and clearing away the heart-fire and can the cool scattered part of the body cavity above the diaphragm housing the heart and lungs.Therefore this product is sore
Carbuncle swells poison and wind-warm syndrome from the beginning of key medicine.Can clearing away the heart-fire, solve sore, but can air-dispersing blood clotting it is poly-, have the function of carbuncle that disappears dissipating bind concurrently.
(7) ivory-white chirita herb, alias stone Radix Notoginseng, Shi Huer, perennial herb have thick rhizomes.Produce Chinese Guangdong the north, Guangxi
The north, Guizhou, the Hunan southeast, South Sichuan and east, West of Hubei Province.It is born in lime mountain forest on stone or limes marginis hayashishita, sea
Pull out 100-1500 meters.Civil herb hyoscine, has clearing lung and relieving cough equivalent.
(8) bamboo rat oil, Chinese medicine name, this product are Rodentia Rhizomyidae hoarybamboo rat, are inhabited under Chinese silvergrass clump or in bamboo grove.
It is food with bamboo shoots, Chinese silvergrass.Fat claims bamboo rat oil, can do medicine for external application.Scald, burn, mosquito or poisonous insect can be treated or poisonous insect bites
The caused diseases such as pain of itching, removing toxic substances, removing itching and pain after smearing.It is used as medicine with fat.Major function removing toxic substances apocenosis, myogenic pain relieving.
(9) Randia cochinchinensis, five potato leaf of alias, smelly Chinese wampee leaf cross bee saage, luxuriant young vanilla, are rutaceae Clausena excavata
Branches and leaves.Function is expelling wind and cold pathogens, promoting qi circulation and relieving pain, dehumidification swelling.Cure mainly cold, fever, malaria, stomachache, oedema, rheumatism joint
It is scorching.Fracture, bruise, eczema are controlled in external application.
(10) dayflower, alias ring dish, duck magpie grass, earrings grass, blue cauliflower, emerald green butterfly, triangle dish, three pod dishes, phyllostachys bambusoides
Grass, blue flower fishscale bamboo grass, lophatherum gracile, are the dry aerial parts of commelianaceae plant dayflower.Gas is micro-, lightly seasoned.Nature and flavor are sweet, light,
It is cold.Return lung, stomach, small intestinl channel.Effect is clearing heat and detoxicating, inducing diuresis for removing edema.For anemopyretic cold, hyperpyrexia, abscess of throat, oedema
Oliguria, puckery pain of heat gonorrhea, carbuncle, swelling and furuncle.
(11) oriental wormwood is the tender dry power grass with short of part, and more shrinkages are curled into bulk.Root lignifying, it is hard
Firmly, surface sepia, interior yellow-white.It grows thickly most seedling stems and petiole, it is thin such as line.It is about 3~10 centimetres.Leaf is two times pinniform depths
It splits, sliver is linear, apex trinacriform.Cauline leaf surface is close to drape over one's shoulders canescence young pilose antler.Soft such as suede.The micro- faint scent of gas, mildly bitter flavor.It is clear wet
Heat, removing jaundice subcutaneous ulcer.With antipyretic, antibacterial, antiviral and other effects, it to be used for jaundice oliguria, itchy sore；Infectious jaundice type hepatitis.
(12) honey is the honey that nectar that honeybee is adopted from the flowering plant's flowers is brewed in honeycomb.Blood can be improved
Ingredient promotes heart and brain and blood vessel function, and edible honey can make up rapidly physical strength, and elimination is tired out, builds up one's resistance to disease
Beneficial effects of the present invention:
1, raw material of the present invention is the Chinese herbal medicine of " integration of drinking and medicinal herbs ", safe without toxic side effect, pollution-free, drug residue free, without resistance to
Pharmacological property, bioavilability is high, significant in efficacy.Overcoming flu pharmaceutical currently on the market, to be also easy to produce drug resistance and side effect big
Disadvantage.
2, rationally, preparation method is simple, and product quality is more stable, and not only antiviral effect is good for formula, but also has anti-
Bacterium, anti-inflammatory, removing toxic substances and heat-clearing function, especially this pill be made of drug concentrate and extract formulation, not only
Easily absorbed with decoction, quick characteristic, and possess pill lasting medicine, save medicinal material, it is easy to carry with take
Feature is the good medicine for treating influenza.
