CN110214141B - 作为ENaC抑制剂的苯并二唑鎓化合物 - Google Patents

作为ENaC抑制剂的苯并二唑鎓化合物 Download PDF

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Publication number
CN110214141B
CN110214141B CN201780084165.3A CN201780084165A CN110214141B CN 110214141 B CN110214141 B CN 110214141B CN 201780084165 A CN201780084165 A CN 201780084165A CN 110214141 B CN110214141 B CN 110214141B
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amino
methyl
pyrrolo
pyrazin
carboxamido
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Chinese (zh)
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CN110214141A (zh
Inventor
C·麦卡锡
J·D·哈格雷夫
D·A·哈伊
T·B·斯科菲尔德
N·温特
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Enterprise Therapeutics Ltd
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Enterprise Therapeutics Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780084165.3A 2016-11-22 2017-11-22 作为ENaC抑制剂的苯并二唑鎓化合物 Active CN110214141B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1619694.1 2016-11-22
GBGB1619694.1A GB201619694D0 (en) 2016-11-22 2016-11-22 Compounds
PCT/GB2017/053499 WO2018096325A1 (en) 2016-11-22 2017-11-22 Benzodiazolium compounds as enac inhibitors

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CN110214141A CN110214141A (zh) 2019-09-06
CN110214141B true CN110214141B (zh) 2022-05-31

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EP (1) EP3544981B1 (enExample)
JP (1) JP6980014B2 (enExample)
KR (1) KR102517273B1 (enExample)
CN (1) CN110214141B (enExample)
AU (1) AU2017364308B2 (enExample)
CA (1) CA3043132A1 (enExample)
DK (1) DK3544981T3 (enExample)
EA (1) EA039607B1 (enExample)
ES (1) ES2890226T3 (enExample)
GB (1) GB201619694D0 (enExample)
HU (1) HUE055692T2 (enExample)
IL (1) IL266745B (enExample)
MA (1) MA46878A (enExample)
MX (1) MX389496B (enExample)
PL (1) PL3544981T3 (enExample)
PT (1) PT3544981T (enExample)
TW (1) TWI756305B (enExample)
WO (1) WO2018096325A1 (enExample)
ZA (1) ZA201902710B (enExample)

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* Cited by examiner, † Cited by third party
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GB201610854D0 (en) 2016-06-21 2016-08-03 Entpr Therapeutics Ltd Compounds
GB201619694D0 (en) 2016-11-22 2017-01-04 Entpr Therapeutics Ltd Compounds
GB201717051D0 (en) * 2017-10-17 2017-11-29 Enterprise Therapeutics Ltd Compounds
GB201801355D0 (en) 2018-01-26 2018-03-14 Enterprise Therapeutics Ltd Compounds
GB201808093D0 (en) * 2018-05-18 2018-07-04 Enterprise Therapeutics Ltd Compounds
GB201908453D0 (en) 2019-06-12 2019-07-24 Enterprise Therapeutics Ltd Compounds for treating respiratory disease
AU2020290049A1 (en) 2019-06-12 2022-02-03 Tmem16A Limited Compounds for treating respiratory disease
GB201910608D0 (en) 2019-07-24 2019-09-04 Enterprise Therapeutics Ltd Compounds
JP2023552638A (ja) 2020-12-11 2023-12-18 ティーエムイーエム１６エー リミテッド 呼吸器疾患を治療するためのベンゾイミダゾール誘導体
CN118852442A (zh) 2023-04-26 2024-10-29 上海麦科思生物医药有限公司 抗ptk7抗体及其用途
GB202406247D0 (en) 2024-05-03 2024-06-19 Enterprise Therapeutics Ltd Compounds and pharmaceutical compositions

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IL266745A (en) 2019-07-31
US12371436B2 (en) 2025-07-29
US10941149B2 (en) 2021-03-09
MX389496B (es) 2025-03-20
KR20190084076A (ko) 2019-07-15
ES2890226T3 (es) 2022-01-18
TWI756305B (zh) 2022-03-01
KR102517273B1 (ko) 2023-04-03
WO2018096325A1 (en) 2018-05-31
PL3544981T3 (pl) 2021-12-20
US20210147432A1 (en) 2021-05-20
CA3043132A1 (en) 2018-05-31
GB201619694D0 (en) 2017-01-04
MA46878A (fr) 2019-10-02
JP2019535747A (ja) 2019-12-12
CN110214141A (zh) 2019-09-06
US20250304590A1 (en) 2025-10-02
NZ753048A (en) 2024-09-27
EP3544981A1 (en) 2019-10-02
BR112019009864A2 (pt) 2019-08-27
EA201991253A1 (ru) 2019-11-29
AU2017364308A1 (en) 2019-05-23
PT3544981T (pt) 2021-09-23
TW201833111A (zh) 2018-09-16
JP6980014B2 (ja) 2021-12-15
EA039607B1 (ru) 2022-02-16
AU2017364308B2 (en) 2021-03-11
DK3544981T3 (da) 2021-09-20
US20190315757A1 (en) 2019-10-17
MX2019005934A (es) 2019-11-12
IL266745B (en) 2021-12-01
US11739094B2 (en) 2023-08-29
ZA201902710B (en) 2021-10-27
EP3544981B1 (en) 2021-06-23
US20240067653A1 (en) 2024-02-29
HUE055692T2 (hu) 2021-12-28

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