3, clinical application proves, has significant curative effect to influenza, and without side-effects, and the body that people have been effectively ensured is strong
Health.
Detailed description of the invention
Fig. 1-5 is 4 safety testing result of embodiment；Fig. 1 administration group pharmaceutical quantities are 0mg/kg, Fig. 2 administration group pharmaceutical quantities
For 2500 mg/kg, Fig. 3 administration group pharmaceutical quantities are 5000 mg/kg, and Fig. 4 administration group pharmaceutical quantities are 10000 mg/kg, Fig. 5 administration
Group pharmaceutical quantities are 20000 mg/kg.
Fig. 6-7 is the PCR testing result that 7 Chinese materia medica preparation infected by influenza of embodiment inhibits test；
2000,1 M:Maker in Fig. 6: positive control, 2: negative control, 3-5: blank control group, 6-8: Tamiflu administration group, 9-
11:250 mg/kg prevention administration group, 12-14:500 mg/kg prevention administration group；
2000,1 M:Maker in Fig. 7: positive control, 2: negative control, 3-5:1000 mg/kg prevention administration group, 6-8: virus
Control group, 9-11:250 mg/kg therapeutic administratp group, 12-14:500 mg/kg therapeutic administratp group, 15-17:1000 mg/kg are controlled
Treat administration group.
Fig. 8-16 is the mouse weight result of variations that 7 Chinese materia medica preparation of embodiment inhibits test to infected by influenza；Fig. 8 is sky
White control group mice changes of weight, Fig. 9 are the variation of virus control group mouse weight, and Figure 10 is the change of Tamiflu control group mice weight
Change, Figure 11 is the variation of 250 mg/kg test group mouse weight of prevention administration, and Figure 12 is that 500 mg/kg test group of prevention administration is small
Mouse changes of weight, Figure 13 are the variation of 1000 mg/kg test group mouse weight of prevention administration, and Figure 14 is 250 mg/kg of therapeutic administratp
The variation of test group mouse weight, Figure 15 are the variation of 500 mg/kg test group mouse weight of therapeutic administratp, and Figure 16 is therapeutic administratp
The variation of 1000 mg/kg test group mouse weights.(note: 3 progress viral diagnosis are slaughtered because of every group at the 6th day, often
Group only has the changes of weight of 5 mouse).
Specific embodiment
The present invention program is described in further detail below with reference to embodiment, following the description is merely to explain this hair
It is bright, its content is not defined.Experimental method used in following embodiments is conventional side unless otherwise specified
Method, material as used in the following examples, reagent etc., is commercially available unless otherwise specified.
Embodiment 1 prepares a kind of Chinese herbal and crude drugs preparations for treating influenza
A kind of Chinese herbal and crude drugs preparations for treating influenza, preparation the following steps are included:
(1) component is weighed according to following parts by weight: 10 g of houttuynia extract, 10 g of dandelion extract, Baical Skullcap root P.E
10 g, 8 g of rheum officinale, 10 g of radix bupleuri, 10 g of Fructus Forsythiae, 10 g of ivory-white chirita herb, 10 g of Randia cochinchinensis, 8 g of dayflower, 8 g of oriental wormwood,
1 g of 5 g of honey and bamboo rat oil.
(2) drinking water is added in rheum officinale, radix bupleuri, Fructus Forsythiae, ivory-white chirita herb, Randia cochinchinensis, dayflower and oriental wormwood, impregnates 20-30 points
Zhong Hou is added water and is not crossed drug, casserole is placed on stove fire and is decocted, after boiling 40-50 minutes, medical fluid is poured out, and obtains first
Secondary medical fluid；Warm water is added in casserole, is carried out second and is decocted, after boiling 30 minutes, pours out medical fluid, it is mixed with first time medical fluid
It closes, after natural cooling, after decocting twice, mixes decocting liquid.
(3) after adding houttuynia extract, dandelion extract and Baical Skullcap root P.E mixing, then the bee tempered is poured into
Honey, side bevelling is stirred at circumference, and after mixing up, the both hands for taking food-grade gloves are uniform agglomerating in basin, then rubbing, then
In addition a little bamboo rat oil and ball are to obtain the final product, every 100 mg of ball.
Embodiment 2
(1) weigh component according to following parts by weight: houttuynia extract 15g, dandelion extract 15g, Baical Skullcap root P.E 15g,
Rheum officinale 15g, radix bupleuri 5g, Fructus Forsythiae 5g, ivory-white chirita herb 5g, Randia cochinchinensis 5g, dayflower 15g, oriental wormwood 15g, honey 20g and bamboo rat oil 5g.
(2) drinking water is added in rheum officinale, radix bupleuri, Fructus Forsythiae, ivory-white chirita herb, Randia cochinchinensis, dayflower and oriental wormwood, impregnates 20-30 points
Zhong Hou is added water and is not crossed drug, casserole is placed on stove fire and is decocted, after boiling 40-50 minutes, medical fluid is poured out, and obtains first
Secondary medical fluid；Warm water is added in casserole, is carried out second and is decocted, after boiling 30 minutes, pours out medical fluid, it is mixed with first time medical fluid
It closes, after natural cooling, after decocting twice, mixes decocting liquid.
(3) after adding houttuynia extract, dandelion extract and Baical Skullcap root P.E mixing, then the bee tempered is poured into
Honey, side bevelling Cheng Yuanzhou agitation, after mixing up, with the both hands of disinfection in basin and be one, then rubbing, in addition a little bamboo rat is oily
To obtain the final product with ball, every 100 mg of ball.
Embodiment 3
(1) component is weighed according to following parts by weight: 12 g of houttuynia extract, 12 g of dandelion extract, Baical Skullcap root P.E
12 g, 10 g of rheum officinale, radix bupleuri 8g, Fructus Forsythiae 8g, 8 g of ivory-white chirita herb, 8 g of Randia cochinchinensis, 10 g of dayflower, 10 g of oriental wormwood, honey
3 g of 10 g and bamboo rat oil.
(2) drinking water is added in rheum officinale, radix bupleuri, Fructus Forsythiae, ivory-white chirita herb, Randia cochinchinensis, dayflower and oriental wormwood, impregnates 20-30 points
Zhong Hou is added water and is not crossed drug, casserole is placed on stove fire and is decocted, after boiling 40-50 minutes, medical fluid is poured out, and obtains first
Secondary medical fluid；Warm water is added in casserole, is carried out second and is decocted, after boiling 30 minutes, pours out medical fluid, it is mixed with first time medical fluid
It closes, after natural cooling, after decocting twice, mixes decocting liquid.
(3) after adding houttuynia extract, dandelion extract and Baical Skullcap root P.E mixing, then the bee tempered is poured into
Honey, side bevelling is stirred at circumference, and after mixing up, the both hands for taking food-grade gloves are uniform agglomerating in basin, then rubbing, then
In addition a little bamboo rat oil and ball are to obtain the final product, every 100 mg of ball.
Application example
4 safety experiment of embodiment
Acute toxicity test of the Chinese herbal and crude drugs preparations for the treatment of influenza prepared by the embodiment of the present invention 1 to mouse, using step and
Effect is as follows:
(1) small white mouse kind mouse 50, half male and half female are taken, every weight about 18-20 g, is randomly divided into 5 groups by every group 10,
I.e. (administration group pharmaceutical quantities are respectively 0,2500,5000,10000 and 20000 mg/kg bodies for blank control group and 4 administration groups
Weight).Administration 6 h fasting (free water) of front and back, the scale of construction that test group presses every small white mouse calculate dosage, metal irrigation stomach device
Disposable gastric infusion.Control group small white mouse keeps being freely eaten and drink water.
(2) result.It is observed that 5 groups of mouse do not reveal any abnormalities reaction, skin, stool, breathing, four limbs activity,
Behavior etc. does not reveal any abnormalities phenomenon；Weight loss after mouse medicine feed, the 2nd day starts to restore, and weight becomes in rising
Gesture (see Fig. 1-5), each group does not have dead mouse.The result shows that the pill is without any side effects to Mouse oral medication.
The test of 5 antipyretic response of embodiment
The Chinese herbal and crude drugs preparations for the treatment of influenza prepared by the embodiment of the present invention 1 test antipyretic response, such as using step and effect
Under:
(1) Wistar rat is chosen.Choose the observation sample that 30 Wistar male rats are studied as this group, every weight
About 240 g；And blank group, model group and administration group each 10 are divided into according to the basal body temperature of rat；Model group with give
Medicine group.
(2) experimentation.Blank group, model group and administration group each 10 are divided into according to the basal body temperature of rat.
12 h are deprived of food but not water before experiment, 1h administration group preventive administration (is spaced 0. 5 h) twice before modeling, by 500 mg/
Isometric distilled water is given in kg (grounds travel dosage) gastric infusion, blank group and model group filling.After 2nd administration, remove
Outer remaining each group dorsal sc injection 2,4-DNP (20 mg/kg) manufacture fever model of blank group, every 2
ML, Normal group inject isometric physiological saline.0. 5,1,2,3 h measure rat anus temperature after modeling.
(3) result.It the results are shown in Table 1 according to the temperature recording measured.The result shows that administration group rat when 0.5 h after modeling
Body temperature be in raising trend, subsequent body temperature is gradually reduced, and rat temperature can be greatly lowered with modeling group, there is good antipyretic work
With.
Table 1. is to the antipyretic test result of rat
The test of 6 anti-inflammatory effects of embodiment
The Chinese herbal and crude drugs preparations anti-inflammatory effects for the treatment of influenza prepared by the embodiment of the present invention 1 are tested, as follows using step and effect:
(1) mice group.Kunming mouse 24 are taken, half male and half female is randomly divided into 2 groups, and one group is control group, Tu Shengli
Salt water, another group is test group, takes orally Chinese herbal and crude drugs preparations.
(2) it tests.Chinese herbal and crude drugs preparations are given in oral stomach-filling to test group mouse respectively, by 500 mg/kg, 1 time a day, continuously
Administration 5 days；The physiological saline of equivalent is given in control group stomach-filling.0. 05 mL dimethylbenzene are applied to by 40 min after the last administration
Each left ear two sides of mouse (each 0. 025 mL in side) cause inflammation, cause 60 min after inflammation to put to death mouse, are existed with 8 mm punch
Mouse or so auricle same area lays auricle, and electronic analytical balance claims quality, and the difference of left and right auricle quality is swelling.
(3) result.Two ear weight differences are swelling, significant with physiological saline group comparing difference, the results showed that Chinese herbal medicine system
Agent can obviously inhibit auricular concha acute inflammation (see Table 2) caused by dimethylbenzene.
Table 2. is to mouse inflammatory effect test result
The test of 7 HIV suppression of embodiment
A kind of Chinese herbal and crude drugs preparations infected by influenza for treating influenza prepared by the embodiment of the present invention 1 inhibits test, uses step
It is as follows with effect:
(1) H1N1 influenza virus GX6 plants of mouse median lethal dose LD50Measurement
Experiment points 7 groups, every group of 8 female BAl BIcs/c mouse, 6-8 week old, weight 18-20g, the cell toxicant that stablize potency be 26
As former poison, since former poison successively 10 times be diluted to 10-5 Connect malicious BALB/c mouse.Control group is set simultaneously.
It is handled before connecing poison with dry ice, after mouse syncope, using the method for collunarium, is grouped according to different virus, every
Mouse awards the virus quantity of 50 μ L.Connect every day entry changes of weight after poison, death condition, after record observation 14 days, according to
LD is calculated in Reed&Muench method50。
As a result H1N1 influenza virus GX6 plants of mouse median lethal dose LD50It is 10-3.58。
(2) pharmacodynamic test
Test grouping.BALB/c mouse kind mouse 72, half male and half female are taken, every weight about 18-20 g is randomly divided into 9
Group.1st group is blank control group, and the 2nd group is virus control group；3rd group is Tamiflu administration group, and the Tamiflu concentration of administration is 50
mg/kg；4th, 5 and 6 group is prevention administration group, and dosage is respectively 250,500 and 1000 mg/kg respectively；7th, 8 and 9 group
It is therapeutic administratp group, dosage is respectively 250,500 and 1000 mg/kg.
Attack poison.1st and the 2nd day, the 4th, 5 and 6 group of prevention administration group, respectively by formulate dosage take orally perfusion, daily 2
Secondary, other groups are normally raised.It connects poison within 3rd day, is first anaesthetized with dry ice, after mouse syncope, using the method for collunarium, the 1st group is connect
50 μ L physiological saline；1st to the 9th group, GX6 plants of H1N1 influenza virus are inoculated with, every connects malicious concentration by 5 LD50Malicious mouse is connect, often
Only 50 μ L.
Administration.1st and the 2nd group is not administered；4th, 5 and 6 group of prevention administration group is filled by the dosage formulated is oral respectively
Medicine is then administered 6 days 2 times a day.2nd day is attacked after poison, and the 3rd group oral to feed Tamiflu, and the concentration of administration is 50 mg/kg, often
It is it 1 time, continuous to feed 7 days；7th, 8 and 9 group, Chinese herbal and crude drugs preparations are fed, perfusion is taken orally by the dosage formulated respectively and connects 2 times a day
Administration 7 days.
Record.See whether symptom (including coat is in disorder, and spirit is depressed, and the back of a bow is rolled up) occur, weighing records daily
Dead, weight, body temperature, diet, mental status are observed continuously 14 days.And the 6th day after attacking poison, every group takes 3 mouse to flutter at random
It kills, lung tissue is taken to carry out viral diagnosis.
Organize viral diagnosis.The lung tissue of acquirement weighs and physiological saline, beveller is added according to the ratio of 20% emulsion
Completely, the speed of 2000 r/min is centrifuged 3min for grinding, takes supernatant, carries out viral diagnosis with PCR.
(3) result
1. PCR testing result.Virus control group, Tamiflu administration group, 250 mg/kg prevention administration groups, 250 mg/kg therapeutic administratps
The influenza nucleic acids positive is detected in the mouse lung tissue of group and 500 mg/kg therapeutic administratp groups, remaining group is all negative
(see Fig. 6 and Fig. 7).The result shows that 500 mg/kg, 1000 mg/kg prevention administration groups and 1000 mg/kg therapeutic administratp group convection current
Influenza Virus proliferation inhibiting effect in Mice Body is obvious, and prophylactic becomes apparent from than treatment medication effect.
2. changes of weight.Virus control group all mouse at the 8th day are all dead；Blank control group, 500 mg/kg are pre-
The mouse body on day 4 of anti-administration group, 1000 mg/kg prevention administration groups, 1000 mg/kg therapeutic administratp groups and Tamiflu administration group
Bottom out again restored normal at the 7-14 days；The mouse of 250 mg/kg prevention administration groups and 500 mg/kg therapeutic administratp groups
Still there is 1 death, remaining 4 were restored normal at the 7-14 days；The mouse of 250 mg/kg therapeutic administratp groups still has 2 death,
Remaininging in 3 has 2 to restore normal at the 7-14 days, and weight is still without recovery when another 1 off-test (be shown in Fig. 8-16).As a result
Show that the Chinese herbal and crude drugs preparations for treating influenza have influenza and prevents and treats effect well.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
The change or replacement expected without creative work, should be covered by the protection scope of the present invention.Therefore, of the invention
Protection scope should be determined by the scope of protection defined in the claims.
Claims (9)
1. a kind of Chinese herbal and crude drugs preparations for treating influenza, which is characterized in that be made of following raw material: houttuynia extract, dandelion
Extract, Baical Skullcap root P.E, rheum officinale, radix bupleuri, Fructus Forsythiae, ivory-white chirita herb, Randia cochinchinensis, dayflower, oriental wormwood, honey and bamboo rat oil.
2. treating the Chinese herbal and crude drugs preparations of influenza according to claim 1, which is characterized in that by the raw material group of following parts by weight
At: 10-15 parts of houttuynia extract, 10-15 parts of Baical Skullcap root P.E, 10-15 parts of dandelion extract, 8-15 parts of rheum officinale, radix bupleuri
5-10 parts, 5-10 parts of Fructus Forsythiae, 5-10 parts of ivory-white chirita herb, 5-10 parts of Randia cochinchinensis, 8-15 parts of dayflower, 8-15 parts of oriental wormwood, honey 5-20
Part and 1-5 parts of bamboo rat oil.
3. treating the Chinese herbal and crude drugs preparations of influenza according to claim 2, which is characterized in that the houttuynia extract mentions
Take method are as follows: after drying cordate houttuynia, clay into power, organic solvent extraction is added, and extract liquor is purified and is obtained；
The organic solvent is the one or more of toluene, methylene chloride and butanol.
4. treating the Chinese herbal and crude drugs preparations of influenza according to claim 2, which is characterized in that the extraction of the dandelion extract
Method are as follows: after drying dandelion, clay into power, organic solvent extraction is added, and extract liquor is purified and is obtained；
The organic solvent is the one or more of toluene, methylene chloride and butanol.
5. treating the Chinese herbal and crude drugs preparations of influenza according to claim 2, which is characterized in that the extracting method of Baical Skullcap root P.E
Are as follows: it after drying radix scutellariae, clays into power, organic solvent extraction is added, and extract liquor is purified and is obtained；
The organic solvent is the one or more of toluene, methylene chloride and butanol.
6. a kind of preparation method of the Chinese herbal and crude drugs preparations of the influenza for the treatment of as claimed in claim 2, which is characterized in that including following step
It is rapid:
(1) each component is weighed respectively according to each raw material weight number；
(2) drinking water is added in rheum officinale, radix bupleuri, Fructus Forsythiae, ivory-white chirita herb, Randia cochinchinensis, dayflower and oriental wormwood, after impregnating 20-30 minutes,
It adds water and does not cross drug, casserole is placed on stove fire and is decocted, after boiling 40-50 minutes, medical fluid is poured out, obtain first time medicine
Liquid；Warm water is added in casserole, is carried out second and is decocted, after boiling 30 minutes, pours out medical fluid, mix with first time medical fluid,
After natural cooling, after decocting twice, decocting liquid is mixed；
(3) after adding houttuynia extract, dandelion extract and Baical Skullcap root P.E mixing, then the honey tempered is poured into,
Side bevelling is stirred at circumference, after mixing up, it is uniform agglomerating, then rubbing, add bamboo rat oil and ball to get.
7. a kind of application method for the Chinese herbal and crude drugs preparations for treating influenza as described in claim 1-5 any one, feature exist
In each continuously to be taken 4-7 days 3 times a day by 100 mg/5 kg bodyweight ps.
8. a kind of Chinese herbal and crude drugs preparations for treating influenza as described in claim 1-5 any one are in the drug of preparation treatment influenza
Using.
9. a kind of Chinese herbal and crude drugs preparations for treating influenza as described in claim 1-5 any one, which is characterized in that the treatment stream
The Chinese herbal and crude drugs preparations of sense are paste.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883651A (en) * | 2006-05-24 | 2006-12-27 | 佛山冯了性药业有限公司 | Chinese medicinal composition for treating wind-heat cold and preparation method thereof |
| CN107019739A (en) * | 2016-08-30 | 2017-08-08 | 河南牧翔动物药业有限公司 | Blue oral liquid of a kind of cordate houttuynia a kind of reed mentioned in ancient books and preparation method thereof and product quality control method |
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2019
- 2019-05-28 CN CN201910451109.XA patent/CN110237157B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883651A (en) * | 2006-05-24 | 2006-12-27 | 佛山冯了性药业有限公司 | Chinese medicinal composition for treating wind-heat cold and preparation method thereof |
| CN107019739A (en) * | 2016-08-30 | 2017-08-08 | 河南牧翔动物药业有限公司 | Blue oral liquid of a kind of cordate houttuynia a kind of reed mentioned in ancient books and preparation method thereof and product quality control method |
Non-Patent Citations (1)
| Title |
|---|
| 陈利民等: "退热合剂治疗甲型H1N1流感发热疗效观察", 《中国中医药信息杂志》 * |
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